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Volumn 41, Issue 5, 2012, Pages 1762-1772

Suppression of lymphangiogenesis in human lymphatic endothelial cells by simultaneously blocking VEGF-C and VEGF-D/VEGFR-3 with norcantharidin

Author keywords

3 Dimensional culture; Antilymphangiogenic therapy; Human lymphatic endothelial cell; Lymphangiogenesis; Norcantharidin

Indexed keywords

MATRIGEL; MESSENGER RNA; NORCANTHARIDIN; VASCULOTROPIN C; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 3;

EID: 84867796318     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2012.1603     Document Type: Article
Times cited : (22)

References (49)
  • 1
    • 33746012247 scopus 로고    scopus 로고
    • Tumor lymphangiogenesis and metastatic spread - New players begin to emerge
    • DOI 10.1002/ijc.21899
    • Achen MG and Stacker SA: Tumor lymphangiogenesis and metastatic spread - new players begin to emerge. Int J Cancer 119: 1755-1760, 2006. (Pubitemid 44356830)
    • (2006) International Journal of Cancer , vol.119 , Issue.8 , pp. 1755-1760
    • Achen, M.G.1    Stacker, S.A.2
  • 3
    • 33750054757 scopus 로고    scopus 로고
    • Tumor and lymph node lymphangiogenesis - Impact on cancer metastasis
    • DOI 10.1189/jlb.1105653
    • Tobler NE and Detmar M: Tumor and lymph node lymphangiogenesis- impact on cancer metastasis. J Leukoc Biol 80: 691-696, 2006. (Pubitemid 44835883)
    • (2006) Journal of Leukocyte Biology , vol.80 , Issue.4 , pp. 691-696
    • Tobler, N.E.1    Detmar, M.2
  • 5
    • 70549104050 scopus 로고    scopus 로고
    • Tumor metastasis and the lymphatic vasculature
    • Sleeman JP and Thiele W: Tumor metastasis and the lymphatic vasculature. Int J Cancer 125: 2747-2756, 2009.
    • (2009) Int J Cancer , vol.125 , pp. 2747-2756
    • Sleeman, J.P.1    Thiele, W.2
  • 9
    • 33749028188 scopus 로고    scopus 로고
    • Vascular endothelial growth factor signaling pathways: Therapeutic perspective
    • DOI 10.1158/1078-0432.CCR-06-1520
    • Kowanetz M and Ferrara N: Vascular endothelial growth factor signaling pathways: therapeutic perspective. Clin Cancer Res 12: 5018-5022, 2006. (Pubitemid 44453326)
    • (2006) Clinical Cancer Research , vol.12 , Issue.17 , pp. 5018-5022
    • Kowanetz, M.1    Ferrara, N.2
  • 10
    • 33845727079 scopus 로고    scopus 로고
    • Pathways targeting tumor lymphangiogenesis
    • DOI 10.1158/1078-0432.CCR-06-1800
    • Wissmann C and Detmar M: Pathways targeting tumor lymphangiogenesis. Clin Cancer Res 12: 6865-6868, 2006. (Pubitemid 44974477)
    • (2006) Clinical Cancer Research , vol.12 , Issue.23 , pp. 6865-6868
    • Wissmann, C.1    Detmar, M.2
  • 11
    • 0035927443 scopus 로고    scopus 로고
    • Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional chinese medicine, with a platinum moiety
    • DOI 10.1021/jm000476t
    • Ho YP, To KK, Au-Yeung SC, Wang X, Lin G and Han X: Potential new antitumor agents from an innovative combination of demethylcantharidin, a modified traditional Chinese medicine, with a platinum moiety. J Med Chem 44: 2065-2068, 2001. (Pubitemid 32861766)
    • (2001) Journal of Medicinal Chemistry , vol.44 , Issue.13 , pp. 2065-2068
    • Ho, Y.-P.1    To, K.K.W.2    Au-Yeung, S.C.F.3    Wang, X.4    Lin, G.5    Han, X.6
  • 12
    • 80054922141 scopus 로고    scopus 로고
    • Norcantharidin analogues: A patent review (2006-2010)
    • Deng L and Tang S: Norcantharidin analogues: a patent review (2006-2010). Expert Opin Ther Pat 21: 1743-1753, 2011.
