Evaluation of mechanism of anti-diabetic activity of Terminalia chebula on alloxan and adrenaline induced diabetic albino rats

International Journal of Pharma and Bio Sciences

Volumn 3, Issue 3, 2012, Pages

  Borgohain, Raktim ^a   Lahon, Kingshuk ^b   Das, Swarnamoni ^c   Gohain, Kalpana ^c  

^a GAUHATI MEDICAL COLLEGE   (India)

^b MAHATMA GANDHI MEDICAL COLLEGE AND RESEARCH INSTITUTE   (India)

^c ASSAM MEDICAL COLLEGE   (India)

Author keywords

Anti diabetic activity; Ethanolic extract; Terminalia chebula

Indexed keywords

ADRENALIN; ALLOXAN; ANTIDIABETIC AGENT; GLIBENCLAMIDE; GLUCOSE; INSULIN; PLANT EXTRACT; TERMINALIA CHERBULA EXTRACT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIDIABETIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIET RESTRICTION; DRUG EFFICACY; FEMALE; FRUIT; GLUCOSE BLOOD LEVEL; GLYCOGEN ANALYSIS; HEART; HYPERGLYCEMIA; HYPOGLYCEMIA; INSULIN RELEASE; LIVER; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; RISK REDUCTION; SKELETAL MUSCLE; TERMINALIA CHEBULA; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 84867708779     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. th edition, McGraw-Hill companies, USA, 2005, pp.2152-2179.
2. th 2011
3. th edition,1992; 825
4. Bailey C J, Caroline D., Traditional plant medicines as treatments for diabetes. Diabetes Care, 12: 553-554, (1989).
5. Wohfmuth H., Triphala: a short review. J Ethnopharmacol, 21:152-163, (1987).
6. Tillotson A, Khalsa KPS, Caldecott T., Haritaki fruit. Canadian Journal of Herbalism, 22:16-44, (2001).
7. Senthil Kumar GP, Arulselvan P, Satish Kumar D, Subramanian SP., Anti-diabetic activity of fruits of Terminalia chebula on streptozotocin induced diabetic rats. Journal of Health Science, 52:283-291, (2006).
8. Rao NK, Nammi S., Antidiabetic and renoprotective effects of the chloroform extract of Terminalia chebula Retz. seeds in streptozotocin-induced diabetic rats. BMC Complement Altern Med, 6:17, (2006).
9. th ed, Mack Publishing Company Easton Pennsylvania:1965, pp.1578-1593.
10. th edition, Vol 1, The chemist and druggist, WE 2, London, 1950, pp.183-184.
11. CPCSEA guidelines for laboratory animal facility. Committee for the purpose of control and supervision of experiments on animals. Indian J Pharmacol, 35:257-274, (2003).
12. rd edition, Hand book of Experimental Pharmacology, Vallabh Prakashan, Delhi, 2005, pp.190-195.
13. Katsumata K, Katsumata Y, Ozawa T, Katsumata Jr., Potentiating effect of combined usage of three sulfonylurea drugs on the occurrence of alloxan diabetes in rats. Horm Metab Res, 25:125-126, (1993).
14. nd edition, Drug discovery and evaluation: Pharmacological assays, Springer-Verlag, Berlin, Heidelberg, New York, 2002, pp.1373.
15. th edition, Jaypee Brothers Medical Publishers Ltd, New Delhi, pp.433-436, (1999).
16. Carroll NV, Longley RW, Roe JH., The determination of glycogen in liver and muscle by use of anthrone reagent. J Biol Chem, 583-593, (1955).
17. Gupta SS, Verma SCL, Garg VP, Rai M., Antidiabetic effects of Tinospora cordifolia-Part I. Effect on fasting blood sugar level, glucose tolerance and adrenaline induced hyperglycaemia. Indian J Med Res, 55:733-745, (1967).
18. Anturlikar SD, Gopumadhavan S, Chauhan BL, Mitra SK., Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats. Indian Journal Physiol Pharmacol, 39:95-100, (1995).
19. Szkudelski T., The mechanism of alloxan and streptozotocin action in B cells of the rat pancreas. Physiol Res, 50:536-546, (2001).
