The phenotype of circulating follicular-helper T cells in patients with rheumatoid arthritis defines CD200 as a potential therapeutic target

Clinical and Developmental Immunology

Volumn 2012, Issue , 2012, Pages

  Chakera, Aron ^a   Bennett, Sophia C ^b   Morteau, Olivier ^b   Bowness, Paul ^c   Luqmani, Raashid A ^b   Cornall, Richard J ^b  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c NUFFIELD ORTHOPAEDIC CENTRE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BIOLOGICAL PRODUCT; CD200 ANTIGEN; TUMOR NECROSIS FACTOR ALPHA INHIBITOR; ANTIGENS, CD200; GAMMA INTERFERON; LEUKOCYTE ANTIGEN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; AUTOIMMUNITY; CELL POLARITY; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY; FEMALE; FLOW CYTOMETRY; FOLLICULAR HELPER T CELL; HELPER CELL; HUMAN; HUMAN CELL; MALE; MOLECULARLY TARGETED THERAPY; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; TH1 CELL; TH17 CELL; TH2 CELL; BLOOD; CASE CONTROL STUDY; IMMUNOLOGY; MIDDLE AGED; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; AUTOIMMUNITY; CASE-CONTROL STUDIES; FEMALE; HUMANS; INTERFERON-GAMMA; MALE; MIDDLE AGED; PHENOTYPE; T-LYMPHOCYTES, HELPER-INDUCER; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

EID: 84867839282     PISSN: 17402522     EISSN: 17402530     Source Type: Journal    
DOI: 10.1155/2012/948218     Document Type: Article

References (47)

1. Klareskog L., Catrina A. I., Paget S., Rheumatoid arthritis. The Lancet 2009 373 9664 659 672 2-s2.0-60249090304 10.1016/S0140-6736(09)60008-8
2. Conrad K., Roggenbuck D., Reinhold D., Dörner T., Profiling of rheumatoid arthritis associated autoantibodies. Autoimmunity Reviews 2010 9 6 431 435 2-s2.0-77949912183 10.1016/j.autrev.2009.11.017
3. Simon M., Girbal E., Sebbag M., Gomes-Daudrix V., Vincent C., Salama G., Serre G., The cytokeratin filament-aggregating protein filaggrin is the target of the so-called antikeratin antibodies autoantibodies specific for rheumatoid arthritis. Journal of Clinical Investigation 1993 92 3 1387 1393 2-s2.0-0027217907
4. MacLennan I. C. M., Germinal centers. Annual Review of Immunology 1994 12 117 139 2-s2.0-0028324816
5. Weyand C. M., Goronzy J. J., Ectopic germinal center formation in rheumatoid synovitis. Annals of the New York Academy of Sciences 2003 987 140 149 2-s2.0-0038240921
6. + T cells in rheumatoid arthritis. Journal of Clinical Investigation 1994 94 5 2068 2076 2-s2.0-0028113950
7. Roux H., Bonnefoy-Cudraz M., Gaborit P., HLA-DR typing in 58 cases of rheumatoid arthritis. Clinical Rheumatology 1982 1 2 112 116 2-s2.0-0020327349
8. Schaerli P., Willimann K., Lang A. B., Lipp M., Loetscher P., Moser B., CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. Journal of Experimental Medicine 2000 192 11 1553 1562 2-s2.0-0034606348 10.1084/jem.192.11.1553
9. Reinhardt R. L., Liang H. E., Locksley R. M., Cytokine-secreting follicular T cells shape the antibody repertoire. Nature Immunology 2009 10 4 385 393 2-s2.0-62849090439 10.1038/ni.1715
10. Vinuesa C. G., Tangye S. G., Moser B., Mackay C. R., Follicular B helper T cells in antibody responses and autoimmunity. Nature Reviews Immunology 2005 5 11 853 865 2-s2.0-27744498868 10.1038/nri1714
11. Gómez-Martín D., Díaz-Zamudio M., Romo-Tena J., Ibarra-Sánchez M. J., Alcocer-Varela J., Follicular helper T cells poise immune responses to the development of autoimmune pathology. Autoimmunity Reviews 2011 10 6 325 330 2-s2.0-79953162451 10.1016/j.autrev.2010.11.007
12. Nurieva R. I., Treuting P., Duong J., Flavell R. A., Dong C., Inducible costimulator is essential for collagen-induced arthritis. Journal of Clinical Investigation 2003 111 5 701 706 2-s2.0-0037370324 10.1172/JCI200317321
