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Volumn 27, Issue 11, 2007, Pages 481-488

Pharmacokinetics of Tramadol and its Metabolites M1, M2 and M5 in Horses Following Intravenous, Immediate Release (Fasted/Fed) and Sustained Release Single Dose Administration

Author keywords

Horse; Metabolism; Pharmacokinetic; Sustained release; Tramadol

Indexed keywords

ANIMALIA; CANIS FAMILIARIS; CAVIA; EQUIDAE; MESOCRICETUS AURATUS; MUS; ORYCTOLAGUS CUNICULUS; RATTUS;

EID: 36248953167     PISSN: 07370806     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jevs.2007.10.004     Document Type: Article
Times cited : (71)

References (25)
  • 1
    • 0027194499 scopus 로고
    • Tramadol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states
    • Lee C.R., McTavish D., and Sorkin E.M. Tramadol: a preliminary review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in acute and chronic pain states. Drugs 46 (1993) 313-340
    • (1993) Drugs , vol.46 , pp. 313-340
    • Lee, C.R.1    McTavish, D.2    Sorkin, E.M.3
  • 3
    • 0030033533 scopus 로고    scopus 로고
    • Contribution of monoaminergic modulation to the analgesic effect of tramadol
    • Desmeules J.A., Piguet V., Collart L., and Dayer P. Contribution of monoaminergic modulation to the analgesic effect of tramadol. Br J Clin Pharmacol 41 (1996) 7-12
    • (1996) Br J Clin Pharmacol , vol.41 , pp. 7-12
    • Desmeules, J.A.1    Piguet, V.2    Collart, L.3    Dayer, P.4
  • 4
    • 33747047219 scopus 로고    scopus 로고
    • Mu opioid receptor-dependent and independent components in effects of tramadol
    • Ide S., Minami M., Ishihara K., Uhl G.R., Sora I., and Ikeda K. Mu opioid receptor-dependent and independent components in effects of tramadol. Neuropharmacology 51 (2006) 651-658
    • (2006) Neuropharmacology , vol.51 , pp. 651-658
    • Ide, S.1    Minami, M.2    Ishihara, K.3    Uhl, G.R.4    Sora, I.5    Ikeda, K.6
  • 5
    • 0037248361 scopus 로고    scopus 로고
    • Adding ketoprofen to intravenous patient-controlled analgesia with tramadol after major gynecological cancer surgery: a double-blinded, randomized, placebo-controlled clinical trial
    • Tuncer S., Pirbudak L., Balat O., and Capar M. Adding ketoprofen to intravenous patient-controlled analgesia with tramadol after major gynecological cancer surgery: a double-blinded, randomized, placebo-controlled clinical trial. Eur J Gynaecol Oncol 24 (2003) 181-184
    • (2003) Eur J Gynaecol Oncol , vol.24 , pp. 181-184
    • Tuncer, S.1    Pirbudak, L.2    Balat, O.3    Capar, M.4
  • 6
    • 13544270927 scopus 로고    scopus 로고
    • Tramadol: does it have a role in emergency medicine?
    • Close B.R. Tramadol: does it have a role in emergency medicine?. Emerg Med Australas 17 (2005) 73-83
    • (2005) Emerg Med Australas , vol.17 , pp. 73-83
    • Close, B.R.1
  • 7
    • 0034201526 scopus 로고    scopus 로고
    • A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department
    • Hoogewijs J., Diltoer M.W., Hubloue I., Spapen H.D., Camu F., Corne L., et al. A prospective, open, single blind, randomized study comparing four analgesics in the treatment of peripheral injury in the emergency department. Eur J Emerg Med 7 (2000) 119-123
    • (2000) Eur J Emerg Med , vol.7 , pp. 119-123
    • Hoogewijs, J.1    Diltoer, M.W.2    Hubloue, I.3    Spapen, H.D.4    Camu, F.5    Corne, L.6
  • 8
