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Volumn 1, Issue 5, 2008, Pages 633-639

High expression of enhancer of zeste homologue 2 indicates poor prognosis in patients with soft tissue sarcomas

Author keywords

EZH2; Ki 67; Prognostic factor; Soft tissue sarcoma

Indexed keywords

ANTINEOPLASTIC AGENT; ENHANCER OF ZESTE HOMOLOGUE 2; KI 67 ANTIGEN; POLYCOMB GROUP PROTEIN; UNCLASSIFIED DRUG;

EID: 69449103976     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr_00000004     Document Type: Article
Times cited : (7)

References (47)
  • 2
    • 0033061037 scopus 로고    scopus 로고
    • Multifactorial analysis of long-term follow-up (more than 5 years) of primary extremity sarcoma
    • DOI 10.1001/archsurg.134.2.190
    • Lewis JJ, Leung D, Casper ES, Woodruff J, Hajdu SI and Brennan MF: Multifactorial analysis of long-term follow-up (more than 5 years) of primary extremity sarcoma. Arch Surg 134: 190-194, 1999. (Pubitemid 29088973)
    • (1999) Archives of Surgery , vol.134 , Issue.2 , pp. 190-194
    • Lewis, J.J.1    Leung, D.2    Casper, E.S.3    Woodruff, J.4    Hajdu, S.I.5    Brennan, M.F.6
  • 3
    • 0033014663 scopus 로고    scopus 로고
    • Prognostic factors in soft tissue sarcoma
    • DOI 10.1002/(SICI)1098-2388(199907/08)17:1<23::AID-SSU4>3.0.CO;2-R
    • Levine EA: Prognostic factors in soft tissue sarcoma. Semin Surg Oncol 17: 23-32, 1999. (Pubitemid 29305113)
    • (1999) Seminars in Surgical Oncology , vol.17 , Issue.1 , pp. 23-32
    • Levine, E.A.1
  • 5
    • 24344451265 scopus 로고    scopus 로고
    • Improved prognostication in soft tissue sarcoma: Independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays
    • DOI 10.1016/j.humpath.2005.07.008, PII S0046817705003394
    • Engellau J, Bendahl PO, Persson A, et al: Improved prognostication in soft tissue sarcoma: independent information from vascular invasion, necrosis, growth pattern, and immunostaining using whole-tumor sections and tissue microarrays. Hum Pathol 36: 994-1002, 2005. (Pubitemid 41253386)
    • (2005) Human Pathology , vol.36 , Issue.9 , pp. 994-1002
    • Engellau, J.1    Bendahl, P.-O.2    Persson, A.3    Domanski, H.A.4    Akerman, M.5    Gustafson, P.6    Alvegard, T.A.7    Nilbert, M.8    Rydholm, A.9
  • 6
    • 13744252792 scopus 로고    scopus 로고
    • Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence
    • preceding table
    • Engellau J: Prognostic factors in soft tissue sarcoma. Tissue microarray for immunostaining, the importance of whole-tumor sections and time-dependence. Acta Orthop Scand 75 (Suppl): 2 p preceding table, 2004.
    • (2004) Acta Orthop Scand , vol.75 , Issue.SUPPL.
    • Engellau, J.1
  • 7
    • 0033987998 scopus 로고    scopus 로고
    • Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma
    • Hasegawa T, Yokoyama R, Lee YH, Shimoda T, Beppu Y and Hirohashi S: Prognostic relevance of a histological grading system using MIB-1 for adult soft-tissue sarcoma. Oncology 58: 66-74, 2000. (Pubitemid 30045312)
    • (2000) Oncology , vol.58 , Issue.1 , pp. 66-74
    • Hasegawa, T.1    Yokoyama, R.2    Lee, Y.H.3    Shimoda, T.4    Beppu, Y.5    Hirohashi, S.6
  • 8
    • 33845933502 scopus 로고    scopus 로고
    • Reassessment of the 1993 Osaka grading system for localized soft tissue sarcoma in Japan
    • Tomita Y, Morooka T, Hoshida Y, et al: Reassessment of the 1993 Osaka grading system for localized soft tissue sarcoma in Japan. Anticancer Res 26: 4665-4669, 2006.