20. Gorus FK, Malaisse WJ, Pipeleers DG., Selective uptake of alloxan by pancreatic Bcells. Biochem J, 208:513-515, (1982).
21. Drews G, Kramer C, Dufer M, Krippeit-Drews P., Contrasting effects of alloxan on islets and single mouse pancreatic β-cells. Biochem J, 352-389, (2000).
22. Sabu MC, Kuttan R., Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J Ethnopharmacol, 81:155-160, (2002).
23. Murali YK, Chandra R, Murthy PS. Antihyperglycemic effect of water extract of dry fruits of Terminalia chebula in experimental diabetes mellitus. Indian J Clin Biochem, 19:202-204, (2004).
24. Singh I, Singh PK, Bhansali S, Shafiq N, Malhotra S, Pandhi P, et al., Effects of three different doses of a fruit extract of Terminalia chebula on metabolic components of metabolic syndrome, in a rat model. Phytother Res, 24:107-112, (2010).
25. Bollen M, Keppens S, Stalmans W., Specific features of glycogen metabolism in the liver. Biochem J, 336:19-31, (1998).
26. Schaftingen EV, Gerin I., The glucose-6-phosphatase system. Biochem J, 362:513-532, (2002).
27. Nikoulina SE, Ciaraldi TP, Carter L, Mudaliar S, Park KS, Henry RR., Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. J Clin Endocrinol Metab, 86:4307-4314, (2001).
28. Davis SN. Insulin, oral hypoglycemic agents, and the pharmacology of the endocrine pancreas. In: Brunton LL, Lazo JS, Parker KL, (eds.), Goodman and Gilman's The Pharmacological basis of therapeutics, 11th ed., McGraw-Hill, Medical Publishing Division, New York, 2006, pp.1613-1645.
29. Murali YK, Anand P, Tandon V, Singh R, Chandra R, Murthy PS., Long-term effects of Terminalia chebula Retz. on hyperglycemia and associated hyperlipidemia, tissue glycogen content and in vitro release of insulin in streptozotocin induced diabetic rats. Exp Clin Endocrinol Diabetes, 115:641-646, (2007).
30. Senthilkumar GP, Subramanian S., Biochemical evaluation of mitochondrial protective effect of Terminalia chebula studied in STZ-induced diabetic rats. International Journal of Biological Chemistry, 1:131-140, (2007).
31. Kraus-Friedmann N., Hormonal regulation of hepatic gluconeogenesis. Physiol Rev, 64:170-177, (1984).
32. Alada AA, Fagbohun TD, Oyebola DO., Effect of adrenaline on glucose uptake by the canine large bowel. Afr J Biomed Res, 4:123-126, (2001).
33. Tripathi KD, Ed. Essentials of Medical Pharmacology, 5th ed, Jaypee Brothers, Medical Publishers (P) Ltd, New Delhi, 103-118, (2004).
34. Juang LJ, Sheu SJ, Lin TC., Determination of hydrolysable tannins in the fruit of Terminalia chebula Retz. by high-performance liquid chromatography and capillary electrophoresis. J Sep Sci, 27:718-724, (2004).
35. Finkel T, Holbrook N J., Oxidants, Oxidative stress and biology of ageing. Nature, 239-247, (2000).
36. Naik GH, Priyadarsini KI, Mohan H., Free radical scavenging reactions and phytochemical analysis of triphala, an ayurvedic formulation. Current Sci., 90:1100-1106, (2006).
37. Gao H, Huang Yi-Nian, Gao B, Kawabata J., Chebulagic Acid Is a Potent α-Glucosidase Inhibitor. Biosci. Biotechnol. Biochem, 72:601-603, (2008).
38. Mukherjee S, Mitra A, Dey S, Thakur G., Alpha-amylase activity of tannin isolated from Terminalia chebula. Proceedings of the Systems in Medicine and Biology (ICSMB) International Conference; 2010 Dec 16-18; Kharagpur, India. Institute of electrical and electronics engineers (IEEE), 2011. doi:10.1109/ICSMB.2010.5735421