Putative genes mediating the effects of orexins in the posterior paraventricular thalamus on neuroendocrine and behavioral adaptations to repeated stress

Brain Research Bulletin

Volumn 89, Issue 5-6, 2012, Pages 203-210

  Heydendael, W ^a   Sengupta, A ^a   Bhatnagar, S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Ador2a; Bax; Crhr1; Cx3cr1; Grm2; Hdac5; Hypocretin; Hypothalamic pituitary adrenal; Mt3; PCR array; Ptgs2; Vegfa

Indexed keywords

1 (2 METHYL 6 BENZOXAZOLYL) 3 (1,5 NAPHTHYRIDIN 4 YL)UREA; ADENOSINE A2A RECEPTOR; CHEMOKINE RECEPTOR CX3CR1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; HISTONE DEACETYLASE 5; MESSENGER RNA; METABOTROPIC RECEPTOR 2; METALLOTHIONEIN III; OREXIN; PROSTAGLANDIN ENDOPEROXIDE SYNTHASE 2; PROSTAGLANDIN SYNTHASE; PROTEIN BAX; UNCLASSIFIED DRUG; VASCULOTROPIN A;

ADAPTIVE BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FORCED SWIMMING TEST; MALE; NONHUMAN; PARAVENTRICULAR THALAMIC NUCLEUS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BLOCKING; REPEATED STRESS; STRESS;

ADAPTATION, PSYCHOLOGICAL; ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BENZOXAZOLES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MIDLINE THALAMIC NUCLEI; NEUROPEPTIDES; NEUROSECRETORY SYSTEMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECURRENCE; STRESS, PSYCHOLOGICAL; UREA; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 84867889952     PISSN: 03619230     EISSN: 18732747     Source Type: Journal    
DOI: 10.1016/j.brainresbull.2012.09.002     Document Type: Article

References (55)

