Chemical-biological studies of subcellular organization in bacteria

Biochemistry

Volumn 50, Issue 36, 2011, Pages 7719-7734

  Foss, Marie H ^a   Eun, Ye Jin ^a   Weibel, Douglas B ^a,b  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b University of Wisconsin Madison   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL CELLS; BIOLOGICAL MOLECULE; CRITICAL DETERMINANT; PEPTIDOGLYCANS; SMALL MOLECULES; SUB-CELLULAR;

BACTERIOLOGY; BIOMOLECULES; LIPID BILAYERS; MOLECULES; PHYSIOLOGY; PROBES;

BACTERIA;

1A G7; 3 [5 [4 OXO 2 THIOXO 3 (3 TRIFLUOROMETHYLPHENY)THIAZOLIDIN 5 YLIDENEMETHYL]FURAN 2 YL]BENZOIC ACID; 8 BROMOGUANOSINE 5' TRIPHOSPHATE; A189; ANTIINFECTIVE AGENT; BERBERINE; CBR 4830; CHRYSOPHAENTIN A; CINNAMALDEHYDE; CURCUMIN; DICHAMANETIN; FM 4 64; FOSFOMYCIN; LANTHIOPEPTIN; PC 170942; PC 190723; RAMOPLANIN; SANGUINARINE; SCEPTRIN; SRI 3072; SRI 7614; TOTAROL; TRA 2A; TUNICAMYCIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VANCOMYCIN; VIRIDITOXIN; ZANTRIN Z1; ZANTRIN Z2; ZANTRIN Z3; ZANTRIN Z4; ZANTRIN Z5; ZARAGOZIC ACID A;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CELL; BACTERIAL GROWTH; BACTERIAL MUTATION; BACTERIAL PHENOMENA AND FUNCTIONS; BINDING AFFINITY; CELL DIVISION; CELL STRUCTURE; CHLOROPLAST; DNA DAMAGE; DRUG INHIBITION; DRUG POTENCY; DRUG SPECIFICITY; ENTEROCOCCUS FAECIUM; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; LIPID BILAYER; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR PROBE; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIA; STRUCTURE ACTIVITY RELATION;

BACTERIA; BACTERIAL PHYSIOLOGICAL PHENOMENA; BACTERIAL PROTEINS; CYTOSKELETAL PROTEINS; LIPID BILAYERS; MOLECULAR PROBES; PEPTIDOGLYCAN;

BACTERIA (MICROORGANISMS); EUKARYOTA;

EID: 80052486494     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200940d     Document Type: Article

References (140)

1. Bi, E. F. and Lutkenhaus, J. (1991) FtsZ ring structure associated with division in Escherichia coli Nature 354, 161-164 (Pubitemid 21896803)
2. Graumann, P. L. (2007) Cytoskeletal elements in bacteria Annu. Rev. Microbiol. 61, 589-618 (Pubitemid 350058222)
3. Shih, Y.-L. and Rothfield, L. (2006) The Bacterial Cytoskeleton Microbiology 70, 729-754 (Pubitemid 44484691)
4. Michie, K. A. and Löwe, J. (2006) Dynamic Filaments of the Bacterial Cytoskeleton Annu. Rev. Biochem. 75, 467-492 (Pubitemid 44118040)
5. Shapiro, L., McAdams, H. H., and Losick, R. (2009) Why and how bacteria localize proteins Science 326, 1225-1228
6. Bardy, S. L. and Maddock, J. R. (2007) Polar explorations Recent insights into the polarity of bacterial proteins Curr. Opin. Microbiol. 10, 617-623 (Pubitemid 350180598)
7. Erickson, H. P. (2007) Evolution of the cytoskeleton BioEssays 29, 668-677 (Pubitemid 47051620)
8. Lowe, J. and Amos, L. A. (2009) Evolution of cytomotive filaments: The cytoskeleton from prokaryotes to eukaryotes Int. J. Biochem. Cell Biol. 41, 323-329
9. Vaughan, S., Wickstead, B., Gull, K., and Addinall, S. G. (2004) Molecular Evolution of FtsZ Protein Sequences Encoded Within the Genomes of Archaea, Bacteria, and Eukaryota J. Mol. Evol. 58, 19-39 (Pubitemid 38117596)
10. Ward, G. E., Carey, K. L., and Westwood, N. J. (2002) Using small molecules to study big questions in cellular microbiology Cell. Microbiol. 4, 471-482 (Pubitemid 34993746)
11. Peterson, J. R. and Mitchison, T. J. (2002) Small molecules, big impact: A history of chemical inhibitors and the cytoskeleton Chem. Biol. 9, 1275-1285 (Pubitemid 36010683)
12. Michie, K. A. and Lowe, J. (2006) Dynamic filaments of the bacterial cytoskeleton Annu. Rev. Biochem. 75, 467-492 (Pubitemid 44118040)
