-
1
-
-
59649101866
-
Retroviral integrase superfamily: the structural perspective
-
Nowotny M. Retroviral integrase superfamily: the structural perspective. EMBO Rep 2009, 10:144-151.
-
(2009)
EMBO Rep
, vol.10
, pp. 144-151
-
-
Nowotny, M.1
-
2
-
-
58149504194
-
Integrase and integration: biochemical activities of HIV-1 integrase
-
Delelis O., Carayon K., Saib A., Deprez E., Mouscadet J.F. Integrase and integration: biochemical activities of HIV-1 integrase. Retrovirology 2008, 5:114.
-
(2008)
Retrovirology
, vol.5
, pp. 114
-
-
Delelis, O.1
Carayon, K.2
Saib, A.3
Deprez, E.4
Mouscadet, J.F.5
-
3
-
-
36749052217
-
High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR)
-
Schmidt M., Schwarzwaelder K., Bartholomae C., Zaoui K., Ball C., Pilz I., Braun S., Glimm H., von Kalle C. High-resolution insertion-site analysis by linear amplification-mediated PCR (LAM-PCR). Nat Methods 2007, 4:1051-1057.
-
(2007)
Nat Methods
, vol.4
, pp. 1051-1057
-
-
Schmidt, M.1
Schwarzwaelder, K.2
Bartholomae, C.3
Zaoui, K.4
Ball, C.5
Pilz, I.6
Braun, S.7
Glimm, H.8
von Kalle, C.9
-
4
-
-
0024431684
-
In vivo footprinting of a muscle specific enhancer by ligation mediated PCR
-
Mueller P.R., Wold B. In vivo footprinting of a muscle specific enhancer by ligation mediated PCR. Science 1989, 246:780-786.
-
(1989)
Science
, vol.246
, pp. 780-786
-
-
Mueller, P.R.1
Wold, B.2
-
5
-
-
0024462602
-
Genomic sequencing and methylation analysis by ligation mediated PCR
-
Pfeifer G.P., Steigerwald S.D., Mueller P.R., Wold B., Riggs A.D. Genomic sequencing and methylation analysis by ligation mediated PCR. Science 1989, 246:810-813.
-
(1989)
Science
, vol.246
, pp. 810-813
-
-
Pfeifer, G.P.1
Steigerwald, S.D.2
Mueller, P.R.3
Wold, B.4
Riggs, A.D.5
-
6
-
-
71549135258
-
Comprehensive genomic access to vector integration in clinical gene therapy
-
Gabriel R., Eckenberg R., Paruzynski A., Bartholomae C.C., Nowrouzi A., Arens A., Howe S.J., Recchia A., Cattoglio C., Wang W., et al. Comprehensive genomic access to vector integration in clinical gene therapy. Nat Med 2009, 15:1431-1436.
-
(2009)
Nat Med
, vol.15
, pp. 1431-1436
-
-
Gabriel, R.1
Eckenberg, R.2
Paruzynski, A.3
Bartholomae, C.C.4
Nowrouzi, A.5
Arens, A.6
Howe, S.J.7
Recchia, A.8
Cattoglio, C.9
Wang, W.10
-
7
-
-
77955220225
-
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
-
Paruzynski A., Arens A., Gabriel R., Bartholomae C.C., Scholz S., Wang W., Wolf S., Glimm H., Schmidt M., von Kalle C. Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protocols 2010, 5:1379-1395.
-
(2010)
Nat Protocols
, vol.5
, pp. 1379-1395
-
-
Paruzynski, A.1
Arens, A.2
Gabriel, R.3
Bartholomae, C.C.4
Scholz, S.5
Wang, W.6
Wolf, S.7
Glimm, H.8
Schmidt, M.9
von Kalle, C.10
-
8
-
-
79959469934
-
A method to sequence and quantify DNA integration for monitoring outcome in gene therapy
-
Brady T., Roth S.L., Malani N., Wang G.P., Berry C.C., Leboulch P., Hacein-Bey-Abina S., Cavazzana-Calvo M., Papapetrou E.P., Sadelain M., et al. A method to sequence and quantify DNA integration for monitoring outcome in gene therapy. Nucleic Acids Res 2011, 39:e72.
-
(2011)
Nucleic Acids Res
, vol.39
-
-
Brady, T.1
Roth, S.L.2
Malani, N.3
Wang, G.P.4
Berry, C.C.5
Leboulch, P.6
Hacein-Bey-Abina, S.7
Cavazzana-Calvo, M.8
Papapetrou, E.P.9
Sadelain, M.10
-
9
-
-
79953083164
-
The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones
-
Gillet N.A., Malani N., Melamed A., Gormley N., Carter R., Bentley D., Berry C., Bushman F.D., Taylor G.P., Bangham C.R. The host genomic environment of the provirus determines the abundance of HTLV-1-infected T-cell clones. Blood 2011, 117:3113-3122.
