Modifications around the hydroxamic acid chelating group of fosmidomycin, an inhibitor of the metalloenzyme 1-deoxyxylulose 5-phosphate reductoisomerase (DXR)

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6563-6567

  Zinglé, Catherine ^a   Kuntz, Lionel ^a   Tritsch, Denis ^a   Grosdemange Billiard, Catherine ^a   Rohmer, Michel ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

1 Deoxy d xylulose 5 phosphate reducto isomerase; Fosmidomycin derivatives; Metal chelating group inhibitors; Metalloenzyme

Indexed keywords

1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; FOSMIDOMYCIN; HYDROXAMIC ACID; ISOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; ENZYME INHIBITION; ENZYME STRUCTURE; ESCHERICHIA COLI;

ALDOSE-KETOSE ISOMERASES; CHELATING AGENTS; ENZYME ACTIVATION; ENZYME INHIBITORS; ESCHERICHIA COLI; FOSFOMYCIN; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; METALLOPROTEINS; MOLECULAR STRUCTURE; PROTEIN BINDING;

ESCHERICHIA COLI;

EID: 84867582796     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.021     Document Type: Article

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