New Potent Bisubstrate Inhibitors of Histone Acetyltransferase p300: Design, Synthesis and Biological Evaluation

Chemical Biology and Drug Design

Volumn 77, Issue 1, 2011, Pages 86-92

  Kwie, Franciane Ho A ^a,b   Briet, Martine ^b,c   Soupaya, David ^a,b   Hoffmann, Pascal ^a,b   Maturano, Marie ^a,b   Rodriguez, Frédéric ^a,b   Blonski, Casimir ^a,b   Lherbet, Christian ^a,b   Baudoin Dehoux, Cécile ^a,b  

^a UPS)   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

^c Université de Toulouse Paul Sabatier   (France)

Author keywords

Bisubstrate inhibitor; Chemical biology; Drug design; HAT; P300

Indexed keywords

ADENOSINE DERIVATIVE; COENZYME A; ENZYME INHIBITOR; HISTONE ACETYLTRANSFERASE PCAF; N [2 (S COENZYME A)ACETYL N TERT BUTYLOXYCARBONYL]BUTANAMIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVE SITE; MOLECULAR DOCKING; PRIORITY JOURNAL;

AMIDES; COENZYME A; ENZYME INHIBITORS; HISTONE ACETYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; RESEARCH DESIGN;

EID: 78650166396     PISSN: 17470277     EISSN: 17470285     Source Type: Journal    
DOI: 10.1111/j.1747-0285.2010.01056.x     Document Type: Article

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