-
(2011)
Blood
, vol.117
, pp. 3113-3122
-
-
Gillet, N.A.1
Malani, N.2
Melamed, A.3
Gormley, N.4
Carter, R.5
Bentley, D.6
Berry, C.7
Bushman, F.D.8
Taylor, G.P.9
Bangham, C.R.10
-
10
-
-
84867744253
-
Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites
-
Arens A., Appelt J.U., Bartholomae C.C., Gabriel R., Paruzynski A., Gustafson D., Cartier N., Aubourg P., Deichmann A., Glimm H., et al. Bioinformatic clonality analysis of next-generation sequencing-derived viral vector integration sites. Hum Gene Ther Methods 2012, 23:111-118.
-
(2012)
Hum Gene Ther Methods
, vol.23
, pp. 111-118
-
-
Arens, A.1
Appelt, J.U.2
Bartholomae, C.C.3
Gabriel, R.4
Paruzynski, A.5
Gustafson, D.6
Cartier, N.7
Aubourg, P.8
Deichmann, A.9
Glimm, H.10
-
11
-
-
79951972332
-
Identifying viral integration sites using SeqMap 2.0
-
Hawkins T.B., Dantzer J., Peters B., Dinauer M., Mockaitis K., Mooney S., Cornetta K. Identifying viral integration sites using SeqMap 2.0. Bioinformatics 2011, 27:720-722.
-
(2011)
Bioinformatics
, vol.27
, pp. 720-722
-
-
Hawkins, T.B.1
Dantzer, J.2
Peters, B.3
Dinauer, M.4
Mockaitis, K.5
Mooney, S.6
Cornetta, K.7
-
12
-
-
80054098367
-
Analyzing the number of common integration sites of viral vectors-new methods and computer programs
-
Abel U., Deichmann A., Nowrouzi A., Gabriel R., Bartholomae C.C., Glimm H., von Kalle C., Schmidt M. Analyzing the number of common integration sites of viral vectors-new methods and computer programs. PLoS One 2011, 6:e24247.
-
(2011)
PLoS One
, vol.6
-
-
Abel, U.1
Deichmann, A.2
Nowrouzi, A.3
Gabriel, R.4
Bartholomae, C.C.5
Glimm, H.6
von Kalle, C.7
Schmidt, M.8
-
13
-
-
80052678100
-
Methodology and software to detect viral integration site hot-spots
-
Presson A.P., Kim N., Xiaofei Y., Chen I.S., Kim S. Methodology and software to detect viral integration site hot-spots. BMC Bioinformatics 2011, 12:367.
-
(2011)
BMC Bioinformatics
, vol.12
, pp. 367
-
-
Presson, A.P.1
Kim, N.2
Xiaofei, Y.3
Chen, I.S.4
Kim, S.5
-
14
-
-
77949365510
-
Retroviral intasome assembly and inhibition of DNA strand transfer
-
Hare S., Gupta S.S., Valkov E., Engelman A., Cherepanov P. Retroviral intasome assembly and inhibition of DNA strand transfer. Nature 2010, 464:232-236.
-
(2010)
Nature
, vol.464
, pp. 232-236
-
-
Hare, S.1
Gupta, S.S.2
Valkov, E.3
Engelman, A.4
Cherepanov, P.5
-
15
-
-
78149434355
-
The mechanism of retroviral integration from X-ray structures of its key intermediates
-
Maertens G.N., Hare S., Cherepanov P. The mechanism of retroviral integration from X-ray structures of its key intermediates. Nature 2010, 468:326-329.
-
(2010)
Nature
, vol.468
, pp. 326-329
-
-
Maertens, G.N.1
Hare, S.2
Cherepanov, P.3
-
16
-
-
77957670046
-
Structure-based modeling of the functional HIV-1 intasome and its inhibition
-
Krishnan L., Li X., Naraharisetty H.L., Hare S., Cherepanov P., Engelman A. Structure-based modeling of the functional HIV-1 intasome and its inhibition. Proc Natl Acad Sci U S A 2010, 107:15910-15915.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15910-15915
-
-
Krishnan, L.1
Li, X.2
Naraharisetty, H.L.3
Hare, S.4
Cherepanov, P.5
Engelman, A.6
-
17
-
-
77955443840
-
Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties
-
Lim K.I., Klimczak R., Yu J.H., Schaffer D.V. Specific insertions of zinc finger domains into Gag-Pol yield engineered retroviral vectors with selective integration properties. Proc Natl Acad Sci U S A 2010, 107:12475-12480.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 12475-12480
-
-
Lim, K.I.1
Klimczak, R.2
Yu, J.H.3
Schaffer, D.V.4
-
18
-
-
84858409977
-
The structural biology of HIV-1: mechanistic and therapeutic insights
-
Engelman A., Cherepanov P. The structural biology of HIV-1: mechanistic and therapeutic insights. Nat Rev Microbiol 2012, 10:279-290.