13. Vinuesa C. G., Cook M. C., Angelucci C., Athanasopoulos V., Rui L., Hill K. M., Yu D., Domaschenz H., Whittle B., Lambe T., Roberts I. S., Copley R. R., Bell J. I., Cornall R. J., Goodnow C. C., A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature 2005 435 7041 452 458 2-s2.0-21144438325 10.1038/nature03555
14. Dong W., Zhu P., Wang Y., Wang Z., Follicular helper T cells in systemic lupus erythematosus: a potential therapeutic target. Autoimmunity Reviews 2011 10 6 299 304 2-s2.0-79953160964 10.1016/j.autrev.2010.11.004
15. Ma J., Zhu C., Ma B., Increased frequency of circulating follicular helper T cells in patients with rheumatoid arthritis. Clinical & Developmental Immunology 2012 2012 7 827480 10.1155/2012/827480
16. Simpson N., Gatenby P. A., Wilson A., Malik S., Fulcher D. A., Tangye S. G., Manku H., Vyse T. J., Roncador G., Huttley G. A., Goodnow C. C., Vinuesa C. G., Cook M. C., Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis and Rheumatism 2010 62 1 234 244 2-s2.0-74849138095 10.1002/art.25032
17. + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011 34 1 108 121 2-s2.0-78751690647 10.1016/j.immuni.2010.12.012
18. Breitfeld D., Ohl L., Kremmer E., Ellwart J., Sallusto F., Lipp M., Förster R., Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. Journal of Experimental Medicine 2000 192 11 1545 1551 2-s2.0-0034606359 10.1084/jem.192.11.1545
19. Arnett F. C., Edworthy S. M., Bloch D. A., McShane D. J., Fries J. F., Cooper N. S., Healey L. A., Kaplan S. R., Liang M. H., Luthra H. S., Medsger T. A., Mitchell D. M., Neustadt D. H., Pinals R. S., Schaller J. G., Sharp J. T., Wilder R. L., Hunder G. G., The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis and Rheumatism 1988 31 3 315 324 2-s2.0-0023945481
20. M'Hidi H., Thibult M. L., Chetaille B., Rey F., Bouadallah R., Nicollas R., Olive D., Xerri L., High expression of the inhibitory receptor BTLA in T-follicular helper cells and in B-cell small lymphocytic lymphoma/chronic lymphocytic leukemia. American Journal of Clinical Pathology 2009 132 4 589 596 2-s2.0-70349560843 10.1309/AJCPPHKGYYGGL39C
21. De Rycke L., Peene I., Hoffman I. E. A., Kruithof E., Union A., Meheus L., Lebeer K., Wyns B., Vincent C., Mielants H., Boullart L., Serre G., Veys E. M., De Keyser F., Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnosis value, associations with radiological progression rate, and extra-articular manifestations. Annals of the Rheumatic Diseases 2004 63 12 1587 1593 2-s2.0-7044279878 10.1136/ard.2003.017574
22. Chen Z., Marsden P. A., Gorczynski R. M., Role of a distal enhancer in the transcriptional responsiveness of the human CD200 gene to interferon- γ and tumor necrosis factor- α Molecular Immunology 2009 46 10 1951 1963 2-s2.0-67349108339 10.1016/j.molimm.2009.03.015
23. Šimelyte E., Criado G., Essex D., Uger R. A., Feldmann M., Williams R. O., CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis. Arthritis and Rheumatism 2008 58 4 1038 1043 2-s2.0-42449121727 10.1002/art.23378
24. Linterman M. A., Rigby R. J., Wong R. K., Yu D., Brink R., Cannons J. L., Schwartzberg P. L., Cook M. C., Walters G. D., Vinuesa C. G., Follicular helper T cells are required for systemic autoimmunity. Journal of Experimental Medicine 2009 206 3 561 576 2-s2.0-63449096041 10.1084/jem.20081886
25. Hu Y. L., Metz D. P., Chung J., Siu G., Zhang M., B7RP-1 blockade ameliorates autoimmunity through regulation of follicular helper T cells. Journal of Immunology 2009 182 3 1421 1428 2-s2.0-63149093151