13. Erickson, H. P., Anderson, D. E., and Osawa, M. (2010) FtsZ in bacterial cytokinesis: Cytoskeleton and force generator all in one Microbiol. Mol. Biol. Rev. 74, 504-528
14. Czaplewski, L. G., Collins, I., Boyd, E. A., Brown, D., East, S. P., Gardiner, M., Fletcher, R., Haydon, D. J., Henstock, V., Ingram, P., Jones, C., Noula, C., Kennison, L., Rockley, C., Rose, V., Thomaides-Brears, H. B., Ure, R., Whittaker, M., and Stokes, N. R. (2009) Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ Bioorg. Med. Chem. Lett. 19, 524-527
15. Haydon, D. J., Stokes, N. R., Ure, R., Galbraith, G., Bennett, J. M., Brown, D. R., Baker, P. J., Barynin, V. V., Rice, D. W., Sedelnikoca, S. E., Heal, J. R., Sheridan, J. M., Aiwale, S. T., Chauhan, P. K., Srivastava, A., Taneja, A., Collins, I., Errington, J., and Czaplewski, L. G. (2008) An Inhibitor of FtsZ with Potent and Selective Anti-Staphylococcal Activity Science 321, 1673-1675
16. Andreu, J. M., Schaffner-Barbero, C., Huecas, S., Alonso, D., Lopez-Rodriguez, M. L., Ruiz-Avila, L. B., Nunez-Ramirez, R., Llorca, O., and Martin-Galiano, A. J. (2010) The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation J. Biol. Chem. 285, 14239-14246
17. Adams, D. W., Wu, L. J., Czaplewski, L. G., and Errington, J. (2011) Multiple effects of benzamide antibiotics on FtsZ function Mol. Microbiol. 80, 68-84
18. Haydon, D. J., Bennett, J. M., Brown, D., Collins, I., Galbraith, G., Lancett, P., Macdonald, R., Stokes, N. R., Chauhan, P. K., Sutariya, J. K., Nayal, N., Srivastava, A., Beanland, J., Hall, R., Henstock, V., Noula, C., Rockley, C., and Czaplewski, L. (2010) Creating an antibacterial with in vivo efficacy: Synthesis and characterization of potent inhibitors of the bacterial cell division protein FtsZ with improved pharmaceutical properties J. Med. Chem. 53, 3927-3936
19. Lappchen, T., Hartog, A. F., Pinas, V. A., Koomen, G. J., and den Blaauwen, T. (2005) GTP analogue inhibits polymerization and GTPase activity of the bacterial protein FtsZ without affecting its eukaryotic homologue tubulin Biochemistry 44, 7879-7884 (Pubitemid 40740771)
20. Lappchen, T., Pinas, V. A., Hartog, A. F., Koomen, G. J., Schaffner-Barbero, C., Andreu, J. M., Trambaiolo, D., Lowe, J., Juhem, A., Popov, A. V., and den Blaauwen, T. (2008) Probing FtsZ and tubulin with C8-substituted GTP analogs reveals differences in their nucleotide binding sites Chem. Biol. 15, 189-199 (Pubitemid 351253617)
21. Jennings, L. D., Foreman, K. W., Rush, T. S., III, Tsao, D. H., Mosyak, L., Kincaid, S. L., Sukhdeo, M. N., Sutherland, A. G., Ding, W., Kenny, C. H., Sabus, C. L., Liu, H., Dushin, E. G., Moghazeh, S. L., Labthavikul, P., Petersen, P. J., Tuckman, M., Haney, S. A., and Ruzin, A. V. (2004) Combinatorial synthesis of substituted 3-(2-indolyl)piperidines and 2-phenyl indoles as inhibitors of ZipA-FtsZ interaction Bioorg. Med. Chem. 12, 5115-5131 (Pubitemid 39200614)
22. Huang, Q., Kirikae, F., Kirikae, T., Pepe, A., Amin, A., Respicio, L., Slayden, R. A., Tonge, P. J., and Ojima, I. (2006) Targeting FtsZ for antituberculosis drug discovery: Noncytotoxic taxanes as novel antituberculosis agents J. Med. Chem. 49, 463-466 (Pubitemid 43157479)
23. White, E. L., Suling, W. J., Ross, L. J., Seitz, L. E., and Reynolds, R. C. (2002) 2-Alkoxycarbonylaminopyridines: Inhibitors of Mycobacterium tuberculosis FtsZ J. Antimicrob. Chemother. 50, 111-114 (Pubitemid 34785263)
24. Kumar, K., Awasthi, D., Lee, S. Y., Zanardi, I., Ruzsicska, B., Knudson, S., Tonge, P. J., Slayden, R. A., and Ojima, I. (2011) Novel Trisubstituted Benzimidazoles, Targeting Mtb FtsZ, as a New Class of Antitubercular Agents J. Med. Chem. 54, 374-381
