메뉴 건너뛰기




Volumn 11, Issue 2, 2011, Pages 111-123

New therapeutic approaches to combat arterial thrombosis

Author keywords

[No Author keywords available]

Indexed keywords

3A,4,4A,5,6,7,8,8A,9,9A DECAHYDRO N [4 [2 [5 (3 FLUOROPHENYL) 2 PYRIDYL]VINYL] 3 METHYL 1 OXO 3H BENZO[F]ISOBENZOFURAN 7 YL]CARBAMIC ACID ETHYL ESTER; ABCIXIMAB; ACETYLSALICYLIC ACID; ACETYLSALICYLIC ACID 3 (NITROXYMETHYL)PHENYL ESTER; ANTITHROMBOCYTIC AGENT; ATOPAXAR; BX 667; CANGRELOR; CILOSTAZOL; CLOPIDOGREL; COLLAGEN; CYTOCHROME P450; DIPYRIDAMOLE; E 5555; ELINOGREL; EPTIFIBATIDE; FIBRINOGEN RECEPTOR ANTAGONIST; GLIBENCLAMIDE; NEW DRUG; PRASUGREL; PROTEINASE ACTIVATED RECEPTOR 1; PURINERGIC P2Y12 RECEPTOR; SARPOGRELATE; SEROTONIN 2A RECEPTOR; TERUTROBAN; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR; TICAGRELOR; TICLOPIDINE; TIROFIBAN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORAPAXAR;

EID: 79955683495     PISSN: 15340384     EISSN: 15432548     Source Type: Journal    
DOI: 10.1124/mi.11.2.9     Document Type: Review
Times cited : (14)

References (99)
  • 1
    • 34248371253 scopus 로고    scopus 로고
    • Clinical aspects of platelet inhibitors and thrombus formation
    • DOI 10.1161/01.RES.0000264509.36234.51, PII 0000301220070511000004
    • Meadows TA and Bhatt DL (2007) Clinical aspects of platelet inhibitors and thrombus formation. Circ Res 100:1261-1275. This detailed review is an excellent introduction to the role of platelets in atherothrombosis and to the anti-platelet drugs that are in current use as well as many that are in development. (Pubitemid 46742917)
    • (2007) Circulation Research , vol.100 , Issue.9 , pp. 1261-1275
    • Meadows, T.A.1    Bhatt, D.L.2
  • 2
    • 67849126851 scopus 로고    scopus 로고
    • Dynamics of platelet thrombus formation
    • Jackson SP, Nesbitt WS, and Westein E (2009) Dynamics of platelet thrombus formation. J Thromb Haemost 7 (Suppl 1):17-20.
    • (2009) J Thromb Haemost , vol.7 , Issue.SUPPL. 1 , pp. 17-20
    • Jackson, S.P.1    Nesbitt, W.S.2    Westein, E.3
  • 3
    • 64249090109 scopus 로고    scopus 로고
    • Platelet adhesion under flow
    • This review includes a very thorough description of the mechanisms responsible for platelet adhesion to the vascular subendothelium after rupture of atherosclerotic plaque
    • Ruggeri ZM (2009) Platelet adhesion under flow. Microcirculation 16:58-83. This review includes a very thorough description of the mechanisms responsible for platelet adhesion to the vascular subendothelium after rupture of atherosclerotic plaque.
    • (2009) Microcirculation , vol.16 , pp. 58-83
    • Ruggeri, Z.M.1
  • 5
    • 77957268771 scopus 로고    scopus 로고
    • Platelets: Pleiotropic roles in atherogenesis and atherothrombosis
    • Linden MD and Jackson DE (2010) Platelets: Pleiotropic roles in atherogenesis and atherothrombosis. Int J Biochem Cell Biol 42:1762-1766.
    • (2010) Int J Biochem Cell Biol , vol.42 , pp. 1762-1766
    • Linden, M.D.1    Jackson, D.E.2
  • 6
    • 66049107647 scopus 로고    scopus 로고
    • Platelet receptors and signaling in the dynamics of thrombus formation
    • Rivera J, Lozano ML, Navarro-Núñez L, and Vicente V (2009) Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 94:700-711.
    • (2009) Haematologica , vol.94 , pp. 700-711
    • Rivera, J.1    Lozano, M.L.2    Navarro-Núnez, L.3    Vicente, V.4
  • 7
    • 42249102617 scopus 로고    scopus 로고
    • P2 receptors, platelet function and pharmacological implications
    • DOI 10.1160/TH07-11-0673
    • Gachet C (2008) P2 receptors, platelet function and pharmacological implications. Thromb Haemost 99:466-472. (Pubitemid 351549282)
    • (2008) Thrombosis and Haemostasis , vol.99 , Issue.3 , pp. 466-472
    • Gachet, C.1
  • 8
    • 70350459370 scopus 로고    scopus 로고
    • Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis
    • Jennings LK (2009) Mechanisms of platelet activation: Need for new strategies to protect against platelet-mediated atherothrombosis. Thromb Haemost 102:248-257.
    • (2009) Thromb Haemost , vol.102 , pp. 248-257
    • Jennings, L.K.1
  • 9
    • 77956788267 scopus 로고    scopus 로고
    • Acute coronary syndrome update for hospitalists
    • Bhatt DL (2010) Acute coronary syndrome update for hospitalists. J Hosp Med 5 (Suppl 4):S15-S21.
    • (2010) J Hosp Med , vol.5 , Issue.SUPPL. 4
    • Bhatt, D.L.1
  • 11
    • 78751616421 scopus 로고    scopus 로고
    • Antiplatelet therapy in coronary heart disease prevention
    • Kolandaivelu K and Bhatt DL (2011) Antiplatelet therapy in coronary heart disease prevention. Cardiol Clin 29:71-85.