    • 0031950478 scopus 로고    scopus 로고
    • Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial
    • Turturro M.A., Paris P.M., and Larkin G.L. Tramadol versus hydrocodone-acetaminophen in acute musculoskeletal pain: a randomized, double-blind clinical trial. Ann Emerg Med 32 (1998) 139-143
    • (1998) Ann Emerg Med , vol.32 , pp. 139-143
    • Turturro, M.A.1    Paris, P.M.2    Larkin, G.L.3
  • 9
    • 0036276786 scopus 로고    scopus 로고
    • Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites
    • Wu W.N., McKown L.A., and Liao S. Metabolism of the analgesic drug ULTRAM (tramadol hydrochloride) in humans: API-MS and MS/MS characterization of metabolites. Xenobiotica 32 (2002) 411-425
    • (2002) Xenobiotica , vol.32 , pp. 411-425
    • Wu, W.N.1    McKown, L.A.2    Liao, S.3
  • 11
    • 0034946742 scopus 로고    scopus 로고
    • Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes
    • Subrahmanyam V., Renwick A.B., Young P.J., Price R.J., Tonelli A.P., and Lake B.G. Identification of cytochrome P-450 isoforms responsible for cis-tramadol metabolism in human liver microsomes. Drug Metab Dispos 29 (2001) 1146-1155
    • (2001) Drug Metab Dispos , vol.29 , pp. 1146-1155
    • Subrahmanyam, V.1    Renwick, A.B.2    Young, P.J.3    Price, R.J.4    Tonelli, A.P.5    Lake, B.G.6
  • 12
    • 0026512239 scopus 로고
    • Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic
    • Raffa R.B., Friderichs E., Reimann W., Shank R.P., Codd E.E., and Vaught J.L. Opioid and nonopioid components independently contribute to the mechanism of action of tramadol, an 'atypical' opioid analgesic. J Pharmacol Exp Ther 260 (1992) 275-285
    • (1992) J Pharmacol Exp Ther , vol.260 , pp. 275-285
    • Raffa, R.B.1    Friderichs, E.2    Reimann, W.3    Shank, R.P.4    Codd, E.E.5    Vaught, J.L.6
  • 13
    • 36248933640 scopus 로고    scopus 로고
    • Kogel B, Englberger W, Hennies HH, Friderichs E. Involvement of metabolites in the analgesic action of tramadol. Proceedings 9th World Congress of Pain; 1999:523.
  • 14
    • 0033901486 scopus 로고    scopus 로고
    • Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor
    • Gillen C., Haurand M., Kobelt D.J., and Wnendt S. Affinity, potency and efficacy of tramadol and its metabolites at the cloned human mu-opioid receptor. Naunyn Schmiedeberg Arch Pharmacol 362 (2000) 116-121
    • (2000) Naunyn Schmiedeberg Arch Pharmacol , vol.362 , pp. 116-121
    • Gillen, C.1    Haurand, M.2    Kobelt, D.J.3    Wnendt, S.4
  • 15
    • 0033808357 scopus 로고    scopus 로고
    • Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats
    • Garrido M.J., Valle M., Campanero M.A., Calvo R., and Troconiz I.F. Modeling of the in vivo antinociceptive interaction between an opioid agonist, (+)-O-desmethyltramadol, and a monoamine reuptake inhibitor, (-)-O-desmethyltramadol, in rats. J Pharmacol Exp Ther 295 (2000) 352-359
    • (2000) J Pharmacol Exp Ther , vol.295 , pp. 352-359
    • Garrido, M.J.1    Valle, M.2    Campanero, M.A.3    Calvo, R.4    Troconiz, I.F.5
  • 16
    • 0037405133 scopus 로고    scopus 로고
    • Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity
    • Garrido M.J., Sayar O., Segura C., Rapado J., Dios-Vieitez M.C., Renedo M.J., et al. Pharmacokinetic/pharmacodynamic modeling of the antinociceptive effects of (+)-tramadol in the rat: role of cytochrome P450 2D activity. J Pharmacol Exp Ther 305 (2003) 710-718
