Cytochrome P-4503A1 catalyzes the formation of MA1 from territrem A in liver microsomes of 7-week-old female Wistar rats

Journal of Toxicology and Environmental Health - Part A

Volumn 66, Issue 5, 2003, Pages 453-467

  Lin Wu, Shiuan Woei ^a   Jean, Wen Chi ^a   Peng, Fu Chuo ^a   Edwards, Robert J ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 3A1; CYTOCHROME P450 INHIBITOR; DEXAMETHASONE; MYCOTOXIN; ORPHENADRINE; PHENOBARBITAL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASPERGILLUS TERREUS; CATALYSIS; CONTROLLED STUDY; FEMALE; LIVER METABOLISM; LIVER MICROSOME; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIBODIES; ARYL HYDROCARBON HYDROXYLASES; BLOTTING, WESTERN; FEMALE; MALE; MICROSOMES, LIVER; MYCOTOXINS; PYRANS; PYRONES; RATS; RATS, WISTAR; SEX FACTORS;

ANIMALIA; ASPERGILLUS; ASPERGILLUS TERREUS; INSECTA; RATTUS NORVEGICUS; UNIDENTIFIED BACULOVIRUS;

EID: 0037436855     PISSN: 15287394     EISSN: None     Source Type: Journal    
DOI: 10.1080/15287390306453     Document Type: Article

References (31)