    • (2011) Expert Opin Ther Pat , vol.21 , pp. 1743-1753
    • Deng, L.1    Tang, S.2
  • 13
    • 33846967813 scopus 로고    scopus 로고
    • Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro
    • Fan YZ, Fu JY, Zhao ZM and Chen CQ: Inhibitory effect of norcantharidin on the growth of human gallbladder carcinoma GBC-SD cells in vitro. Hepatobiliary Pancreat Dis Int 6: 72-80, 2007.
    • (2007) Hepatobiliary Pancreat Dis Int , vol.6 , pp. 72-80
    • Fan, Y.Z.1    Fu, J.Y.2    Zhao, Z.M.3    Chen, C.Q.4
  • 14
    • 77955608840 scopus 로고    scopus 로고
    • Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo
    • Fan YZ, Zhao ZM, Fu JY, Chen CQ and Sun W: Norcantharidin inhibits growth of human gallbladder carcinoma xenografted tumors in nude mice by inducing apoptosis and blocking the cell cycle in vivo. Hepatobiliary Pancreat Dis Int 9: 414-422, 2010.
    • (2010) Hepatobiliary Pancreat Dis Int , vol.9 , pp. 414-422
    • Fan, Y.Z.1    Zhao, Z.M.2    Fu, J.Y.3    Chen, C.Q.4    Sun, W.5
  • 15
    • 70349748544 scopus 로고    scopus 로고
    • Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect
    • Chen YJ, Tsai YM, Kuo CD, Ku KL, Shie HS and Liao HF: Norcantharidin is a small-molecule synthetic compound with anti-angiogenesis effect. Life Sci 85: 642-651, 2009.
    • (2009) Life Sci , vol.85 , pp. 642-651
    • Chen, Y.J.1    Tsai, Y.M.2    Kuo, C.D.3    Ku, K.L.4    Shie, H.S.5    Liao, H.F.6
  • 16
    • 84860295704 scopus 로고    scopus 로고
    • Norcantharidin: A potential antiangiogenic agent for gallbladder cancers in vitro and in vivo
    • Zhang JT, Fan YZ, Chen CQ, Zhao ZM and Sun W: Norcantharidin: a potential antiangiogenic agent for gallbladder cancers in vitro and in vivo. Int J Oncol 40: 1501-1514, 2012.
    • (2012) Int J Oncol , vol.40 , pp. 1501-1514
    • Zhang, J.T.1    Fan, Y.Z.2    Chen, C.Q.3    Zhao, Z.M.4    Sun, W.5
  • 18
    • 35748957169 scopus 로고    scopus 로고
    • Potential therapeutic strategies for lymphatic metastasis
    • DOI 10.1016/j.mvr.2007.08.006, PII S0026286207001094, Therapeutic Applications of Angiogenesis and Anti-angiogenesis
    • Zwaans BM and Bielenberg DR: Potential therapeutic strategies for lymphatic metastasis. Microvasc Res 74: 145-158, 2007. (Pubitemid 350051029)
    • (2007) Microvascular Research , vol.74 , Issue.2-3 , pp. 145-158
    • Zwaans, B.M.M.1    Bielenberg, D.R.2
  • 19
    • 0025619733 scopus 로고
    • The lymphatics and lymphoreticular tissues in relation to the action of sex hormones
    • Kotani M: The lymphatics and lymphoreticular tissues in relation to the action of sex hormones. Arch Histol Cytol 53 (Suppl): 1-76, 1990.
    • (1990) Arch Histol Cytol , vol.53 , Issue.SUPPL. , pp. 1-76
    • Kotani, M.1
  • 20
    • 77956625989 scopus 로고    scopus 로고
    • Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer - A review of mechanisms
    • Zhang Z, Helman JI and Li LJ: Lymphangiogenesis, lymphatic endothelial cells and lymphatic metastasis in head and neck cancer - a review of mechanisms. Int J Oral Sci 2: 5-14, 2010.
    • (2010) Int J Oral Sci , vol.2 , pp. 5-14
    • Zhang, Z.1    Helman, J.I.2    Li, L.J.3
  • 21
    • 0038345318 scopus 로고    scopus 로고
    • Insights into the mechanisms of lymph node metastasis
    • Nathanson SD: Insights into the mechanisms of lymph node metastasis. Cancer 98: 413-423, 2003.