    • (2003) J Pharmacol Exp Ther , vol.305 , pp. 710-718
    • Garrido, M.J.1    Sayar, O.2    Segura, C.3    Rapado, J.4    Dios-Vieitez, M.C.5    Renedo, M.J.6
  • 18
    • 4344658830 scopus 로고    scopus 로고
    • Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs
    • KuKanich B., and Papich M.G. Pharmacokinetics of tramadol and the metabolite O-desmethyltramadol in dogs. J Vet Pharmacol Ther 27 (2004) 239-246
    • (2004) J Vet Pharmacol Ther , vol.27 , pp. 239-246
    • KuKanich, B.1    Papich, M.G.2
  • 19
    • 0031460240 scopus 로고    scopus 로고
    • Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol
    • Paar W.D., Poche S., Gerloff J., and Dengler H.J. Polymorphic CYP2D6 mediates O-demethylation of the opioid analgesic tramadol. Eur J Clin Pharmacol 53 (1997) 235-239
    • (1997) Eur J Clin Pharmacol , vol.53 , pp. 235-239
    • Paar, W.D.1    Poche, S.2    Gerloff, J.3    Dengler, H.J.4
  • 20
    • 0033893537 scopus 로고    scopus 로고
    • Tramadol: a review of its use in perioperative pain
    • Scott L.J., and Perry C.M. Tramadol: a review of its use in perioperative pain. Drugs 60 (2000) 139-176
    • (2000) Drugs , vol.60 , pp. 139-176
    • Scott, L.J.1    Perry, C.M.2
  • 21
    • 0035691828 scopus 로고    scopus 로고
    • Oxidative monensin metabolism and cytochrome P450 3A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats
    • Nebbia C., Ceppa L., Dacasto M., Nachtmann C., and Carletti M. Oxidative monensin metabolism and cytochrome P450 3A content and functions in liver microsomes from horses, pigs, broiler chicks, cattle and rats. J Vet Pharmacol Ther 24 (2003) 399-403
    • (2003) J Vet Pharmacol Ther , vol.24 , pp. 399-403
    • Nebbia, C.1    Ceppa, L.2    Dacasto, M.3    Nachtmann, C.4    Carletti, M.5
  • 23
    • 0034885572 scopus 로고    scopus 로고
    • Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog
    • Wu W.N., McKown L.A., Gauthier A.D., Jones W.J., and Raffa R.B. Metabolism of the analgesic drug, tramadol hydrochloride, in rat and dog. Xenobiotica 31 (2001) 423-441
    • (2001) Xenobiotica , vol.31 , pp. 423-441
    • Wu, W.N.1    McKown, L.A.2    Gauthier, A.D.3    Jones, W.J.4    Raffa, R.B.5
  • 24
    • 30444449964 scopus 로고    scopus 로고
    • Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma
    • Rouini M.R., Ardakani Y.H., Soltani F., Aboul-Enein H.Y., and Foroumadi A. Development and validation of a rapid HPLC method for simultaneous determination of tramadol, and its two main metabolites in human plasma. J Chromatogr B 830 (2006) 207-211
    • (2006) J Chromatogr B , vol.830 , pp. 207-211
    • Rouini, M.R.1    Ardakani, Y.H.2    Soltani, F.3    Aboul-Enein, H.Y.4    Foroumadi, A.5
  • 25
    • 0032804758 scopus 로고    scopus 로고
    • Pharmacokinetic properties of tramadol sustained release capsules. 2nd communication: investigation of relative bioavailability and food interaction
    • Raber M., Schulz H.U., Schurer M., Bias-Imhoff U., and Momberger H. Pharmacokinetic properties of tramadol sustained release capsules. 2nd communication: investigation of relative bioavailability and food interaction. Arzneim Forsch Drug Res 49 (1999) 588-593
    • (1999) Arzneim Forsch Drug Res , vol.49 , pp. 588-593
    • Raber, M.1    Schulz, H.U.2    Schurer, M.3    Bias-Imhoff, U.4    Momberger, H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.