    • (2006) Anticancer Res , vol.26 , pp. 4665-4669
    • Tomita, Y.1    Morooka, T.2    Hoshida, Y.3
  • 9
    • 0037103001 scopus 로고    scopus 로고
    • Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk
    • DOI 10.1002/cncr.10728
    • Hasegawa T, Yamamoto S, Yokoyama R, Umeda T, Matsuno Y and Hirohashi S: Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 95: 843-851, 2002. (Pubitemid 34839677)
    • (2002) Cancer , vol.95 , Issue.4 , pp. 843-851
    • Hasegawa, T.1    Yamamoto, S.2    Yokoyama, R.3    Umeda, T.4    Matsuno, Y.5    Hirohashi, S.6
  • 10
    • 15644366857 scopus 로고    scopus 로고
    • Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: A retrospective immunohistological study including 216 soft tissue sarcomas
    • DOI 10.1046/j.1365-2559.1998.t01-1-00425.x
    • Jensen V, Sorensen FB, Bentzen SM, et al: Proliferative activity (MIB-1 index) is an independent prognostic parameter in patients with high-grade soft tissue sarcomas of subtypes other than malignant fibrous histiocytomas: a retrospective immuno-histological study including 216 soft tissue sarcomas. Histopathology 32: 536-546, 1998. (Pubitemid 28277554)
    • (1998) Histopathology , vol.32 , Issue.6 , pp. 536-546
    • Jensen, V.1    Brandt Sorensen, F.2    Bentzen, S.M.3    Ladekarl, M.4    Steen Nielsen, O.5    Keller, J.6    Jensen, O.M.7
  • 11
    • 0025215271 scopus 로고
    • The relevance of the DNA index and proliferation rate in the grading of benign and malignant soft tissue tumors
    • Kroese MC, Rutgers DH, Wils IS, van Unnik JA and Roholl PJ: The relevance of the DNA index and proliferation rate in the grading of benign and malignant soft tissue tumors. Cancer 65: 1782-1788, 1990.
    • (1990) Cancer , vol.65 , pp. 1782-1788
    • Kroese, M.C.1    Rutgers, D.H.2    Wils, I.S.3    Van Unnik, J.A.4    Roholl, P.J.5
  • 14
    • 27144432661 scopus 로고    scopus 로고
    • Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: Role of laparoscopy and core needle biopsy
    • DOI 10.1007/s00464-004-2094-6
    • Musella M, Fazioli F, Lombardi S, et al: Assessment of cyclin D1 overexpression as a prognostic factor in soft tissue sarcomas: role of laparoscopy and core needle biopsy. Surg Endosc 19: 1120-1124, 2005. (Pubitemid 41494832)
    • (2005) Surgical Endoscopy , vol.19 , Issue.8 , pp. 1120-1124
    • Musella, M.1    Fazioli, F.2    Lombardi, S.3    Servodio, C.I.4    De Martino, C.5    Iacono, V.6    Cigala, F.7    Jovino, R.8
  • 17
    • 20244389571 scopus 로고    scopus 로고
    • Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: A clinicopathologic study of 281 cases
    • Sato O, Wada T, Kawai A, et al: Expression of epidermal growth factor receptor, ERBB2 and KIT in adult soft tissue sarcomas: a clinicopathologic study of 281 cases. Cancer 103: 1881-1890, 2005.
    • (2005) Cancer , vol.103 , pp. 1881-1890
    • Sato, O.1    Wada, T.2    Kawai, A.3
  • 20
    • 24344464300 scopus 로고    scopus 로고
    • Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas
    • DOI 10.1158/1078-0432.CCR-05-0548
    • Weng WH, Ahlen J, Astrom K, Lui WO and Larsson C: Prognostic impact of immunohistochemical expression of ezrin in highly malignant soft tissue sarcomas. Clin Cancer Res 11: 6198-6204, 2005. (Pubitemid 41262948)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6198-6204