    • (2003) Cancer , vol.98 , pp. 413-423
    • Nathanson, S.D.1
  • 22
    • 78049503100 scopus 로고    scopus 로고
    • Deguelin - An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model
    • Hu J, Ye H, Fu A, Chen X, Wang Y, Chen X, Ye X, Xiao W, Duan X, Wei Y and Chen L: Deguelin - an inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor-D in lung tumor model. Int J Cancer 127: 2455-2466, 2010.
    • (2010) Int J Cancer , vol.127 , pp. 2455-2466
    • Hu, J.1    Ye, H.2    Fu, A.3    Chen, X.4    Wang, Y.5    Chen, X.6    Ye, X.7    Xiao, W.8    Duan, X.9    Wei, Y.10    Chen, L.11
  • 23
    • 79953887903 scopus 로고    scopus 로고
    • Endostar, a recombined humanized endostatin, inhibits lymphangiogenesis and lymphatic metastasis of lewis lung carcinoma xenograft in mice
    • Dong X, Zhao X, Xiao T, Tian H and Yun C: Endostar, a recombined humanized endostatin, inhibits lymphangiogenesis and lymphatic metastasis of lewis lung carcinoma xenograft in mice. Thorac Cardiovasc Surg 59: 133-136, 2011.
    • (2011) Thorac Cardiovasc Surg , vol.59 , pp. 133-136
    • Dong, X.1    Zhao, X.2    Xiao, T.3    Tian, H.4    Yun, C.5
  • 24
    • 79551514772 scopus 로고    scopus 로고
    • Silencing Id-1 inhibits lymphangiogenesis through downregulation of VEGF-C in oral squamous cell carcinoma
    • Dong Z, Wei F, Zhou C, Sumida T, Hamakawa H, Hu Y and Liu S: Silencing Id-1 inhibits lymphangiogenesis through downregulation of VEGF-C in oral squamous cell carcinoma. Oral Oncol 47: 27-32, 2011.
    • (2011) Oral Oncol , vol.47 , pp. 27-32
    • Dong, Z.1    Wei, F.2    Zhou, C.3    Sumida, T.4    Hamakawa, H.5    Hu, Y.6    Liu, S.7
  • 27
    • 77957768682 scopus 로고    scopus 로고
    • Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3
    • Rinderknecht M, Villa A, Ballmer-Hofer K, Neri D and Detmar M: Phage-derived fully human monoclonal antibody fragments to human vascular endothelial growth factor-C block its interaction with VEGF receptor-2 and 3. PLoS One 5: e11941, 2010.
    • (2010) PLoS One , vol.5
    • Rinderknecht, M.1    Villa, A.2    Ballmer-Hofer, K.3    Neri, D.4    Detmar, M.5
  • 28
    • 77950263970 scopus 로고    scopus 로고
    • Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein
    • Zhang D, Li B, Shi J, Zhao L, Zhang X, Wang C, Hou S, Qian W, Kou G, Wang H and Guo Y: Suppression of tumor growth and metastasis by simultaneously blocking vascular endothelial growth factor (VEGF)-A and VEGF-C with a receptor-immunoglobulin fusion protein. Cancer Res 70: 2495-2503, 2010.
    • (2010) Cancer Res , vol.70 , pp. 2495-2503
    • Zhang, D.1    Li, B.2    Shi, J.3    Zhao, L.4    Zhang, X.5    Wang, C.6    Hou, S.7    Qian, W.8    Kou, G.9    Wang, H.10    Guo, Y.11
  • 29
    • 70549112947 scopus 로고    scopus 로고
    • Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference
    • Lui Z, Ma Q, Wang X and Zhang Y: Inhibiting tumor growth of colorectal cancer by blocking the expression of vascular endothelial growth factor receptor 3 using interference vector-based RNA interference. Int J Mol Med 25: 59-64, 2010.