    • (2011) Cardiol Clin , vol.29 , pp. 71-85
    • Kolandaivelu, K.1    Bhatt, D.L.2
  • 12
    • 67649981100 scopus 로고    scopus 로고
    • Review of prasugrel for the secondary prevention of atherothrombosis
    • Spinler SA and Rees C (2009) Review of prasugrel for the secondary prevention of atherothrombosis. J Manag Care Pharm 15:383-395.
    • (2009) J Manag Care Pharm , vol.15 , pp. 383-395
    • Spinler, S.A.1    Rees, C.2
  • 13
    • 77649198522 scopus 로고    scopus 로고
    • Oral antiplatelet therapy for acute and chronic management of NSTE ACS: Residual ischemic risk and opportunities for improvement
    • Cohen M (2009) Oral antiplatelet therapy for acute and chronic management of NSTE ACS: Residual ischemic risk and opportunities for improvement. Cardiovasc Drugs Ther 23:489-499.
    • (2009) Cardiovasc Drugs Ther , vol.23 , pp. 489-499
    • Cohen, M.1
  • 14
    • 0242300217 scopus 로고    scopus 로고
    • Antiplatelet therapy: In search of the 'magic bullet'
    • Jackson SP and Schoenwaelder SM (2003) Antiplatelet therapy: In search of the 'magic bullet'. Nat Rev Drug Discov 2:775-789. (Pubitemid 37361810)
    • (2003) Nature Reviews Drug Discovery , vol.2 , Issue.10 , pp. 775-789
    • Jackson, S.P.1    Schoenwaelder, S.M.2
  • 16
    • 77951755914 scopus 로고    scopus 로고
    • Prostacyclin in vascular diseases: Recent insights and future perspectives
    • Kawabe J-I, Ushikubi F, and Hasebe N (2011) Prostacyclin in vascular diseases: Recent insights and future perspectives. Circ J 74:836-843.
    • (2011) Circ J , vol.74 , pp. 836-843
    • Kawabe, J-.I.1    Ushikubi, F.2    Hasebe, N.3
  • 17
    • 65849268320 scopus 로고    scopus 로고
    • Aspirin in the primary and secondary prevention of vascular disease: Collaborative metaanalysis of individual participant data from randomised trials
    • Antithrombotic Trialists' (ATT Collaboration This recent meta-analysis of data from six primary prevention trials and 16 secondary prevention trials confirms the effectiveness of anti-platelet therapy with aspirin at suppressing atherothrombosis
    • Antithrombotic Trialists' (ATT) Collaboration (2009) Aspirin in the primary and secondary prevention of vascular disease: Collaborative metaanalysis of individual participant data from randomised trials. Lancet 373:1849-1860. This recent meta-analysis of data from six primary prevention trials and 16 secondary prevention trials confirms the effectiveness of anti-platelet therapy with aspirin at suppressing atherothrombosis.
    • (2009) Lancet , vol.373 , pp. 1849-1860
  • 18
    • 34250703278 scopus 로고    scopus 로고
    • Resistance to antiplatelet drugs: Molecular mechanisms and laboratory detection
    • DOI 10.1111/j.1538-7836.2007.02498.x, State of the Art 2007: XXI Congress of the International Society on Thrombosis and Haemostasis
    • Cattaneo M (2011) Resistance to antiplatelet drugs: Molecular mechanisms and laboratory detection. J Thromb Haemost 5 (Suppl 1):230- 237. The author of this recent review provides a useful discussion of the concept, frequency, and clinical consequence of resistance to the anti-platelet drugs aspirin and clopidogrel. (Pubitemid 46958838)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.SUPPL. 1 , pp. 230-237
    • Cattaneo, M.1
  • 19
    • 34447503098 scopus 로고    scopus 로고
    • Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: A systematic review and meta-analysis
    • DOI 10.1001/archinte.167.15.1593
    • Snoep JD, Hovens MMC, Eikenboom JCJ, van der Bom JG, and Huisman MV (2007) Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: A systematic review and meta-analysis. Arch Intern Med 167:1593-1599. (Pubitemid 47280339)
    • (2007) Archives of Internal Medicine , vol.167 , Issue.15 , pp. 1593-1599
    • Snoep, J.D.1    Hovens, M.M.C.2    Eikenboom, J.C.J.3    Van Der Bom, J.G.4    Huisman, M.V.5
  • 20
    • 0030590746 scopus 로고    scopus 로고
    • A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE)
    • CAPRIE Steering Committee The CAPRIE clinical trial reported in this study was the first to establish the effectiveness of clopidogrel as a single-drug therapy for atherothrombosis
    • CAPRIE Steering Committee (1996) A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). Lancet 348:1329-1339. The CAPRIE clinical trial reported in this study was the first to establish the effectiveness of clopidogrel as a single-drug therapy for atherothrombosis.
    • (1996) Lancet , vol.348 , pp. 1329-1339
  • 21
    • 77950635286 scopus 로고    scopus 로고
    • Basic principles of platelet biology and clinical implications
    • Angiolillo DJ, Ueno M, and Goto S (2010) Basic principles of platelet biology and clinical implications. Circ J 74:597-607.