1. 19 steroids by five highly purified and reconstituted rat hepatic cytochrome P450 isozymes. J. Biol. Chem. 258:8839-8847.
2. Alvares, A. P., and Mannering, G. J. 1970. Two-substrate kinetics of drug-metabolizing enzyme systems of hepatic microsomes. Mol. Pharmacol. 6:206-212.
3. Ander, M. W., and Mannering, G. J. 1966. Inhibition of drug metabolism. I. Kinetics of the inhibition of the N-demethylation of ethyhorphine by 2-diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A) and related compounds. Mol. Pharmacol. 2:319-327.
4. Arlotto, M. P., Sonderfan, A. J., Klaassen, C. D., and Parkinson, A. 1987. Studies on the pregnenolone 16α-carbonitrile-inducible form of rat liver microsomal P450 and UDP-glucuronyltransferase. Biochem. Pharmacol. 36:3859-3866.
5. Ates, Z., Suzen, S., Buyukbingol, E., Can, E. B., and Iscan, M. 1997. Effects of a benzimidazole compound on monooxygenase activities. Farmacogie 52:703-706.
6. Buening, M. K., and Franklin, M. R. 1976. SKF 525-A inhibition, induction and 542 nm complex formation. Drug Metab. Dispos. 4:244-255.
7. Chen, J. W., Luo, Y. L., Hwang, M. J., Peng, F. C., and Ling, K. H. 1999. Territrem B, tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J. Biol. Chem. 274:34916-34923.
8. Chung, C. H., Ling, K. H., Tung, S. S., and Tung, T. C. 1971. Study on fungi of the stored unhulled rice of Taiwan. (2) Aflatoxin B-like compounds from the culture of Aspergillus genus. J. Formosan Med. Assoc. 70:258-266.
9. Ellman, G. L., Courtney, K. D., Jr., Anders, V., and Featherstone, R. M. 1961. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem. Pharmacol. 7:88-95.
10. Fumiyshi, K., Otoguro, K., Shiomi, K., Iwai, Y., and Stoshi, O. 1996. Arisugacins A and B, novel and selective acetylcholinesterase inhibitors from Penicillium sp. FO-4259. J. Antibiot. 49:742-746.
11. Gonzalez, F. J., Nebert, D. W., Hardwick, J. P., and Kasper, C. B. 1985. Complete cDNA and protein sequence of a pregnenolone 16α-carbonitrile-induced cytochrome P-450. A representative of a new gene family. J. Biol. Chem. 260:7435-7441.
12. Gonzalez, F. J., Song, B. J., and Hardwick, J. P. 1986. Pregnenolone 16α-carbonitrile-inducible P-450 gene family: Gene conversion and differential regulation. Mol. Cell Biol. 6:2969-2976.
13. Guengerich, F. P., Wang, P., and Davidson, N. K. 1982. Estimation of isoenzymes of microsomal cytochrome P-450 in rats, rabbit, and human using immunochemical staining coupled with sodium dodecyl sulfate electrophoresis. Biochemistry 21:1698-1706.
14. Hayes, J. R., Mgbodile, M. U. K., and Campbell, T. C. 1973. Effect on protein deficiency on the inducibility of the hepatic microsomal drug-metabolizing enzyme system - I. Effect on substrate interaction with cytochrome P-450. Biochem. Pharmacol. 22:1005-1014.
15. Kato, R., and Yamazoe, Y. 1992. Sex specific cytochrome P450 as a cause of sex- and species related differences in drug toxicity. Toxicol. Lett. 64/65:661-667.
16. 4. Nature 227:680-685.
17. Ling, K. H. 1994. Territrem, tremorgenic mycotoxins isolated from Aspergillus terreus. J. Toxicol. Toxin Rev. 13:243-252.
18. Ling, K. H., Liou, H. H., Fu, T. C., Kuo, L., Tasi, M. C., and Lin, M. Y. 1986. Mechanism of action of the territrem, tremorgenic mycotoxin isolated from Aspergillus terreus. In Mycotoxins and phycotoxins, 6th International IUPAC Symposium on Mycotoxins and Phycotoxins, eds. P. S. Steyn and R. Velggaar, pp. 387-398. Amsterdam: Elsevier.
19. Ling, K. H., Wang, J. J., Wu, R., Tung, T. C., Lin, C. K., Lin, S. S., and Lin, T. M. 1967. Intoxication possibly caused by aflatoxin B1 in the moldy rice in Shuang-Chih Township. J. Formosan Med. Assoc. 66:517-525.
20. Ling, K. H., Yang, C. K., and Peng, F. T. 1979. Territrem, tremorgenic mycotoxins of Aspergillus terreus. Appl. Environ. Microbiol. 37:355-357.
21. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein determinations with Folin phenol reagent. J. Biol. Chem. 193:265-275.
22. Negata, K., Gonzalez, F. J., Yamazoe, Y., and Kato, R. 1990. Purification and characterization of four catalytically active testosterone 6β-hydroxylase P450s from rat liver microsomes: Comparison of a novel form with three structurally and functionally related forms. J. Biochem. 107:716-725.
23. Omura, T., and Sato, R. 1964. The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 239:2370-2378.
24. Peng, F. C., and Lin Wu, S. W. 2002. Metabolism of territrem A in liver microsomes from male Wistar rats: Cytochrome P450 isoforms catalyzing TRA metabolism. J. Toxicol. Environ. Health 65:2163-2175.
25. Peng, F. C., Lin Wu, S. W., and Lin, J. J. 2001. Metabolism of TRA in liver microsomes from male Wistar rats: (2) Sex differences and regulation with gonadal hormones and phenobarbital. J. Toxicol. Environ. Health A 64:661-671.
26. Peng, F. C., Lin Wu, S. W., and Wang, B. L. 2001. Metabolism of TRA in liver microsomes from male Wistar rats: (1) Identification of metabolites and their metabolic pathway. J. Toxicol. Environ. Health A 64:579-593.
27. Phillips, A. H., and Langdon, R. G. 1962. Hepatic triphosphopyridine nucleotide-cytochrome c reductase: Isolation, characterization and kinetic studies. J. Biol. Chem. 237:2652-2660.
28. Reidy, G. F., Mehta, I., and Murray, M. 1989. Inhibition of oxidative drug metabolism by orphenadrine: In vitro and in vivo evidence for isoenzyme-specific complexation of cytochrome P-450 and inhibition kinetics. Mol. Pharmacol. 35:736-743.
29. Testa, B., and Jenner, P. 1981. Inhibitors of cytochrome P450s and their mechanism of action. Drug Metab. Rev. 12:1-117.
30. Towbin, H., Staehelin, T., and Gordon, J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: Procedure and some applications. Proc. Natl. Acad. Sci. USA 76:4350-4354.
31. Tung, S. S., Ling, K. H., Tasi, S. E., Chung, C. H., Wang, J. J., and Tung, T. C. 1971. Study of fungi of the stored unhulled rice of Taiwan (1) Mycological survey of the stored unhulled rice. J. Formosan Meal. Assoc. 70:251-257.