-
(2012)
Nat Rev Microbiol
, vol.10
, pp. 279-290
-
-
Engelman, A.1
Cherepanov, P.2
-
19
-
-
79959350868
-
HIV DNA is heavily uracilated, which protects it from autointegration
-
Yan N., O'Day E., Wheeler L.A., Engelman A., Lieberman J. HIV DNA is heavily uracilated, which protects it from autointegration. Proc Natl Acad Sci U S A 2011, 108:9244-9249.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9244-9249
-
-
Yan, N.1
O'Day, E.2
Wheeler, L.A.3
Engelman, A.4
Lieberman, J.5
-
20
-
-
0037166281
-
HIV-1 integrase interaction with U3 and U5 terminal sequences in vitro defined using substrates with random sequences
-
Brin E., Leis J. HIV-1 integrase interaction with U3 and U5 terminal sequences in vitro defined using substrates with random sequences. J Biol Chem 2002, 277:18357-18364.
-
(2002)
J Biol Chem
, vol.277
, pp. 18357-18364
-
-
Brin, E.1
Leis, J.2
-
21
-
-
17844381584
-
Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites
-
Holman A.G., Coffin J.M. Symmetrical base preferences surrounding HIV-1, avian sarcoma/leukosis virus, and murine leukemia virus integration sites. Proc Natl Acad Sci U S A 2005, 102:6103-6107.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 6103-6107
-
-
Holman, A.G.1
Coffin, J.M.2
-
22
-
-
16244386233
-
Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses
-
Wu X., Li Y., Crise B., Burgess S.M., Munroe D.J. Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses. J Virol 2005, 79:5211-5214.
-
(2005)
J Virol
, vol.79
, pp. 5211-5214
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
Munroe, D.J.5
-
23
-
-
0037841763
-
Transcription start regions in the human genome are favored targets for MLV integration
-
Wu X., Li Y., Crise B., Burgess S.M. Transcription start regions in the human genome are favored targets for MLV integration. Science 2003, 300:1749-1751.
-
(2003)
Science
, vol.300
, pp. 1749-1751
-
-
Wu, X.1
Li, Y.2
Crise, B.3
Burgess, S.M.4
-
24
-
-
33745684269
-
Retroviral DNA integration: viral and cellular determinants of target-site selection
-
Lewinski M.K., Yamashita M., Emerman M., Ciuffi A., Marshall H., Crawford G., Collins F., Shinn P., Leipzig J., Hannenhalli S., et al. Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS Pathog 2006, 2:e60.
-
(2006)
PLoS Pathog
, vol.2
-
-
Lewinski, M.K.1
Yamashita, M.2
Emerman, M.3
Ciuffi, A.4
Marshall, H.5
Crawford, G.6
Collins, F.7
Shinn, P.8
Leipzig, J.9
Hannenhalli, S.10
-
25
-
-
19344375031
-
Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences
-
Mitchell R.S., Beitzel B.F., Schroder A.R., Shinn P., Chen H., Berry C.C., Ecker J.R., Bushman F.D. Retroviral DNA integration: ASLV, HIV, and MLV show distinct target site preferences. PLoS Biol 2004, 2:E234.
-
(2004)
PLoS Biol
, vol.2
-
-
Mitchell, R.S.1
Beitzel, B.F.2
Schroder, A.R.3
Shinn, P.4
Chen, H.5
Berry, C.C.6
Ecker, J.R.7
Bushman, F.D.8
-
26
-
-
0037162715
-
HIV-1 integration in the human genome favors active genes and local hotspots
-
Schroeder A.R., Shinn P., Chen H., Berry C., Ecker J.R., Bushman F. HIV-1 integration in the human genome favors active genes and local hotspots. Cell 2002, 110:521-529.
