Comparison of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) disposition following pulmonary, oral, dermal, and parenteral exposures to rats

Toxicology and Applied Pharmacology

Volumn 138, Issue 1, 1996, Pages 158-168

  Diliberto, Janet J ^a   Jackson, Joseph A ^a   Birnbaum, Linda S ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION; FECES; INGESTION; INHALATION; INTRAVENOUS ADMINISTRATION; LIVER; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; SKIN ABSORPTION; TISSUE DISTRIBUTION; TOXICOKINETICS; URINARY EXCRETION;

ANIMALIA;

EID: 0029890699     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0109     Document Type: Article

References (68)

1. Abraham, K., Krowke, R., and Neubert, D. (1988). Pharmacokinetics and biological activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin. I. Dose-dependent tissue distribution and induction of hepatic ethoxyresorufin O-deethylase in rats following a single injection. Arch. Toxicol. 62, 359-368.
2. Banks, Y. B., and Birnbaum, L. S. (1991). Absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) after low dose dermal exposure. Toxicol. Appl. Pharmacol. 107, 302-310.
3. Banks, Y. B., Brewster, D. W., and Birnbaum, L. S. (1990). Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,7,8-pentachlorodibenzo-p-dioxin. Fundam. Appl. Toxicol. 15, 163-173.
4. Beck, H., Eckart, K., Mathar, W., and Wittkowski, R. (1989). Levels of PCDDs and PCDFs in adipose tissue of occupational exposed workers. Chemosphere 18, 507-516.
5. Birnbaum, L. S. (1985). The role of structure in the disposition of halogenated aromatic xenobiotics. Environ. Health Perspect. 61, 11-20.
6. Birnbaum, L. S. (1994). The mechanism of dioxin toxicity: Relationship to risk assessment. Environ. Health Perspect. 102, 157-167.
7. Birnbaum, L. S., Decad, G. M., and Matthews, H. B. (1980). Disposition and excretion of 2,3,7,8-tetrachlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 66, 342-352.
8. Bond, J. A., Baker, S. M., and Bechtold, W. E. (1985). Correlation of the octanol/water partition coefficient with clearance halftimes of intratracheally instilled aromatic hydrocarbons in rats. Toxicology. 36, 285-295.
9. Brain, J. D., Knudson, D. E., Sorokin, S. P., and Davis, M. A. (1976). Pulmonary distribution of particles given by intratracheal instillation or by aerosol inhalation. Environ. Res. 11, 13-33.
10. Brewster, D. W., Banks, Y. B., Clark, A. M., and Birnbaum, L. S. (1989). Comparative dermal absorption of 2,3,7,8-tetrachlorodibenzo-dioxin and three polychlorinated dibenzofurans. Toxicol. Appl. Pharmacol. 97, 156-166.
11. Brewster, D. W., and Birnbaum, L. S. (1988). Disposition of 1,2,3,7,8-pentrachlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 95, 490-498.
12. Christmann, W., Kloppel, K. D., Partscht, H., and Rotard, W. (1989). Determination of PCDD/PCDF in ambient air. Chemosphere 19, 521-526.
13. Clement, R. E., Tashiro, C., Suter, S., Reiner, E., and Hollinger, D. (1989). Chlorinated dibenzo-p-dioxins (CDDs) and dibenzofurans (CDFs) in effluents and sludges from pulp and paper mills. Chemosphere 18, 1189-1197.
14. Costa, D. L., Lehmann, J. R., Harold, W. M., and Drew, R. T. (1986). Transoral tracheal intubation of rodents using a fiberoptic laryngoscope. Lab. Anim. Sci. 36(3), 256-261.
15. Diliberto, J. J., Akubue, P. I., Luebke, R. W., and Birnbaum, L. S. (1995). Dose-response relationships of tissue distribution and induction of CYP1A1 and CYP1A2 enzymatic activities following acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice. Toxicol. Appl. Pharmacol. 130, 197-208.
