The novel ETA receptor antagonist HJP-272 prevents cerebral microvascular hemorrhage in cerebral malaria and synergistically improves survival in combination with an artemisinin derivative

Life Sciences

Volumn 91, Issue 13-14, 2012, Pages 687-692

  Dai, Minxian ^a   Freeman, Brandi ^a   Bruno, Fernando P ^a   Shikani, Henry J ^a   Tanowitz, Herbert B ^a   Weiss, Louis M ^a   Reznik, Sandra E ^a,b   Stephani, Ralph A ^b   Desruisseaux, Mahalia S ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b ST JOHN'S UNIVERSITY   (United States)

Author keywords

Brain hemorrhage; Experimental cerebral malaria; Vasculopathy

Indexed keywords

1,3,6 TRISUBSTITUTED 2 CARBOXY QUINOL 4 ONE; ARTEMETHER; ENDOTHELIN 1; ENDOTHELIN A RECEPTOR ANTAGONIST; HJP 272; QUINOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; BRAIN HEMORRHAGE; BRAIN MALARIA; CONFERENCE PAPER; CONTROLLED STUDY; DRUG POTENTIATION; DRUG SYNTHESIS; FEMALE; GLUCOSE BLOOD LEVEL; MOUSE; NEUROPROTECTION; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI INFECTION; SURVIVAL; WEIGHT CHANGE;

ANIMALS; ANTIMALARIALS; ARTEMISININS; CEREBRAL HEMORRHAGE; DRUG SYNERGISM; DRUG THERAPY, COMBINATION; ENDOTHELIN-1; FEMALE; HYDROXYQUINOLINES; MALARIA, CEREBRAL; MICE; MICE, INBRED C57BL; MICROVESSELS; PARASITEMIA; PLASMODIUM BERGHEI; RANDOM ALLOCATION; RECEPTOR, ENDOTHELIN A; SURVIVAL;

MUS; PLASMODIUM BERGHEI;

EID: 84867575903     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.07.006     Document Type: Conference Paper

References (39)

