Environmentally relevant mixtures in cumulative assessments: An acute study of toxicokinetics and effects on motor activity in rats exposed to a mixture of pyrethroids

Toxicological Sciences

Volumn 130, Issue 2, 2012, Pages 309-318

  Starr, James M ^a   Scollon, Edward J ^a,b   Hughes, Michael F ^b   Ross, David G ^b   Graham, Stephen E ^a   Crofton, Kevin M ^b   Wolansky, Marcelo J ^b,c   DeVito, Michael J ^b,d   Tornero Velez, Rogelio ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Cumulative risk; Motor activity; Pyrethroids; Toxicokinetics

Indexed keywords

BETA CYFLUTHRIN; CIPERMETHRIN; DELTAMETHRIN; FAT; FENVALERATE; PERMETHRIN; PYRETHROID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD SAMPLING; BRAIN; CONCENTRATION (PARAMETERS); EXPOSURE; LIVER; MALE; MOTOR ACTIVITY; NEUROTOXICITY; NONHUMAN; RAT; TOXICOKINETICS;

ADIPOSE TISSUE; ANIMALS; BEHAVIOR, ANIMAL; BODY BURDEN; BRAIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL MONITORING; ENVIRONMENTAL POLLUTANTS; HALF-LIFE; INSECTICIDES; LIMIT OF DETECTION; LIVER; MALE; MODELS, ANIMAL; MODELS, BIOLOGICAL; MOTOR ACTIVITY; NEUROTOXICITY SYNDROMES; PYRETHRINS; RATS; RATS, LONG-EVANS; REPRODUCIBILITY OF RESULTS; RISK ASSESSMENT; TISSUE DISTRIBUTION;

ANIMALIA; RATTUS;

EID: 84867756587     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs245     Document Type: Article

References (42)

