Drug enterocyte adducts: Possible causal factor for diclofenac enteropathy in rats

Gastroenterology

Volumn 119, Issue 6, 2000, Pages 1537-1547

  Atchison, Chessley R ^a   West, A Brian ^a   Balakumaran, Arun ^a   Hargus, Sally J ^a   Pohl, Lance R ^a   Daiker, Davis H ^a   Aronson, Judith F ^a   Hoffmann, Walter E ^a   Shipp, Bryan K ^a   Treinen Moslen, Mary ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICLOFENAC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CONTROLLED STUDY; DOSE RESPONSE; DRUG INDUCED DISEASE; ENTEROHEPATIC CIRCULATION; ENTEROPATHY; IMMUNOHISTOCHEMISTRY; INTESTINE CELL; MACROMOLECULE; METABOLITE; NONHUMAN; PRIORITY JOURNAL; RAT; ULCER;

EID: 0034463602     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2000.20186     Document Type: Article

References (34)

1. Blood and protein loss via small-intestinal inflammation induced by non-steroidal anti-inflammatory drugs
2. Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans
3. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs
4. Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
5. Nonsteroidal anti-inflammatory drugs and gastrointestinal disease
6. High prevalence of NSAID enteropathy as shown by a simple faecal test
7. Selective protein adduct formation of diclofenac glucuronide is critically dependent on the rat canalicular conjugate export pump (Mrp2)
8. Immunohistochemical detection of liver protein adducts of the nonsteroidal antiinflammatory drug diclofenac
9. Diclofenac decreases serum alkaline phosphatase isozymes and forms protein adducts in multiple tissues
10. Gastrointestinal ulcerations induced by anti-inflammatory drugs in rats. Physiochemical and biochemical factors involved
11. The functional morphology of the mucosa of the small intestine
12. Biliary function studies during multiple time periods in freely moving rats: A useful system and set of marker solutes
13. Characteristics of ulcers of the small bowel induced by non-steroidal anti-inflammatory drugs in the rat: Implications for clinical practice
14. Indomethacin-induced intestinal lesions in the rat
15. Vascular anatomy defines sites of indomethacin induced jejunal ulceration along the mesenteric margin
16. The use of non-steroidal anti-inflammatory drugs for the relief of pain in laboratory rodents and rabbits
17. Nonsteroidal anti-inflammatory drug enteropathy in rats: Role of permeability, bacteria, and enterohepatic circulation
18. Induction of nitric oxide synthetase and microvascular injury in the rat jejunum provoked by indomethacin
19. Diclofenac acyl glucuronide, a major biliary metabolite, is directly involved in small intestinal injury in rats
20. Local absorption kinetics into the portal system using the portal-venous concentration difference after an oral dose of diclofenac in the awakening rat. Accelerative effect of bile on intestinal absorption of diclofenac
21. Acute indomethacin-induced jejunal injury in the rat: Early morphological and biochemical changes
22. Role of covalent and noncovalent interactions in cell toxicity: Effect on proteins
23. Selective protein covalent binding and target organ toxicity
24. Pretreatment of mice with macrophage inactivators decreases acetaminophen hepatoxicity and the formation of reactive oxygen and nitrogen species
25. Metabolic activation and immunochemical localization of liver protein adducts of the nonsteroidal anti-inflammatory drug diclofenac
26. Immunochemical detection and identification of protein adducts of diclofenac in the small intestine of rats: Possible role in allergic reactions
27. Relationship of the enterohepatic cycle to ulcerogenesis in the rat small bowel with flufenamic acid
28. Acyl glucuronides revisited: Is the glucuronidation process a toxification as well as a detoxification mechanism?
29. Mechanism of covalent adduct formation of diclofenac to rat hepatic microsomal proteins. Retention of the glucuronic acid moiety in the adduct
30. Activated phase II metabolites: Comparison of alkylation by 1-0-acyl glucuronides and acyl sulfates
31. Intestinal UDP glucuronosyltransferase activities in rat and rabbit
32. The biochemical basis of non-steroidal anti-inflammatory drug-induced damage to the gastrointestinal tract: A review and a hypothesis
33. Experimental enteropathy in athymic and euthymic rats: Synergistic role of lipopolysaccharide and indomethacin
34. Oxidation of diclofenac to reactive intermediates by neutrophils, myeloperoxidase, and hypochlorous acid