    • (2010) Circ J , vol.74 , pp. 597-607
    • Angiolillo, D.J.1    Ueno, M.2    Goto, S.3
  • 22
    • 0035908781 scopus 로고    scopus 로고
    • Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study
    • DOI 10.1016/S0140-6736(01)05701-4
    • Mehta SR, Yusuf S, Peters RJG, Bertrand ME, Lewis BS, Natarajan MK, Malmberg K, Rupprecht H-J, Zhao F, Chrolavicius S, et al., for the Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators (2001) Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: The PCI-CURE study. Lancet 358:527-533. The PCI-CURE trial reported in this article provided the basis for dual anti-platelet therapy as a means to prevent atherothrombotic events in the context of percutaneous coronary intervention. (Pubitemid 32772726)
    • (2001) Lancet , vol.358 , Issue.9281 , pp. 527-533
    • Mehta, S.R.1    Yusuf, S.2    Peters, R.J.G.3    Bertrand, M.E.4    Lewis, B.S.5    Natarajan, M.K.6    Malmberg, K.7    Rupprecht, H.-J.8    Zhao, F.9    Chrolavicius, S.10    Copland, I.11    Fox, K.A.A.12
  • 24
    • 34447576539 scopus 로고    scopus 로고
    • Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis
    • DOI 10.1016/j.ahj.2007.04.014, PII S0002870307003213
    • Snoep JD, Hovens MMC, Eikenboom JCJ, van der Bom JG, Jukema JW, and Huisman MV (2007) Clopidogrel nonresponsiveness in patients undergoing percutaneous coronary intervention with stenting: A systematic review and meta-analysis. Am Heart J 154:221-231. (Pubitemid 47069129)
    • (2007) American Heart Journal , vol.154 , Issue.2 , pp. 221-231
    • Snoep, J.D.1    Hovens, M.M.C.2    Eikenboom, J.C.J.3    Van Der Bom, J.G.4    Jukema, J.W.5    Huisman, M.V.6
  • 25
    • 33749339075 scopus 로고    scopus 로고
    • Cytochrome P450 2C19 loss-of-function polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects
    • DOI 10.1182/blood-2006-04-013052
    • Hulot J-S, Bura A, Villard E, Azizi M, Remones V, Goyenvalle C, Aiach M, Lechat P, and Gaussem P (2006) Cytochrome P450 2C19 loss-offunction polymorphism is a major determinant of clopidogrel responsiveness in healthy subjects. Blood 108:2244-2247. (Pubitemid 44497506)
    • (2006) Blood , vol.108 , Issue.7 , pp. 2244-2247
    • Hulot, J.-S.1    Bura, A.2    Villard, E.3    Azizi, M.4    Remones, V.5    Goyenvalle, C.6    Aiach, M.7    Lechat, P.8    Gaussem, P.9
  • 27
    • 78049326068 scopus 로고    scopus 로고
    • Reducedfunction CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A metaanalysis
    • This recent meta-analysis of data from nine studies establishes the role of cytochrome P450 2C19 as an important determinant of the clinically relevant responsiveness of patients to clopidogrel therapy
    • Mega JL, Simon T, Collet J-P, Anderson JL, Antman EM, Bliden K, Cannon CP, Danchin N, Giusti B, Gurbel P, et al. (2010) Reducedfunction CYP2C19 genotype and risk of adverse clinical outcomes among patients treated with clopidogrel predominantly for PCI: A metaanalysis. J Am Med Assoc 304:1821-1830. This recent meta-analysis of data from nine studies establishes the role of cytochrome P450 2C19 as an important determinant of the clinically relevant responsiveness of patients to clopidogrel therapy.
    • (2010) J Am Med Assoc , vol.304 , pp. 1821-1830
    • Mega, J.L.1    Simon, T.2    Collet, J-.P.3    Anderson, J.L.4    Antman, E.M.5    Bliden, K.6    Cannon, C.P.7    Danchin, N.8    Giusti, B.9    Gurbel, P.10
  • 29
    • 77958105401 scopus 로고    scopus 로고
    • Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis
    • Mega JL, Close SL, Wiviott SD, Shen L, Walker JR, Simon T, Antman EM, Braunwald E, and Sabatine MS (2010) Genetic variants in ABCB1 and CYP2C19 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: A pharmacogenetic analysis. Lancet 376:1312-1319.
    • (2010) Lancet , vol.376 , pp. 1312-1319
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3    Shen, L.4    Walker, J.R.5    Simon, T.6    Antman, E.M.7    Braunwald, E.8    Sabatine, M.S.9
  • 30
    • 75949128633 scopus 로고    scopus 로고
    • Antiplatelet therapies for the treatment of cardiovascular disease
    • Michelson AD (2010) Antiplatelet therapies for the treatment of cardiovascular disease. Nat Rev Drug Discov 9:154-169.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 154-169
    • Michelson, A.D.1
  • 31
    • 0038797895 scopus 로고    scopus 로고
    • Abciximab: An updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation
    • DOI 10.2165/00003495-200363110-00014
    • Ibbotson T, McGavin JK, and Goa KL (2003) Abciximab: An updated review of its therapeutic use in patients with ischaemic heart disease undergoing percutaneous coronary revascularisation. Drugs 63:1121-1163. (Pubitemid 36700391)
    • (2003) Drugs , vol.63 , Issue.11 , pp. 1121-1163
    • Ibbotson, T.1    McGavin, J.K.2    Goa, K.L.3
  • 32
    • 79952714061 scopus 로고    scopus 로고
    • Targeting the platelet integrin GPIIb/ IIIa
    • Hagemeyer CE and Peter K (2010) Targeting the platelet integrin GPIIb/ IIIa. Curr Pharm Des 16:4119-4133.