    • (2010) Int J Mol Med , vol.25 , pp. 59-64
    • Lui, Z.1    Ma, Q.2    Wang, X.3    Zhang, Y.4
  • 31
    • 67649233079 scopus 로고    scopus 로고
    • Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma
    • Guo B, Zhang Y, Luo G, Li L and Zhang J: Lentivirus-mediated small interfering RNA targeting VEGF-C inhibited tumor lymphangiogenesis and growth in breast carcinoma. Anat Rec 292: 633-639, 2009.
    • (2009) Anat Rec , vol.292 , pp. 633-639
    • Guo, B.1    Zhang, Y.2    Luo, G.3    Li, L.4    Zhang, J.5
  • 32
    • 49749127985 scopus 로고    scopus 로고
    • Artemisinin inhibits tumor lymphangiogenesis by suppression of vascular endothelial growth factor C
    • Wang J, Zhang B, Guo Y, Li G, Xie Q, Zhu B, Gao J and Chen Z: Artemisinin inhibits tumor lymphangiogenesis by suppression of vascular endothelial growth factor C. Pharmacology 82: 148-155, 2008.
    • (2008) Pharmacology , vol.82 , pp. 148-155
    • Wang, J.1    Zhang, B.2    Guo, Y.3    Li, G.4    Xie, Q.5    Zhu, B.6    Gao, J.7    Chen, Z.8
  • 34
    • 70349554281 scopus 로고    scopus 로고
    • Low molecular weight heparin suppresses lymphatic endothelial cell proliferation induced by vascular endothelial growth factor C in vitro
    • Cao G, Wu JX and Wu QH: Low molecular weight heparin suppresses lymphatic endothelial cell proliferation induced by vascular endothelial growth factor C in vitro. Chin Med J 122: 1570-1574, 2009.
    • (2009) Chin Med J , vol.122 , pp. 1570-1574
    • Cao, G.1    Wu, J.X.2    Wu, Q.H.3
  • 35
    • 1142275237 scopus 로고    scopus 로고
    • Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270
    • DOI 10.1111/j.1349-7006.2004.tb03166.x
    • Nakamura ES, Koizumi K, Kobayashi M and Saiki I: Inhibition of lymphangiogenesis-related properties of murine lymphatic endothelial cells and lymph node metastasis of lung cancer by the matrix metalloproteinase inhibitor MMI270. Cancer Sci 95: 25-31, 2004. (Pubitemid 38208403)
    • (2004) Cancer Science , vol.95 , Issue.1 , pp. 25-31
    • Nakamura, E.S.1    Koizumi, K.2    Kobayashi, M.3    Saiki, I.4
  • 36
    • 77957355134 scopus 로고    scopus 로고
    • Cold shock domain protein A (CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse model of squamous cell carcinoma
    • Matsumoto G, Yajima N, Saito H, Nakagami H, Omi Y, Lee U and Kaneda Y: Cold shock domain protein A (CSDA) overexpression inhibits tumor growth and lymph node metastasis in a mouse model of squamous cell carcinoma. Clin Exp Metastasis 27: 539-547, 2010.
    • (2010) Clin Exp Metastasis , vol.27 , pp. 539-547
    • Matsumoto, G.1    Yajima, N.2    Saito, H.3    Nakagami, H.4    Omi, Y.5    Lee, U.6    Kaneda, Y.7
  • 38
    • 4444241129 scopus 로고    scopus 로고
    • Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways
    • An WW, Wang MW, Tashiro S, Onodera S and Ikejima T: Norcantharidin induces human melanoma A375-S2 cell apoptosis through mitochondrial and caspase pathways. J Korean Med Sci 19: 560-566, 2004. (Pubitemid 39194221)
    • (2004) Journal of Korean Medical Science , vol.19 , Issue.4 , pp. 560-566
    • An, W.-W.1    Wang, M.-W.2    Tashiro, S.-I.3    Onodera, S.4    Ikejima, T.5
  • 39
    • 0026095943 scopus 로고
    • Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro
    • Yi SN, Wass J, Vincent P and Iland H: Inhibitory effect of norcantharidin on K562 human myeloid leukemia cells in vitro. Leuk Res 15: 883-886, 1991.
    • (1991) Leuk Res , vol.15 , pp. 883-886
    • Yi, S.N.1    Wass, J.2    Vincent, P.3    Iland, H.4
  • 40
    • 77649186034 scopus 로고    scopus 로고
    • Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis
    • Yang PY, Chen MF, Tsai CH, Hu DN, Chang FR and Wu YC: Involvement of caspase and MAPK activities in norcantharidin-induced colorectal cancer cell apoptosis. Toxicol In Vitro 24: 766-775, 2010.