25. Ito, H., Ura, A., Oyamada, Y., Tanitame, A., Yoshida, H., Yamada, S., Wachi, M., and Yamagishi, J. (2006) A 4-aminofurazan derivative-A189-inhibits assembly of bacterial cell division protein FtsZ in vitro and in vivo Microbiol. Immunol. 50, 759-764 (Pubitemid 44624706)
26. Beuria, T. K., Santra, M. K., and Panda, D. (2005) Sanguinarine blocks cytokinesis in bacteria by inhibiting FtsZ assembly and bundling Biochemistry 44, 16584-16593 (Pubitemid 41832040)
27. Domadia, P. N., Bhunia, A., Sivaraman, J., Swarup, S., and Dasgupta, D. (2008) Berberine targets assembly of Escherichia coli cell division protein FtsZ Biochemistry 47, 3225-3234 (Pubitemid 351364915)
28. Boberek, J. M., Stach, J., and Good, L. (2010) Genetic evidence for inhibition of bacterial division protein FtsZ by berberine PLoS One 5, e13745
29. Hill, T. M., Sharma, B., Valjavec-Gratian, M., and Smith, J. (1997) sfi-independent filamentation in Escherichia coli is lexA dependent and requires DNA damage for induction J. Bacteriol. 179, 1931-1939 (Pubitemid 27123075)
30. Rooney, J. P., Patil, A., Zappala, M. R., Conklin, D. S., Cunningham, R. P., and Begley, T. J. (2008) A molecular bar-coded DNA repair resource for pooled toxicogenomic screens DNA Repair 7, 1855-1868
31. Bhattacharya, R. and Beck, D. J. (2002) Survival and SOS induction in cisplatin-treated Escherichia coli deficient in Pol II, RecBCD and RecFOR functions DNA Repair 1, 955-966
32. Domadia, P., Swarup, S., Bhunia, A., Sivaraman, J., and Dasgupta, D. (2007) Inhibition of bacterial cell division protein FtsZ by cinnamaldehyde Biochem. Pharmacol. 74, 831-840 (Pubitemid 47212076)
33. Rai, D., Singh, J. K., Roy, N., and Panda, D. (2008) Curcumin inhibits FtsZ assembly: Aan attractive mechanism for its antibacterial activity Biochem. J. 410, 147-155 (Pubitemid 351300334)
34. Moussavi, M., Assi, K., Gomez-Munoz, A., and Salh, B. (2006) Curcumin mediates ceramide generation via the de novo pathway in colon cancer cells Carcinogenesis 27, 1636-1644 (Pubitemid 44288053)
35. Ka, H., Park, H. J., Jung, H. J., Choi, J. W., Cho, K. S., Ha, J., and Lee, K. T. (2003) Cinnamaldehyde induces apoptosis by ROS-mediated mitochondrial permeability transition in human promyelocytic leukemia HL-60 cells Cancer Lett. 196, 143-152 (Pubitemid 36830893)
36. Wang, J., Galgoci, A., Kodali, S., Herath, K. B., Jayasuriya, H., Dorso, K., Vicente, F., Gonzalez, A., Cully, D., Bramhill, D., and Singh, S. (2003) Discovery of a small molecule that inhibits cell division by blocking FtsZ, a novel therapeutic target of antibiotics J. Biol. Chem. 278, 44424-44428 (Pubitemid 37377193)
37. Urgaonkar, S., La Pierre, H. S., Meir, I., Lund, H., RayChaudhuri, D., and Shaw, J. T. (2005) Synthesis of Antimicrobial Natural Products Targeting FtsZ: (±)-Dichamanetin and (±)-2′-Hydroxy-5′- benzylisouvarinol-B Org. Lett. 7, 5609-5612 (Pubitemid 43010811)
38. Margalit, D. N., Romberg, L., Mets, R. B., Hebert, A. M., Mitchison, T. J., Kirschner, M. W., and RayChaudhuri, D. (2004) Targeting cell division: Small-molecule inhibitors of FtsZ GTPase perturb cytokinetic ring assembly and induce bacterial lethality Proc. Natl. Acad. Sci. U.S.A. 101, 11821-11826 (Pubitemid 39095378)
39. Mukherjee, S., Robinson, C. A., Howe, A. G., Mazor, T., Wood, P. A., Urgaonkar, S., Hebert, A. M., Raychaudhuri, D., and Shaw, J. T. (2007) N-Benzyl-3-sulfonamidopyrrolidines as novel inhibitors of cell division in E. coli Bioorg. Med. Chem. Lett. 17, 6651-6655 (Pubitemid 350026310)
40. Foss, M. H., Hurley, K. A., Sorto, N. A., Lackner, L. L., Thornton, K. M., Shaw, J. T., and Weibel, D. B. (2011) N -Benzyl-3-sulfonamidopyrrolidines Are a New Class of Bacterial DNA Gyrase Inhibitors ACS Med. Chem. Lett. 2, 289-292