-
(2002)
Cell
, vol.110
, pp. 521-529
-
-
Schroeder, A.R.1
Shinn, P.2
Chen, H.3
Berry, C.4
Ecker, J.R.5
Bushman, F.6
-
27
-
-
79954733266
-
Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection
-
Biffi A., Bartolomae C.C., Cesana D., Cartier N., Aubourg P., Ranzani M., Cesani M., Benedicenti F., Plati T., Rubagotti E., et al. Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection. Blood 2011, 117:5332-5339.
-
(2011)
Blood
, vol.117
, pp. 5332-5339
-
-
Biffi, A.1
Bartolomae, C.C.2
Cesana, D.3
Cartier, N.4
Aubourg, P.5
Ranzani, M.6
Cesani, M.7
Benedicenti, F.8
Plati, T.9
Rubagotti, E.10
-
28
-
-
84860505761
-
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity
-
Suerth J.D., Maetzig T., Brugman M.H., Heinz N., Appelt J.U., Kaufmann K.B., Schmidt M., Grez M., Modlich U., Baum C., et al. Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity. Mol Ther 2012, 20:1022-1032.
-
(2012)
Mol Ther
, vol.20
, pp. 1022-1032
-
-
Suerth, J.D.1
Maetzig, T.2
Brugman, M.H.3
Heinz, N.4
Appelt, J.U.5
Kaufmann, K.B.6
Schmidt, M.7
Grez, M.8
Modlich, U.9
Baum, C.10
-
29
-
-
33646161948
-
Genome-wide mapping of foamy virus vector integrations into a human cell line
-
Nowrouzi A., Dittrich M., Klanke C., Heinkelein M., Rammling M., Dandekar T., von Kalle C., Rethwilm A. Genome-wide mapping of foamy virus vector integrations into a human cell line. J Gen Virol 2006, 87:1339-1347.
-
(2006)
J Gen Virol
, vol.87
, pp. 1339-1347
-
-
Nowrouzi, A.1
Dittrich, M.2
Klanke, C.3
Heinkelein, M.4
Rammling, M.5
Dandekar, T.6
von Kalle, C.7
Rethwilm, A.8
-
30
-
-
31944444349
-
Foamy virus vector integration sites in normal human cells
-
Trobridge G.D., Miller D.G., Jacobs M.A., Allen J.M., Kiem H.P., Kaul R., Russell D.W. Foamy virus vector integration sites in normal human cells. Proc Natl Acad Sci U S A 2006, 103:1498-1503.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 1498-1503
-
-
Trobridge, G.D.1
Miller, D.G.2
Jacobs, M.A.3
Allen, J.M.4
Kiem, H.P.5
Kaul, R.6
Russell, D.W.7
-
31
-
-
77950961510
-
Transcription factor binding sites are genetic determinants of retroviral integration in the human genome
-
Felice B., Cattoglio C., Cittaro D., Testa A., Miccio A., Ferrari G., Luzi L., Recchia A., Mavilio F. Transcription factor binding sites are genetic determinants of retroviral integration in the human genome. PLoS One 2009, 4:e4571.
-
(2009)
PLoS One
, vol.4
-
-
Felice, B.1
Cattoglio, C.2
Cittaro, D.3
Testa, A.4
Miccio, A.5
Ferrari, G.6
Luzi, L.7
Recchia, A.8
Mavilio, F.9
-
32
-
-
84855282765
-
Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors
-
Ambrosi A., Glad I.K., Pellin D., Cattoglio C., Mavilio F., Di Serio C., Frigessi A. Estimated comparative integration hotspots identify different behaviors of retroviral gene transfer vectors. PLoS Comput Biol 2011, 7:e1002292.
-
(2011)
PLoS Comput Biol
, vol.7
-
-
Ambrosi, A.1
Glad, I.K.2
Pellin, D.3
Cattoglio, C.4
Mavilio, F.5
Di Serio, C.6
Frigessi, A.7
-
33
-
-
79953296630
-
Lentiviral vector integration profiles differ in rodent postmitotic tissues
-
Bartholomae C.C., Arens A., Balaggan K.S., Yanez-Munoz R.J., Montini E., Howe S.J., Paruzynski A., Korn B., Appelt J.U., Macneil A., et al. Lentiviral vector integration profiles differ in rodent postmitotic tissues. Mol Ther 2011, 19:703-710.
-
(2011)
Mol Ther
, vol.19
, pp. 703-710
-
-
Bartholomae, C.C.1
Arens, A.2
Balaggan, K.S.3
Yanez-Munoz, R.J.4
Montini, E.5
Howe, S.J.6
Paruzynski, A.7
Korn, B.8
Appelt, J.U.9
Macneil, A.10
-
34
-
-
68649099762
-
HIV integration site distributions in resting and activated CD4+ T cells infected in culture
-
Brady T., Agosto L.M., Malani N., Berry C.C., O'Doherty U., Bushman F. HIV integration site distributions in resting and activated CD4+ T cells infected in culture. AIDS 2009, 23:1461-1471.