    • (2010) Curr Pharm Des , vol.16 , pp. 4119-4133
    • Hagemeyer, C.E.1    Peter, K.2
  • 33
    • 44449175655 scopus 로고    scopus 로고
    • Antiplatelet therapy for secondary prevention of noncardioembolic stroke: A critical review
    • O'Donnell MJ, Hankey GJ, and Eikelboom JW (2008) Antiplatelet therapy for secondary prevention of noncardioembolic stroke: A critical review. Stroke 39:1638-1646.
    • (2008) Stroke , vol.39 , pp. 1638-1646
    • O'Donnell, M.J.1    Hankey, G.J.2    Eikelboom, J.W.3
  • 34
    • 77958527092 scopus 로고    scopus 로고
    • Controversies and future perspectives of antiplatelet therapy in secondary stroke prevention
    • Weber R and Diener H-C (2010) Controversies and future perspectives of antiplatelet therapy in secondary stroke prevention. J Cell Mol Med 14:2371-2380.
    • (2010) J Cell Mol Med , vol.14 , pp. 2371-2380
    • Weber, R.1    Diener, H-.C.2
  • 35
    • 0037335810 scopus 로고    scopus 로고
    • Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: In vitro and in vivo/ex vivo studies
    • DOI 10.1161/01.STR.0000056527.34434.59
    • Aktas B, Utz A, Hoenig-Liedl P, Walter U, and Geiger J (2003) Dipyridamole enhances NO/cGMP-mediated vasodilator-stimulated phosphoprotein phosphorylation and signaling in human platelets: In vitro and in vivo/ex vivo studies. Stroke 34:764-769. (Pubitemid 36307408)
    • (2003) Stroke , vol.34 , Issue.3 , pp. 764-769
    • Aktas, B.1    Utz, A.2    Hoenig-Liedl, P.3    Walter, U.4    Geiger, J.5
  • 36
    • 34250714831 scopus 로고    scopus 로고
    • The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite
    • DOI 10.1111/j.1538-7836.2007.02598.x
    • Sugidachi A, Ogawa T, Kurihara A, Hagihara K, Jakubowski JA, Hashimoto M, Niitsu Y, and Asai F (2007) The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost 5:1545-1551. (Pubitemid 46965386)
    • (2007) Journal of Thrombosis and Haemostasis , vol.5 , Issue.7 , pp. 1545-1551
    • Sugidachi, A.1    Ogawa, T.2    Kurihara, A.3    Hagihara, K.4    Jakubowski, J.A.5    Hashimoto, M.6    Niitsu, Y.7    Asai, F.8
  • 38
    • 70350568827 scopus 로고    scopus 로고
    • New antiplatelet agents: Why they are needed
    • Franchini M and Mannucci PM (2009) New antiplatelet agents: Why they are needed. Eur J Intern Med 20:733-738.
    • (2009) Eur J Intern Med , vol.20 , pp. 733-738
    • Franchini, M.1    Mannucci, P.M.2
  • 39
    • 33646732608 scopus 로고    scopus 로고
    • Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease
    • Jernberg T, Payne CD, Winters KJ, Darstein C, Brandt JT, Jakubowski JA, Naganuma H, Siegbahn A, and Wallentin L (2006) Prasugrel achieves greater inhibition of platelet aggregation and a lower rate of non-responders compared with clopidogrel in aspirin-treated patients with stable coronary artery disease. Eur Heart J 27:1166-1173.
    • (2006) Eur Heart J , vol.27 , pp. 1166-1173
    • Jernberg, T.1    Payne, C.D.2    Winters, K.J.3    Darstein, C.4    Brandt, J.T.5    Jakubowski, J.A.6    Naganuma, H.7    Siegbahn, A.8    Wallentin, L.9
  • 40
    • 33748680917 scopus 로고    scopus 로고
    • Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38)
    • DOI 10.1016/j.ahj.2006.04.012, PII S0002870306003486
    • Wiviott SD, Antman EM, Gibson CM, Montalescot G, Riesmeyer J, Weerakkody G, Winters KJ, Warmke JW, McCabe CH, and Braunwald E, for the TRITON-TIMI 38 Investigators (2006) Evaluation of prasugrel compared with clopidogrel in patients with acute coronary syndromes: Design and rationale for the TRial to assess Improvement in Therapeutic Outcomes by optimizing platelet InhibitioN with prasugrel Thrombolysis In Myocardial Infarction 38 (TRITON-TIMI 38). Am Heart J 152:627-635. (Pubitemid 44396884)
    • (2006) American Heart Journal , vol.152 , Issue.4 , pp. 627-635
    • Wiviott, S.D.1    Antman, E.M.2    Gibson, C.M.3    Montalescot, G.4    Riesmeyer, J.5    Weerakkody, G.6    Winters, K.J.7    Warmke, J.W.8    McCabe, C.H.9    Braunwald, E.10
  • 43
    • 42149119040 scopus 로고    scopus 로고
    • Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: A subanalysis of a randomised trial
    • for the TRITON-TIMI 38 Investigators Follow-up data analysis in this article describes the remarkable reduction in stent thrombosis in patients receiving prasugrel in the TRITON-TIMI 38 clinical trial
    • Wiviott SD, Braunwald E, McCabe CH, Horvath I, Keltai M, Herrman J-PR, Van de Werf F, Downey WE, Scirica BM, Murphy SA, et al., for the TRITON-TIMI 38 Investigators (2008) Intensive oral antiplatelet therapy for reduction of ischaemic events including stent thrombosis in patients with acute coronary syndromes treated with percutaneous coronary intervention and stenting in the TRITON-TIMI 38 trial: A subanalysis of a randomised trial. Lancet 371:1353-1363. Follow-up data analysis in this article describes the remarkable reduction in stent thrombosis in patients receiving prasugrel in the TRITON-TIMI 38 clinical trial.
