Development and validation of a new GC-MS method for the detection of tramadol,: O-desmethyltramadol, 6-acetylmorphine and morphine in blood, brain, liver and kidney: Of wistar rats treated with the combination of heroin and tramadol

Journal of Analytical Toxicology

Volumn 36, Issue 8, 2012, Pages 548-559

  Mahdy, Tarek ^a   El Shihi, Taha H ^b   Emara, Mostafa M ^c   Chericoni, Silvio ^d   Giusiani, Mario ^d   Giorgi, Mario ^d  

^a Ministry of Justice   (Egypt)

^b National Centre for Social and Criminological Research   (Egypt)

^c Assiut Branch   (Egypt)

^d UNIVERSITY OF PISA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

DIAMORPHINE; DRUG METABOLITE; MORPHINE; MORPHINE 6 ACETATE; O NORTRAMADOL; TRAMADOL;

ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DERIVATIZATION; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DISPOSITION; DRUG LIVER LEVEL; EGYPT; HALF LIFE TIME; KIDNEY; LIQUID LIQUID EXTRACTION; MASS FRAGMENTOGRAPHY; NONHUMAN; RAT; SEIZURE; SENSITIVITY AND SPECIFICITY; VALIDATION PROCESS;

EID: 84867669875     PISSN: 01464760     EISSN: 19452403     Source Type: Journal    
DOI: 10.1093/jat/bks069     Document Type: Article

References (48)

