A Pilot Investigation of Visceral Fat Adiposity and Gene Expression Profile in Peripheral Blood Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Yamaoka, Masaya ^a   Maeda, Norikazu ^a   Nakamura, Seiji ^b   Kashine, Susumu ^a   Nakagawa, Yasuhiko ^a   Hiuge Shimizu, Aki ^a   Okita, Kohei ^a   Imagawa, Akihisa ^a   Matsuzawa, Yuji ^c   Matsubara, Ken ichi ^b   Funahashi, Tohru ^a   Shimomura, Iichiro ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b DNA CHIP RESEARCH INC   (Japan)

^c SUMITOMO HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA HOMOLOG; MESSENGER RNA; PERIOD HOMOLOG 1 PROTEIN; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BIOENERGY; BLOOD CELL; BODY MASS; CIRCADIAN RHYTHM; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA MICROARRAY; FEMALE; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENOME; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPEDANCE; INFLAMMATION; INTRAABDOMINAL FAT; JAPANESE; LIPID STORAGE; MAJOR CLINICAL STUDY; MALE; MICROARRAY ANALYSIS; OBESITY; OXIDATIVE STRESS; PATHOGENESIS; PER1 GENE; PILOT STUDY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADIPOSITY; ADULT; AGED; BLOOD CELLS; BODY MASS INDEX; FEMALE; HUMANS; INTRA-ABDOMINAL FAT; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PERIOD CIRCADIAN PROTEINS; TRANSCRIPTOME;

EID: 84867593268     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047377     Document Type: Article

References (25)

1. Matsuzawa Y, (2006) Therapy Insight: adipocytokines in metabolic syndrome and related cardiovascular disease. Nat Clin Pract Cardiovasc Med 3: 35-42.
2. Hotamisligil GS, (2010) Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917.
3. Flier JS, (2004) Obesity wars: molecular progress confronts an expanding epidemic. Cell 116: 337-350.
4. Neels JG, Olefsky JM, (2006) Inflamed fat: what starts the fire? J Clin Invest 116: 33-35.
5. Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-939.
6. Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
7. Winer DA, Winer S, Shen L, Wadia PP, Yantha J, et al. (2011) B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17: 610-617.
8. Wu D, Molofsky AB, Liang HE, Ricardo-Gonzalez RR, Jouihan HA, et al. (2011) Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis. Science 332: 243-247.
9. Examination Committee of Criteria for 'Obesity Disease' in Japan (2002) Japan Society for the Study of Obesity. New criteria for 'obesity disease' in Japan. Circ J 66: 987-992.
10. Ryo M, Maeda K, Onda T, Katashima M, Okumiya A, et al. (2005) A new simple method for the measurement of visceral fat accumulation by bioelectrical impedance. Diabetes Care 28: 451-453.
11. Nakatsuji H, Kishida K, Funahashi T, Noguchi M, Ogawa T, et al. (2010) One-year reductions in body weight and blood pressure, but not in visceral fat accumulation and adiponectin, improve urinary albumin-to-creatinine ratio in middle-aged Japanese men. Diabetes Care 33: e110-111.
12. Bass J, Takahashi JS, (2010) Circadian integration of metabolism and energetics. Science 330: 1349-1354.
13. Gimble JM, Sutton GM, Bunnell BA, Ptitsyn AA, Floyd ZE, (2011) Prospective influences of circadian clocks in adipose tissue and metabolism. Nat Rev Endocrinol 7: 98-107.
14. Maury E, Ramsey KM, Bass J, (2010) Circadian rhythms and metabolic syndrome: from experimental genetics to human disease. Circ Res 106: 447-462.
15. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
16. Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
17. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, et al. (2004) Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761.
18. Kullo IJ, Hensrud DD, Allison TG, (2002) Comparison of numbers of circulating blood monocytes in men grouped by body mass index (<25, 25 to <30, > or = 30). Am J Cardiol 89: 1441-1443.
19. Turek FW, Joshu C, Kohsaka A, Lin E, Ivanova G, et al. (2005) Obesity and metabolic syndrome in circadian Clock mutant mice. Science 308: 1043-1045.
20. Dallmann R, Weaver DR, (2010) Altered body mass regulation in male mPeriod mutant mice on high-fat diet. Chronobiol Int 27: 1317-1328.
21. Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, et al. (2007) High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab 6: 414-421.
22. Fukuya H, Emoto N, Nonaka H, Yagita K, Okamura H, et al. (2007) Circadian expression of clock genes in human peripheral leukocytes. Biochem Biophys Res Commun 354: 924-928.
23. Zvonic S, Ptitsyn AA, Conrad SA, Scott LK, Floyd ZE, et al. (2006) Characterization of peripheral circadian clocks in adipose tissues. Diabetes 55: 962-970.
24. Ando H, Yanagihara H, Hayashi Y, Obi Y, Tsuruoka S, et al. (2005) Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue. Endocrinology 146: 5631-5636.
25. Haimovich B, Calvano J, Haimovich AD, Calvano SE, Coyle SM, et al. (2010) In vivo endotoxin synchronizes and suppresses clock gene expression in human peripheral blood leukocytes. Crit Care Med 38: 751-758.