Focus on Molecules: Norrin

Experimental Eye Research

Volumn 102, Issue , 2012, Pages 109-110

  Ohlmann, Andreas ^a   Merkl, Rainer ^a   Tamm, Ernst R ^a  

^a UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Norrie disease; Norrin; Wnt

Indexed keywords

BETA CATENIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR; CYSTEINE; ENDOTHELIN 2; FIBROBLAST GROWTH FACTOR 2; HEPARIN; LENS EPITHELIUM DERIVED GROWTH FACTOR; LEUKEMIA INHIBITORY FACTOR; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 6; MESSENGER RNA; NORRIN; PROTEIN; SECRETED FRIZZLED RELATED PROTEIN 4; UNCLASSIFIED DRUG; WNT PROTEIN;

ANGIOGENESIS; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CRYPTORCHISM; EXON; EXTRACELLULAR MATRIX; EXUDATIVE RETINITIS; HYPOGONADISM; IMMUNE DEFICIENCY; MENTAL DEFICIENCY; MICROCEPHALY; MICROVASCULAR ENDOTHELIAL CELL; MUELLER CELL; MUTATION; MYOCLONUS; NONHUMAN; NORRIE DISEASE; OLIGOMERIZATION; PERCEPTION DEAFNESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; PROTEIN STRUCTURE; RETINA DEVELOPMENT; RETINA GANGLION CELL; RETROLENTAL FIBROPLASIA; SEIZURE; SHORT SURVEY; VITREORETINOPATHY;

BETA CATENIN; BLINDNESS; EYE PROTEINS; HUMANS; NERVE TISSUE PROTEINS; NERVOUS SYSTEM DISEASES; PROTEIN STRUCTURE, TERTIARY; SPASMS, INFANTILE; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84865596187     PISSN: 00144835     EISSN: 10960007     Source Type: Journal    
DOI: 10.1016/j.exer.2011.06.016     Document Type: Short Survey

References (4)

1. Junge H.J., Yang S., Burton J.B., Paes K., Shu X., French D.M., Costa M., Rice D.S., Ye W. TSPAN12 regulates retinal vascular development by promoting Norrin- but not Wnt-induced Fzd4/β-catenin signaling. Cell 2009, 139:299-311.
2. Ohlmann A., Seitz R., Braunger B., Seitz D., Bösl M.R., Tamm E.R. Norrin promotes vascular regrowth after oxygen-induced retinal vessel loss and suppresses retinopathy in mice. J. Neurosci. 2010, 30:183-193.
3. Seitz R., Hackl S., Seibuchner T., Tamm E.R., Ohlmann A. Norrin mediates neuroprotective effects on retinal ganglion cells via activation of the Wnt/β-catenin signaling pathway and the induction of neuroprotective growth factors in Muller cells. J. Neurosci. 2010, 30:5998-6010.
4. Ye X., Wang Y., Cahill H., Yu M., Badea T.C., Smallwood P.M., Peachey N.S., Nathans J. Norrin, Frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 2009, 139:285-298.