CD200R1 regulates the severity of arthritis but has minimal impact on the adaptive immune response

Clinical and Experimental Immunology

Volumn 162, Issue 1, 2010, Pages 163-168

  Simelyte E ^a   Alzabin, S ^a   Boudakov, I ^a   Williams, R ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

CD200; collagen induced arthritis; immunoregulation; rheumatoid arthritis

Indexed keywords

CD200 ANTIGEN; CD200 RECEPTOR; CD200 RECEPTOR 1; COLLAGEN TYPE 2; UNCLASSIFIED DRUG;

ADAPTIVE IMMUNITY; ARTHRITIS; ARTICLE; B LYMPHOCYTE; DISEASE COURSE; DISEASE SEVERITY; IMMUNE RESPONSE; IMMUNIZATION; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; T LYMPHOCYTE; UPREGULATION;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGENS, CD; ANTIGENS, SURFACE; ARTHRITIS, EXPERIMENTAL; CELL PROLIFERATION; CELLS, CULTURED; CYTOKINES; FEMALE; FLOW CYTOMETRY; GENE EXPRESSION PROFILING; KINETICS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, KNOCKOUT; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEVERITY OF ILLNESS INDEX; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

EID: 77956496702     PISSN: 00099104     EISSN: 13652249     Source Type: Journal    
DOI: 10.1111/j.1365-2249.2010.04227.x     Document Type: Article

References (17)

1. Gorczynski RM, Chen Z, Yu K, Hu J. CD200 immunoadhesin suppresses collagen-induced arthritis in mice. Clin Immunol 2001 101 : 328 334.
2. Simelyte E, Criado G, Essex D, Uger RA, Feldmann M, Williams RO. CD200-Fc, a novel antiarthritic biologic agent that targets proinflammatory cytokine expression in the joints of mice with collagen-induced arthritis. Arthritis Rheum 2008 58 : 1038 1043.
3. Hoek RM, Ruuls SR, Murphy CA et al. Down-regulation of the macrophage lineage through interaction with OX2 (CD200). Science 2000 290 : 1768 1771.
4. Broderick C, Hoek RM, Forrester JV, Liversidge J, Sedgwick JD, Dick AD. Constitutive retinal CD200 expression regulates resident microglia and activation state of inflammatory cells during experimental autoimmune uveoretinitis. Am J Pathol 2002 161 : 1669 1677.
5. Snelgrove RJ, Goulding J, Didierlaurent AM et al. A critical function for CD200 in lung immune homeostasis and the severity of influenza infection. Nat Immunol 2008 9 : 1074 1083.
6. Wright GJ, Cherwinski H, Foster-Cuevas M et al. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol 2003 171 : 3034 3046.
7. Gorczynski R, Chen Z, Kai Y, Lee L, Wong S, Marsden PA. CD200 is a ligand for all members of the CD200R family of immunoregulatory molecules. J Immunol 2004 172 : 7744 7749.
8. Hatherley D, Cherwinski HM, Moshref M, Barclay AN. Recombinant CD200 protein does not bind activating proteins closely related to CD200 receptor. J Immunol 2005 175 : 2469 2474.
9. Boudakov I, Liu J, Fan N, Gulay P, Wong K, Gorczynski RM. Mice lacking CD200R1 show absence of suppression of lipopolysaccharide-induced tumor necrosis factor-alpha and mixed leukocyte culture responses by CD200. Transplantation 2007 84 : 251 257.
10. Williams RO, Feldmann M, Maini RN. Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci USA 1992 89 : 9784 9788.
11. Simelyte E, Rosengren S, Boyle DL, Corr M, Green DR, Firestein GS. Regulation of arthritis by p53: critical role of adaptive immunity. Arthritis Rheum 2005 52 : 1876 1884.
12. Inglis JJ, Simelyte E, McCann FE, Criado G, Williams RO. Protocol for the induction of arthritis in C57BL/6 mice. Nat Protoc 2008 3 : 612 618.
13. Cherwinski HM, Murphy CA, Joyce BL et al. The CD200 receptor is a novel and potent regulator of murine and human mast cell function. J Immunol 2005 174 : 1348 1356.
14. Zhang S, Cherwinski H, Sedgwick JD, Phillips JH. Molecular mechanisms of CD200 inhibition of mast cell activation. J Immunol 2004 173 : 6786 6793.
15. Wright GJ, Puklavec MJ, Willis AC et al. Lymphoid/neuronal cell surface OX2 glycoprotein recognizes a novel receptor on macrophages implicated in the control of their function. Immunity 2000 13 : 233 242.
16. Barclay AN, Wright GJ, Brooke G, Brown MH. CD200 and membrane protein interactions in the control of myeloid cells. Trends Immunol 2002 23 : 285 290.
17. Gorczynski RM. CD200 and its receptors as targets for immunoregulation. Curr Opin Investig Drugs 2005 6 : 483 488.