Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation

Developmental Dynamics

Volumn 241, Issue 11, 2012, Pages 1695-1707

  Herr, Anabel ^a,c   Longworth, Michelle ^a,d   Ji, Jun Yuan ^a,e   Korenjak, Michael ^a   Macalpine, David M ^b   Dyson, Nicholas J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c MONASH UNIVERSITY   (Australia)

^d LERNER RESEARCH INSTITUTE   (United States)

^e TEXAS A M COLLEGE OF MEDICINE   (United States)

Author keywords

Drosophila; E2F; ORC; PCNA

Indexed keywords

ORIGIN RECOGNITION COMPLEX; RNA; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1;

ALLELE; ARTICLE; CELL CYCLE; CELL PROLIFERATION; CONTROLLED STUDY; DROSOPHILA; FEEDBACK SYSTEM; GENE EXPRESSION; GENE IDENTIFICATION; GENE INTERACTION; GENE REPLICATION; GENE TARGETING; IN VIVO STUDY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

ALLELES; ANIMALS; CELL PROLIFERATION; DROSOPHILA; DROSOPHILA PROTEINS; E2F TRANSCRIPTION FACTORS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MODELS, BIOLOGICAL; ORIGIN RECOGNITION COMPLEX; TRANSCRIPTION FACTORS;

EID: 84867704976     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.23857     Document Type: Article

References (58)