41. Jaiswal, R., Beuria, T. K., Mohan, R., Mahajan, S. K., and Panda, D. (2007) Totarol inhibits bacterial cytokinesis by perturbing the assembly dynamics of FtsZ Biochemistry 46, 4211-4220 (Pubitemid 46559388)
42. Haraguchi, H., Oike, S., Muroi, H., and Kubo, I. (1996) Mode of Antibacterial Action of Totarol, a Diterpene from Podocarpus nagi Planta Med. 62, 122-125 (Pubitemid 26163213)
43. Strahl, H. and Hamoen, L. W. (2010) Membrane potential is important for bacterial cell division Proc. Natl. Acad. Sci. U.S.A. 107, 12281-12286
44. Beuria, T. K., Singh, P., Surolia, A., and Panda, D. (2009) Promoting assembly and bundling of FtsZ as a strategy to inhibit bacterial cell division: A new approach for developing novel antibacterial drugs Biochem. J. 423, 61-69
45. Stokes, N. R., Sievers, J., Barker, S., Bennett, J. M., Brown, D. R., Collins, I., Errington, V. M., Foulger, D., Hall, M., Halsey, R., Johnson, H., Rose, V., Thomaides, H. B., Haydon, D. J., Czaplewski, L. G., and Errington, J. (2005) Novel inhibitors of bacterial cytokinesis identified by a cell-based antibiotic screening assay J. Biol. Chem. 280, 39709-39715 (Pubitemid 41779103)
46. Plaza, A., Keffer, J. L., Bifulco, G., Lloyd, J. R., and Bewley, C. A. (2010) Chrysophaentins A-H, antibacterial bisdiarylbutene macrocycles that inhibit the bacterial cell division protein FtsZ J. Am. Chem. Soc. 132, 9069-9077
47. Vollmer, W. (2006) The prokaryotic cytoskeleton: A putative target for inhibitors and antibiotics? Appl. Microbiol. Biotechnol. 73, 37-47 (Pubitemid 44627722)
48. Awasthi, D., Kumar, K., and Ojima, I. (2011) Therapeutic potential of FtsZ inhibition: A patent perspective Expert Opin. Ther. Pat. 21, 657-679
49. Shaevitz, J. W. and Gitai, Z. (2010) The structure and function of bacterial actin homologs Cold Spring Harbor Perspect. Biol. 2, a000364
50. Ebersbach, G. and Gerdes, K. (2005) Plasmid segregation mechanisms Annu. Rev. Genet. 39, 453-479 (Pubitemid 43011123)
51. White, C. L., Kitich, A., and Gober, J. W. (2010) Positioning cell wall synthetic complexes by the bacterial morphogenetic proteins MreB and MreD Mol. Microbiol. 76, 616-633
52. Gitai, Z., Dye, N., and Shapiro, L. (2004) An actin-like gene can determine cell polarity in bacteria Proc. Natl. Acad. Sci. U.S.A. 101, 8643-8648 (Pubitemid 38745824)
53. Gitai, Z., Dye, N. A., Reisenauer, A., Wachi, M., and Shapiro, L. (2005) MreB Actin-Mediated Segregation of a Specific Region of a Bacterial Chromosome Cell 120, 329-341 (Pubitemid 40222428)
54. Kruse, T., Moller-Jensen, J., Lobner-Olesen, A., and Gerdes, K. (2003) Dysfunctional MreB inhibits chromosome segregation in Escherichia coli EMBO J. 22, 5283-5292 (Pubitemid 37222047)
55. Garner, E. C., Bernard, R., Wang, W., Zhuang, X., Rudner, D. Z., and Mitchison, T. (2011) Coupled, circumferential motions of the cell wall synthesis machinery and MreB filaments in B. subtilis Science 333, 222-225
56. Dominguez-Escobar, J., Chastanet, A., Crevenna, A. H., Fromion, V., Wedlich-Soldner, R., and Carballido-Lopez, R. (2011) Processive movement of MreB-associated cell wall biosynthetic complexes in bacteria Science 333, 225-228
57. Swulius, M. T., Chen, S., Jane Ding, H., Li, Z., Briegel, A., Pilhofer, M., Tocheva, E. I., Lybarger, S. R., Johnson, T. L., Sandkvist, M., and Jensen, G. J. (2011) Long helical filaments are not seen encircling cells in electron cryotomograms of rod-shaped bacteria Biochem. Biophys. Res. Commun. 407, 650-655
58. Teeffelen, S. v., Wang, S., Furchtgott, L., Huang, K. C., Wingreen, N. S., Shaevitz, J. W., and Gitai, Z. The bacterial actin MreB rotates and rotation depends on cell-wall assembly. Proc. Natl. Acad. Sci. U.S.A. 2011, in press.