    • Weng, W.-H.1    Ahlen, J.2    Astrom, K.3    Lui, W.-O.4    Larsson, C.5
  • 22
    • 0038176163 scopus 로고    scopus 로고
    • Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas
    • Takahiro T, Shinichi K and Toshimitsu S: Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Clin Cancer Res 9: 2204-2212, 2003. (Pubitemid 36687644)
    • (2003) Clinical Cancer Research , vol.9 , Issue.6 , pp. 2204-2212
    • Takahiro, T.1    Shinichi, K.2    Toshimitsu, S.3
  • 25
    • 16644388513 scopus 로고    scopus 로고
    • Cyclooxygenase-2 in human malignant fibrous histiocytoma: Correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase
    • Yamashita H, Osaki M, Ardyanto TD, Osaki M, Yoshida H and Ito H: Cyclooxygenase-2 in human malignant fibrous histiocytoma: correlations with intratumoral microvessel density, expression of vascular endothelial growth factor and thymidine phosphorylase. Int J Mol Med 14: 565-570, 2004.
    • (2004) Int J Mol Med , vol.14 , pp. 565-570
    • Yamashita, H.1    Osaki, M.2    Ardyanto, T.D.3    Osaki, M.4    Yoshida, H.5    Ito, H.6
  • 27
    • 0036674838 scopus 로고    scopus 로고
    • Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: Correlations with Ki-67 and P53 expression, and apoptosis
    • Osaki M, Osaki M, Yamashita H, Shomori K, Yoshida H and Ito H: Expression of minichromosome maintenance-2 in human malignant fibrous histiocytomas: correlations with Ki-67 and P53 expression, and apoptosis. Int J Mol Med 10: 161-168, 2002.
    • (2002) Int J Mol Med , vol.10 , pp. 161-168
    • Osaki, M.1    Osaki, M.2    Yamashita, H.3    Shomori, K.4    Yoshida, H.5    Ito, H.6
  • 29
    • 0030588658 scopus 로고    scopus 로고
    • Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2
    • DOI 10.1006/geno.1996.0588
    • Chen H, Rossier C and Antonarakis SE: Cloning of a human homolog of the Drosophila enhancer of zeste gene (EZH2) that maps to chromosome 21q22.2. Genomics 38: 30-37, 1996. (Pubitemid 26423910)
    • (1996) Genomics , vol.38 , Issue.1 , pp. 30-37
    • Chen, H.1    Rossier, C.2    Antonarakis, S.E.3
  • 30
    • 18644382388 scopus 로고    scopus 로고
    • The polycomb group protein EZH2 is involved in progression of prostate cancer
    • Varambally S, Dhanasekaran SM, Zhou M, et al: The polycomb group protein EZH2 is involved in progression of prostate cancer. Nature 419: 624-629, 2002.
    • (2002) Nature , vol.419 , pp. 624-629
    • Varambally, S.1    Dhanasekaran, S.M.2    Zhou, M.3
  • 33
    • 33750318686 scopus 로고    scopus 로고
    • Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast
    • DOI 10.1158/0008-5472.CAN-06-2384
    • Ding L and Kleer CG: Enhancer of Zeste 2 as a marker of preneoplastic progression in the breast. Cancer Res 66: 9352-9355, 2006. (Pubitemid 44623628)
    • (2006) Cancer Research , vol.66 , Issue.19 , pp. 9352-9355
    • Ding, L.1    Kleer, C.G.2
  • 36
    • 29344439946 scopus 로고    scopus 로고
    • Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas
    • Weikert S, Christoph F, Kollermann J, et al: Expression levels of the EZH2 polycomb transcriptional repressor correlate with aggressiveness and invasive potential of bladder carcinomas. Int J Mol Med 16: 349-353, 2005.
    • (2005) Int J Mol Med , vol.16 , pp. 349-353
    • Weikert, S.1    Christoph, F.2    Kollermann, J.3
  • 37
    • 29344445843 scopus 로고    scopus 로고
    • Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder
    • DOI 10.1158/1078-0432.CCR-05-1047
    • Raman JD, Mongan NP, Tickoo SK, Boorjian SA, Scherr DS and Gudas LJ: Increased expression of the polycomb group gene, EZH2, in transitional cell carcinoma of the bladder. Clin Cancer Res 11: 8570-8576, 2005. (Pubitemid 43005902)
    • (2005) Clinical Cancer Research , vol.11 , Issue.24 , pp. 8570-8576
    • Raman, J.D.1    Mongan, N.P.2    Tickoo, S.K.3    Boorjian, S.A.4    Scherr, D.S.5    Gudas, L.J.6
  • 38
    • 33744519651 scopus 로고    scopus 로고
    • Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer
    • DOI 10.1111/j.1349-7006.2006.00203.x
    • Matsukawa Y, Semba S, Kato H, Ito A, Yanagihara K and Yokozaki H: Expression of the enhancer of zeste homolog 2 is correlated with poor prognosis in human gastric cancer. Cancer Sci 97: 484-491, 2006. (Pubitemid 43811589)
    • (2006) Cancer Science , vol.97 , Issue.6 , pp. 484-491
    • Matsukawa, Y.1    Semba, S.2    Kato, H.3    Ito, A.4    Yanagihara, K.5    Yokozaki, H.6
  • 39
    • 33845437420 scopus 로고    scopus 로고
    • Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer
    • Mattioli E, Vogiatzi P, Sun A, et al: Immunohistochemical analysis of pRb2/p130, VEGF, EZH2, p53, p16(INK4A), p27(KIP1), p21(WAF1), Ki-67 expression patterns in gastric cancer. J Cell Physiol 210: 183-191, 2007.
    • (2007) J Cell Physiol , vol.210 , pp. 183-191
    • Mattioli, E.1    Vogiatzi, P.2    Sun, A.3
  • 41
    • 0035050744 scopus 로고    scopus 로고
    • The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma
    • Visser HP, Gunster MJ, Kluin-Nelemans HC, et al: The Polycomb group protein EZH2 is upregulated in proliferating, cultured human mantle cell lymphoma. Br J Haematol 112: 950-958, 2001.
    • (2001) Br J Haematol , vol.112 , pp. 950-958
    • Visser, H.P.1    Gunster, M.J.2    Kluin-Nelemans, H.C.3
  • 44
    • 4143054651 scopus 로고    scopus 로고
    • Activated p53 suppresses the histone methyltransferase EZH2 gene
    • DOI 10.1038/sj.onc.1207706
    • Tang X, Milyavsky M, Shats I, Erez N, Goldfinger N and Rotter V: Activated p53 suppresses the histone methyltransferase EZH2 gene. Oncogene 23: 5759-5769, 2004. (Pubitemid 39093021)
    • (2004) Oncogene , vol.23 , Issue.34 , pp. 5759-5769
    • Tang, X.1    Milyavsky, M.2    Shats, I.3    Erez, N.4    Goldfinger, N.5    Rotter, V.6
  • 45
    • 34447125133 scopus 로고    scopus 로고
    • The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2
    • DOI 10.1038/sj.onc.1210248, PII 1210248
    • Beke L, Nuytten M, van Eynde A, Beullens M and Bollen M: The gene encoding the prostatic tumor suppressor PSP94 is a target for repression by the Polycomb group protein EZH2. Oncogene 26: 4590-4595, 2007. (Pubitemid 47037047)
    • (2007) Oncogene , vol.26 , Issue.31 , pp. 4590-4595
    • Beke, L.1    Nuytten, M.2    Van Eynde, A.3    Beullens, M.4    Bollen, M.5
  • 46
    • 0020694123 scopus 로고
    • Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation
    • DOI 10.1002/ijc.2910310104
    • Gerdes J, Schwab U, Lemke H and Stein H: Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. Int J Cancer 31: 13-20, 1983. (Pubitemid 13179545)
    • (1983) International Journal of Cancer , vol.31 , Issue.1 , pp. 13-20
    • Gerdes, J.1    Schwab, U.2    Lemke, H.3    Stein, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.