Discovery and characterization of NK13650s, naturally occurring p300-selective histone acetyltransferase inhibitors

Journal of Organic Chemistry

Volumn 77, Issue 20, 2012, Pages 9044-9052

  Tohyama, Shigehiro ^a   Tomura, Arihiro ^b   Ikeda, Noriko ^a   Hatano, Masaki ^a   Odanaka, Junko ^b   Kubota, Yumiko ^a   Umekita, Maya ^a   Igarashi, Masayuki ^a   Sawa, Ryuichi ^a   Morino, Tomio ^b  

^a INSTITUTE OF MICROBIAL CHEMISTRY   (Japan)

^b Research and Development Group   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ABSOLUTE CONFIGURATION; ANDROGEN RECEPTORS; BIOSYNTHETIC PRECURSORS; CANCER CELLS; HISTONE ACETYLTRANSFERASES; INHIBITORY ACTIVITY; NATURALLY OCCURRING; PRODUCTION STRAIN; PROSTATE CANCER CELLS; QUATERNARY CARBON; TRANSCRIPTIONAL ACTIVATIONS;

AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; DISEASES;

CELLS;

ACYLTRANSFERASE INHIBITOR; HISTONE ACETYLTRANSFERASE PCAF; NK 13650A; NK 13650B; UNCLASSIFIED DRUG;

ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PROSTATE CANCER; STRUCTURE ANALYSIS;

ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; CELLS, CULTURED; CITRATES; DIKETOPIPERAZINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; HEK293 CELLS; HISTONE ACETYLTRANSFERASES; HUMANS; MOLECULAR CONFORMATION; PENICILLIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867724868     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo301534b     Document Type: Article

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