-
(2009)
AIDS
, vol.23
, pp. 1461-1471
-
-
Brady, T.1
Agosto, L.M.2
Malani, N.3
Berry, C.C.4
O'Doherty, U.5
Bushman, F.6
-
35
-
-
79551518877
-
Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell
-
Biasco L., Ambrosi A., Pellin D., Bartholomae C., Brigida I., Roncarolo M.G., Di Serio C., von Kalle C., Schmidt M., Aiuti A. Integration profile of retroviral vector in gene therapy treated patients is cell-specific according to gene expression and chromatin conformation of target cell. EMBO Mol Med 2011, 3:89-101.
-
(2011)
EMBO Mol Med
, vol.3
, pp. 89-101
-
-
Biasco, L.1
Ambrosi, A.2
Pellin, D.3
Bartholomae, C.4
Brigida, I.5
Roncarolo, M.G.6
Di Serio, C.7
von Kalle, C.8
Schmidt, M.9
Aiuti, A.10
-
36
-
-
4143092604
-
LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes
-
Llano M., Vanegas M., Fregoso O., Saenz D., Chung S., Peretz M., Poeschla E.M. LEDGF/p75 determines cellular trafficking of diverse lentiviral but not murine oncoretroviral integrase proteins and is a component of functional lentiviral preintegration complexes. J Virol 2004, 78:9524-9537.
-
(2004)
J Virol
, vol.78
, pp. 9524-9537
-
-
Llano, M.1
Vanegas, M.2
Fregoso, O.3
Saenz, D.4
Chung, S.5
Peretz, M.6
Poeschla, E.M.7
-
37
-
-
28644443483
-
A role for LEDGF/p75 in targeting HIV DNA integration
-
Ciuffi A., Llano M., Poeschla E., Hoffmann C., Leipzig J., Shinn P., Ecker J.R., Bushman F. A role for LEDGF/p75 in targeting HIV DNA integration. Nat Med 2005, 11:1287-1289.
-
(2005)
Nat Med
, vol.11
, pp. 1287-1289
-
-
Ciuffi, A.1
Llano, M.2
Poeschla, E.3
Hoffmann, C.4
Leipzig, J.5
Shinn, P.6
Ecker, J.R.7
Bushman, F.8
-
38
-
-
77649250416
-
LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin
-
Gijsbers R., Ronen K., Vets S., Malani N., De Rijck J., McNeely M., Bushman F.D., Debyser Z. LEDGF hybrids efficiently retarget lentiviral integration into heterochromatin. Mol Ther 2010, 18:552-560.
-
(2010)
Mol Ther
, vol.18
, pp. 552-560
-
-
Gijsbers, R.1
Ronen, K.2
Vets, S.3
Malani, N.4
De Rijck, J.5
McNeely, M.6
Bushman, F.D.7
Debyser, Z.8
-
39
-
-
77949707011
-
Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein
-
Silvers R.M., Smith J.A., Schowalter M., Litwin S., Liang Z., Geary K., Daniel R. Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein. Hum Gene Ther 2010, 21:337-349.
-
(2010)
Hum Gene Ther
, vol.21
, pp. 337-349
-
-
Silvers, R.M.1
Smith, J.A.2
Schowalter, M.3
Litwin, S.4
Liang, Z.5
Geary, K.6
Daniel, R.7
-
40
-
-
77649259825
-
Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration
-
Ferris A.L., Wu X., Hughes C.M., Stewart C., Smith S.J., Milne T.A., Wang G.G., Shun M.C., Allis C.D., Engelman A., et al. Lens epithelium-derived growth factor fusion proteins redirect HIV-1 DNA integration. Proc Natl Acad Sci U S A 2010, 107:3135-3140.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 3135-3140
-
-
Ferris, A.L.1
Wu, X.2
Hughes, C.M.3
Stewart, C.4
Smith, S.J.5
Milne, T.A.6
Wang, G.G.7
Shun, M.C.8
Allis, C.D.9
Engelman, A.10
-
41
-
-
79953288618
-
HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2
-
Ocwieja K.E., Brady T.L., Ronen K., Huegel A., Roth S.L., Schaller T., James L.C., Towers G.J., Young J.A., Chanda S.K., et al. HIV integration targeting: a pathway involving Transportin-3 and the nuclear pore protein RanBP2. PLoS Pathog 2011, 7:e1001313.