    • (2008) Lancet , vol.371 , pp. 1353-1363
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3    Horvath, I.4    Keltai, M.5    Herrman, J.-P.R.6    Van De Werf, F.7    Downey, W.E.8    Scirica, B.M.9    Murphy, S.A.10
  • 44
    • 55949103494 scopus 로고    scopus 로고
    • Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel - thrombolysis in myocardial infarction 38
    • for the TRITON-TIMI 38 Investigators This report establishes the particular effectiveness of prasugrel at suppressing atherothrombosis in patients with diabetes mellitus; it is also based on further analysis of data from the TRITON-TIMI 38 trial
    • Wiviott SD, Braunwald E, Angiolillo DJ, Meisel S, Dalby AJ, Verheugt FWA, Goodman SG, Corbalan R, Purdy DA, Murphy SA, et al., for the TRITON-TIMI 38 Investigators (2008) Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel - thrombolysis in myocardial infarction 38. Circulation 118:1626-1636. This report establishes the particular effectiveness of prasugrel at suppressing atherothrombosis in patients with diabetes mellitus; it is also based on further analysis of data from the TRITON-TIMI 38 trial.
    • (2008) Circulation , vol.118 , pp. 1626-1636
    • Wiviott, S.D.1    Braunwald, E.2    Angiolillo, D.J.3    Meisel, S.4    Dalby, A.J.5    Verheugt, F.W.A.6    Goodman, S.G.7    Corbalan, R.8    Purdy, D.A.9    Murphy, S.A.10
  • 45
    • 77954182060 scopus 로고    scopus 로고
    • Prasugrel as a potential cancer promoter: Review of the unpublished data
    • Floyd JS and Serebruany VL (2010) Prasugrel as a potential cancer promoter: Review of the unpublished data. Arch Intern Med 170:1078-1080.
    • (2010) Arch Intern Med , vol.170 , pp. 1078-1080
    • Floyd, J.S.1    Serebruany, V.L.2
  • 47
    • 77955868263 scopus 로고    scopus 로고
    • Novel antiplatelet agents in the prevention of cardiovascular complications - focus on ticagrelor
    • Marczewski MM, Postula M, and Kosior D (2010) Novel antiplatelet agents in the prevention of cardiovascular complications - focus on ticagrelor. Vasc Health Risk Manag 6:419-429.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 419-429
    • Marczewski, M.M.1    Postula, M.2    Kosior, D.3
  • 48
    • 79952048493 scopus 로고    scopus 로고
    • Ticagrelor: An investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome
    • Abergel E and Nikolsky E (2010) Ticagrelor: An investigational oral antiplatelet treatment for reduction of major adverse cardiac events in patients with acute coronary syndrome. Vasc Health Risk Manag 6:963-977.
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 963-977
    • Abergel, E.1    Nikolsky, E.2
  • 49
    • 33646261670 scopus 로고    scopus 로고
    • Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin
    • Husted S, Emanuelsson H, Heptinstall S, Sandset PM, Wickens M, and Peters G (2006) Pharmacodynamics, pharmacokinetics, and safety of the oral reversible P2Y12 antagonist AZD6140 with aspirin in patients with atherosclerosis: A double-blind comparison to clopidogrel with aspirin. Eur Heart J 27:1038-1047.
    • (2006) Eur Heart J , vol.27 , pp. 1038-1047
    • Husted, S.1    Emanuelsson, H.2    Heptinstall, S.3    Sandset, P.M.4    Wickens, M.5    Peters, G.6
  • 50
    • 62949141274 scopus 로고    scopus 로고
    • Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial
    • James S, Åkerblom A, Cannon CP, Emanuelsson H, Husted S, Katus H, Skene A, Steg PG, Storey RF, Harrington R, et al. (2009) Comparison of ticagrelor, the first reversible oral P2Y12 receptor antagonist, with clopidogrel in patients with acute coronary syndromes: Rationale, design and baseline characteristics of the PLATelet inhibition and patient Outcomes (PLATO) trial. Am Heart J 157:599-605.
    • (2009) Am Heart J , vol.157 , pp. 599-605
    • James, S.A.1    Kerblom, A.2    Cannon, C.P.3    Emanuelsson, H.4    Husted, S.5    Katus, H.6    Skene, A.7    Steg, P.G.8    Storey, R.F.9    Harrington, R.10
  • 51
    • 70149101223 scopus 로고    scopus 로고
    • Ticagrelor versus clopidogrel in patients with acute coronary syndromes
    • for the PLATO Investigators This article reports the findings of the PLATO clinical trial, which established the effectiveness of ticagrelor as an anti-platelet agent in patients with acute coronary syndrome and led to its approval by the European Commission
    • Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, Horrow J, Husted S, James S, Katus H, et al., for the PLATO Investigators (2009) Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 361:1045-1057. This article reports the findings of the PLATO clinical trial, which established the effectiveness of ticagrelor as an anti-platelet agent in patients with acute coronary syndrome and led to its approval by the European Commission.
    • (2009) N Engl J Med , vol.361 , pp. 1045-1057
    • Wallentin, L.1    Becker, R.C.2    Budaj, A.3    Cannon, C.P.4    Emanuelsson, H.5    Held, C.6    Horrow, J.7    Husted, S.8    James, S.9    Katus, H.10
  • 52
    • 79751525043 scopus 로고    scopus 로고
    • Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding ticagrelor
    • Gaglia MA and Waksman R (2011) Overview of the 2010 Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee meeting regarding ticagrelor. Circulation 123:451-456.