1. Aguilera G., Nikodemova M., Wynn P.C., Catt K.J. Corticotropin releasing hormone receptors: two decades later. Peptides 2004, 25:319-329.
2. Berendse H.W., Groenewegen H.J. Restricted cortical termination fields of the midline and intralaminar thalamic nuclei in the rat. Neuroscience 1991, 42:73-102.
3. Bhatnagar S., Dallman M.F. Neuroanatomical basis for facilitation of hypothalamic-pituitary-adrenal responses to a novel stressor after chronic stress. Neuroscience 1998, 84:1025-1039.
4. Bhatnagar S., Huber R., Nowak N., Trotter P. Lesions of the posterior paraventricular thalamus block habituation of hypothalamic-pituitary-adrenal responses to repeated restraint. Journal of Neuroendocrinology 2002, 14:403-410.
5. Bhatnagar S., Viau V., Chu A., Soriano L., Meijer O., Dallman M. A cholecystokinin-mediated pathway to the paraventricular thalamus is recruited in chronically stressed rats and regulates hypothalamic-pituitary-adrenal function. Journal of Neuroscience 2000, 20:5564-5573.
6. Bhatnagar S., Vining C., Iyer V., Kinni V. Changes in hypothalamic-pituitary-adrenal function, body temperature, body weight and food intake with repeated social stress exposure in rats. Journal of Neuroendocrinology 2006, 18:13-24.
7. Brzozowski T., Konturek P.C., Sliwowski Z., Drozdowicz D., Burnat G., Pajdo R., Pawlik M., Bielanski W., Kato I., Kuwahara A., Konturek S.J., Pawlik W.W. Gastroprotective action of orexin-A against stress-induced gastric damage is mediated by endogenous prostaglandins, sensory afferent neuropeptides and nitric oxide. Regulatory Peptides 2008, 148:6-20.
8. Cluderay J.E., Harrison D.C., Hervieu G.J. Protein distribution of the orexin-2 receptor in the rat central nervous system. Regulatory Peptides 2002, 104:131-144.
9. Cunha R.A., Ferré S., Vaugeois J.M., Chen J.F. Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders. Current Pharmaceutical Design 2008, 14:1512-1524.
10. Dallman M.F., Akana S.F., Scriber K.A., Bradbury M.J., Walker C.D., Strack A.M., Cascio C.S. Stress, feedback and facillitation in the hypothalamo-pituitary-adrenal axis. Journal of Neruoendocrinology 1992, 4:517-526.
11. Dautzenberg F.M., Kilpatrick G.J., Hauger R.L., Moreau J. Molecular biology of the CRH receptors-in the mood. Peptides 2001, 22:753-760.
12. Dong H.W., Swanson L. Projections from bed nuclei of the stria terminalis, anteromedial area: cerebral hemisphere integration of neuroendocrine, autonomic, and behavioral aspects of energy balance. Journal of Comparative Neurology 2006, 494:142-178.
13. Dunn A.J., Berridge C.W. Physiological and behavioral responses to corticotropin-releasing factor administration: is CRF a mediator of anxiety or stress. Brain Research Reviews 1990, 15:71-100.
14. Ferré S., Diamond I., Goldberg S.R., Yao L., Hourani S.M., Huang Z.L., Urade Y., Kitchen I. Adenosine A2A receptors in ventral striatum, hypothalamus and nociceptive circuitry implications for drug addiction, sleep and pain. Progress in Neurobiology 2007, 83:332-347.
15. Feyissa A.M., Woolverton W.L., Miguel-Hidalgo J.J., Wang Z., Kyle P.B., Hasler G., Stockmeier C.A., Iyo A.H., Karolewicz B. Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2010, 34:279-283.
16. Grissom N., Kerr W., Bhatnagar S. Struggling behavior during restraint is regulated by stress experience. Behavioural Brain Research 2008, 191:219-226.
17. Grissom N.M., Bhatnagar S. The basolateral amygdala regulates adaptation to stress via β-adrenergic receptor-mediated reductions in phosphorylated extracellular signal-regulated kinase. Neuroscience 2011, 178:108-122.
18. Hammack S.E., Pepin J.L., DesMarteau J.S., Watkins L.R., Maier S.F. Low doses of corticotropin-releasing hormone injected into the dorsal raphe nucleus block the behavioral consequences of uncontrollable stress. Behavioural Brain Research 2003, 147:55-64.
19. Hermes M.L., Renaud L.P. Postsynaptic and presynaptic group II metabotropic glutamate receptor activation reduces neuronal excitability in rat midline paraventricular thalamic nucleus. Journal of Pharmacology and Experimental Therapeutics 2011, 336:840-849.
20. Hewett S.J., Bell S.C., Hewett J.A. Contributions of cyclooxygenase-2 to neuroplasticity and neuropathology of the central nervous system. Pharmacology and Therapeutics 2006, 112:335-357.
21. Heydendael W., Sharma K., Iyer V., Luz S., Piel D., Beck S., Bhatnagar S. Orexins/Hypocretins act in the posterior paraventricular thalamic nucleus during repeated stress to regulate facilitation to novel stress. Endocrinology 2011, 152:4738-4752.
22. Hsu D.T., Prince J.L. Paraventricular thalamic nucleus: subcortical connections and innervation by serotonin, orexin and corticotropin-releasing hormone in macaque monkeys. Journal of Comparative Neurology 2009, 512:825-848.
23. Huang Z.L., Urade Y., Hayaishi O. The role of adenosine in the regulation of sleep. Current Topics in Medicinal Chemistry 2011, 8:1047-1057.
24. Jaferi A., Bhatnagar S. Corticosterone can act at the posterior paraventricular thalamus to inhibit hypothalamic-pituitary-adrenal activity in animals that habituate to repeated stress. Endocrinology 2006, 147:4917-4930.
25. Kerman I.A., Bernard R., Rosenthal D., Beals J., Akil H., Watson S.J. Distinct populations of presympathetic premotor neurons express orexin or melanin-concentrating hormone in the rat lateral hypothalamus. Journal of Comparative Neurology 2007, 505:586-601.
26. Kim H.G., Hwang Y.P., Jeong H.G. Metallothionein-III induces HIF-1alpha-mediated VEGF expression in brain endothelial cells. Biochemical and Biophysical Research Communications 2008, 369:666-671.
