Exportin T and Exportin 5: tRNA and miRNA biogenesis-and beyond

Biological Chemistry

Volumn 393, Issue 7, 2012, Pages 599-604

  Leisegang, Matthias S ^a   Martin, Roman ^a,b   Ramírez, Ana S ^a   Bohnsack, Markus T ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Gene expression; Nuclear export; Ribosome; RNA transport; RNP biogenesis; Translation

Indexed keywords

CELL NUCLEUS RECEPTOR; EXPORTIN 5; EXPORTIN T; GUANOSINE TRIPHOSPHATASE; KARYOPHERIN BETA; MESSENGER RNA; MICRORNA; NUCLEOPORIN; RIBONUCLEASE III; RNA POLYMERASE II; TRANSFER RNA; UNCLASSIFIED DRUG;

ALPHA HELIX; BIOGENESIS; CELL NUCLEUS; CYTOPLASM; EUKARYOTIC CELL; GENE EXPRESSION; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; INTRON; LARGE RIBOSOMAL SUBUNIT; MICROSATELLITE INSTABILITY; NONHUMAN; NUCLEAR PORE COMPLEX; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; REVIEW; RNA SPLICING; RNA STRUCTURE; RNA SYNTHESIS; RNA TRANSLATION;

HUMANS; KARYOPHERINS; MICRORNAS; RNA, TRANSFER;

EID: 84867826076     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/hsz-2012-0146     Document Type: Review

References (31)