1. Abu-Qare, A. W., and Abou-Donia, M. B. (2002). Binding of pyridostigmine bromide, N,N-diethyl-m-toluamide and permethrin, alone and in combinations, to human serum albumin. Arch. Toxicol. 76, 203-208.
2. Anadón, A., Martinez-Larrañaga, M. R., Diaz, M. J., and Bringas, P. (1991). Toxicokinetics of permethrin in the rat. Toxicol. Appl. Pharmacol. 110, 1-8.
3. Anadón, A., Martinez-Larrañaga, M. R., Fernandez-Cruz, M. L., Diaz, M. J., Fernandez, M. C., and Martinez, M. A. (1996). Toxicokinetics of deltamethrin and its 4'-HO-metabolite in the rat. Toxicol. Appl. Pharmacol. 141, 8-16.
4. Anadón, A., Martínez, M., Martínez, M. A., Díaz, M. J., and Martínez-Larrañaga, M. R. (2006). Toxicokinetics of lambda-cyhalothrin in rats. Toxicol. Lett. 165, 47-56.
5. Breckenridge, C. B., Holden, L., Sturgess, N., Weiner, M., Sheets, L., Sargent, D., Soderlund, D. M., Choi, J. S., Symington, S., Clark, J. M., et al. (2009). Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides. Neurotoxicology 30(Suppl. 1), S17-S31.
6. Catinot, R., Hoellinger, H., Sonnier, M., Do-Cao-Thang, Pichon, J., and Nguyen-Hoang-Nam. (1989). In vitro covalent binding of the pyrethroids cismethrin, cypermethrin and deltamethrin to rat liver homogenate and microsomes. Arch. Toxicol. 63, 214-220.
7. Crofton, K. M., Kehn, L. S., and Gilbert, M. E. (1995). Vehicle and route dependent effects of a pyrethroid insecticide, deltamethrin, on motor function in the rat. Neurotoxicol. Teratol. 17, 489-495.
8. Crow, J. A., Borazjani, A., Potter, P. M., and Ross, M. K. (2007). Hydrolysis of pyrethroids by human and rat tissues: Examination of intestinal, liver and serum carboxylesterases. Toxicol. Appl. Pharmacol. 221, 1-12.
9. Diliberto, J. J., Jackson, J. A., and Birnbaum, L. S. (1996). Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) disposition following pulmonary, oral, dermal, and parenteral exposures to rats. Toxicol. Appl. Pharmacol. 138, 158-168.
10. Dmitrienko, A., Chuang-Stein, C., and D'Agnostio, R. (2007). Pharmaceutical Statistics Using SAS: A Practical Guide. SAS Press, SAS Institute Inc., Cary, NC.
11. Ghiasuddin, S. M., and Soderlund, D. M. (1984). Hydrolysis of pyrethroid insecticides by soluble mouse brain esterases. Toxicol. Appl. Pharmacol. 74, 390-396.
12. Godin, S. J., DeVito, M. J., Hughes, M. F., Ross, D. G., Scollon, E. J., Starr, J. M., Setzer, R. W., Conolly, R. B., and Tornero-Velez, R. (2010). Physiologically based pharmacokinetic modeling of deltamethrin: Development of a rat and human diffusion-limited model. Toxicol. Sci. 115, 330-343.
13. Graham, S. E., and McCurdy, T. (2004). Developing meaningful cohorts for human exposure models. J. Expo. Anal. Environ. Epidemiol. 14, 23-43.
14. Hoellinger, H., Sonnier, M., Gray, A. J., Connors, T. A., Pichon, J., and Nguyen, H. N. (1985). In vitro covalent binding of cismethrin, bioresmethrin, and their common alcohol to hepatic proteins. Toxicol. Appl. Pharmacol. 77, 11-18.
15. Hoellinger, H., Sonnier, M., Pichon, J., Lecorsier, A., Do, C. T., and Nguyen, H. N. (1983). In vivo covalent binding of cismethrin and bioresmethrin to hepatic proteins. Toxicol. Lett. 19, 179-187.
16. Hutson, D. H., and Logan, C. J. (1986). The metabolic fate in rats of the pyrethroid insectide WL85871, a mixture of two isomers of cypermethrin. Pestic. Sci. 17, 548-558.
17. Kim, K. B., Anand, S. S., Kim, H. J., White, C. A., and Bruckner, J. V. (2008). Toxicokinetics and tissue distribution of deltamethrin in adult Sprague Dawley rats. Toxicol. Sci. 101, 197-205.
18. Marei, A. E., Ruzo, L. O., and Casida, J. E. (1982). Analysis and persistence of permethrin, cypermethrin, deltamethrin, and fenvalerate in the fat and brain of treated rats. J. Agric. Food Chem. 30, 558-562.
19. Mirfazaelian, A., Kim, K. B., Anand, S. S., Kim, H. J., Tornero-Velez, R., Bruckner, J. V., and Fisher, J. W. (2006). Development of a physiologically based pharmacokinetic model for deltamethrin in the adult male Sprague Dawley rat. Toxicol. Sci. 93, 432-442.
20. Morgan, M. K., Sheldon, L. S., and Croghan, C. W. (2004). A Pilot Study of Children's Total Exposure to Persistant Pesticides and Other Persistant Organic Pollutants (CTEPP). EPA/600/R-041/193. Volume I: Final Report. U.S. Environmental Protection Agency, Research Triangle Park, NC.
21. Morgan, M. K., Sheldon, L. S., Croghan, C. W., Jones, P. A., Chuang, J. C., and Wilson, N. K. (2007). An observational study of 127 preschool children at their homes and daycare centers in Ohio: Environmental pathways to cisand trans-permethrin exposure. Environ. Res. 104, 266-274.
