Brugada-like EKG pattern and myocardial effects in a chronic propofol abuser

Clinical Toxicology

Volumn 47, Issue 4, 2009, Pages 358-363

  Riezzo, Irene ^a   Centini, Fabio ^b   Neri, Margherita ^a   Rossi, Giuseppina ^b   Spanoudaki, Elpis ^c   Turillazzi, Emanuela ^a   Fineschi, Vittorio ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF SIENA   (Italy)

^c UNIVERSITY OF CRETE   (Greece)

Author keywords

Apoptosis; EKG pattern; Propofol; Recreational abuse; TNF

Indexed keywords

PROPOFOL; TUMOR NECROSIS FACTOR ALPHA; INTRAVENOUS ANESTHETIC AGENT;

ADULT; APOPTOSIS; ARTICLE; BRUGADA SYNDROME; CARDIOTOXICITY; DRUG ABUSE; ELECTROCARDIOGRAM; FOREARM; HEART MUSCLE CELL; HEART VENTRICLE FIBRILLATION; HOSPITAL ADMISSION; HUMAN; HYPOTENSION; INTENSIVE CARE UNIT; MALE; METABOLIC ACIDOSIS; MORPHOLOGY; PATIENT MONITORING; QT INTERVAL; QT PROLONGATION; ST SEGMENT ELEVATION; SUDDEN DEATH; SYRINGE; CASE REPORT; CHEMICALLY INDUCED DISORDER; ELECTROCARDIOGRAPHY; FATALITY; PATHOPHYSIOLOGY; SUBSTANCE ABUSE; TIME;

ADULT; ANESTHETICS, INTRAVENOUS; BRUGADA SYNDROME; DEATH, SUDDEN, CARDIAC; ELECTROCARDIOGRAPHY; FATAL OUTCOME; HUMANS; MALE; PROPOFOL; SUBSTANCE ABUSE, INTRAVENOUS; TIME FACTORS;

EID: 67649184173     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.1080/15563650902887842     Document Type: Article

References (21)

1. Vernooy K, Delhaas T, Cremer OL, Di Diego JM, Oliva A, Timmermans C, Volders PG, Prinzen FW, Crijns HJ, Antzelevitch C, Kalkman CJ, Rodriguez LM, Brugada R. Electrocardiographic changes predicting sudden death in propofol-related infusion syndrome. Heart Rhythm 2006; 3:131-137.
2. Branca D, Roberti MS, Lorenzin P, Vincenti E, Scutari G. Influence of the anesthetic 2,6-diisopropylphenol on the oxidative phosphorylation of isolated rat liver mitochondria. Biochem Pharmacol 1991; 42:87-90.
3. Schenkman KA, Yan S. Propofol impairment of mitochondrial respiration in isolated perfused guinea pig hearts determined by reflectance spectroscopy. Crit Care Med 2000; 28:172-177.
4. Yamamoto S, Kawana S, Miyamoto A, Ohshika H, Namiki A. Propofol- induced depression of cultured rat ventricular myocytes is related to the M2-acetylcholine receptor-NO-cGMP signalling pathway. Anesthesiology 1999; 91:1712-1719.
5. Kurokawa H, Murray PA, Damron DS. Propofol attenuates betaadrenoreceptor- mediated signal transduction via a protein kinase C-dependent pathway in cardiomyocytes. Anesthesiology 2002; 96:688-698.
6. Fineschi V, Neri M, Di Padua M, Fiore C, Riezzo I, Turillazzi E. Morphology, TNFalpha expression and apoptosis in the hearts of patients who died of abdominal compartment syndrome: an immunohistochemical study. Int J Cardiol 2007; 116:236-241.
7. Ernest D, French C. Propofol infusion syndrome - report of an adult fatality. Anaesth Intensive Care 2003; 31:316-319.
8. Eriksen J, Povey HM. A case of suspected non-surgical adult fatal propofol infusion syndrome. Acta Anaesthesiol Scand 2006; 50:117-119.
9. Wysowski DK, Pollock ML. Reports of death with use of protocol (Diprivan) for nonprocedural (long-term) sedation and literature review. Anesthesiology 2006; 105:1047-1051.
10. Iwersen-Bergmann S, Rösner P, Kühnau HC, Junge M, Schmoldt A. Death after excessive propofol abuse. Int J Legal Med 2001; 114:248-251.
11. Kranioti EF, Mavroforou A, Mylonakis P, Michalodimitrakis M. Lethal self administration of propofol (Diprivan). A case report and review of the literature. Forensic Sci Int 2007; 167:56-58.
12. Roussin A, Montastruc JL, Lapeyre-Mestre M. Pharmacological and clinical evidences on the potential for abuse and dependence of propofol: a review of the literature. Fundam Clin Pharmacol 2007; 21:459-466.
13. Cirimele V, Kintz P, Doray S, Ludes B. Determination of chronic abuse of the anaesthetic agents midazolam and propofol as demonstrated by hair analysis. Int J Legal Med 2002; 116:54-57.
14. Roussin A, Mirepoix M, Lassabe G, Dumestre-Toulet V, Gardette V, Montastruc JL, Lapeyre-Mestre M. Death related to a recreational abuse of propofol at therapeutic dose range. Br J Anaesth 2006; 97:268.
15. Stelow EB, Johari VP, Smith SA, Crosson JT, Apple FS. Propofolassociated rhabdomyolysis with cardiac involvement in adults: chemical and anatomic findings. Clin Chem 2000; 46:577-581.
16. Wilde AA, Antzelevitch C, Borggrefe M, Brugada J, Brugada R, Brugada P, Corrado D, Hauer RN, Kass RS, Nademanee K, Priori SG, Towbin JA, Study Group on the Molecular Basis of Arrhythmias of the European Society of Cardiology. Proposed diagnostic criteria for the Brugada syndrome: consensus report. Circulation 2002; 106:2514-2519. (Pubitemid 35278811)
17. Lee CJ, Subeq YM, Lee RP, Wu WT, Hsu BG. Low-dose propofol ameliorates haemorrhagic shock-induced organ damage in conscious rats. Clin Exp Pharmacol Physiol 2008; 35:766-774.
18. Taniguchi T, Kanakura H, Yamamoto K. Effects of post-treatment with propofol on mortality and cytokine responses to endotoxin-induced shock in rats. Crit Care Med 2002; 30:904-907.
19. Casserly B, O'Mahony E, Timm EG, Haqqie S, Eisele G, Urizar R. Propofol infusion syndrome: an unusual cause of renal failure. Am J Kidney Dis 2004; E98-E101.
20. Neri M, Cerretani D, Fiaschi AI, Laghi PF, Lazzerini PE, Maffione AB, Micheli L, Bruni G, Nencini C, Giorgi G, D'Errico S, Fiore C, Pomara C, Riezzo I, Turillazzi E, Fineschi V. Correlation between cardiac oxidative stress and myocardial pathology due to acute and chronic norepinephrine administration in rats. J Cell Mol Med 2007; 11:156-170.
21. Junttila MJ, Gonzalez M, Lizotte E, Benito B, Vernooy K, Sarkozy A, Huikuri HV, Brugada P, Brugada J, Brugada R. Induced Brugada-type electrocardiogram, a sign for imminent malignant arrhythmias. Circulation 2008; 117:1890-1893.