1. Shou, W.Z., Pelzer, M., Addison, T., Jiang, X.G., Weng, N.D. (2002) An automatic 96-well solid phase extraction and liquid chromatography-tandem mass spectrometry method for the analysis of morphine, morphine-3-glucuronide and morphine-6-glucuronide in human plasma. Journal of Pharmaceutical and Biomedical Analysis, 27, 143-152.
2. Popa, D., Loghin, F., Imre, S., Curea, E. (2003) The study of codeinegluthetimide pharmacokinetic interaction in rats. Journal of Pharmaceutical and Biomedical Analysis, 32, 867-877.
3. Kikura-Hanajiri, R., Kaniwa, N., Ishibashi, M., Makino, Y., Kojima, S. (2003) Liquid chromatographic-atmospheric pressure chemical ionization mass spectrometric analysis of opiates and metabolites in rat urine after inhalation of opium. Journal of Chromatography B, 789, 139-150.
4. Glass, L.R., Ingalls, S.T., Schilling, C.L., Hoppel, C.L. (1997) Atypical urinary opiate excretion pattern. Journal of Analytical Toxicology, 21, 509-514.
5. Capella-Peiro, M.-E., Bose, D., Gil-Agusti, M., Esteve-Romero, J., Carda-Broch, S. (2005) Direct injection determination of benzoylecgonine, heroin, 6-monoacetylmorphine and morphine in serum by MLC. Journal of Chromatography A, 1073, 277-283.
6. Meadway, C., George, S., Braithwaite, R. (1998) Opiate concentrations following the ingestion of poppy seed products-Evidence for "the poppy seed defence." Forensic Science International, 96, 29-38.
7. Baker, P.B., Gough, T.A. (1981) The separation and quantitation of the narcotic components of illicit heroin using reversed-phase high performance liquid chromatography. Journal of Chromatographic Science, 19, 483-489.
8. Lurie, I.S., Sottolano, S.M., Blasof, S. (1982) High performance liquid chromatographic analysis of heroin by reverse phase ion-pair chromatography. Journal of Forensic Sciences, 27, 519-526.
9. White, P.C., Jane, I., Scott, A., Connett, B.E. (1983) Use of highperformance liquid chromatography to quantities the opiate and sugar content of illicit heroin preparations. Journal of Chromatography, 265, 293-300.
10. Kaa, E., Kaempe, B. (1986) Impurities, adulterants and diluents of illicit heroin in Denmark (Jutland and Funen). Forensic Science International, 31, 195-210.
11. O'Neil, P.J., Pitts, J.E. (1992) Illicitly imported heroin products (1984 to 1989): some physical and chemical features indicative of their origin. Journal of Pharmacy and Pharmacology, 44, 1-6.
12. Chiarotti, M., Fucci, N. (1999) Comparative analysis of heroin and cocaine seizures. Journal of Chromatography B, 733, 127.
13. th Annual Meeting of The International Association of Forensic Toxicologists (TIAFT), Geneva, Switzerland.
14. Gambaro, V., Benvenuti, C., De Ferrari, L., Dell'Acqua, L., Fare, F. (2003) Validation of a GC/MS method for the determination of tramadol in human plasma after intravenous bolus. Il Farmaco, 58, 947-950.
15. Lintz, W., Erlacin, S., Frankus, E., Uragg, H. (1981) Biotransformation of tramadol in man and animal. Arzneimittelforschung, 31, 1932.
16. Giorgi, M., Soldani, G., Manera, C., Ferrarini, P.L., Sgorbini, M., Saccomanni, G. (2007) Pharmacokinetics of tramadol and its metabolites M1, M2 and M5 in horses following intravenous, immediate release (fasted/fed) and sustained release single dose administration. Journal of Equine Veterinary Science, 27, 481-488.
17. Pypendop, B.H., Ilkiw, J.E. (2008) Pharmacokinetics of tramadol, and its metabolite O-desmethyl tramadol, in cats. Journal of Veterinary Pharmacology and Therapeutics, 31, 52-59.
18. De Sousa, A.B., Santos, A.C.D., Schramm, S.G., Porta, V., Gorniak, S.L., Florio, J.C. et al. (2008) Pharmacokinetics of tramadol and O-desmethyl tramadol in goats after intravenous and oral administration. Journal of Veterinary Pharmacology and Therapeutics, 31, 45-51.
19. Giorgi, M. (2008) Pharmacokinetic differences of tramadol in several animal species and human beings. Journal of Veterinary Research, 63, 1-4.
20. Subrahmanyam, V., Renwick, A.B., Walters, D.G., Young, P.G., Price, R.J., Tonelli, A.P. et al. (2001) Identification of cytochrome P-450 isoformsresponsible for cis-tramadol metabolism in human liver microsomes. Drug Metabolism and Disposition, 29, 1146-1155.
21. Grond, S., Sablotzki, A. (2004) Clinical pharmacology of tramadol. Clinical Pharmacokinetics, 43, 879-923.
22. Wang, W.L., Darwin, W.D., Cone, E.J. (1994) Simultaneous assay of cocaine, heroin and metabolites in hair, plasma, saliva and urine by gas chromatography-mass spectrometry. Journal of Chromatography B, 660, 279-290.
23. Jenkins, A.J., Oyler, J.M., Cone, E.J. (1995) Comparison of heroin and cocaine concentrations in saliva with concentrations in blood and plasma. Journal of Analytical Toxicology, 19, 359-374.
24. Jones, J., Tomlinson, K., Moore, C. (2002) The simultaneous determination of codeine, morphine, hydrocodone, hydromorphone, 6-acetylmorphine, and oxycodone in hair and oral fluid. Journal of Analytical Toxicology, 26, 171-175.
25. Guillot, E., de Mazancourt, P., Durigon, M., Alvarez, J.C. (2007) Morphine and 6-acetylmorphine concentrations in blood, brain, spinal cord, bone marrow and bone after lethal acute or chronic diacetylmorphine administration to mice. Forensic Science International, 166, 139-144.