1. Bennasser, Y., Chable-Bessia, C., Triboulet, R., Gibbings, D., Gwizdek, C., Dargemont, C., Kremer, E. J., Voinnet, O., and Benkirane, M. (2011). Competition for XPO5 binding between Dicer mRNA, pre-miRNA and viral RNA regulates human Dicer levels. Nat. Struct. Mol. Biol. 18, 323-327.
2. Bohnsack, M. T., Regener, K., Schwappach, B., Saffrich, R., Paraskeva, E., Hartmann, E., and Görlich, D. (2002). Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm. EMBO J. 21, 6205-6215.
3. Bohnsack, M. T., Czaplinski, K., and Görlich, D. (2004). Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 10, 185-191.
4. Brownawell, A. M. and Macara, I. G. (2002). Exportin-5, a novel karyo pherin, mediates nuclear export of double-stranded RNA binding proteins. J. Cell Biol. 156, 53-64.
5. Calado, A., Treichel, N., Müller, E. C., Otto, A., and Kutay, U. (2002). Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNA. EMBO J. 21, 6216-6224.
6. Cazalla, D., Xie, M., and Steitz, J. A. (2011). A primate herpesvirus uses the integrator complex to generate viral microRNAs. Mol. Cell 43, 982-992.
7. Chen, T., Brownawell, A. M., and Macara, I. G. (2004). Nucleocytoplasmic shuttling of JAZ, a new cargo protein for exportin-5. Mol. Cell. Biol. 24, 6608-6619.
8. Cook, A. G., Fukuhara, N., Jinek, M., and Conti, E. (2009). Structures of the tRNA export factor in the nuclear and cytosolic states. Nature 461, 60-65.
9. Fritz, J., Strehblow, A., Taschner, A., Schopoff, S., Pasierbek, P., and Jantsch, M. F. (2009). RNA-regulated interaction of transportin-1 and exportin-5 with the double-stranded RNA-binding domain regulates nucleocytoplasmic shuttling of ADAR1. Mol. Cell. Biol. 29, 1487-1497.
10. Güttler, T. and Görlich, D. (2011). Ran-dependent nuclear export mediators: a structural perspective. EMBO J. 30, 3457-3474.
11. Gwizdek, C., Ossareh-Nazari, B., Brownawell, A. M., Doglio, A., Bertrand, E., Macara, I. G., and Dargemont, C. (2003). Exportin-5 mediates nuclear export of minihelix-containing RNAs. J. Biol. Chem. 278, 5505-5508.
12. Gwizdek, C., Ossareh-Nazari, B., Brownawell, A. M., Evers, S., Macara, I. G., and Dargemont, C. (2004). Minihelix-containing RNAs mediate exportin-5-dependent nuclear export of the double-stranded RNA-binding protein ILF3. J. Biol. Chem. 279, 884-891.
13. Hopper, A. K., Pai, D. A., and Engelke, D. R. (2010). Cellular dynamics of tRNAs and their genes. FEBS Lett. 584, 310-317.
14. Kim, M. S., Oh, J. E., Kim, Y. R., Park, S. W., Kang, M. R., Kim, S. S., Ahn, C. H., Yoo, N. J., and Lee, S. H. (2010). Somatic mutations and losses of expression of microRNA regulation-related genes AGO2 and TNRC6A in gastric and colorectal cancers. J. Pathol. 221, 139-146.
15. Köhler, A. and Hurt, E. (2007). Exporting RNA from the nucleus to the cytoplasm. Nat. Rev. Mol. Cell Biol. 8, 761-773.
16. Leaderer, D., Hoffman, A. E., Zheng, T., Fu, A., Weidhaas, J., Paranjape, T., and Zhu, Y. (2011). Genetic and epigenetic association studies suggest a role of microRNA biogenesis gene expor-tin-5 (XPO5) in breast tumorigenesis. Int. J. Mol. Epidemiol. Genet. 2, 9-18.
17. Lee, S. T., Chu, K., Im, W. S., Yoon, H. J., Im, J. Y., Park, J. E., Park, K. H., Jung, K. H., Lee, S. K., Kim, M., et al. (2011). Altered microRNA regulation in Huntington's disease models. Exp. Neurol. 227, 172-179.
18. Lu, J., Getz, G., Miska, E. A., Alvarez-Saavedra, E., Lamb, J., Peck, D., Sweet-Cordero, A., Ebert, B. L., Mak, R. H., Ferrando, A. A., et al. (2005). MicroRNA expression profiles classify human cancers. Nature 435, 834-838.
19. Lund, E., Güttinger, S., Calado, A., Dahlberg, J. E., and Kutay, U. (2004). Nuclear export of microRNA precursors. Science 303, 95-98.
20. Macchi, P., Brownawell, A. M., Grunewald, B., Des Groseillers, L., Macara, I. G., and Kiebler, M. A. (2004). The brain-specific double-stranded RNA-binding protein Staufen2: nucleolar accumulation and isoform-specific exportin-5-dependent export. J. Biol. Chem. 279, 31440-31444.
21. Melo, S. A., Moutinho, C., Ropero, S., Calin, G. A., Rossi, S., Spizzo, R., Fernandez, A. F., Davalos, V., Villanueva, A., Montoya, G., et al. (2010). A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cells. Cancer Cell 18, 303-315.
22. Miyoshi, K., Miyoshi, T., and Siomi, H. (2010). Many ways to generate microRNA-like small RNAs: non-canonical pathways for microRNA production. Mol. Genet. Genomics 284, 95-103.
23. Okada, C., Yamashita, E., Lee, S. J., Shibata, S., Katahira, J., Nakagawa, A., Yoneda, Y., and Tsukihara, T. (2009). A high-resolution structure of the pre-microRNA nuclear export machinery. Science 326, 1275-1279.
24. Screaton, R. A., Kiessling, S., Sansom, O. J., Millar, C. B., Maddison, K., Bird, A., Clarke, A. R., and Frisch, S. M. (2003). Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosis. Proc. Natl. Acad. Sci. USA 100, 5211-5216.
25. Shibata, S., Sasaki, M., Miki, T., Shimamoto, A., Furuichi, Y., Katahira, J., and Yoneda, Y. (2006). Exportin-5 orthologues are functionally divergent among species. Nucleic Acids Res. 34, 4711-4721.
26. Wang, X., Xu, X., Ma, Z., Huo, Y., Xiao, Z., Li, Y., and Wang, Y. (2011). Dynamic mechanisms for pre-miRNA binding and export by Exportin-5. RNA 17, 1511-1528.
27. Wild, T., Horvath, P., Wyler, E., Widmann, B., Badertscher, L., Zemp, I., Kozak, K., Csucs, G., Lund, E., and Kutay, U. (2010). A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit export. PLoS Biol. 8, e1000522.
28. Yi, R., Qin, Y., Macara, I. G., and Cullen, B. R. (2003). Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs. Genes Dev. 17, 3011-3016.
29. Yi, R., Doehle, B. P., Qin, Y., Macara, I. G., and Cullen, B. R. (2005). Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAs. RNA 11, 220-226.
30. Yoshida, K. and Blobel, G. (2001). The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins. J. Cell Biol. 152, 729-740.
31. Zeng, Y. and Cullen, B. R. (2004). Structural requirements for pre-microRNA binding and nuclear export by Exportin 5. Nucleic Acids Res. 32, 4776-4785.