    • (2011) Circulation , vol.123 , pp. 451-456
    • Gaglia, M.A.1    Waksman, R.2
  • 53
    • 0035085132 scopus 로고    scopus 로고
    • 2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes
    • Storey RF, Oldroyd KG, and Wilcox RG (2001) Open multicentre study of the P2T receptor antagonist AR-C69931MX assessing safety, tolerability and activity in patients with acute coronary syndromes. Thromb Haemost 85:401-407. (Pubitemid 32233008)
    • (2001) Thrombosis and Haemostasis , vol.85 , Issue.3 , pp. 401-407
    • Storey, R.F.1    Oldroyd, K.G.2    Wilcox, R.G.3
  • 56
    • 77954510334 scopus 로고    scopus 로고
    • Elinogrel: Pharmacological principles, preclinical and early phase clinical testing
    • Ueno M, Rao SV, and Angiolillo DJ (2011) Elinogrel: Pharmacological principles, preclinical and early phase clinical testing. Future Cardiol 6:445-453.
    • (2011) Future Cardiol , vol.6 , pp. 445-453
    • Ueno, M.1    Rao, S.V.2    Angiolillo, D.J.3
  • 57
    • 77955677366 scopus 로고    scopus 로고
    • Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y12-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI)
    • Leonardi S, Rao SV, Harrington RA, Bhatt DL, Gibson CM, Roe MT, Kochman J, Huber K, Zeymer U, Madan M, et al. (2010) Rationale and design of the randomized, double-blind trial testing INtraveNous and Oral administration of elinogrel, a selective and reversible P2Y12-receptor inhibitor, versus clopidogrel to eVAluate Tolerability and Efficacy in nonurgent Percutaneous Coronary Interventions patients (INNOVATE-PCI). Am Heart J 160:65-72.
    • (2010) Am Heart J , vol.160 , pp. 65-72
    • Leonardi, S.1    Rao, S.V.2    Harrington, R.A.3    Bhatt, D.L.4    Gibson, C.M.5    Roe, M.T.6    Kochman, J.7    Huber, K.8    Zeymer, U.9    Madan, M.10
  • 59
    • 48049095007 scopus 로고    scopus 로고
    • Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization
    • Post JM, Alexander S, Wang Y-X, Vincelette J, Vergona R, Kent L, Bryant J, Sullivan ME, Dole WP, Morser J, et al. (2008) Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): Pharmacodynamic and pharmacokinetic characterization. Thromb Res 122:533-540.
    • (2008) Thromb Res , vol.122 , pp. 533-540
    • Post, J.M.1    Alexander, S.2    Wang, Y-.X.3    Vincelette, J.4    Vergona, R.5    Kent, L.6    Bryant, J.7    Sullivan, M.E.8    Dole, W.P.9    Morser, J.10
  • 62
    • 33845715319 scopus 로고    scopus 로고
    • Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders
    • DOI 10.1111/j.1527-3466.2006.00148.x
    • Gresele P and Momi S (2006) Pharmacologic profile and therapeutic potential of NCX 4016, a nitric oxide-releasing aspirin, for cardiovascular disorders. Cardiovasc Drug Rev 24:148-168. (Pubitemid 46696922)
    • (2006) Cardiovascular Drug Reviews , vol.24 , Issue.2 , pp. 148-168
    • Gresele, P.1    Momi, S.2
  • 63
    • 34247160029 scopus 로고    scopus 로고
    • Nitric oxide-releasing aspirin: Will it say NO to atherothrombosis?
    • DOI 10.1016/j.ijcard.2006.08.002, PII S0167527306007790
    • Antoniades C, Tousoulis D, and Stefanadis C (2007) Nitric oxidereleasing aspirin: Will it say NO to atherothrombosis? Int J Cardiol 118:170-172. (Pubitemid 46601645)
    • (2007) International Journal of Cardiology , vol.118 , Issue.2 , pp. 170-172
    • Antoniades, C.1    Tousoulis, D.2    Stefanadis, C.3
  • 64
    • 15444374171 scopus 로고    scopus 로고
    • Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice
    • DOI 10.1160/TH04-07-0464
    • Momi S, Pitchford SC, Alberti PF, Minuz P, Del Soldato P, and Gresele P (2005) Nitroaspirin plus clopidogrel versus aspirin plus clopidogrel against platelet thromboembolism and intimal thickening in mice. Thromb Haemost 93:535-543. (Pubitemid 40394142)
    • (2005) Thrombosis and Haemostasis , vol.93 , Issue.3 , pp. 535-543
    • Momi, S.1    Pitchford, S.C.2    Alberti, P.F.3    Minuz, P.4    Del Soldato, P.5    Gresele, P.6
  • 65
    • 33947323564 scopus 로고    scopus 로고
    • Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication
    • DOI 10.1160/TH06-10-0555
    • Gresele P, Migliacci R, Procacci A, De Monte P, and Bonizzoni E (2007) Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudication. Thromb Haemost 97:444-450. (Pubitemid 46437807)
    • (2007) Thrombosis and Haemostasis , vol.97 , Issue.3 , pp. 444-450
    • Gresele, P.1    Migliacci, R.2    Procacci, A.3    De Monte, P.4    Bonizzoni, E.5
  • 66
    • 77950522051 scopus 로고    scopus 로고
    • Platelet function and isoprostane biology: Should isoprostanes be the newest member of the orphan ligand family?
    • Ting HJ and Khasawneh FT (2010) Platelet function and isoprostane biology: Should isoprostanes be the newest member of the orphan ligand family? J Biomed Sci 17:24.