    • (2010) Toxicol in Vitro , vol.24 , pp. 766-775
    • Yang, P.Y.1    Chen, M.F.2    Tsai, C.H.3    Hu, D.N.4    Chang, F.R.5    Wu, Y.C.6
  • 41
    • 36549025029 scopus 로고    scopus 로고
    • Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells
    • Chen YJ, Kuo CD, Tsai YM, Yu CC, Wang GS and Liao HF: Norcantharidin induces anoikis through Jun-N-terminal kinase activation in CT26 colorectal cancer cells. Anticancer Drugs 19: 55-64, 2008.
    • (2008) Anticancer Drugs , vol.19 , pp. 55-64
    • Chen, Y.J.1    Kuo, C.D.2    Tsai, Y.M.3    Yu, C.C.4    Wang, G.S.5    Liao, H.F.6
  • 44
    • 33748075460 scopus 로고    scopus 로고
    • Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: Therapeutic implications
    • DOI 10.1158/0008-5472.CAN-06-1392
    • Hoshida T, Isaka N, Hagendoorn J, di Tomaso E, Chen YL, Pytowski B, Fukumura D, Padera TP and Jain RK: Imaging steps of lymphatic metastasis reveals that vascular endothelial growth factor-C increases metastasis by increasing delivery of cancer cells to lymph nodes: therapeutic implications. Cancer Res 66: 8065-8075, 2006. (Pubitemid 44299172)
    • (2006) Cancer Research , vol.66 , Issue.16 , pp. 8065-8075
    • Hoshida, T.1    Isaka, N.2    Hagendoorn, J.3    Di, T.E.4    Chen, Y.-L.5    Pytowski, B.6    Fukumura, D.7    Padera, T.P.8    Jain, R.K.9
  • 45
    • 54949113912 scopus 로고    scopus 로고
    • Lymphangiogenesis in kidney cancer: Expression of VEGF-C, VEGF-D and VEGFR-3 in clear cell and papillary renal cell carcinoma
    • Bierer S, Herrmann E, Kopke T, Neumann J, Eltze E, Hertle L and Wülfing C: Lymphangiogenesis in kidney cancer: expression of VEGF-C, VEGF-D and VEGFR-3 in clear cell and papillary renal cell carcinoma. Oncol Rep 20: 721-725, 2008.
    • (2008) Oncol Rep , vol.20 , pp. 721-725
    • Bierer, S.1    Herrmann, E.2    Kopke, T.3    Neumann, J.4    Eltze, E.5    Hertle, L.6    Wülfing, C.7
  • 46
    • 50449108166 scopus 로고    scopus 로고
    • Correlation of vascular endothelial growth factor-D expression and VEGFR-3-positive vessel density with lymph node metastasis in gastric carcinoma
    • Choi JH, Oh YH, Park YW, Baik HK, Lee YY and Kim IS: Correlation of vascular endothelial growth factor-D expression and VEGFR-3-positive vessel density with lymph node metastasis in gastric carcinoma. J Korean Med Sci 23: 592-597, 2008.
    • (2008) J Korean Med Sci , vol.23 , pp. 592-597
    • Choi, J.H.1    Oh, Y.H.2    Park, Y.W.3    Baik, H.K.4    Lee, Y.Y.5    Kim, I.S.6
  • 48
    • 25444489567 scopus 로고    scopus 로고
    • Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival
    • DOI 10.1158/0008-5472.CAN-05-0885
    • Chen Z, Varney ML, Backora MW, Cowan K, Solheim JC, Talmadge JE and Singh RK: Down-regulation of vascular endothelial cell growth factor-C expression using small interfering RNA vectors in mammary tumors inhibits tumor lymphangiogenesis and spontaneous metastasis and enhances survival. Cancer Res 65: 9004-9011, 2005. (Pubitemid 41377392)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 9004-9011
    • Chen, Z.1    Varney, M.L.2    Backora, M.W.3    Cowan, K.4    Solheim, J.C.5    Talmadge, J.E.6    Singh, R.K.7


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