Morphine and 6-acetylmorphine concentrations in blood, brain, spinal cord, bone marrow and bone after lethal acute or chronic diacetylmorphine administration to mice

Forensic Science International

Volumn 166, Issue 2-3, 2007, Pages 139-144

  Guillot, Emmanuelle ^a   de Mazancourt, Philippe ^a   Durigon, Michel ^a   Alvarez, Jean Claude ^a  

^a RAYMOND POINCARÉ HOSPITAL   (France)

Author keywords

Bone; Bone marrow; Diacetylmorphine; Overdose; Toxicology

Indexed keywords

DIAMORPHINE; MORPHINE; MORPHINE 6 ACETATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW; CONTROLLED STUDY; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG BONE LEVEL; DRUG BRAIN LEVEL; GAS CHROMATOGRAPHY; LONG TERM EXPOSURE; MASS SPECTROMETRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPINAL CORD; TISSUE DISTRIBUTION; TOXICOKINETICS;

EID: 33847096914     PISSN: 03790738     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.forsciint.2006.03.029     Document Type: Article

References (25)

1. Tagliaro F., De Battisti Z., Smith F.P., and Marigo M. Death from diacetylmorphine overdose: findings from hair analysis. Lancet 351 (1998) 1923-1925
2. Darke S., Hall W., Kaye S., Ross J., and Duflou J. Hair morphine concentrations of fatal diacetylmorphine overdose cases and living diacetylmorphine users. Addiction 97 (2002) 977-984
3. Engelhart D.A., and Jenkins A.J. Detection of cocaine analytes and opiates in nails postmortem cases. J. Anal. Toxicol. 26 (2002) 489-492
4. Cattaneo C., Gigli F., Lodi F., and Grandi M. The detection of morphine and codeine in human teeth: an aid in the identification and study of human skeletal remains. J. Forensic Odontostomatol. 21 (2003) 1-5
5. Raikos N., Tsoukali H., and Njau S.N. Determination of opiates in postmortem bone and bone marrow. Forensic Sci. Int. 123 (2001) 140-141
6. Moriya F., and Hashimoto Y. Distribution of free and conjugated morphine in body fluids and tissues in a fatal diacetylmorphine overdose: is conjugated morphine stable in postmortem specimens?. J. Forensic Sci. 42 (1997) 736-740
7. Pacifici R., Di Carlo S., Bacosi A., Pichini S., and Zuccaro P. Pharmacokinetics and cytokine production in diacetylmorphine and morphine-treated mice. Int. J. Immunopharmacol. 22 (2000) 603-614
8. Noguchi T.T., Nakamura G.R., and Griesemer E.C. Drug analysis of skeletonizing remains. J. Forensic Sci. 23 (1978) 490-492
9. Winek C.L., Morris E.M., and Wahba W.W. The use of bone marrow in the study of postmortem redistribution of nortriptyline. J. Anal. Toxicol. 17 (1993) 93-98
10. Kojima T., Okameto I., Miyazaki T., Chikasue F., Yashiki M., and Nakamura K. Detection of metamphetamine and amphetamine in a skeletonized body buried for 5 years. Forensic Sci. Int. 31 (1986) 93-102
11. Kudo K., Sugie H., Syoui N., Kurihara K., Jitsufuchi N., Imamura T., and Ikeda N. Detection of triazolam in skeletal remains buried for 4 years. Int. J. Legal Med. 110 (1997) 281-283
12. Maeda H., Oritani S., Nagai K., Tanaka T., and Tanaka N. Detection of bromisovalum from the bone marrow of skeletonized human remains: a case report with comparison between gas chromatography/mass spectrometry (GC/MS) and high-performance liquid chromatography/mass spectrometry (LC/MS). Med. Sci. Law 37 (1997) 248-253
13. Winek C.L., Costantino A.G., Wahba W.W., and Collom W.D. Blood versus bone marrow pentobarbital concentrations. Forensic Sci. Int. 27 (1985) 15-24
14. Winek C.L., Pluskota M., and Wahba W.W. Plasma versus bone marrow flurazepam concentration in rabbits. Forensic Sci. Int. 19 (1982) 151-163
15. Winek C.L., Westwood S.E., and Wahba W.W. Plasma versus bone marrow desipramine: a comparative study. Forensic Sci. Int. 48 (1990) 49-57
16. Nagata T., Kimura K., Hara K., and Kudo K. Metamphetamine and amphetamine concentrations in post mortem rabbit tissues. Forensic Sci. Int. 48 (1990) 39-47
17. McIntyre I.M., King C.V., Boratto M., and Drummer O.H. Post-mortem drug analyses in bone and bone marrow. Ther. Drug Monit. 22 (2000) 79-83
18. Terazawa K., and Takatori T. Determination of aminopyrine and cyclobarbital from a skeleton by radioimmunoassay. J. Forensic Sci. 27 (1982) 844-847
19. Gorczynski L.Y., and Melbye F.J. Detection of benzodiazepines in different tissues, including bone, using a quantitative ELISA assay. J. Forensic Sci. 46 (2001) 916-918
20. Gaillard Y., Pepin G., Marquet P., Kintz P., Deveaux M., and Mura P. Identification et dosage de la benzoylecgonine, cocaïne, méthylecgonine-ester, codéine, morphine et 6-acétylmorphine dans le sang total. Toxicorama VIII (1996) 17-22
21. Kintz P., and Mangin M. Simultaneous determination of opiates, cocaine and major metabolites of cocaine in human hair by gas chromatography/mass spectrometry (GC/MS). Forensic Sci. Int. 73 (1995) 93-100
22. Nakamura G.R., Thornton J.L., and Noguchi T.T. Kinetics of diacetylmorphine deacetylation in aqueous alkaline solution and in human serum and whole blood. J. Chromatogr. 110 (1975) 81-89
23. Umans J.G., and Inturrisi C.E. Pharmacodynamics of subcutaneously administered diacetylmorphine, 6-acetylmorphine and morphine in mice. J. Pharmacol. Exp. Ther. 218 (1981) 409-415
24. Salmon A.Y., Goren Z., Avissar Y., and Soreq H. Human erythrocyte but not brain acetylcholinesterase hydrolyses heroin to morphine. Clin. Exp. Pharmacol. Physiol. 26 (1999) 596-600
25. Schwarzinger S., Hartmann M., Kremminger P., and Muller N. Hydrophobic forms of morphine-6-glucosides. Bioorg. Med. Chem. Lett. 11 (2001) 1455-1459