59. Wang, S., Arellano-Santoyo, H., Combs, P. A., and Shaevitz, J. W. (2010) Actin-like cytoskeleton filaments contribute to cell mechanics in bacteria Proc. Natl. Acad. Sci. U.S.A. 107, 9182-9185
60. Iwai, N., Nagai, K., and Wachi, M. (2002) Novel S-Benzylisothiourea Compound That Induces Spherical Cells in Escherichia coli Probably by Acting on a Rod-shape-determining Protein(s) Other Than Penicillin-binding Protein 2 Biosci., Biotechnol., Biochem. 66, 2658-2662 (Pubitemid 39251140)
61. Iwai, N., Ebata, T., Nagura, H., Kitazume, T., Nagai, K., and Wachi, M. (2004) Structure-activity relationship of S-benzylisothiourea derivatives to induce spherical cells in Escherichia coli Biosci., Biotechnol., Biochem. 68, 2265-2269 (Pubitemid 40033499)
62. Iwai, N., Fujii, T., Nagura, H., Wachi, M., and Kitazume, T. (2007) Structure-activity relationship study of the bacterial actin-like protein MreB inhibitors: Effects of substitution of benzyl group in S-benzylisothiourea Biosci., Biotechnol., Biochem. 71, 246-248 (Pubitemid 46155172)
63. Bean, G. J., Flickinger, S. T., Westler, W. M., McCully, M. E., Sept, D., Weibel, D. B., and Amann, K. J. (2009) A22 disrupts the bacterial actin cytoskeleton by directly binding and inducing a low-affinity state in MreB Biochemistry 48, 4852-4857
64. Shebelut, C. W., Jensen, R. B., and Gitai, Z. (2009) Growth Conditions Regulate the Reguirements for Caulobacter Chromosome Segregation J. Bacteriol. 191, 1097-1100
65. Formstone, A. and Errington, J. (2005) A magnesium-dependent mreB null mutant: Implications for the role of mreB in Bacillus subtilis Mol. Microbiol. 55, 1646-1657 (Pubitemid 40445203)
66. Karczmarek, A., Martinez-Arteaga, R., Alexeeva, S., Hansen, F. G., Vicente, M., Nanninga, N., and den Blaauwen, T. (2007) DNA and origin region segregation are not affected by the transition from rod to sphere after inhibition of Escherichia coli MreB by A22 Mol. Microbiol. 65, 51-63 (Pubitemid 46934491)
67. Uehara, T. and Park, J. T. (2008) Growth of Escherichia coli: Significance of peptidoglycan degradation during elongation and septation J. Bacteriol. 190, 3914-3922 (Pubitemid 351732870)
68. Takacs, C. N., Poggio, S., Charbon, G., Pucheault, M., Vollmer, W., and Jacobs-Wagner, C. (2010) MreB drives de novo rod morphogenesis in Caulobacter crescentus via remodeling of the cell wall J. Bacteriol. 192, 1671-1684
69. Rodriguez, A. D., Lear, M. J., and La Clair, J. J. (2008) Identification of the binding of sceptrin to MreB via a bidirectional affinity protocol J. Am. Chem. Soc. 130, 7256-7258 (Pubitemid 351813217)
70. Cipres, A., O'Malley, D. P., Li, K., Finlay, D., Baran, P. S., and Vuori, K. (2010) Sceptrin, a marine natural compound, inhibits cell motility in a variety of cancer cell lines ACS Chem. Biol. 5, 195-202
71. O'Malley, D. P., Li, K., Maue, M., Zografos, A. L., and Baran, P. S. (2007) Total synthesis of dimeric pyrrole-imidazole alkaloids: Sceptrin, ageliferin, nagelamide e, oxysceptrin, nakamuric acid, and the axinellamine carbon skeleton J. Am. Chem. Soc. 129, 4762-4775 (Pubitemid 46648775)
72. Robertson, G. T., Doyle, T. B., Du, Q., Duncan, L., Mdluli, K. E., and Lynch, A. S. (2007) A novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM J. Bacteriol. 189, 6870-6881 (Pubitemid 47525431)
73. Vollmer, W., Blanot, D., and de Pedro, M. A. (2008) Peptidoglycan structure and architecture FEMS Microbiol. Rev. 32, 149-167 (Pubitemid 351257814)
74. Vollmer, W. and Seligman, S. J. (2010) Architecture of peptidoglycan: More data and more models Trends Microbiol. 18, 59-66
75. Cabeen, M. T. and Jacobs-Wagner, C. (2007) Skin and bones: The bacterial cytoskeleton, cell wall, and cell morphogenesis J. Cell Biol. 179, 381-387 (Pubitemid 350074783)
76. Cabeen, M. T. and Jacobs-Wagner, C. (2005) Bacterial cell shape Nat. Rev. Microbiol. 3, 601-610 (Pubitemid 41052147)
77. Young, K. D. (2010) Bacterial shape: Two-dimensional questions and possibilities Annu. Rev. Microbiol. 64, 223-240
78. Elbaz, M. and Ben-Yehuda, S. (2010) The metabolic enzyme ManA reveals a link between cell wall integrity and chromosome morphology PLoS Genet. 6, 1-12