    • (2010) J Biomed Sci , vol.17 , pp. 24
    • Ting, H.J.1    Khasawneh, F.T.2
  • 67
    • 0028140168 scopus 로고
    • Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction: The Ridogrel versus Aspirin Patency Trial (RAPT)
    • The RAPT Investigators
    • The RAPT Investigators (1994) Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction: The Ridogrel versus Aspirin Patency Trial (RAPT). Circulation 89:588-595.
    • (1994) Circulation , vol.89 , pp. 588-595
  • 68
    • 33751162130 scopus 로고    scopus 로고
    • Preclinical evaluation of S18886 in an experimental model of coronary arterial thrombosis
    • Hong T-T, Huang J, Driscoll E, and Lucchesi BR (2006) Preclinical evaluation of S18886 in an experimental model of coronary arterial thrombosis. J Cardiovasc Pharmacol 48:239-248.
    • (2006) J Cardiovasc Pharmacol , vol.48 , pp. 239-248
    • Hong, T-.T.1    Huang, J.2    Driscoll, E.3    Lucchesi, B.R.4
  • 69
    • 34548694091 scopus 로고    scopus 로고
    • 2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis
    • DOI 10.1160/TH07-04-0272
    • Vilahur G, Casani L, and Badimon L (2007) A thromboxane A2/prostaglandin H2 receptor antagonist (S18886) shows high antithrombotic efficacy in an experimental model of stent-induced thrombosis. Thromb Haemost 98:662-669. (Pubitemid 47412894)
    • (2007) Thrombosis and Haemostasis , vol.98 , Issue.3 , pp. 662-669
    • Vilahur, G.1    Casani, L.2    Badimon, L.3
  • 70
    • 0037414069 scopus 로고    scopus 로고
    • 2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin
    • DOI 10.1016/S0735-1097(03)00048-2
    • Belhassen L, Pelle G, Dubois-Rande J-L, and Adnot S (2003) Improved endothelial function by the thromboxane A2 receptor antagonist S 18886 in patients with coronary artery disease treated with aspirin. J Am Coll Cardiol 41:1198-1204. (Pubitemid 36384909)
    • (2003) Journal of the American College of Cardiology , vol.41 , Issue.7 , pp. 1198-1204
    • Belhassen, L.1    Pelle, G.2    Dubois-Rande, J.-L.3    Adnot, S.4
  • 71
    • 70049118536 scopus 로고    scopus 로고
    • Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke
    • Bal dit Sollier C, Crassard I, Simoneau G, Bergmann JF, Bousser MG, and Drouet L (2009) Effect of the thromboxane prostaglandin receptor antagonist terutroban on arterial thrombogenesis after repeated administration in patients treated for the prevention of ischemic stroke. Cerebrovasc Dis 28:505-513.
    • (2009) Cerebrovasc Dis , vol.28 , pp. 505-513
    • Bal Dit Sollier, C.1    Crassard, I.2    Simoneau, G.3    Bergmann, J.F.4    Bousser, M.G.5    Drouet, L.6
  • 72
    • 64549164466 scopus 로고    scopus 로고
    • Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/ day in stroke patients: The prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study
    • PERFORM Study Investigators
    • Bousser MG, Amarenco P, Chamorro A, Fisher M, Ford I, Fox K, Hennerici MG, Mattle HP, Rothwell PM, and PERFORM Study Investigators (2009) Rationale and design of a randomized, double-blind, parallel-group study of terutroban 30 mg/day versus aspirin 100 mg/ day in stroke patients: The prevention of cerebrovascular and cardiovascular events of ischemic origin with terutroban in patients with a history of ischemic stroke or transient ischemic attack (PERFORM) study. Cerebrovasc Dis 27:509-518.
    • (2009) Cerebrovasc Dis , vol.27 , pp. 509-518
    • Bousser, M.G.1    Amarenco, P.2    Chamorro, A.3    Fisher, M.4    Ford, I.5    Fox, K.6    Hennerici, M.G.7    Mattle, H.P.8    Rothwell, P.M.9
  • 73
    • 76949098047 scopus 로고    scopus 로고
    • Repurposing an old drug for a new use: Glybenclamide exerts antiplatelet activity by interacting with the thromboxane A2 receptor
    • Ting HJ, Murray WJ, and Khasawneh FT (2010) Repurposing an old drug for a new use: Glybenclamide exerts antiplatelet activity by interacting with the thromboxane A2 receptor. Acta Pharmacol Sin 31:150-159.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 150-159
    • Ting, H.J.1    Murray, W.J.2    Khasawneh, F.T.3
  • 74
    • 73949157474 scopus 로고    scopus 로고
    • Platelet thrombin receptor antagonism and atherothrombosis
    • Angiolillo DJ, Capodanno D, and Goto S (2010) Platelet thrombin receptor antagonism and atherothrombosis. Eur Heart J 31:17-28.
    • (2010) Eur Heart J , vol.31 , pp. 17-28
    • Angiolillo, D.J.1    Capodanno, D.2    Goto, S.3
  • 75
    • 79955682088 scopus 로고    scopus 로고
    • Vascular PAR-1: Activity and antagonism
    • Epub ahead of print, doi: 10.1111/j.1755-5922.2010.00140.x
    • Lang NN, Guomundsdóttir IJ, and Newby DE (2010) Vascular PAR-1: Activity and antagonism. Cardiovasc Ther. Epub ahead of print, doi: 10.1111/j.1755-5922.2010.00140.x
    • (2010) Cardiovasc Ther
    • Lang, N.N.1    Guomundsdóttir, I.J.2    Newby, D.E.3
  • 76
    • 84870243949 scopus 로고    scopus 로고
    • Protease-activated receptor-1 antagonists: Focus on SCH 530348
    • Epub ahead of print, doi: 10.1097/MJT.0b013e3181ff7c16
    • Sugunaraj JP, Mehta V, Kalra A, Sukhija R, and Palaniswamy C (2011) Protease-activated receptor-1 antagonists: Focus on SCH 530348. Am J Ther. Epub ahead of print, doi: 10.1097/MJT.0b013e3181ff7c16
    • (2011) Am J Ther.