26. Lachenal F., Berger F., Ghesquières H., Biron P., Hot A., Callet-Bauchu E., Chassagne C., Coiffier B., Durieu I., Rousset H., Salles G., Angioimmunoblastic T-cell lymphoma: clinical and laboratory features at diagnosis in 77 patients. Medicine 2007 86 5 282 292 2-s2.0-34548661515 10.1097/MD.0b013e3181573059
27. Takemura S., Braun A., Crowson C., Kurtin P. J., Cofield R. H., O'Fallon W. M., Goronzy J. J., Weyand C. M., Lymphoid neogenesis in rheumatoid synovitis. Journal of Immunology 2001 167 2 1072 1080 2-s2.0-0035879123
28. Raychaudhuri S., Thomson B. P., Remmers E. F., Eyre S., Hinks A., Guiducci C., Catanese J. J., Xie G., Stahl E. A., Chen R., Alfredsson L., Amos C. I., Ardlie K. G., Barton A., Bowes J., Burtt N. P., Chang M., Coblyn J., Costenbader K. H., Criswell L. A., Crusius J. B. A., Cui J., De Jager P. L., Ding B., Emery P., Flynn E., Harrison P., Hocking L. J., Huizinga T. W. J., Kastner D. L., Ke X., Kurreeman F. A. S., Lee A. T., Liu X., Li Y., Martin P., Morgan A. W., Padyukov L., Reid D. M., Seielstad M., Seldin M. F., Shadick N. A., Steer S., Tak P. P., Thomson W., Van Der Helm-Van Mil A. H. M., Van Der Horst-Bruinsma I. E., Weinblatt M. E., Wilson A. G., Wolbink G. J., Wordsworth P., Altshuler D., Karlson E. W., Toes R. E. M., De Vries N., Begovich A. B., Siminovitch K. A., Worthington J., Klareskog L., Gregersen P. K., Daly M. J., Plenge R. M., Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk. Nature Genetics 2009 41 12 1313 1318 2-s2.0-70649086092 10.1038/ng.479
29. Lessard C. J., Adrianto I., Kelly J. A., Kaufman K. M., Grundahl K. M., Adler A., Williams A. H., Gallant C. J., Anaya J. M., Bae S. C., Boackle S. A., Brown E. E., Chang D. M., Criswell L. A., Edberg J. C., Freedman B. I., Gregersen P. K., Gilkeson G. S., Jacob C. O., James J. A., Kamen D. L., Kimberly R. P., Martin J., Merrill J. T., Niewold T. B., Park S. Y., Petri M. A., Pons-Estel B. A., Ramsey-Goldman R., Reveille J. D., Song Y. W., Stevens A. M., Tsao B. P., Vila L. M., Vyse T. J., Yu C. Y., Guthridge J. M., Bruner G. R., Langefeld C. D., Montgomery C., Harley J. B., Scofield R. H., Gaffney P. M., Moser K. L., Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. American Journal of Human Genetics 2011 88 1 83 91 2-s2.0-78650862201 10.1016/j.ajhg.2010.11.014
30. Yoshinaga S. K., Whorlskey J. S., Khare S. D., Sarmiento U., Guo J., Horan T., Shih G., Zhang M., Coccia M. A., Kohno T., Tafuri-Bladt A., Brankow D., Campbell P., Chang D., Chiu L., Dal T., Duncan G., Elliott G. S., Hul A., McCabe S. M., Scully S., Shahinlan A., Shaklee C. L., Van G., Mak T. W., Senaidi G., T-cell co-stimulation through B7RP-1 and ICOS. Nature 1999 402 6763 827 830 2-s2.0-0033576707 10.1038/45582
31. Dong C., Juedes A. E., Temann U. A., Shresta S., Allison J. P., Ruddle N. H., Flavell R. A., ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001 409 6816 97 101 2-s2.0-0035804254 10.1038/35051100
32. Katsumata Y., Harigai M., Sugiura T., Kawamoto M., Kawaguchi Y., Matsumoto Y., Kohyama K., Soejima M., Kamatani N., Hara M., Attenuation of experimental autoimmune myositis by blocking ICOS-ICOS ligand interaction. Journal of Immunology 2007 179 6 3772 3779 2-s2.0-34548566284
33. Iwai H., Kozono Y., Hirose S., Akiba H., Yagita H., Okumura K., Kohsaka H., Miyasaka N., Azuma M., Amelioration of collagen-induced arthritis by blockade of inducible costimulator-B7 homologous protein costimulation. Journal of Immunology 2002 169 8 4332 4339 2-s2.0-0037108363
34. Kuwana M., Nomura S., Fujimura K., Nagasawa T., Muto Y., Kurata Y., Tanaka S., Ikeda Y., Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura. Blood 2004 103 4 1229 1236 2-s2.0-0842264044 10.1182/blood-2003-06-2167
