Airway smooth muscle STIM1 and Orai1 are upregulated in asthmatic mice and mediate PDGF-activated SOCE, CRAC currents, proliferation, and migration

Pflugers Archiv European Journal of Physiology

Volumn 464, Issue 5, 2012, Pages 481-492

  Spinelli, Amy M ^a   González Cobos, José C ^a   Zhang, Xuexin ^a   Motiani, Rajender K ^a   Rowan, Sarah ^a   Zhang, Wei ^a   Garrett, Joshua ^a   Vincent, Peter A ^a   Matrougui, Khalid ^b   Singer, Harold A ^a   Trebak, Mohamed ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Asthma; CRAC; Orai1; Smooth muscle remodeling; SOCE; STIM1

Indexed keywords

ALUMINUM HYDROXIDE; CALCIUM CHANNEL; CALCIUM RELEASE ACTIVATED CALCIUM CHANNEL 1; INTERLEUKIN 13; OVALBUMIN; PLATELET DERIVED GROWTH FACTOR; STROMAL INTERACTION MOLECULE 1; THAPSIGARGIN;

AIRWAY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CALCIUM TRANSPORT; CELL LEVEL; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GENETIC TRANSFECTION; LUNG LAVAGE; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; SOCE SIGNALING PATHWAY; UPREGULATION;

ANIMALS; ASTHMA; CALCIUM; CALCIUM CHANNELS; CALCIUM SIGNALING; CELL MOVEMENT; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE POTENTIALS; MICE; MICE, INBRED C57BL; MYOCYTES, SMOOTH MUSCLE; PLATELET-DERIVED GROWTH FACTOR; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TRACHEA; UP-REGULATION;

EID: 84867862501     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-012-1160-5     Document Type: Article

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