Imbalanced intrahepatic cytokine expression of interferon-γ, tumor necrosis factor-α, and interleukin-10 in patients with acute-on-chronic liver failure associated with hepatitis B virus infection

Journal of Clinical Gastroenterology

Volumn 43, Issue 2, 2009, Pages 182-190

  Zou, Zhengsheng ^a   Li, Baosen ^a   Xu, Dongping ^a   Zhang, Zheng ^a   Zhao, Jing Min ^a   Zhou, Guangde ^a   Sun, Yanling ^a   Huang, Lei ^b   Fu, Junliang ^a   Yang, Yongping ^a   Jin, Lei ^a   Zhang, Wei ^a   Zhao, Jun ^a   Sun, Ying ^a   Xin, Shaojie ^a   Wang, Fu Sheng ^a  

^a BEIJING 302 HOSPITAL   (China)

^b PEKING UNIVERSITY   (China)

Author keywords

Acute on chronic liver failure; Immunohistochemistry; Interferon ; Interleukin 10; Tumor necrosis factor

Indexed keywords

CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE;

ACUTE ON CHRONIC LIVER FAILURE; ADULT; AGED; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CHINA; CHRONIC LIVER DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HEPATITIS B; HISTOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; KUPFFER CELL; LIVER FAILURE; MALE; PRIORITY JOURNAL; CYTOLOGY; HEPATITIS B VIRUS; IMMUNOLOGY; LIVER; LIVER CIRRHOSIS; LYMPHOCYTE ACTIVATION; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOPHYSIOLOGY; UPREGULATION; VIROLOGY;

ADULT; AGED; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; FEMALE; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; IMMUNOHISTOCHEMISTRY; INTERFERON-GAMMA; INTERLEUKIN-10; KUPFFER CELLS; LIVER; LIVER CIRRHOSIS; LIVER FAILURE, ACUTE; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; TUMOR NECROSIS FACTOR-ALPHA; UP-REGULATION;

EID: 64749115624     PISSN: 01920790     EISSN: None     Source Type: Journal    
DOI: 10.1097/MCG.0b013e3181624464     Document Type: Article

References (40)