-
(2011)
PLoS Pathog
, vol.7
-
-
Ocwieja, K.E.1
Brady, T.L.2
Ronen, K.3
Huegel, A.4
Roth, S.L.5
Schaller, T.6
James, L.C.7
Towers, G.J.8
Young, J.A.9
Chanda, S.K.10
-
42
-
-
0345863840
-
RTCGD: retroviral tagged cancer gene database
-
Akagi K., Suzuki T., Stephens R.M., Jenkins N.A., Copeland N.G. RTCGD: retroviral tagged cancer gene database. Nucleic Acids Res 2004, 32:D523-D527.
-
(2004)
Nucleic Acids Res
, vol.32
-
-
Akagi, K.1
Suzuki, T.2
Stephens, R.M.3
Jenkins, N.A.4
Copeland, N.G.5
-
43
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S., Von Kalle C., Schmidt M., McCormack M.P., Wulffraat N., Leboulch P., Lim A., Osborne C.S., Pawliuk R., Morillon E., et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003, 302:415-419.
-
(2003)
Science
, vol.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
McCormack, M.P.4
Wulffraat, N.5
Leboulch, P.6
Lim, A.7
Osborne, C.S.8
Pawliuk, R.9
Morillon, E.10
-
44
-
-
51349158298
-
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
Howe S.J., Mansour M.R., Schwarzwaelder K., Bartholomae C., Hubank M., Kempski H., Brugman M.H., Pike-Overzet K., Chatters S.J., de Ridder D., et al. Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 2008, 118:3143-3150.
-
(2008)
J Clin Invest
, vol.118
, pp. 3143-3150
-
-
Howe, S.J.1
Mansour, M.R.2
Schwarzwaelder, K.3
Bartholomae, C.4
Hubank, M.5
Kempski, H.6
Brugman, M.H.7
Pike-Overzet, K.8
Chatters, S.J.9
de Ridder, D.10
-
45
-
-
80053512736
-
Development of novel efficient SIN vectors with improved safety features for Wiskott-Aldrich syndrome stem cell based gene therapy
-
Avedillo Diez I., Zychlinski D., Coci E.G., Galla M., Modlich U., Dewey R.A., Schwarzer A., Maetzig T., Mpofu N., Jaeckel E., et al. Development of novel efficient SIN vectors with improved safety features for Wiskott-Aldrich syndrome stem cell based gene therapy. Mol Pharm 2011, 8:1525-1537.
-
(2011)
Mol Pharm
, vol.8
, pp. 1525-1537
-
-
Avedillo Diez, I.1
Zychlinski, D.2
Coci, E.G.3
Galla, M.4
Modlich, U.5
Dewey, R.A.6
Schwarzer, A.7
Maetzig, T.8
Mpofu, N.9
Jaeckel, E.10
-
46
-
-
76249131912
-
Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease
-
Stein S., Ott M.G., Schultze-Strasser S., Jauch A., Burwinkel B., Kinner A., Schmidt M., Kramer A., Schwable J., Glimm H., et al. Genomic instability and myelodysplasia with monosomy 7 consequent to EVI1 activation after gene therapy for chronic granulomatous disease. Nat Med 2010, 16:198-204.
-
(2010)
Nat Med
, vol.16
, pp. 198-204
-
-
Stein, S.1
Ott, M.G.2
Schultze-Strasser, S.3
Jauch, A.4
Burwinkel, B.5
Kinner, A.6
Schmidt, M.7
Kramer, A.8
Schwable, J.9
Glimm, H.10
-
47
-
-
77949327872
-
Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils
-
Kang E.M., Choi U., Theobald N., Linton G., Long Priel D.A., Kuhns D., Malech H.L. Retrovirus gene therapy for X-linked chronic granulomatous disease can achieve stable long-term correction of oxidase activity in peripheral blood neutrophils. Blood 2010, 115:783-791.
-
(2010)
Blood
, vol.115
, pp. 783-791
-
-
Kang, E.M.1
Choi, U.2
Theobald, N.3
Linton, G.4
Long Priel, D.A.5
Kuhns, D.6
Malech, H.L.7
-
48
-
-
80052050274
-
Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction
-
Gaspar H.B., Cooray S., Gilmour K.C., Parsley K.L., Zhang F., Adams S., Bjorkegren E., Bayford J., Brown L., Davies E.G., et al. Hematopoietic stem cell gene therapy for adenosine deaminase-deficient severe combined immunodeficiency leads to long-term immunological recovery and metabolic correction. Sci Transl Med 2011, 3:97ra80.