79. Aaron, M., Charbon, G., Lam, H., Schwarz, H., Vollmer, W., and Jacobs-Wagner, C. (2007) The tubulin homologue FtsZ contributes to cell elongation by guiding cell wall precursor synthesis in Caulobacter crescentus Mol. Microbiol. 64, 938-952 (Pubitemid 46743973)
80. Valbuena, N., Letek, M., Ordonez, E., Ayala, J., Daniel, R. A., Gil, J. A., and Mateos, L. M. (2007) Characterization of HMW-PBPs from the rod-shaped actinomycete Corynebacterium glutamicum: Peptidoglycan synthesis in cells lacking actin-like cytoskeletal structures Mol. Microbiol. 66, 643-657 (Pubitemid 47621851)
81. Daniel, R. A. and Errington, J. (2003) Control of Cell Morphogenesis in Bacteria: Two Distinct Ways to Make a Rod-Shaped Cell Cell 113, 767-776 (Pubitemid 36724940)
82. Tiyanont, K., Doan, T., Lazarus, M. B., Fang, X., Rudner, D. Z., and Walker, S. (2006) Imaging peptidoglycan biosynthesis in Bacillus subtilis with fluorescent antibiotics Proc. Natl. Acad. Sci. U.S.A. 103, 11033-11038 (Pubitemid 44148413)
83. Zhao, G., Meier, T. I., Kahl, S. D., Gee, K. R., and Blaszczak, L. C. (1999) BOCILLIN FL, a sensitive and commercially available reagent for detection of penicillin-binding proteins Antimicrob. Agents Chemother. 43, 1124-1128 (Pubitemid 29214735)
84. Jovetic, S., Zhu, Y., Marcone, G. L., Marinelli, F., and Tramper, J. (2010) β-Lactam and glycopeptide antibiotics: First and last line of defense? Trends Biotechnol. 28, 596-604
85. Fang, X., Tiyanont, K., Zhang, Y., Wanner, J., Boger, D., and Walker, S. (2006) The mechanism of action of ramoplanin and enduracidin Mol. BioSyst. 2, 69-76
86. Divakaruni, A. V., Baida, C., White, C. L., and Gober, J. W. (2007) The cell shape proteins MreB and MreC control cell morphogenesis by positioning cell wall synthetic complexes Mol. Microbiol. 66, 174-188 (Pubitemid 47414799)
87. Thanky, N. R., Young, D. B., and Robertson, B. D. (2007) Unusual features of the cell cycle in mycobacteria: Polar-restricted growth and the snapping-model of cell division Tuberculosis 87, 231-236 (Pubitemid 46551845)
88. Gilbert, Y., Deghorain, M., Wang, L., Xu, B., Pollheimer, P. D., Gruber, H. J., Errington, J., Hallet, B., Haulot, X., Verbelen, C., Hols, P., and Dufrene, Y. F. (2007) Single-molecule force spectroscopy and imaging of the vancomycin/ d -Ala- d -Ala interaction Nano Lett. 7, 796-801 (Pubitemid 46516068)
89. Pinho, M. G. and Errington, J. (2003) Dispersed mode of Staphylococcus aureus cell wall synthesis in the absence of the division machinery Mol. Microbiol. 50, 871-881 (Pubitemid 37372250)
90. Turner, R. D., Ratcliffe, E. C., Wheeler, R., Golestanian, R., Hobbs, J. K., and Foster, S. J. (2010) Peptidoglycan architecture can specify division planes in Staphylococcus aureus Nat. Commun. 1, 1-9
91. Rafelski, S. M. and Theriot, J. A. (2006) Mechanism of polarization of Listeria monocytogenes surface protein ActA Mol. Microbiol. 59, 1262-1279
92. Kawai, Y., Daniel, R. A., and Errington, J. (2009) Regulation of cell wall morphogenesis in Bacillus subtilis by recruitment of PBP1 to the MreB helix Mol. Microbiol. 71, 1131-1144
93. Varma, A., de Pedro, M. A., and Young, K. D. (2007) FtsZ directs a second mode of peptidoglycan synthesis in Escherichia coli J. Bacteriol. 189, 5692-5704 (Pubitemid 47206416)
94. Flardh, K. (2010) Cell polarity and the control of apical growth in Streptomyces Curr. Opin. Microbiol. 13, 758-765
95. Letek, M., Ordonez, E., Vaquera, J., Margolin, W., Flardh, K., Mateos, L. M., and Gil, J. A. (2008) DivIVA is required for polar growth in the MreB-lacking rod-shaped actinomycete Corynebacterium glutamicum J. Bacteriol. 190, 3283-3292 (Pubitemid 351581424)
96. Parthasarathy, R., Subramanian, S., and Boder, E. T. (2007) Sortase A as a novel molecular "stapler" for sequence-specific protein conjugation Bioconjugate Chem. 18, 469-476 (Pubitemid 46493518)
97. Nelson, J. W., Chamessian, A. G., McEnaney, P. J., Murelli, R. P., Kazmiercak, B. I., and Spiegel, D. A. (2010) A biosynthetic strategy for re-engineering the Staphylococcus aureus cell wall with non-native small molecules ACS Chem. Biol. 5, 1147-1155
