Cellular stress and injury responses in the brains of adult Vietnamese patients with fatal Plasmodium falciparum malaria

Neuropathology and Applied Neurobiology

Volumn 27, Issue 6, 2001, Pages 421-433

  Medana, I M ^a,d   Mai, N T H ^c   Day, N P J ^b,c   Hien, T T ^c   Bethell, D ^b,c   Phu, N H ^c   Farrar, J ^c   White, N J ^b,c   Turner, G D H ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c CHO QUAN HOSPITAL   (Viet Nam)

^d JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Caspase 3; Heat shock; Poly(ADP) ribose polymerase

Indexed keywords

CASPASE 3; DNA DEPENDENT PROTEIN KINASE; HEAT SHOCK PROTEIN 70; HEME OXYGENASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE);

ADULT; APOPTOSIS; ARTICLE; BRAIN MALARIA; BRAIN STEM; CATALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVE CELL LESION; NEUROPATHOLOGY; OXIDATIVE STRESS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRAMIDAL TRACT; VIET NAM;

ADULT; APOPTOSIS; BRAIN STEM; CASPASE 3; CASPASES; CAUSE OF DEATH; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FEMALE; HEME OXYGENASE (DECYCLIZING); HEME OXYGENASE-1; HSP70 HEAT-SHOCK PROTEINS; HUMANS; MALARIA, CEREBRAL; MALE; MEMBRANE PROTEINS; MIDDLE AGED; NEUROGLIA; NUCLEAR PROTEINS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; PROTEIN-SERINE-THREONINE KINASES; VIETNAM;

EID: 0035728052     PISSN: 03051846     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0305-1846.2001.00360.x     Document Type: Article

References (33)

1. Activation of the CED3/ICE-related protease CPP32 in cerebellar granule neurons undergoing apoptosis but not necrosis
2. HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
3. Cerebral malaria: The sequestration hypothesis
4. Neurological sequelae of cerebral malaria in children
5. The pathological anatomy of malaria
6. Poly(ADP-ribose) polymerase is found in both the nucleus and the cytoplasm of human CNS neurons
7. Electroencephalographic and clinical features of cerebral malaria
8. Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells
9. Quantitative image analysis of the chromatolysis in rat facial and hypoglossal motoneurons following axotomy with and without reinnervation
10. A controlled trial of artemether or quinine in Vietnamese adults with severe falciparum malaria
11. DNA repair: PARP - Another guardian angel?
12. Activation of CPP32 during apoptosis of neurons and astrocytes
13. Neuronal accumulation of poly(ADP-ribose) after brain ischaemia
14. Activation of caspase-3 in permanent and transient brain ischaemia in man
15. Neuronal death in brain infarcts in man
16. Increased c-fos expression in the brain during experimental murine cerebral malaria: Possible association with neurologic complications
17. On summer-autumnal malaria fevers
18. Co-induction of HSP70 and heme oxygenase-1 in macrophages and glia after spinal cord contusion in the rat
19. Redistribution and degeneration of retinal astrocytes in experimental murine cerebral malaria: Relationship to disruption of the blood-retinal barrier
20. Heat-shock 70 messenger RNA levels in human brain: Correlation with agonal fever
21. Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia
22. Cerebral malaria
23. Emerging roles of caspase-3 in apoptosis
24. Neuroglial activation repertoire in the injured brain: Graded response, molecular mechanisms and cues to physiological function
25. Widespread expression of MRP8 and MRP14 in human cerebral malaria by microglial cells
26. Heme oxygenase-1 in lesions of human cerebral malaria
27. Heat-shock protein protection
28. A quantitative analysis of the microvascular sequestration of malaria parasites in the human brain
29. The pathology of acute falciparum malaria
30. Cerebral malaria
31. Disorders of consciousness
32. Dexamethasone proves deleterious in cerebral malaria. A double-blind trial in 100 comatose patients
33. Severe falciparum malaria