-
(2011)
Sci Transl Med
, vol.3
-
-
Gaspar, H.B.1
Cooray, S.2
Gilmour, K.C.3
Parsley, K.L.4
Zhang, F.5
Adams, S.6
Bjorkegren, E.7
Bayford, J.8
Brown, L.9
Davies, E.G.10
-
49
-
-
78449233751
-
Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency
-
Ferrua F., Brigida I., Aiuti A. Update on gene therapy for adenosine deaminase-deficient severe combined immunodeficiency. Curr Opin Allergy Clin Immunol 2010, 10:551-556.
-
(2010)
Curr Opin Allergy Clin Immunol
, vol.10
, pp. 551-556
-
-
Ferrua, F.1
Brigida, I.2
Aiuti, A.3
-
50
-
-
70449427834
-
Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy
-
Cartier N., Hacein-Bey-Abina S., Bartholomae C.C., Veres G., Schmidt M., Kutschera I., Vidaud M., Abel U., Dal-Cortivo L., Caccavelli L., et al. Hematopoietic stem cell gene therapy with a lentiviral vector in X-linked adrenoleukodystrophy. Science 2009, 326:818-823.
-
(2009)
Science
, vol.326
, pp. 818-823
-
-
Cartier, N.1
Hacein-Bey-Abina, S.2
Bartholomae, C.C.3
Veres, G.4
Schmidt, M.5
Kutschera, I.6
Vidaud, M.7
Abel, U.8
Dal-Cortivo, L.9
Caccavelli, L.10
-
51
-
-
77956928344
-
Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia
-
Cavazzana-Calvo M., Payen E., Negre O., Wang G., Hehir K., Fusil F., Down J., Denaro M., Brady T., Westerman K., et al. Transfusion independence and HMGA2 activation after gene therapy of human beta-thalassaemia. Nature 2010, 467:318-322.
-
(2010)
Nature
, vol.467
, pp. 318-322
-
-
Cavazzana-Calvo, M.1
Payen, E.2
Negre, O.3
Wang, G.4
Hehir, K.5
Fusil, F.6
Down, J.7
Denaro, M.8
Brady, T.9
Westerman, K.10
-
52
-
-
84860555634
-
Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations
-
Cesana D., Sgualdino J., Rudilosso L., Merella S., Naldini L., Montini E. Whole transcriptome characterization of aberrant splicing events induced by lentiviral vector integrations. J Clin Invest 2012, 122:1667-1676.
-
(2012)
J Clin Invest
, vol.122
, pp. 1667-1676
-
-
Cesana, D.1
Sgualdino, J.2
Rudilosso, L.3
Merella, S.4
Naldini, L.5
Montini, E.6
-
53
-
-
84860594261
-
Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts
-
Moiani A., Paleari Y., Sartori D., Mezzadra R., Miccio A., Cattoglio C., Cocchiarella F., Lidonnici M.R., Ferrari G., Mavilio F. Lentiviral vector integration in the human genome induces alternative splicing and generates aberrant transcripts. J Clin Invest 2012, 122:1653-1666.
-
(2012)
J Clin Invest
, vol.122
, pp. 1653-1666
-
-
Moiani, A.1
Paleari, Y.2
Sartori, D.3
Mezzadra, R.4
Miccio, A.5
Cattoglio, C.6
Cocchiarella, F.7
Lidonnici, M.R.8
Ferrari, G.9
Mavilio, F.10
-
54
-
-
84861869590
-
Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia
-
Heckl D., Schwarzer A., Haemmerle R., Steinemann D., Rudolph C., Skawran B., Knoess S., Krause J., Li Z., Schlegelberger B., et al. Lentiviral vector induced insertional haploinsufficiency of Ebf1 causes murine leukemia. Mol Ther 2012.
-
(2012)
Mol Ther
-
-
Heckl, D.1
Schwarzer, A.2
Haemmerle, R.3
Steinemann, D.4
Rudolph, C.5
Skawran, B.6
Knoess, S.7
Krause, J.8
Li, Z.9
Schlegelberger, B.10
-
55
-
-
84864880316
-
Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus
-
Nagel J., Gross B., Meggendorfer M., Preiss C., Grez M., Brack-Werner R., Dietzel S. Stably integrated and expressed retroviral sequences can influence nuclear location and chromatin condensation of the integration locus. Chromosoma 2012, 121:353-367.