27. Kim W.U., Kang S.S., Yoo S.A., Hong K.H., Bae D.G., Lee M.S., Hong S.W., Chae C.B., Cho C.S. Interaction of vascular endothelial growth factor 165 with neuropilin-1 protects rheumatoid synoviocytes from apoptotic death by regulating Bcl-2 expression and Bax translocation. Journal of Immunology 2006, 177:5727-5735.
28. Kirouac G., Parsons M., Li S. Orexin (hypocretin) innervation of the paraventricular nucleus of the thalamus. Brain Research 2005, 1059:179-188.
29. Liebsch G., Landgraf R., Engelmann M., Lorscher P., Holsboer F. Differential behavioral effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain. Journal of Psychiatric Research 1999, 33:153-163.
30. Lu X.Y., Bagnol D., Burke S., Akil H., Watson S.J. Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Hormones and Behavior 2000, 37:335-344.
31. Marcus J.N., Aschkenasi C.J., Lee C.E., Chemelli R.M., Saper C.B., Yanagisawa M., Elmquist J.K. Differential expression of orexin receptors 1 and 2 in the rat brain. Journal of Comparative Neurology 2001, 435:6-25.
32. Marti H.H., Risau W. Systemic hypoxia changes the organ-specific distribution of vascular endothelial growth factor and its receptors. Proceedings of the National Academy of Sciences of the United States of America 1998, 95:15809-15814.
33. Moga M.M., Weiss R.P., Moore R.Y. Efferent projections of the paraventricular thalamic nucleus in the rat. Journal of Comparative Neurology 1995, 359:221-238.
34. Nambu T., Sakurai T., Mizukami K., Hosoya Y., Yanagisawa M., Goto K. Distribution of orexin neurons in the adult rat brain. Brain Research 1999, 827:243-260.
35. Nishiyori A., Minami M., Ohtani Y., Takami S., Yamamoto J., Kawaguchi N., Kume T., Akaike A., Satoh M. Localization of fractalkine and CX3CR1 mRNAs in rat brain: does fractalkine play a role in signaling from neuron to microglia?. FEBS Letters 1998, 429:167-172.
36. Oltvai Z.N., Milliman C.L., Korsmeyer S.J. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that acceleratesprogrammed cell death. Cell 1993, 74:609-619.
37. Peyron C., Tighe D.K., Van den Pol A.N., De Lecea L., Heller H.C., Sutcliffe J.G., Kilduff T.S. Neurons containing hypocretin (orexin) project to multiple neuronal systems. Journal of Neuroscience 1998, 18:9996-10015.
38. Renthal W., Maze I., Krishnan V., Covington H.E.r., Xiao G., Kumar A., Russo S.J., Graham A., Tsankova N., Kippin T.E., Kerstetter K.A., Neve R.L., Haggarty S.J., McKinsey T.A., Bassel-Duby R., Olson E.N., Nestler E.J. Histone deacetylase 5 epigenetically controls behavioral adaptations to chronic emotional stimuli. Neuron 2007, 56:517-529.
39. Rogers J.T., Morganti J.M., Bachstetter A.D., Hudson C.E., Peters M.M., Grimmig B.A., Weeber E.J., Bickford P.C., Gemma C. CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity. Journal of Neuroscience 2011, 31:16241-16250.
40. Romanowski C.P., Fenzl T., Flachskamm C., Wurst W., Holsboer F., Deussing J.M., Kimura M. Central deficiency of corticotropin-releasing hormone receptor type 1 (CRH-R1) abolishes effects of CRH on NREM but not on REM sleep in mice. Sleep 2010, 33:427-436.
41. Sakurai T., Mieda M. Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Trends in Pharmacological Sciences 2011, 32:451-462.
42. Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative CT method. Nature Protocols 2008, 3:1101-1108.
43. Shin M.C., Kim C.J., Min B.I., Ogawa S., Tanaka E., Akaike N. A selective t-type Ca2+ channel blocker R(-) efonidipine. Naunyn-Schmiedebergs Archives of Pharmacology 2008, 377:411-421.
44. Sillaber I., Rammes G., Zimmermann S., Mahal B., Zieglgänsberger W., Wurst W., Holsboer F., Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science 2002, 5569:931-933.
45. Smith G.W., Aubry J.M., Dellu F., Contarino A., Bilezikjian L.M., Gold L.H., Chen R., Marchuk Y., Hauser C., Bentley C.A., Sawchenko P.E., Koob G.F., Vale W., Lee K.F. Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development. Neuron 1998, 6:1093-1102.
46. Sondell M., Sundler F., Kanje M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. European Journal of Neuroscience 2000, 12:4243-4254.
47. Su H.-S., Bentivoglio M. Thalamic midline cell populations projecting to the nucleus accumbens, amygdala, and hippocampus in the rat. Journal of Comparative Neurology 1990, 297:582-593.
48. Timpl P., Spanagel R., Sillaber I., Kresse A., Reul J.M., Stalla G.K., Blanquet V., Steckler T., Holsboer F., Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics 1998, 2:162-166.
49. Trivedi P., Yu H., MacNeil D.J., Van der Ploeg L.H., Guan X.M. Distribution of orexin receptor mRNA in the rat brain. Federation of European Biochemical Societies 1998, 438:71-75.
50. Tsankova N., Renthal W., Kumar A., Nestler E.J. Epigenetic regulation in psychiatric disorders. Nature Reviews Neuroscience 2007, 8:355-367.
51. Turner B.H., Herkenham M. Thalamoamygdaloid projections in the rat: a test of the amygdalaís role in sensory processing. Journal of Comparative Neurology 1991, 313:295-325.
52. Uchida Y., Gomi F., Masumizu T., Miura Y. Growth inhibitory factor prevents neurite extension and the death of cortical neurons caused by high oxygen exposure through hydroxyl radical scavenging. Journal of Biological Chemistry 2002, 277:32353-32359.
53. Valentino R.J., Van Bockstaele E.J. Corticotropin-releasing factor: putative neurotransmitter actions of a neurohormone. Hormones, Brain and Behavior 2002, vol. 4:81-102. Academic Press, San Diego.
54. Winsky-Sommerer R., Boutrel B., de Lecea L. Stress and arousal: the corticotrophin-releasing factor/hypocretin circuitry. Molecular Neurobiology 2005, 32:285-294.
55. Winsky-Sommerer R., Yamanaka A., Diano S., Borok E., Roberts A.J., Sakurai T., Kilduff T.S., Horvath T.L., de Lecea L. Interaction between the corticotropin-releasing factor system and hypocretins (orexins): a novel circuit mediating stress response. Journal of Neuroscience 2004, 24:11439-11448.