Suppressive effect of accumulated aluminum trichloride on the hepatic microsomal cytochrome P450 enzyme system in rats

Food and Chemical Toxicology

Volumn 51, Issue 1, 2013, Pages 210-214

  Zhu, Yanzhu ^a,b   Han, Yanfei ^b   Zhao, Hansong ^c   Li, Jing ^d   Hu, Chongwei ^d   Li, Yanfei ^b   Zhang, Zhigang ^b  

^a INSTITUTE OF PLANT PROTECTION   (China)

^b NORTHEAST AGRICULTURAL UNIVERSITY   (China)

^c Animal Husbandry and Veterinary Bureau of Zhucheng   (China)

^d FUJIAN AGRICULTURE AND FORESTRY UNIVERSITY   (China)

Author keywords

AlCl3; CYP450 enzyme system; Hepatic microsomes; Toxicology

Indexed keywords

ALUMINUM CHLORIDE; ALUMINUM TRICHLORIDE; AMINOPYRINE N DEMETHYLASE; ANILINE 4 HYDROXYLASE; CYTOCHROME B5; CYTOCHROME P450; ERYTHROMYCIN N DEMETHYLASE; MICROSOME ENZYME; N DEMETHYLASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHEMICAL PARAMETERS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; EXPOSURE; LIVER MICROSOME; MALE; NONHUMAN; RAT;

ALUMINUM COMPOUNDS; ANIMALS; BODY WEIGHT; CHLORIDES; CYTOCHROME P-450 ENZYME SYSTEM; CYTOCHROMES B5; DRINKING WATER; ENVIRONMENTAL POLLUTANTS; LIVER; MALE; MICROSOMES, LIVER; RATS; RATS, WISTAR;

RATTUS; RATTUS NORVEGICUS;

EID: 84867799205     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.09.035     Document Type: Article

References (36)

