3,3′-Disubstituted bipolar biphenyls as inhibitors of nuclear receptor coactivator binding

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6587-6590

  Weiser, Patrick T ^a   Williams, Anna B ^a   Chang, Ching Yi ^b   McDonnell, Donald P ^b   Hanson, Robert N ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Coactivator binding inhibition; Nuclear receptor; Proteomimetics

Indexed keywords

BIPHENYL DERIVATIVE; NUCLEAR RECEPTOR COACTIVATOR; ESTROGEN RECEPTOR ALPHA; NUCLEAR RECEPTOR COACTIVATOR 2;

ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; GENE ACTIVATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IN VITRO STUDY; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; BINDING COMPETITION; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; METABOLISM; SYNTHESIS; TUMOR CELL LINE;

BINDING SITES; BINDING, COMPETITIVE; BIPHENYL COMPOUNDS; CELL LINE, TUMOR; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; MOLECULAR STRUCTURE; NUCLEAR RECEPTOR COACTIVATOR 2; NUCLEAR RECEPTOR COACTIVATORS; PROTEIN BINDING;

EID: 84867579061     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.09.007     Document Type: Article

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