-
(2012)
Chromosoma
, vol.121
, pp. 353-367
-
-
Nagel, J.1
Gross, B.2
Meggendorfer, M.3
Preiss, C.4
Grez, M.5
Brack-Werner, R.6
Dietzel, S.7
-
56
-
-
33644822908
-
Effective gene therapy with nonintegrating lentiviral vectors
-
Yanez-Munoz R.J., Balaggan K.S., MacNeil A., Howe S.J., Schmidt M., Smith A.J., Buch P., MacLaren R.E., Anderson P.N., Barker S.E., et al. Effective gene therapy with nonintegrating lentiviral vectors. Nat Med 2006, 12:348-353.
-
(2006)
Nat Med
, vol.12
, pp. 348-353
-
-
Yanez-Munoz, R.J.1
Balaggan, K.S.2
MacNeil, A.3
Howe, S.J.4
Schmidt, M.5
Smith, A.J.6
Buch, P.7
MacLaren, R.E.8
Anderson, P.N.9
Barker, S.E.10
-
57
-
-
84862114271
-
Lentiviral vectors encoding shRNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in CNS neurons
-
Hutson T.H., Foster E., Dawes J.M., Hindges R., Yanez-Munoz R.J., Moon L.D. Lentiviral vectors encoding shRNAs efficiently transduce and knockdown LINGO-1 but induce an interferon response and cytotoxicity in CNS neurons. J Gene Med 2012, 14:299-315.
-
(2012)
J Gene Med
, vol.14
, pp. 299-315
-
-
Hutson, T.H.1
Foster, E.2
Dawes, J.M.3
Hindges, R.4
Yanez-Munoz, R.J.5
Moon, L.D.6
-
58
-
-
80052766645
-
An unbiased genome-wide analysis of zinc-finger nuclease specificity
-
Gabriel R., Lombardo A., Arens A., Miller J.C., Genovese P., Kaeppel C., Nowrouzi A., Bartholomae C.C., Wang J., Friedman G., et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol 2011, 29:816-823.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 816-823
-
-
Gabriel, R.1
Lombardo, A.2
Arens, A.3
Miller, J.C.4
Genovese, P.5
Kaeppel, C.6
Nowrouzi, A.7
Bartholomae, C.C.8
Wang, J.9
Friedman, G.10
-
59
-
-
35948946526
-
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
-
Lombardo A., Genovese P., Beausejour C.M., Colleoni S., Lee Y.L., Kim K.A., Ando D., Urnov F.D., Galli C., Gregory P.D., et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol 2007, 25:1298-1306.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1298-1306
-
-
Lombardo, A.1
Genovese, P.2
Beausejour, C.M.3
Colleoni, S.4
Lee, Y.L.5
Kim, K.A.6
Ando, D.7
Urnov, F.D.8
Galli, C.9
Gregory, P.D.10
-
60
-
-
67649890518
-
Hybrid lentivirus-transposon vectors with a random integration profile in human cells
-
Staunstrup N.H., Moldt B., Mates L., Villesen P., Jakobsen M., Ivics Z., Izsvak Z., Mikkelsen J.G. Hybrid lentivirus-transposon vectors with a random integration profile in human cells. Mol Ther 2009, 17:1205-1214.
-
(2009)
Mol Ther
, vol.17
, pp. 1205-1214
-
-
Staunstrup, N.H.1
Moldt, B.2
Mates, L.3
Villesen, P.4
Jakobsen, M.5
Ivics, Z.6
Izsvak, Z.7
Mikkelsen, J.G.8
-
61
-
-
67649836071
-
Sleeping beauty transposition from nonintegrating lentivirus
-
Vink C.A., Gaspar H.B., Gabriel R., Schmidt M., McIvor R.S., Thrasher A.J., Qasim W. Sleeping beauty transposition from nonintegrating lentivirus. Mol Ther 2009, 17:1197-1204.
-
(2009)
Mol Ther
, vol.17
, pp. 1197-1204
-
-
Vink, C.A.1
Gaspar, H.B.2
Gabriel, R.3
Schmidt, M.4
McIvor, R.S.5
Thrasher, A.J.6
Qasim, W.7
-
62
-
-
79955114567
-
Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk
-
Matrai J., Cantore A., Bartholomae C.C., Annoni A., Wang W., Acosta-Sanchez A., Samara-Kuko E., De Waele L., Ma L., Genovese P., et al. Hepatocyte-targeted expression by integrase-defective lentiviral vectors induces antigen-specific tolerance in mice with low genotoxic risk. Hepatology 2011, 53:1696-1707.
-
(2011)
Hepatology
, vol.53
, pp. 1696-1707
-
-
Matrai, J.1
Cantore, A.2
Bartholomae, C.C.3
Annoni, A.4
Wang, W.5
Acosta-Sanchez, A.6
Samara-Kuko, E.7
De Waele, L.8
Ma, L.9
Genovese, P.10
|