1. Alemmari A., Miller G.G., Arnold C.J., Zello G.A. Parenteral aluminum induces liver injury in a newborn piglet model. J. Pediatr. Surg. 2011, 46:883-887.
2. Anghileri L.J., Mayayo E., Domingo J.L. Aluminum, calcium, ion and radiofrequecy synergism in acceleration of lymphomagenesis. Immunopharmacol. Immunotoxicol. 2009, 31:358-362.
3. Chellappa S., Huntingford F.A., Strang R.H.C., Thomson R.Y. Condition factor and hepatosomatic index as estimates of energy status in male three-spined stickleback. J. Fish Biol. 2006, 47:775-787.
4. Bertz R.J., Granneman G.R. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin. Pharmacokinet. 1997, 32:210-258.
5. Bidlack W.R., Brown R.C., Meskin M.S., Lee T.C., Klein G.L. Effect of aluminum on the hepatic mixed function oxidase and drug metabolism. Drug Nutr. Interact. 1987, 5:33-42.
6. Bozcaarmutlu A. Mechanism of inhibition of pirified leaping mullet (Liza saliens) NADPH-cytochrome P450 reductase by toxic metals: aluminum and thallium. J. Biochem. Mol. Toxicol. 2007, 21:340-347.
7. Chen X., Han G.Z., Sun H.J. Effects of tea polyphenols on cytochrome P450 and b5 in mice. Asian J. Drug Metabol. Pharmacokinet. 2006, 6:203-205.
8. 3 on the Zinc and copper in plasma and spleen of mice. J. North Chin. Coal. Med. College 2001, 3:684-685.
9. Chmielnicka J., Nasiadek M., Lewandowska-Zyndul E. The effect of aluminum chloride on some steps of heme biosynthesis in rats after oral exposure. Biol. Trace Elem. Res. 1994, 40:127-136.
10. Fulton B., Jeffery E.H. The temporal relationship between hepatic GSH loss, heme oxygenase induction and cytochrome P450 loss following intraperitoneal aluminum administration to mice. Toxicol. Appl. Pharmacol. 1994, 127:291-297.
11. Garrosa M., Llanes F., Gayoso M.J. Histopathological changes in gerbil liver and kidney after aluminum subchronic intoxication. Histol. Histopathol. 2011, 26:883-892.
12. Gonzalez F.J. Role of cytochromes P450 in chemical toxicity and oxidative stress: studies with CYP2E1. Mutat. Res. 2005, 569:101-110.
13. Guengerich F.P. Cytochrome P450 and chemical toxicology. Chem. Res. Toxicol. 2008, 21:70-83.
14. Jover R., Lindberg R.L., Meyer U.A. Role of heme in cytochrome P450 transcription and function in mice treated with lead acetate. Mol. Pharmacol. 1996, 50:474-481.
15. Lynch T., Price A. The effect of cytochrome P450 metabolism on drug response, interactions, and adverse effects. Am. Fam. Phys. 2007, 76:391-396.
16. Lin Wu S.W., Jean W.C., Peng F.C., Edwards R.J. Cytochrome P-450 3A1 catalyzes the formation of MA1 from territrem a in liver microsomes of 7-week-old female wistar rats. J. Toxicol. Environ. Health A 2003, 66:453-467.
17. Lyakhovich V., Mishin V., Pokrovsky A. Relationship between the reduction of oxygen, artificial acceptors and cytochrome P-450 by NADPH-cytochrome c reductase. Biochem. J. 1977, 168:133-139.
18. Mailloux R.J., Lemire J., Appanna V.D. Hepatic response to aluminum toxicity: dyslipidemia and liver diseases. Exp. Cell Res. 2011, 317:2231-2238.
19. Mayer R.T., Durrant J.L. Preparation of homogeneous NADPH cytochrome c (P-450) reductase from house flies using affinity chromatography techniques. J. Biol. Chem. 1979, 254:756-761.
20. Nasiadek M., Chmielnicka J., Subdys J. Analysis of urinary porphyrins in rats exposed to aluminum and iron. Ecotoxicol. Environ. Saf. 2001, 48:11-17.
21. Neve E.P., Ingelman-Sundberg M. Cytochrome P450 proteins: retention and distribution from the endoplasmic reticulum. Curr. Opin. Drug Discov. Devel. 2010, 13:78-85.
22. Navascués J., Pérez-Rontomé C., Sánchez D.H., Staudinger C., Wienkoop S., Rellán-álvarez R., Becana M. Oxidative stress is a consequence, not a cause, of aluminum toxicity in the forage legumelotus corniculatus. New Phytol. 2012, 193:625-636.
23. Omura T. Forty years of cytochrome P450. Biochem. Biophys. Res. Commun. 1999, 266:690-698.
24. Pustylnyak V., Kazakova Y., Yarushkin A., Slynko N., Gulyaeva L. Effect of several analogs of 2,4,6-triphenyldioxane-1,3 on CYP2B induction in mouse liver. Chem. Biol. Interact. 2011, 194:134-138.
25. Porter T.D. The roles of cytochrome b5 in cytochrome P450 reactions. J. Biochem. Mol. Toxicol. 2002, 16:311-316.
26. Rawy S.M., Morsy G.M., Elshibani M.M. Lethality, accumulation and toxickinetics of aluminum in some tissues of male albino rats. Toxicol. Ind. Health 2012, 10.1177/0748233711432576.
27. Sharma P., Dubey R.S. Involvement of oxidative stress and role of antioxidative defense system in growing rice seedlings exposed to toxic concentrations of aluminum. Plant Cell Rep. 2007, 26:2027-2038.
28. Tompkins L.M., Wallace A.D. Mechanisms of cytochrome P450 induction. J. Biochem. Mol. Toxicol. 2007, 21:176-181.
29. Wilson Z.E., Rostami-Hodjegan A., Burn J.L., Tooley A., Boyle J., Ellis S.W., Tucker G.T. Inter-individual variability in levels of human microsomal protein and hepatocellularity per gram of liver. Br. J. Clin. Pharmacol. 2003, 56:433-440.
30. Xu Z.M., Squires E.J., Bray T.M. Effects of dietary zinc deficiency on the expression of hepatic microsomal cytochrome P450 2E1 in rats. J. Nutr. Biochem. 1994, 5:308-313.
31. Xu Z., Squires E.J., Bray T.M. Effects of dietary Zinc deficiency on the hepatic microsimal P450 2B in rats. Can J. Physiol. Pharmacol. 1994, 72:211-216.
32. Yang H.F., Jiang S.X. Methodological study on determination of activities of hepatic microsomal cytochrome P450s in chickens. Vet. Sci. Chin. 2006, 36:147-150.
33. Zangar R.C., Benson J.M., Burnett V.L. Cytochrome P450 2E1 is the primary enzyme responsible for low-Dose carbon tetrachloride metabolism in human liver microsome. Chem. Biol. Interact. 2000, 125:233-243.
34. Zhang L.C., Li X.W., Gu Q.Y., Zhu Y.Z., Zhao H.S., Li Y.F., Zhang Z.G. Effects of subchronic aluminum exposure on serum concentrations of iron and iron-associated proteins in rats. Biol. Trace Elem. Res. 2011, 141:246-253.
35. Zhu Y.Z., Zhao H.S., Li X.W., Zhang L.C., Hu C.W., Shao B., Sun H., Bah A.A., Li Y.F., Zhang Z.G. Effects of subchronic aluminum exposure on the immune function of erythrocytes in rats. Biol. Trace Elem. Res. 2011, 143:1576-1580.
36. Zhu Y.Z., Li X.W., Chen C.X., Wang F., Li J., Hu C.W., Li Y.F., Miao L.G. Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats. Food Chem. Toxicol. 2012, 10.1016/j.fct.2012.05.041.