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Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 22, 2010, Pages 6840-6844

Synthesis and pharmacological activity of 1,3,6-trisubstituted-4-oxo-1,4- dihydroquinoline-2-carboxylic acids as selective ETA antagonists

(5) Patel, Hardik J a Olgun, Nicole a Lengyel, István a Reznik, Sandra a Stephani, Ralph A a

a ST JOHN'S UNIVERSITY (United States)

Author keywords

4 Oxo 1,4 dihydroquinoline 2 carboxylic acids; Endothelin; ETA antagonists; ETAR selectivity versus ETBR

Indexed keywords

1,3,6 TRISUBSTITUTED 4 OXO 1,4 DIHYDROQUINOLINE 2 CARBOXYLIC ACID; 4 OXO 1,4 DIHYDROQUINOLINE DIACID; 6 O 1 BUTYL; 6 O CYCLOPROPYLMETHYL; 6 O ETHYL; 6 O N BUTYL; 6 O N PROPYL; 6 O PROPAN 3 OL; 6 O SEC BUTYL; CARBOXYLIC ACID; ENDOTHELIN A RECEPTOR; ENDOTHELIN A RECEPTOR ANTAGONIST; ENDOTHELIN B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG DESIGN; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; MOUSE; NONHUMAN; PNEUMONIA; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBOXYLIC ACIDS; FEMALE; IODINE RADIOISOTOPES; MICE; PREGNANCY; RECEPTOR, ENDOTHELIN A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77958069806 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/j.bmcl.2010.08.074 Document Type: Article

Times cited : (8)

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