Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage

Neurobiology of Disease

Volumn 50, Issue 1, 2013, Pages 1-12

  Braunger, Barbara M ^a   Ohlmann, Andreas ^a   Koch, Marcus ^a   Tanimoto, Naoyuki ^b   Volz, Cornelia ^a   Yang, Ying ^c   Bösl, Michael R ^d   Cvekl, Ales ^c   Jägle, Herbert ^a   Seeliger, Mathias W ^b   Tamm, Ernst R ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

Author keywords

Brain derived neurotrophic factor; Endothelin receptor B; Glial fibrillary acidic protein; PI3K Akt; Retinal degeneration

Indexed keywords

BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR; DICKKOPF 1 PROTEIN; ENDOTHELIN 2; ENDOTHELIN RECEPTOR; ENDOTHELIN RECEPTOR B; EYE PROTEIN; GLIAL FIBRILLARY ACIDIC PROTEIN; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; NORRIN; PROTEIN KINASE B; RNA; UNCLASSIFIED DRUG; WNT PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; LIGHT DAMAGE; MICROSCOPY; MOUSE; NEUROPROTECTION; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; PROTECTION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RETINA; RETINA ANGIOGRAPHY; RNA ANALYSIS; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; BETA CATENIN; BLOTTING, WESTERN; ENDOTHELIN-2; EYE PROTEINS; LIGHT; MICE; MICE, TRANSGENIC; NERVE TISSUE PROTEINS; PHOTORECEPTOR CELLS; REAL-TIME POLYMERASE CHAIN REACTION; RETINA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 84867652327     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2012.09.008     Document Type: Article

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