26. Merslavic, M., Zupancic-Kralij, L. (1997) Determination of tramadol in human plasma by capillary gas chromatography-mass spectrometry using solid-phase extraction. Journal of Chromatography B, 693, 222-227.
27. Hadidi, K.A., Almasad, J.K., Al-Nsour, T., Abu-Ragheib, S. (2003) Determination of tramadol in hair using solid phase extraction and GC-MS. Forensic Science International, 135, 129-136.
28. Chytil, L., Stácha, M., Matousková, O., PerlÍk, F., Slanar, O. (2009) Enatiomeric determination of tramadol and O-desmethyltramadol in human urine by gas chromatography-mass spectrometry. Journal of Chromatography B, 877, 1937-1942.
29. Yeh, G.C., Sheu, M.T., Yen, C.L., Wang, Y.W., Liu, C.H., Ho, H.O. (1999) High-performance liquid chromatographic method for determination of tramadol in human plasma. Journal of Chromatography B, 723, 247-253.
30. Gan, S.H., Ismail, R., Wan Adnan, W.A., Wan, Z. (2002) Method development and validation of a high-performance liquid chromatographic method for tramadol in human plasma using liquid-liquid extraction. Journal of Chromatography B, 772, 123-129.
31. Saccomanni, G., Del Carlo, S., Giorgi, M., Manera, C., Saba, A., Macchia, M. (2010) Determination of tramadol and metabolites by HPLC-FL and HPLC-MS/MS in urine of dogs. Journal of Pharmaceutical and Biomedical Analysis, 53, 194-199.
32. Moffat, A.C., Osselton, M.D., Widdop, B., Galichet, L. (2005) Clarke's analysis of drugs and poisons, 3rd edition. Pharmaceutical Press, Philadelphia, PA.
33. [2009(] Guideline on bioanalytical method validation. EMEA/ CHMP/EWP/192217/2009.
34. Mahdy, T., El-Shihi, T.H., Emara, M.M., Giorgi, M. (2012) New HPLC method to detect individual opioids (heroin and tramadol) and their metabolites in the blood of rats on combination treatment. Journal of Chromatographic Science, 50, 658-665.
35. Gunnar, T., Mykkánen, S., Ariniemi, K., Lillsunde, P. (2004) Validated semiquantitative/quantitative screening of 51 drugs in whole blood as silylated derivatives by gas chromatography-selected ion monitoring mass spectrometry and gas chromatography electron capture detection. Journal of Chromatography B, 806, 205-219.
36. Krogh, M., Christophersen, A.S., Rasmussen, K.E. (1993) Automated sample preparation by on-line dialysis and trace enrichment. Analysis of morphine, 6-monoacetylmorphine, codeine, ethylmorphine and pholcodine in plasma and whole blood by capillary gas chromatography and capillary gas chromatography-mass spectrometry. Journal of Chromatography, 621, 41-48.
37. Huang, W., Andollo, W., Hearn, W.L. (1992) A solid phase extraction technique for the isolation and identification of opiates in urine. Journal of Analytical Toxicology, 16, 307-310.
38. Yeh, S.Y., McQuinn, R.L., Gorodetzky, C.W. (1976) Urinary excretion of heroin and its metabolites in man. Journal of Pharmacology and Experimental Therapeutics, 196, 249-256.
39. Salmon, A.Y., Goren, Z., Avissar, Y., Soreq, H. (1999) Human erythrocyte but not brain acetylchloninesterase hydrolyses heroin to morphine. Clinical and Experimental Pharmacology and Physiology, 26, 596-600.
40. Omar, O.A., Hoskin, P.J., Johnston, A., Hanks, G.W., Turner, P. (1989) Diamorphine stability in aqueous solution for subcutaneous infusion. Journal of Pharmacy and Pharmacology, 41, 275-277.
41. Barrett, D.A., Dyssegaard, A.L.P., Shaw, P.N. (1992) The effect of temperature and pH on the deacetylation in aqueous solution and in human plasma. Journal of Pharmacy and Pharmacology, 44, 606-608.
42. Wyman, J., Blutman, S. (2004) Postmortem distribution of heroin metabolites in femoral blood, liver, cerebrospinal fluid, and vitreous humor. Journal of Analytical Toxicology, 28, 260-263.
43. Goldberger, B.A., Cone, E.J., Grant, T.M., Caplan, Y.H., Levine, B.S., Smialek, J.E. (1994) Disposition of heroin and its metabolites in heroin-related deaths. Journal of Analytical Toxicology, 18, 22-28.
44. Baselt, R.C. (2002) Disposition of toxic drugs and chemicals in man, 6th edition. Chemical Toxicology Institute, Foster City, CA, p. 720-723.
45. Rop, P.P., Grimaldi, F., Burlea, J., Saint Legera, M.N.D., Viala, A. (1994) Determination of 6-monoacetylmorphine and morphine in plasma, whole blood and urine using high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B, 661, 245-253.
46. Way, E.L., Kemp, J.W., Young, J.M., Grassetti, D.R. (1960) The pharmacologic effects of heroin in relationship to its rate of biotransformation. Journal of Pharmacology and Experimental Therapeutics, 129, 144-154.
47. Umans, J.G., Inturrisi, C.E. (1981) Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. Journal of Pharmacology and Experimental Therapeutics, 218, 409-415.
48. Godoy, A.L., De Moraes, N.V., Martinez, E.Z., Carvalho, T.M., Marques, M.P., Lanchote, V.L. (2011) Simultaneous analysis of tramadol, O-desmethyltramadol, and N-desmethyltramadol enantiomers in rat plasma by high-performance liquid chromatographytandem mass spectrometry: application to pharacokinetics. Chirality, 23, 287-293.