35. Barclay A. N., Wright G. J., Brooke G., Brown M. H., CD200 and membrane protein interactions in the control of myeloid cells. Trends in Immunology 2002 23 6 285 290 2-s2.0-0036606950 10.1016/S1471-4906(02)02223-8
36. Jenmalm M. C., Cherwinski H., Bowman E. P., Phillips J. H., Sedgwick J. D., Regulation of myeloid cell function through the CD200 receptor. Journal of Immunology 2006 176 1 191 199 2-s2.0-29644432278
37. Zhang S., Cherwinski H., Sedgwick J. D., Phillips J. H., Molecular mechanisms of CD200 inhibition of mast cell activation. Journal of Immunology 2004 173 11 6786 6793 2-s2.0-9144224962
38. Koning N., Bö L., Hoek R. M., Huitinga I., Downregulation of macrophage inhibitory molecules in multiple sclerosis lesions. Annals of Neurology 2007 62 5 504 514 2-s2.0-37349018717 10.1002/ana.21220
39. Copland D. A., Calder C. J., Raveney B. J. E., Nicholson L. B., Phillips J., Cherwinski H., Jenmalm M., Sedgwick J. D., Dick A. D., Monoclonal antibody-mediated CD200 receptor signaling suppresses macrophage activation and tissue damage in experimental autoimmune uveoretinitis. American Journal of Pathology 2007 171 2 580 588 2-s2.0-34548306817 10.2353/ajpath.2007.070272
40. Rosenblum M. D., Olasz E. B., Yancey K. B., Woodliff J. E., Lazarova Z., Gerber K. A., Truitt R. L., Expression of CD200 on epithelial cells of the murine hair follicle: a role in tissue-specific immune tolerance? Journal of Investigative Dermatology 2004 123 5 880 887 2-s2.0-6344225337 10.1111/j.0022-202X.2004.23461.x
41. Garza L. A., Yang C. C., Zhao T., Blatt H. B., Lee M., He L., Stanton D. C., Carrasco L., Spiegel J. H., Tobias J. W., Cotsarelis G., Bald scalp in men with androgenetic alopecia retains hair follicle stem cells but lacks CD200-rich and CD34-positive hair follicle progenitor cells. Journal of Clinical Investigation 2011 121 2 613 622 2-s2.0-79551525437 10.1172/JCI44478
42. Hoek R. H., Ruuls S. R., Murphy C. A., Wright G. J., Goddard R., Zurawski S. M., Blom B., Homola M. E., Streit W. J., Brown M. H., Barclay A. N., Sedgwick J. D., Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000 290 5497 1768 1771 2-s2.0-17744388105 10.1126/science.290.5497.1768
43. Söderströma K., Stein E., Colmenero P., Purath U., Müller-Ladner U., De Matos C. T., Tarner I. H., Robinson W. H., Engleman E. G., Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. Proceedings of the National Academy of Sciences of the United States of America 2010 107 29 13028 13033 2-s2.0-77955612745 10.1073/pnas.1000546107
44. Rijkers E. S. K., de Ruiter T., Baridi A., Veninga H., Hoek R. M., Meyaard L., The inhibitory CD200R is differentially expressed on human and mouse T and B lymphocytes. Molecular Immunology 2008 45 4 1126 1135 2-s2.0-35548979999 10.1016/j.molimm.2007.07.013
45. Snelgrove R. J., Goulding J., Didierlaurent A. M., Lyonga D., Vekaria S., Edwards L., Gwyer E., Sedgwick J. D., Barclay A. N., Hussell T., A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nature Immunology 2008 9 9 1074 1083 2-s2.0-50049100345 10.1038/ni.1637
46. Šimelyte E., Alzabin S., Boudakov I., Williams R., CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response. Clinical and Experimental Immunology 2010 162 1 163 168 2-s2.0-77956496702 10.1111/j.1365-2249.2010.04227.x
47. Appay V., Reynard S., Voelter V., Romero P., Speiser D. E., Leyvraz S., Immuno-monitoring of CD8+ T cells in whole blood versus PBMC samples. Journal of Immunological Methods 2006 309 1-2 192 199 2-s2.0-31944438409 10.1016/j.jim.2005.11.007