1. Abraham RT. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15: 2177-2196.
2. Ahlander J, Chen XB, Bosco G. 2008. The N-terminal domain of the Drosophila retinoblastoma protein Rbf1 interacts with ORC and associates with chromatin in an E2F independent manner. PLoS One 3: e2831.
3. Andrew DJ, Henderson KD, Seshaiah P. 2000. Salivary gland development in Drosophila melanogaster. Mech Dev 92: 5-17.
4. Arias EE, Walter JC. 2005. Replication-dependent destruction of Cdt1 limits DNA replication to a single round per cell cycle in Xenopus egg extracts. Genes Dev 19: 114-126.
5. Arias EE, Walter JC. 2006. PCNA functions as a molecular platform to trigger Cdt1 destruction and prevent re-replication. Nat Cell Biol 8: 84-90.
6. Asano M, Nevins JR, Wharton RP. 1996. Ectopic E2F expression induces S phase and apoptosis in Drosophila imaginal discs. Genes Dev 10: 1422-1432.
7. Bell SP, Mitchell J, Leber J, Kobayashi R, Stillman B. 1995. The multidomain structure of Orc1p reveals similarity to regulators of DNA replication and transcriptional silencing. Cell 83: 563-568.
8. Blais A, Dynlacht BD. 2004. Hitting their targets: an emerging picture of E2F and cell cycle control. Curr Opin Genet Dev 14: 527-532.
9. Bosco G, Du W, Orr-Weaver TL. 2001. DNA replication control through interaction of E2F-RB and the origin recognition complex. Nat Cell Biol 3: 289-295.
10. Bracken AP, Ciro M, Cocito A, Helin K. 2004. E2F target genes: unraveling the biology. Trends Biochem Sci 29: 409-417.
11. Brook A, Xie JE, Du W, Dyson N. 1996. Requirements for dE2F function in proliferating cells and in post-mitotic differentiating cells. Embo J 15: 3676-3683.
12. Cayirlioglu P, Ward WO, Silver Key SC, Duronio RJ. 2003. Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cells. Mol Cell Biol 23: 2123-2134.
13. Celniker SE, Dillon LA, Gerstein MB, Gunsalus KC, Henikoff S, Karpen GH, Kellis M, Lai EC, Lieb JD, MacAlpine DM, Micklem G, Piano F, Snyder M, Stein L, White KP, Waterston RH. 2009. Unlocking the secrets of the genome. Nature 459: 927-930.
14. DeGregori J, Johnson DG. 2006. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6: 739-748.
15. DePamphilis ML. 2003. The "ORC cycle": a novel pathway for regulating eukaryotic DNA replication. Gene 310: 1-15.
16. Dillin A, Rine J. 1997. Separable functions of ORC5 in replication initiation and silencing in Saccharomyces cerevisiae. Genetics 147: 1053-1062.
17. Dimova DK, Dyson NJ. 2005. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24: 2810-2826.
18. Dimova DK, Stevaux O, Frolov MV, Dyson NJ. 2003. Cell cycle-dependent and cell cycle-independent control of transcription by the Drosophila E2F/RB pathway. Genes Dev 17: 2308-2320.
19. Dobrowolski SF, Stacey DW, Harter ML, Stine JT, Hiebert SW. 1994. An E2F dominant negative mutant blocks E1A induced cell cycle progression. Oncogene 9: 2605-2612.
20. Du W. 2000. Suppression of the rbf null mutants by a de2f1 allele that lacks transactivation domain. Development 127: 367-379.
21. Du W, Xie JE, Dyson N. 1996. Ectopic expression of dE2F and dDP induces cell proliferation and death in the Drosophila eye. Embo J 15: 3684-3692.
22. Duronio RJ, O'Farrell PH. 1995. Developmental control of the G1 to S transition in Drosophila: cyclin Eis a limiting downstream target of E2F. Genes Dev 9: 1456-1468.
23. Duronio RJ, O'Farrell PH, Xie JE, Brook A, Dyson N. 1995. The transcription factor E2F is required for S phase during Drosophila embryogenesis. Genes Dev 9: 1445-1455.
24. Dutta A, Bell SP. 1997. Initiation of DNA replication in eukaryotic cells. Annu Rev Cell Dev Biol 13: 293-332.
25. Fox CA, Loo S, Dillin A, Rine J. 1995. The origin recognition complex has essential functions in transcriptional silencing and chromosomal replication. Genes Dev 9: 911-924.
26. Frolov MV, Moon NS, Dyson NJ. 2005. dDP is needed for normal cell proliferation. Mol Cell Biol 25: 3027-3039.
27. Hu J, Xiong Y. 2006. An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in response to DNA damage. J Biol Chem 281: 3753-3756.
28. Hu J, McCall CM, Ohta T, Xiong Y. 2004. Targeted ubiquitination of CDT1 by the DDB1-CUL4A-ROC1 ligase in response to DNA damage. Nat Cell Biol 6: 1003-1009.
29. Huang DW, Fanti L, Pak DT, Botchan MR, Pimpinelli S, Kellum R. 1998. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins. J Cell Biol 142: 307-318.
30. Ishida S, Huang E, Zuzan H, Spang R, Leone G, West M, Nevins JR. 2001. Role for E2F in control of both DNA replication and mitotic functions as revealed from DNA microarray analysis. Mol Cell Biol 21: 4684-4699.
31. Ishizaki J, Nevins JR, Sullenger BA. 1996. Inhibition of cell proliferation by an RNA ligand that selectively blocks E2F function. Nat Med 2: 1386-1389.