1. B.D. Akanmori, J.A. Kurtzhals, B.Q. Goka, V. Adabayeri, M.F. Ofori, and F.K. Nkrumah Distinct patterns of cytokine regulation in discrete clinical forms of Plasmodium falciparum malaria Eur Cytokine Netw 11 2000 113 118
2. H. Arai, S. Hori, I. Aramori, H. Ohkubo, and S. Nakanishi Cloning and expression of a cDNA encoding an endothelin receptor Nature 348 1990 730 732
3. K.I. Barnes, P. Chanda, and G. Ab Barnabas Impact of the large-scale deployment of artemether/lumefantrine on the malaria disease burden in Africa: case studies of South Africa, Zambia and Ethiopia Malar J 8 Suppl. 1 2009 S8
4. F. Bohm, and J. Pernow The importance of endothelin-1 for vascular dysfunction in cardiovascular disease Cardiovasc Res 76 2007 8 18
5. P. Cabrales, G.M. Zanini, D. Meays, J.A. Frangos, and L.J.M. Carvalho Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine Am J Pathol 176 2010 1306 1315
6. E.R. Camargos, C.R. Machado, A.L. Teixeira, L.L. Rocha, A.J. Ferreira, and A.P. Almeida Role of endothelin during experimental Trypanosoma cruzi infection in rats Clin Sci (Lond) 103 Suppl. 48 2002 64S 67S
7. M. Dai, S.E. Reznik, D.C. Spray, L.M. Weiss, H.B. Tanowitz, and M. Gulinello Persistent cognitive and motor deficits after successful antimalarial treatment in murine cerebral malaria Microbes Infect 12 2010 1198 1207
8. M. D'Amico, L. Berrino, S. Maione, A. Filippelli, V. de Novellis, and F. Rossi Endothelin-1 in periaqueductal gray area of mice induces analgesia via glutamatergic receptors Pain 65 1996 205 209
9. F.G. Davoodi, F. Motamedi, N. Naghdi, and E. Akbari Effect of reversible inactivation of the reuniens nucleus on spatial learning and memory in rats using Morris water maze task Behav Brain Res 198 2009 130 135
10. M.S. Desruisseaux, M. Gulinello, D.N. Smith, S.C. Lee, M. Tsuji, and L.M. Weiss Cognitive dysfunction in mice infected with Plasmodium berghei strain ANKA J Infect Dis 197 2008 1621 1627
11. S.A. Douglas, and E.H. Ohlstein Signal transduction mechanisms mediating the vascular actions of endothelin J Vasc Res 34 1997 152 164
12. A.E. Frosch, M. Venkatesan, and M.K. Laufer Patterns of chloroquine use and resistance in sub-Saharan Africa: a systematic review of household survey and molecular data Malar J 10 2011 116
13. N.H. Hunt, and G.E. Grau Cytokines: accelerators and brakes in the pathogenesis of cerebral malaria Trends Immunol 24 2003 491 499
14. K.I. Ishibashi, T. Imamura, P.M. Sharma, J. Huang, S. Ugi, and J.M. Olefsky Chronic endothelin-1 treatment leads to heterologous desensitization of insulin signaling in 3T3-L1 adipocytes J Clin Invest 107 2001 1193 1202
15. R.M. Kedzierski, and M. Yanagisawa Endothelin system: the double-edged sword in health and disease Annu Rev Pharmacol Toxicol 41 2001 851 876
16. R.P. Kennan, F.S. Machado, S.C. Lee, M.S. Desruisseaux, M. Wittner, and M. Tsuji Reduced cerebral blood flow and N-acetyl aspartate in a murine model of cerebral malaria Parasitol Res 96 2005 302 307
17. D.L. Klayman Qinghaosu (artemisinin): an antimalarial drug from China Science 228 1985 1049 1055
18. J.W. Leung, M.C. Ho, A.C. Lo, S.S. Chung, and S.K. Chung Endothelial cell-specific over-expression of endothelin-1 leads to more severe cerebral damage following transient middle cerebral artery occlusion J Cardiovasc Pharmacol 44 Suppl. 1 2004 S293 S300
19. J. Lopez, M. Wolff, L. Lecourtier, B. Cosquer, B. Bontempi, and J. Dalrymple-Alford The intralaminar thalamic nuclei contribute to remote spatial memory J Neurosci 29 2009 3302 3306
20. J. Lou, R. Lucas, and G.E. Grau Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans Clin Microbiol Rev 14 2001 810 820 [table of contents]
21. F.S. Machado, M.S. Desruisseaux, Nagajyothi, R.P. Kennan, H.P. Hetherington, and M. Wittner Endothelin in a murine model of cerebral malaria Exp Biol Med (Maywood) 231 2006 1176 1181
22. Y. Matsuo, S. Mihara, M. Ninomiya, and M. Fujimoto Protective effect of endothelin type A receptor antagonist on brain edema and injury after transient middle cerebral artery occlusion in rats Stroke 32 2001 2143 2148
23. I.M. Medana, N.T.H. Mai, N.P.J. Day, T.T. Hien, D. Bethell, and N.H. Phu Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malaria Neuropathol Appl Neurobiol 27 2001 421 433
24. J. Montgomery, D.A. Milner Jr., M.T. Tse, A. Njobvu, K. Kayira, and C.P. Dzamalala Genetic analysis of circulating and sequestered populations of Plasmodium falciparum in fatal pediatric malaria J Infect Dis 194 2006 115 122
25. N.S. Olgun, R.A. Stephani, H.J. Patel, and S.E. Reznik Blockade of endothelin-1 with a novel series of 1,3,6,-trisubstituted-2-carboxy-quinol-4- one's controls infection-associated preterm birth Am J Pathol 177 2010 1929 1935
26. A antagonists Bioorg Med Chem Lett 20 2010 6840 6844
27. M.F. Penet, A. Viola, S. Confort-Gouny, Y. Le Fur, G. Duhamel, and F. Kober Imaging experimental cerebral malaria in vivo: significant role of ischemic brain edema J Neurosci 25 2005 7352 7358
28. P.A. Reis, C.M. Comim, F. Hernani, B. Silva, T. Barichello, and A.C. Portella Cognitive dysfunction is sustained after rescue therapy in experimental cerebral malaria, and is reduced by additive antioxidant therapy PLoS Pathog 6 2010 e1000963
29. S. Schinelli The brain endothelin system as potential target for brain-related pathologies Curr Drug Targets CNS Neurol Disord 1 2002 543 553
30. D. Shao, J.E. Park, and S.J. Wort The role of endothelin-1 in the pathogenesis of pulmonary arterial hypertension Pharmacol Res 63 2011 504 511
31. N.R. Sibson, A.M. Blamire, V.H. Perry, J. Gauldie, P. Styles, and D.C. Anthony TNF-alpha reduces cerebral blood volume and disrupts tissue homeostasis via an endothelin- and TNFR2-dependent pathway Brain 125 2002 2446 2459
32. D. Sinclair, B. Zani, S. Donegan, P. Olliaro, and P. Garner Artemisinin-based combination therapy for treating uncomplicated malaria Cochrane Database Syst Rev 2009 CD007483
33. A.M. Sutcliffe, D.L. Clarke, D.A. Bradbury, L.M. Corbett, J.A. Patel, and A.J. Knox Transcriptional regulation of monocyte chemotactic protein-1 release by endothelin-1 in human airway smooth muscle cells involves NF-kappaB and AP-1 Br J Pharmacol 157 2009 436 450
34. T.E. Taylor, W.J. Fu, R.A. Carr, R.O. Whitten, J.S. Mueller, and N.G. Fosiko Differentiating the pathologies of cerebral malaria by postmortem parasite counts Nat Med 10 2004 143 145
35. P. Teder, and P.W. Noble A cytokine reborn? Endothelin-1 in pulmonary inflammation and fibrosis Am J Respir Cell Mol Biol 23 2000 7 10
36. I. Usui, T. Imamura, J.L. Babendure, H. Satoh, J.C. Lu, and C.J. Hupfeld G protein-coupled receptor kinase 2 mediates endothelin-1-induced insulin resistance via the inhibition of both Galphaq/11 and insulin receptor substrate-1 pathways in 3T3-L1 adipocytes Mol Endocrinol 19 2005 2760 2768
37. C. Wenisch, H. Wenisch, P. Wilairatana, S. Looareesuwan, S. Vannaphan, and O. Wagner Big endothelin in patients with complicated Plasmodium falciparum malaria J Infect Dis 173 1996 1281 1284
38. H. Yamada, and K. Kurokawa Histochemical studies on endothelin and the endothelin-A receptor in the hypothalamus J Cardiovasc Pharmacol 31 Suppl. 1 1998 S215 S218
39. A.R. Zampronio, J.B. Kuzmiski, C.M. Florence, S.J. Mulligan, and Q.J. Pittman Opposing actions of endothelin-1 on glutamatergic transmission onto vasopressin and oxytocin neurons in the supraoptic nucleus J Neurosci 30 2010 16855 16863