98. Sadamoto, R., Niikura, K., Sears, P. S., Liu, H., Wong, C. H., Suksomcheep, A., Tomita, F., Monde, K., and Nishimura, S. (2002) Cell-wall engineering of living bacteria J. Am. Chem. Soc. 124, 9018-9019 (Pubitemid 34847640)
99. Yi, W., Liu, X., Li, Y., Li, J., Xia, C., Zhou, G., Zhang, W., Zhao, W., Chen, X., and Wang, P. G. (2009) Remodeling bacterial polysaccharides by metabolic pathway engineering Proc. Natl. Acad. Sci. U.S.A. 106, 4207-4212
100. Olrichs, N. K., Aarsman, M. E., Verheul, J., Arnusch, C. J., Martin, N. I., Herve, M., Vollmer, W., de Kruijff, B., Breukink, E., and den Blaauwen, T. (2011) A novel in vivo cell-wall labeling approach sheds new light on peptidoglycan synthesis in Escherichia coli ChemBioChem 12, 1124-1133
101. Cabeen, M. T. and Jacobs-Wagner, C. (2010) The bacterial cytoskeleton Annu. Rev. Genet. 44, 365-392
102. Jani, C., Eoh, H., Lee, J. J., Hamasha, K., Sahana, M. B., Han, J. S., Nyayapathy, S., Lee, J. Y., Suh, J. W., Lee, S. H., Rehse, S. J., Crick, D. C., and Kang, C. M. (2010) Regulation of polar peptidoglycan biosynthesis by Wag31 phosphorylation in mycobacteria BMC Microbiol. 10, 327
103. Claessen, D., Emmins, R., Hamoen, L. W., Daniel, R. A., Errington, J., and Edwards, D. H. (2008) Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis Mol. Microbiol. 68, 1029-1046 (Pubitemid 351581066)
104. Ebersbach, G. and Jacobs-Wagner, C. (2007) Exploration into the spatial and temporal mechanisms of bacterial polarity Trends Microbiol. 15, 101-108 (Pubitemid 46356980)
105. Schermelleh, L., Heintzmann, R., and Leonhardt, H. (2010) A guide to super-resolution fluorescence microscopy J. Cell Biol. 190, 165-175
106. Toomre, D. and Bewersdorf, J. (2010) A new wave of cellular imaging Annu. Rev. Cell Dev. Biol. 26, 285-314
107. Mileykovskaya, E. and Dowhan, W. (2005) Role of membrane lipids in bacterial division-site selection Curr. Opin. Microbiol. 8, 135-142 (Pubitemid 40417953)
108. Epand, R. M. and Epand, R. F. (2009) Domains in bacterial membranes and the action of antimicrobial agents Mol. BioSyst. 5, 580-587
109. Dowhan, W. (1997) Molecular basis for membrane phospholipid diversity: Why are there so many lipids? Annu. Rev. Biochem. 66, 199-232 (Pubitemid 27274656)
110. Radhakrishnan, R., Gupta, C. M., Erni, B., Robson, R. J., Curatolo, W., Majumdar, A., Ross, A. H., Takagaki, Y., and Khorana, H. G. (1980) Phospholipids containing photoactivable groups in studies of biological membranes Ann. N.Y. Acad. Sci. 346, 165-198
111. Garner, J., Durrer, P., Kitchen, J., Brunner, J., and Crooke, E. (1998) Membrane-mediated release of nucleotide from an initiator of chromosomal replication, Escherichia coli DnaA, occurs with insertion of a distinct region of the protein into the lipid bilayer J. Biol. Chem. 273, 5167-5173 (Pubitemid 28108678)
112. de Bony, J., Lopez, A., Gilleron, M., Welby, M., Laneelle, G., Rousseau, B., Beaucourt, J. P., and Tocanne, J. F. (1989) Transverse and lateral distribution of phospholipids and glycolipids in the membrane of the bacterium Micrococcus luteus Biochemistry 28, 3728-3737 (Pubitemid 19125415)
113. Fishov, I. and Woldringh, C. L. (1999) Visualization of membrane domains in Escherichia coli Mol. Microbiol. 32, 1166-1172 (Pubitemid 29286657)
114. Mileykovskaya, E. and Dowhan, W. (2009) Cardiolipin membrane domains in prokaryotes and eukaryotes Biochim. Biophys. Acta 1788, 2084-2091
115. Nishibori, A., Kusaka, J., Hara, H., Umeda, M., and Matsumoto, K. (2005) Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes J. Bacteriol. 187, 2163-2174 (Pubitemid 40316247)
116. Christensen, H., Garton, N. J., Horobin, R. W., Minnikin, D. E., and Barer, M. R. (1999) Lipid domains of mycobacteria studied with fluorescent molecular probes Mol. Microbiol. 31, 1561-1572 (Pubitemid 29110111)
117. Vanounou, S., Parola, A. H., and Fishov, I. (2003) Phosphatidylethanolamine and phosphatidylglycerol are segregated into different domains in bacterial membrane. A study with pyrene-labelled phospholipids Mol. Microbiol. 49, 1067-1079 (Pubitemid 36981350)
118. Vanounou, S., Pines, D., Pines, E., Parola, A. H., and Fishov, I. (2002) Coexistence of domains with distinct order and polarity in fluid bacterial membranes Photochem. Photobiol. 76, 1-11