32. Jin J, Arias EE, Chen J, Harper JW, Walter JC. 2006. A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1. Mol Cell 23: 709-721.
33. Johnson DG, Schwarz JK, Cress WD, Nevins JR. 1993. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365: 349-352.
34. Kohzaki H, Murakami Y. 2005. Transcription factors and DNA replication origin selection. Bioessays 27: 1107-1116.
35. Landis G, Kelley R, Spradling AC, Tower J. 1997. The k43 gene, required for chorion gene amplification and diploid cell chromosome replication, encodes the Drosophila homolog of yeast origin recognition complex subunit 2. Proc Natl Acad Sci USA 94: 3888-3892.
36. Lukas J, Herzinger T, Hansen K, Moroni MC, Resnitzky D, Helin K, Reed SI, Bartek J. 1997. Cyclin E-induced S phase without activation of the pRb/E2F pathway. Genes Dev 11: 1479-1492.
37. MacAlpine DM, Rodriguez HK, Bell SP. 2004. Coordination of replication and transcription along a Drosophila chromosome. Genes Dev 18: 3094-3105.
38. Machida YJ, Hamlin JL, Dutta A. 2005. Right place, right time, and only once: replication initiation in metazoans. Cell 123: 13-24.
39. Morris EJ, Ji J-Y, Yang F, Di Stefano L, Herr A, Moon N-S, Kwon E-J, Haigis KM, Naar AM, Dyson NJ. 2008. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455: 552-556.
40. Muller H, Bracken AP, Vernell R, Moroni MC, Christians F, Grassilli E, Prosperini E, Vigo E, Oliner JD, Helin K. 2001. E2Fs regulate the expression of genes involved in differentiation, development, proliferation, and apoptosis. Genes Dev 15: 267-285.
41. Ohtani K, DeGregori J, Leone G, Herendeen DR, Kelly TJ, Nevins JR. 1996. Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor. Mol Cell Biol 16: 6977-6984.
42. Orlando DA, Lin CY, Bernard A, Wang JY, Socolar JE, Iversen ES, Hartemink AJ, Haase SB. 2008. Global control of cell-cycle transcription by coupled CDK and network oscillators. Nature 453: 944-947.
43. Pak DT, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P, Botchan MR. 1997. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell 91: 311-323.
44. Pflumm MF, Botchan MR. 2001. Orc mutants arrest in metaphase with abnormally condensed chromosomes. Development 128: 1697-1707.
45. Prasanth SG, Mendez J, Prasanth KV, Stillman B. 2004. Dynamics of pre-replication complex proteins during the cell division cycle. Philos Trans R Soc Lond B Biol Sci 359: 7-16.
46. Prasanth SG, Shen Z, Prasanth KV, Stillman B. 2010. Human origin recognition complex is essential for HP1 binding to chromatin and heterochromatin organization. Proc Natl Acad Sci USA 107: 15093-15098.
47. Ren B, Cam H, Takahashi Y, Volkert T, Terragni J, Young RA, Dynlacht BD. 2002. E2F integrates cell cycle progression with DNA repair, replication, and G(2)/M checkpoints. Genes Dev 16: 245-256.
48. Royzman I, Whittaker AJ, Orr-Weaver TL. 1997. Mutations in Drosophila DP and E2F distinguish G1-S progression from an associated transcriptional program. Genes Dev 11: 1999-2011.
49. Sellers WR, Rodgers JW, Kaelin WG, Jr. 1995. A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites. Proc Natl Acad Sci USA 92: 11544-11548.
50. Senga T, Sivaprasad U, Zhu W, Park JH, Arias EE, Walter JC, Dutta A. 2006. PCNA is a cofactor for Cdt1 degradation by CUL4/DDB1-mediated N-terminal ubiquitination. J Biol Chem 281: 6246-6252.
51. Shibutani ST, de la Cruz AF, Tran V, Turbyfill WJ, 3rd, Reis T, Edgar BA, Duronio RJ. 2008. Intrinsic negative cell cycle regulation provided by PIP box- and Cul4Cdt2-mediated destruction of E2f1 during S phase. Dev Cell 15: 890-900.
52. Shore D. 2001. Transcriptional silencing: replication redux. Curr Biol 11: R816-819.
53. Stanelle J, Stiewe T, Theseling CC, Peter M, Putzer BM. 2002. Gene expression changes in response to E2F1 activation. Nucleic Acids Res 30: 1859-1867.
54. Stevaux O, Dimova DK, Ji JY, Moon NS, Frolov MV, Dyson NJ. 2005. Retinoblastoma family 2 is required in vivo for the tissue-specific repression of dE2F2 target genes. Cell Cycle 4: 1272-1280.
55. Syljuasen RG, Sorensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J. 2005. Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage. Mol Cell Biol 25: 3553-3562.
56. Thacker SA, Bonnette PC, Duronio RJ. 2003. The contribution of E2F-regulated transcription to Drosophila PCNA gene function. Curr Biol 13: 53-58.
57. Weinmann AS, Yan PS, Oberley MJ, Huang TH, Farnham PJ. 2002. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes Dev 16: 235-244.
58. Wu CL, Classon M, Dyson N, Harlow E. 1996. Expression of dominant-negative mutant DP-1 blocks cell cycle progression in G1. Mol Cell Biol 16: 3698-3706.