22. Nakamura, Y., Sugihara, K., Sone, T., Isobe, M., Ohta, S., and Kitamura, S. (2007). The in vitro metabolism of a pyrethroid insecticide, permethrin, and its hydrolysis products in rats. Toxicology 235, 176-184.
23. Narahashi, T., Ginsburg, K. S., Nagata, K., Song, J. H., and Tatebayashi, H. (1998). Ion channels as targets for insecticides. Neurotoxicology 19, 581-590.
24. Ohkawa, H., Kaneko, H., Tsuji, H., and Miyamoto, J. (1979). Metabolism of fenvalerate (sumicidin) in rats. J. Pestic. Sci. 4, 143-155.
25. Poulin, P., and Krishnan, K. (1995). An algorithm for predicting tissue: Blood partition coefficients of organic chemicals from n-octanol: Water partition coefficient data. J. Toxicol. Environ. Health 46, 117-129.
26. Schoeffner, D. J., Warren, D. A., Muralidara, S., Bruckner, J. V., and Simmons, J. E. (1999). Organ weights and fat volume in rats as a function of strain and age. J. Toxicol. Environ. Health Part A 56, 449-462.
27. Scollon, E. J., Starr, J. M., Crofton, K. M., Wolansky, M. J., DeVito, M. J., and Hughes, M. F. (2011). Correlation of tissue concentrations of the pyrethroid bifenthrin with neurotoxicity in the rat. Toxicology 290, 1-6.
28. Scollon, E. J., Starr, J. M., Godin, S. J., DeVito, M. J., and Hughes, M. F. (2009). In vitro metabolism of pyrethroid pesticides by rat and human hepatic microsomes and cytochrome p450 isoforms. Drug Metab. Dispos. 37, 221-228.
29. Soderlund, D. M., and Bloomquist, J. R. (1989). Neurotoxic actions of pyrethroid insecticides. Annu. Rev. Entomol. 34, 77-96.
30. Soderlund, D. M., and Casida, J. E. (1977). Effects of pyrethroid structure on rates of hydrolysis and oxidation by mouse liver microsomal enzymes. Pestic. Biochem. Physiol. 7, 391-401.
31. Soderlund, D. M., Clark, J. M., Sheets, L. P., Mullin, L. S., Piccirillo, V. J., Sargent, D., Stevens, J. T., and Weiner, M. L. (2002). Mechanisms of pyrethroid neurotoxicity: Implications for cumulative risk assessment. Toxicology 171, 3-59.
32. Stout, D. M., 2nd, Bradham, K. D., Egeghy, P. P., Jones, P. A., Croghan, C. W., Ashley, P. A., Pinzer, E., Friedman, W., Brinkman, M. C., Nishioka, M. G., et al. (2009). American Healthy Homes Survey: A national study of residential pesticides measured from floor wipes. Environ. Sci. Technol. 43, 4294-4300.
33. Taylor, J. K. (1987). Quality Assurance of Chemical Measurements. Lewis Publishers, New York.
34. Tornero-Velez, R., Egeghy, P. P., and Cohen Hubal, E. A. (2012). Biogeographical analysis of chemical co-occurrence data to identify priorities for mixtures research. Risk Anal. 32, 224-236.
35. Tornero-Velez, R., Mirfazaelian, A., Kim, K. B., Anand, S. S., Kim, H. J., Haines, W. T., Bruckner, J. V., and Fisher, J. W. (2010). Evaluation of deltamethrin kinetics and dosimetry in the maturing rat using a PBPK model. Toxicol. Appl. Pharmacol. 244, 208-217.
36. Tulve, N. S., Jones, P. A., Nishioka, M. G., Fortmann, R. C., Croghan, C. W., Zhou, J. Y., Fraser, A., Cavel, C., and Friedman, W. (2006). Pesticide measurements from the first national environmental health survey of child care centers using a multi-residue GC/MS analysis method. Environ. Sci. Technol. 40, 6269-6274.
37. U.S. EPA. (2011). Pyrethrins/Pyrethroids Cumulative Risk Assessment; Notice of Availability. EPA-HQ-OPP-2011-0746; FRL-8888-9. U.S. Environmental Protection Agency, Research Triangle Park, NC.
38. Weiner, M. L., Nemec, M., Sheets, L., Sargent, D., and Breckenridge, C. (2009). Comparative functional observational battery study of twelve commercial pyrethroid insecticides in male rats following acute oral exposure. Neurotoxicology 30(Suppl. 1), S1-S16.
39. White, I. N. H., Verschoyle, R. D., Moradian, M. H., and Barnes, J. M. (1976). The relationship between brain levels of cismethrin and bioresmethrin in female rats and neurotoxic effects. Pestic. Biochem. Physiol. 6, 491-500.
40. Wolansky, M. J., Gennings, C., and Crofton, K. M. (2006). Relative potencies for acute effects of pyrethroids on motor function in rats. Toxicol. Sci. 89, 271-277.
41. Wolansky, M. J., Gennings, C., DeVito, M. J., and Crofton, K. M. (2009). Evidence for dose-additive effects of pyrethroids on motor activity in rats. Environ. Health Perspect. 117, 1563-1570.
42. Wolansky, M. J., McDaniel, K. L., Moser, V. C., and Crofton, K. M. (2007). Influence of dosing volume on the neurotoxicity of bifenthrin. Neurotoxicol. Teratol. 29, 377-384.