119. Choung, S. Y., Kobayashi, T., Inoue, J., Takemoto, K., Ishitsuka, H., and Inoue, K. (1988) Hemolytic activity of a cyclic peptide Ro09-0198 isolated from Streptoverticillium Biochim. Biophys. Acta 940, 171-179
120. 1H NMR analyses in dimethyl sulfoxide solution Biochemistry 29, 113-118 (Pubitemid 20033712)
121. Mileykovskaya, E., Dowhan, W., Birke, R. L., Zheng, D., Lutterodt, L., and Haines, T. H. (2001) Cardiolipin binds nonyl acridine orange by aggregating the dye at exposed hydrophobic domains on bilayer surfaces FEBS Lett. 507, 187-190 (Pubitemid 33001539)
122. Allen, J. A., Halverson-Tamboli, R. A., and Rasenick, M. M. (2007) Lipid raft microdomains and neurotransmitter signalling Nat. Rev. Neurosci. 8, 128-140 (Pubitemid 46146951)
123. Lingwood, D. and Simons, K. (2010) Lipid rafts as a membrane-organizing principle Science 327, 46-50
124. Campbell, J. W. and Cronan, J. E., Jr. (2001) Bacterial fatty acid biosynthesis: Targets for antibacterial drug discovery Annu. Rev. Microbiol. 55, 305-332 (Pubitemid 32978108)
125. Heath, R. J., White, S. W., and Rock, C. O. (2002) Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics Appl. Microbiol. Biotechnol. 58, 695-703
126. Wright, H. T. and Reynolds, K. A. (2007) Antibacterial targets in fatty acid biosynthesis Curr. Opin. Microbiol. 10, 447-453 (Pubitemid 350052682)
127. Lopez, D. and Kolter, R. (2010) Functional microdomains in bacterial membranes Genes Dev. 24, 1893-1902
128. Kawai, F., Shoda, M., Harashima, R., Sadaie, Y., Hara, H., and Matsumoto, K. (2004) Cardiolipin domains in Bacillus subtilis Marburg membranes J. Bacteriol. 186, 1475-1483 (Pubitemid 38248738)
129. Mileykovskaya, E. and Dowhan, W. (2000) Visualization of phospholipid domains in Escherichia coli by using the cardiolipin-specific fluorescent dye 10-N-nonyl acridine orange J. Bacteriol. 182, 1172-1175 (Pubitemid 30075045)
130. Emoto, K. and Umeda, M. (2001) Membrane lipid control of cytokinesis Cell Struct. Funct. 26, 659-665 (Pubitemid 34464434)
131. Ramamurthi, K. S. and Losick, R. (2009) Negative membrane curvature as a cue for subcellular localization of a bacterial protein Proc. Natl. Acad. Sci. U.S.A. 106, 13541-13545
132. Mukhopadhyay, R., Huang, K. C., and Wingreen, N. S. (2008) Lipid localization in bacterial cells through curvature-mediated microphase separation Biophys. J. 95, 1034-1049
133. Barak, I., Muchova, K., Wilkinson, A. J., O'Toole, P. J., and Pavlendova, N. (2008) Lipid spirals in Bacillus subtilis and their role in cell division Mol. Microbiol. 68, 1315-1327 (Pubitemid 351670204)
134. Romantsov, T., Helbig, S., Culham, D. E., Gill, C., Stalker, L., and Wood, J. M. (2007) Cardiolipin promotes polar localization of osmosensory transporter ProP in Escherichia coli Mol. Microbiol. 64, 1455-1465 (Pubitemid 46889896)
135. Gold, V. A., Robson, A., Bao, H., Romantsov, T., Duong, F., and Collinson, I. (2010) The action of cardiolipin on the bacterial translocon Proc. Natl. Acad. Sci. U.S.A. 107, 10044-10049
136. van den Brink-van der Laan, E., Boots, J. W., Spelbrink, R. E., Kool, G. M., Breukink, E., Killian, J. A., and de Kruijff, B. (2003) Membrane interaction of the glycosyltransferase MurG: A special role for cardiolipin J. Bacteriol. 185, 3773-3779 (Pubitemid 36735927)
137. Renner, L. D. and Weibel, D. B. (2011) Cardiolipin microdomains localize to negatively curved regions of Escherichia coli membranes Proc. Natl. Acad. Sci. U.S.A. 108, 6264-6269
138. Romantsov, T., Battle, A. R., Hendel, J. L., Martinac, B., and Wood, J. M. (2010) Protein localization in Escherichia coli cells: Comparison of the cytoplasmic membrane proteins ProP, LacY, ProW, AqpZ, MscS, and MscL J. Bacteriol. 192, 912-924
139. Backus, K. M., Boshoff, H. I., Barry, C. S., Boutureira, O., Patel, M. K., D'Hooge, F., Lee, S. S., Via, L. E., Tahlan, K., Barry, C. E., III, and Davis, B. G. (2011) Uptake of unnatural trehalose analogs as a reporter for Mycobacterium tuberculosis Nat. Chem. Biol. 7, 228-235
140. Camberg, J. L., Johnson, T. L., Patrick, M., Abendroth, J., Hol, W. G., and Sandkvist, M. (2007) Synergistic stimulation of EpsE ATP hydrolysis by EpsL and acidic phospholipids EMBO J. 26, 19-27 (Pubitemid 46094696)