16. 3H]-tetrabromodibenzo-p-dioxin (TBDD) in the rat. Toxicol. Appl. Pharmacol. 120, 315-326.
17. Furst, P., Furst, C., and Wilmers, K. (1991). Body burden with PCDD and PCDF from food. In Biological Basis for Risk Assessment of Dioxins and Related Compounds, Banbury Report 35 (M. A. Gallo, R. J. Scheuplein, and K. A. Van Der Heijden, Eds.), pp. 133-142. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
18. Gillner, M., Brittebo, E. B., Brandt, I., Söderkvist, P., Appelgren, L-B., and Gustafsson, J-Å. (1987). Uptake and specific binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the olfactory mucosa of mice and rats. Cancer Res. 47, 4150-4159.
19. Goldfarb, T. D., and Harrad, S. J. (1991). Consideration of the environmental impact of the volatilization of PCDDs and PCDFs. Chemosphere 23, 1669-1674.
20. Goldstein, J. A., and Linko, P. (1984). Differential induction of two 2,3,7,8-tetrachlorodibenzo-p-dioxin-inducible forms of cytochrome P-450 in extrahepatic versus hepatic tissues. Mol. Pharmacol. 25, 185-191.
21. Guy, R. H., and Hadgraft, J. (1989). Structure-activity correlations in percutaneous absorption. In Percutaneous Absorption: Mechanism-Methodology-Drug Delivery (R. L. Bronaugh, and H. I. Maibach, Eds.), pp. 95-110. Dekker, New York.
22. Hutzinger, O., and Fiedler, H. (1989). Sources and emissions of PCDD/ PCDF. Chemosphere 18, 23-32.
23. Jackson, J. A., Diliberto, J. J., and Birnbaum, L. S. (1993). Estimation of octanol-water partition coefficients and correlation with dermal absorption for several polyhalogenated aromatic hydrocarbons. Fundam. Appl. Toxicol. 21, 334-344.
24. Jayyosi, A., and Thomas, P. W. (1990). Identification of cytochrome P-450 isozymes and characterization of testosterone oxidation pathways in rat nasal epithelium. FASEB J. 4, A1971.
25. Jensen, A. A. (1991). Transfer of chemical contaminants into human milk. In Chemical Contaminants in Human Milk. (A. A. Jensen and S. A. Slorach Eds.), pp. 9-19. CRC Press, Boca Raton, FL.
26. Jödicke, B., Ende, M., Helge, H., and Neubert, D. (1992). Fecal excretion of PCDDs/PCDFs in a 3-month-old breast-fed infant. Chemosphere 25, 1061-1065.
27. Kedderis, L. B., Andersen, M. E., and Birnbaum, L. S. (1993). Effect of dose, time, and pretreatment on the biliary excretion and tissue distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. Fundam. Appl. Toxicol. 21, 405-411.
28. Keith, I. M., Olson, E. B., Wilson, N. M., and Jefcoate, C. R. (1987). Immunological identification and effects of 3-methylcholanthrene and phenobarbital on rat pulmonary cytochrome P450. Cancer Res. 47,1878-1882.
29. Kimbrough, R. D., Falk, H., Stehr, P., and Fries, G. (1984). Health implications of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) contamination of residential soil. J. Toxicol. Environ. Health 14, 47-93.
30. Lakshmanan, M. R., Campbell, B. S., Chirtel, S. J., Ekarohita, N., and Ezekiel, M. (1986). Studies on the mechanism of absorption and distribution of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat. J. Pharmacol. Exp. Ther. 239, 673-677.
31. Leung, H. W., Ku, R. H., Paustenback, D. J., and Andersen, M. E. (1988). A physiological-based pharmacokinetic model for 2,3,7,8-tetrachlorodibenzo-p-dioxin in C57BL/6J and DBA/2J mice. Toxicol. Lett. 42, 15-28.
32. Lippmann, M., Yeates, and Albert, R. E. (1980). Deposition, retention, and clearance of inhaled particles. Br. J. Ind. Med. 37, 337-362.
33. Lucier, G. W., Rumbaugh, R. C., McCoy, Z., Hass, R., Harvan, D., and Albro, P. (1986). Ingestion of soil contaminated with 2,3,7,8-tetrachloro-dibenzo-p-dioxin (TCDD) alters hepatic enzyme activities in rats. Fundam. Appl. Toxicol. 6, 364-371.