1. Sen S, Williams R, Jalan R. The pathophysiological basis of acute-on-chronic liver failure. Liver. 2002;22(suppl 2):5-13.
2. Sen S, Davies NA, Mookerjee RP, et al. Pathophysiological effects of albumin dialysis in acute-on-chronic liver failure: a randomized controlled study. Liver Transpl. 2004;10: 1109-1119. (Pubitemid 39248408)
3. Sen S, Jalan R, Williams R. Extracorporeal albumin dialysis in acute-on-chronic liver failure: will it stand the test of time? Hepatology. 2002;36(4 Pt 1):949-958.
4. Jalan R, Williams R. Acute-on-chronic liver failure: pathophysiological basis of therapeutic options. Blood Purif. 2002;20: 252-261. (Pubitemid 34195668)
5. Wasmuth HE, Kunz D, Yagmut E, et al. Patients with acute on chronic liver failure display 'sepsis-like' immune paralysis. J Hepatol. 2005;42:195-201.
6. Liu CL, Fan ST, Lo CM, et al. Liver-donor liver transplatation for acute-on-chronic hepatitis B liver failure. Transplantation. 2003;76:1174-1179. (Pubitemid 37339640)
7. Chinese Society of Infectious Diseases and Parasitology and Chinese Society of Hepatology of Chinese Medical Association. Management scheme of diagnositic and therapy criteria of viral hepatitis. Zhonghua Gan Zang Bing Za Zhi (Chin J Hepatol). 2000;8:324-329.
8. Ke WM, Ye YN, Huang S. Discriminant function for prognostic indexes and probability of death in chronic severe hepatitis B. J Gastroenterol. 2003;38:861-864. (Pubitemid 37322033)
9. Zou Z, Chen J, Xin S, et al. Features of chronic severe hepatitis in 520 cases with chronic severe hepatitis. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi (Chin J Exp Clin Virol). 2002;16:246-248.
10. Custer B, Sullivan SD, Hazlet TK, et al. Global epidemiology of hepatitis B virus. J Clin Gastroenterol. 2004;38(10 suppl): S158-S168.
11. Ando K, Moriyama T, Guidotti LG, et al. Mechanisms of class I restricted immunopathology: a trangenic mouse model of fulminant hepatitis. J Exp Med. 1993;178:1541-1554. (Pubitemid 23318433)
12. Ohta A, Sekimoto M, Sato M, et al. Indispensable role for TNF-alpha and IFN-gamma at the effector phase of liver injury mediated by Th1 cells specific to hepatitis B virus surface antigen. J Immunol. 2000;165:956-961. (Pubitemid 30484764)
13. Nishimura T, Ohta A. A critical role for antigen-specific Th1 cells in acute liver injury in mice. J Immunol. 1999;162: 6503-6509. (Pubitemid 29309372)
14. Schumann J, Wolf D, Pahl A, et al. Importance of Kupffer cells for T-cell-dependent liver injury in mice. Am J Pathol. 2000;157:1671-1683. (Pubitemid 30943224)
15. Ohta S, Nakamuta M, Fukushima M, et al. Beraprost sodium, a prostacyclin (PGI) analogue, ameliorates concanavalin a-induced liver injury in mice. Liver Int. 2005;25:1061-1068. (Pubitemid 41404030)
16. Odeh M. Endotoxin and tumor necrosis factor-alpha in the pathogenesis of hepatic encephalopathy. J Clin Gastroenterol. 1994;19:146-153. (Pubitemid 24267572)
17. Ishida Y, Kondo T, Tsuneyama K, et al. The pathogenic roles of tumor necrosis factor receptor p55 in acetaminopheninduced liver injury in mice. J Leukoc Biol. 2004;75:59-67. (Pubitemid 38166780)
18. Louis H, Le Moine O, Peny MO, et al. Production and role of interleukin-10 in concanavalin A-induced hepatitis in mice. Hepatology. 1997;25:1382-1389. (Pubitemid 27250758)
19. Di Marco R, Xiang M, Zaccone P, et al. Concanavalin A-induced hepatitis in mice is prevented by interleukin (IL)-10 and exacerbated by endogenous IL-10 deficiency. Autoimmunity. 1999;31:75-83. (Pubitemid 30110396)
20. Kato M, Ikeda N, Matsushita E, et al. Involvement of IL-10, an anti-inflammatory cytokine in murine liver injury induced by concanavalin A. Hepatol Res. 2001;20:232-243. (Pubitemid 33734027)
21. Nagaki M, Tanaka M, Sugiyama A, et al. Interleukin-10 inhibits hepatic injury and tumor necrosis factor-α and interferon-γ mRNA expression induced by staphylococcal enterotoxin B or lipopolysaccharide in galactosamine-sensitized mice. J Hepatol. 1999;31:815-824. (Pubitemid 29514214)
22. Leifeld L, Cheng S, Ramakers J, et al. Imbalanced intrahepatic expression of interleukin 12, interferon gamma, and interleukin 10 in fulminant hepatitis B. Hepatology. 2002;36(4 Pt 1): 1001-1008.
23. Mita A, Hashikura Y, Tagawa Y-I, et al. Expression of Fas Ligand by hepatic macrophages in patients with fulminant hepatic failure. Am J Gastroenterol. 2005;100:2551-2559. (Pubitemid 43919690)
24. Streetz K, Leifeld L, Grundmann D, et al. Tumor necrosis factor a in the pathogenesis of human and murine fulminant hepatic failure. Gastroenterology. 2000;119:446-460. (Pubitemid 30621995)
25. Zhou GD, Zhao JM, Wang SS, et al. Clinical and pathological analysis on characteristics of primary biliary cirrhosis. Zhonghua Gan Zang Bing Za Zhi (Chin J Hepatol). 2003;11: 483-486.
26. Nelson DR, Lauwers GY, Lau JY, et al. Interleukin 10 treatment reduces fibrosis in patients with chronic hepatitis C: a pilot trial of interferon nonresponders. Gastroenterology. 2000;118:655-660. (Pubitemid 30171614)
27. Farrar MA, Schreiber RD. The molecular cell biology of interferon-γ and its receptor. Ann Rev Immunol. 1993;11: 571-611. (Pubitemid 23115018)
28. Tanaka Y, Takahashi A, Kobayashi K, et al. Establishment of a T cell-dependent nude mouse liver injury model induced by Propionibacterium acnes and LPS. J Immunol Methods. 1995; 182:21-28.
29. Franco A, Guidotti LG, Hobbs MV, et al. Pathogenetic effector function of CD4-positive T helper 1 cells in hepatitis B virus transgenic mice. J Immunol. 1997;159:2001-2008. (Pubitemid 127484191)
30. Gantner F, Leist M, Lohse AW, et al. Concanavalin A-induced T cell- mediated hepatic injury in mice: the role of tumor necrosis factor. Hepatology. 1995;21:190-198.
31. Kusters S, Gantner F, Kunstle G, et al. Interferon-γ plays a critical role in T cell-dependent liver injury in mice initiated by concanavalin A. Gastroenterology. 1996;111:462-471. (Pubitemid 26256736)
32. Tanaka Y, Takahashi A, Watanabe K, et al. A pivotal role of IL-12 in Th1-dependent mouse liver injury. Int Immunol. 1996;8:569-576. (Pubitemid 26115872)
33. Gilles PN, Guerrette DL, Ulevitch RJ, et al. HBsAg retention sensitizes the hepatocytes to injury by physiological concentrations of interferon-γ. Hepatology. 1992;16:655-663.
34. Talmadge JE, Bowersox O, Tribble H, et al. Toxicity of tumor necrosis factor is synergistic with g-interferon and can be reduced with cyclooxygenase inhibitors. Am J Pathol. 1987; 128:410-425. (Pubitemid 17139893)
35. Adamson GM, Billings RE. Cytokine toxicity and induction of NO synthase activity in cultured mouse hepatocytes. Toxicol Appl Pharmacol. 1993;119:100-107. (Pubitemid 23109421)
36. Doherty GM, Lange JR, Langstein HN, et al. Evidence for IFN-γ as a mediator of the lethality of endotoxin and tumor necrosis factor-α. J Immunol. 1992;149:1666-1670.
37. Aggarwal BB, Eessalu TE, Hass PE. Characterization of receptors for tumor necrosis factor and their regulation by gamma-interferon. Nature. 1985;318:665-667. (Pubitemid 16172416)
38. Ruggiero V, Tavernier J, Fiers W, et al. Induction of the synthesis of tumor necrosis factor receptors by interferongamma. J Immunol. 1986;136:2445-2450. (Pubitemid 16136821)
39. Schiller JH, Bittner G, Storer B, et al. Synergistic antitumor effects of tumor necrosis factor and g-interferon on human colon carcinoma cell lines. Cancer Res. 1987;47:2809-2813. (Pubitemid 17113420)
40. Campbell IL, Iscaro A, Harrison LC. IFN-γ and tumor necrosis factor-α: cytotoxicity to murine islets of Langerhans. J Immunol. 1988;141:2325-2329. (Pubitemid 18237461)