34. McLachlan, M. S. (1993). Digestive tract absorption of polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls in a nursing infant. Toxicol. Appl. Pharmacol. 123, 68-72.
35. McKinley, M. K., Kedderis, L. B., and Birnbaum, L. S. (1993). The effect of pretreatment on the biliary excretion of 2,3,7,8-tetrachlorodibenzo-p-dioxin, 2,3,7,8-tetrachlorodibenzofuran, and 3,3,′,4,4′-tetrachlorobiphenyl in the rat. Fundam. Appl. Toxicol. 21, 425-432.
36. Morrill, L. G., Mahilum, B. C., and Mohiuddin, S. H. (1982). Organic Compounds in Soils: Sorption, Degradation and Persistence, pp. 35-54. Ann Arbor Science Publ., Ann Arbor, MI.
37. Muto, H., and Takizawa, Y. (1992). Potential health risk via inhalation/ ingestion exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans. Bull. Environ. Contam. Toxicol. 49, 701-707.
38. Muto, H., and Takizawa, Y. (1989). Dioxins in cigarette smoke. Arch. Environ. Health 44, 171-174.
39. Nessel, C. S., Amoruso, M. A., Umbreit, T. H., and Gallo, M. A. (1990). Hepatic aryl hydrocarbon hydroxylase and cytochrome P450 induction following the transpulmonary absorption of TCDD from intratracheally instilled particles. Fundam. Appl. Toxicol. 12, 500-509.
40. Nessel, C. S., Amoruso, M. A., Umbreit, T. H., Meeker, R. J., and Gallo, M. A. (1992). Pulmonary availability and fine particle enrichment of 2,3,7,8-TCDD in respirable soil particles. Fundam. Appl. Toxicol. 19, 279-285.
41. Olson, J. R., Gasiewicz, T. A., and Neal, R. A. (1980). Tissue distribution, excretion, and metabolism of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the golden Syrian hamster. Toxicol. Appl. Pharmacol. 56, 78-85.
42. Päpke, O., Ball, M., and Lis, A. (1992). Various PCDD/PCDF patterns in human blood resulting from different occupational exposures. Chemosphere 25, 1101-1108.
43. Pegram, R. A., Diliberto, J. J., Moore, T. C., Gao, P., and Birnbaum, L. S. (1995). 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) distribution and cytochrome P4501A induction in young adult and senescent male mice. Toxicol. Lett. 76, 119-126.
44. 14C-TCDD in a TCDD-susceptible and a TCDD-resistant rat strain. Pharmacol. Toxicol. 66, 93-100.
45. Poiger, H., and Schlatter, C. (1980). Influence of solvents and adsorbents on dermal and intestinal absorption of TCDD. Food Cosmet. Toxicol. 18, 477-481.
46. 125I]2-Iodo-3,7,8-trichl-orodibenzo-p-dioxin-binding species in mouse liver induced by agonists for the Ah receptor: Characterization and identification. Mol. Pharmacol. 36, 113-120.
47. 125I]2-iodo-3,7,8-trichlorodibenzo-p-dioxin by the administration of agonists for the Ah receptor. Mol. Pharmacol. 36, 121-127.
48. Rappe, C., Marklund, S., Kjeller, L. O., and Lindskog, A. (1989). Long-range transport of PCDDs and PCDFs on airborne particles. Chemosphere 18, 1283-1290.
49. Rappe, C., and Kjeller, L. O. (1987). PCDDs and PCDFs in environmental samples, air particles, sediments and soil. Chemosphere 16, 1775-1780.
50. Reddy, S. L., Kim, S. G., States, J. C., Dahl, A. R., Hotchkiss, J., and Novak, R. F. (1991). RT-PCR detection of CYP1A1, 1A2 and 2E1 mRNAs in rat nasal tissue. FASEB J. 5, A1162.
51. Rose, J. Q., Ramsey, J. C., Wentzler, T. H., Hummer, R. A., and Gehring, P/J. (1976). The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat. Toxicol. Appl. Pharmacol. 36, 209-226.
52. Schaum, J., Cleverly, D., Lorber, M., Phillips, L., and Schweer, G. (1994). Organohalogen Compounds: Dioxin '94. Environmental Levels, Sources and Formation, Metabolism of PCB and Related Compounds, Polar Environment, National Overviews. Vol. 20, pp. 237-241. Kyoto University, Kyoto, Japan.
53. Schlesinger, R. B. (1985). Comparative deposition of inhaled aerosols in experimental animals and humans: A review. J. Toxicol. Environ. Health 15, 197-214.
54. Shu, H., Paustenbach, D., Murray, F. J., Marple, L., Brunck, B., Dei Rossi, D., and Teitelbaum, P. (1988a). Bioavailability of soil-bound TCDD: Oral bioavailability in the rat. Fundam. Appl. Toxicol. 10, 648-654.
55. Shu, H., Teitelbaum, P., Webb, A. S., Marple, L., Brunck, B., Dei Rossi, D., Murray, F. J., and Paustenbach, D. (1988b). Bioavailability of soilbound TCDD: Dermal bioavailability in the rat. Fundam. Appl. Toxicol. 10, 335-343.
56. Stevens, J. B., and Swackhamer, D. L. (1989). Environmental pollution: A multimedia approach to modeling human exposure. Environ. Sci, Technol. 23, 1180-1186.
57. Svensson, B-G., Nilsson, A., Hansson, M., Rappe, C., Akesson, B., and Skerfving, S. (1991). Exposure to dioxins and dibenzofurans through the consumption of fish. N. Engl. J. Med. 324, 8-12.
58. Swanson, S. E., Rappe, C., Malmström, J., and Kringstad, K. P. (1988). Emissions of PCDDs and PCDFs from the pulp industry. Chemosphere 17, 681-691.
59. Thoma, H. (1988). PCDD/F concentrations in chimney soot from house heating systems. Chemosphere 17, 1369-1379.
60. Traber, P. G., McDonnell, W. M., Wang, W., and Florence, R. (1992). Expression and regulation of cytochrome P-4501 genes (CYP1A1 and CYP1A2) in the rat alimentary tract. Biochim. Biophys. Acta 1171, 167-175.
61. Umbreit, T. H., Hesse, E. J., and Gallo, M. A. (1986). Comparative toxicity of TCDD contaminated soil from Times Beach, Missouri, and Newark, New Jersey. Chemosphere 15, 2121-2124.
62. van den Berg, M., de Vroom, E., Olie, K., and Hutzinger, O. (1986). Bioavailability of PCDDs and PCDFs on fly ash after semi-chronic oral ingestion by guinea pig and Syrian golden hamster. Chemosphere 15, 519-533.
63. van den Berg, M., de Vroom, E., van Greeven-broek, M., Olie, K., and Hutzinger, O. (1985). Bioavailability of PCDDs and PCDFs absorbed on fly ash in rat, guinea pig and Syrian golden hamster. Chemosphere 14, 865-869.
64. van den Berg, M., Olie, K., and Hutzinger, O. (1983). Uptake and selective retention in rats of orally administered chlorinated dioxins and dibenzofurans from fly ash and fly ash extract. Chemosphere 12, 537-544.
65. Voorman, R., and Aust, S. D. (1987). Specific binding of polyhalogenated aromatic hydrocarbon inducers of cytochrome P-450d to the cytochrome and inhibition of its estradiol 2-hydroxylase activity. Toxicol. Appl. Pharmacol. 90, 69-78.
66. Voorman, R., and Aust, S. D. (1989). TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) is a tight binding inhibitor of cytochrome P-450d. J. Biochem. Toxicol. 4, 105-109.
67. Wevers, M., De Fré, R., Van Cleuvenbergen, R., and Rymen, T. (1993). Concentrations of PCDDs and PCDFs in ambient air at selected locations in Flanders. In Organohalogen Compounds: Dioxin '93. Emission Control, Transport and Fate, Environmental Levels and Ecotoxicology. Vol. 12, pp. 123-126. Univ. of Bayreuth, Bayreuth, Germany.
68. Winters, D., Lorber, M., Cleverly, D., Schaum, J., Harless, R., Dupuy, A., McDaniel, D., Ferrario, J., Byrne, C., Ellis, R., Deyrup, C., Meier, K., Leese, W., and Walcott, J. (1994). A statistical survey of dioxin-like compounds in the United States beef supply. In Organohalogen Compounds: Dioxin '94. Environmental Levels, Sources and Formation, Metabolism of PCB and Related Compounds, Polar Environment, National Overviews. Vol. 20, pp. 73-77. Kyoto University, Kyoto, Japan.