    • Sugunaraj, J.P.1    Mehta, V.2    Kalra, A.3    Sukhija, R.4    Palaniswamy, C.5
  • 77
    • 61849180442 scopus 로고    scopus 로고
    • Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study
    • for the TRA-PCI Investigators The phase 2 trial reported in this article established the safety of vorapaxar as a potential new approach for anti-platelet therapy in patients undergoing percutaneous coronary intervention
    • Becker RC, Moliterno DJ, Jennings LK, Pieper KS, Pei J, Niederman A, Ziada KM, Berman G, Strony J, Joseph D, et al., for the TRA-PCI Investigators (2009) Safety and tolerability of SCH 530348 in patients undergoing non-urgent percutaneous coronary intervention: A randomised, double-blind, placebo-controlled phase II study. Lancet 373:919-928. The phase 2 trial reported in this article established the safety of vorapaxar as a potential new approach for anti-platelet therapy in patients undergoing percutaneous coronary intervention.
    • (2009) Lancet , vol.373 , pp. 919-928
    • Becker, R.C.1    Moliterno, D.J.2    Jennings, L.K.3    Pieper, K.S.4    Pei, J.5    Niederman, A.6    Ziada, K.M.7    Berman, G.8    Strony, J.9    Joseph, D.10
  • 78
    • 67749086022 scopus 로고    scopus 로고
    • The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease
    • Serebruany VL, Kogushi M, Dastros-Pitei D, Flather M, and Bhatt DL (2009) The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb Haemost 102:111-119.
    • (2009) Thromb Haemost , vol.102 , pp. 111-119
    • Serebruany, V.L.1    Kogushi, M.2    Dastros-Pitei, D.3    Flather, M.4    Bhatt, D.L.5
  • 79
    • 78149355554 scopus 로고    scopus 로고
    • Double-blind, placebo-controlled phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or highrisk coronary artery disease
    • on behalf of the J-LANCELOT (Japanese-Lesson from Antagonizing the Cellular Effect of Thrombin) Investigators
    • Goto S, Ogawa H, Takeuchi M, Flather MD, and Bhatt DL, on behalf of the J-LANCELOT (Japanese-Lesson from Antagonizing the Cellular Effect of Thrombin) Investigators (2010) Double-blind, placebo-controlled phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or highrisk coronary artery disease. Eur Heart J 31:2601-2613.
    • (2010) Eur Heart J , vol.31 , pp. 2601-2613
    • Goto, S.1    Ogawa, H.2    Takeuchi, M.3    Flather, M.D.4    Bhatt, D.L.5
  • 80
    • 6944222950 scopus 로고    scopus 로고
    • 2A receptor and its antagonists in the cardiovascular system
    • DOI 10.1016/j.pharmthera.2004.08.005, PII S016372580400107X
    • Nagatomo T, Rashid M, Muntasir HA, and Komiyama T (2004) Functions of 5-HT2A receptor and its antagonists in the cardiovascular system. Pharmacol Ther 104:59-81. (Pubitemid 39410563)
    • (2004) Pharmacology and Therapeutics , vol.104 , Issue.1 , pp. 59-81
    • Nagatomo, T.1    Rashid, M.2    Abul Muntasir, H.3    Komiyama, T.4
  • 81
    • 33746530099 scopus 로고    scopus 로고
    • 2a receptor antagonist in intermittent claudication. A Phase II European study
    • DOI 10.1191/1358863x06vm657oa
    • Norgren L, Jawien A, Mátyás L, Rieger H, Arita K, and the European MCI-9042 Study Group (2006) Sarpogrelate, a 5-HT2A receptor antagonist in intermittent claudication: A phase II European study. Vasc Med 11:75-83. (Pubitemid 44130375)
    • (2006) Vascular Medicine , vol.11 , Issue.2 , pp. 75-83
    • Norgren, L.1    Jawien, A.2    Matyas, L.3    Rieger, H.4    Arita, K.5
  • 82
    • 46249118961 scopus 로고    scopus 로고
    • Sarpogrelate-aspirin comparative clinical study for efficacy and safety in secondary prevention of cerebral infarction (S-ACCESS): A randomized, double-blind, aspirin-controlled trial
    • for the S-ACCESS Study Group
    • Shinohara Y, Nishimaru K, Sawada T, Terashi A, Handa S, Hirai S, Hayashi K, Tohgi H, Fukuuchi Y, Uchiyama S, et al., for the S-ACCESS Study Group (2008) Sarpogrelate-aspirin comparative clinical study for efficacy and safety in secondary prevention of cerebral infarction (S-ACCESS): A randomized, double-blind, aspirin-controlled trial. Stroke 39:1827-1833.
    • (2008) Stroke , vol.39 , pp. 1827-1833
    • Shinohara, Y.1    Nishimaru, K.2    Sawada, T.3    Terashi, A.4    Handa, S.5    Hirai, S.6    Hayashi, K.7    Tohgi, H.8    Fukuuchi, Y.9    Uchiyama, S.10
  • 83
    • 68749112764 scopus 로고    scopus 로고
    • Sarpogrelate versus aspirin in secondary prevention of cerebral infarction: Differential efficacy in diabetes? Subgroup analysis from S-ACCESS
    • for the S-ACCESS Study Group The subgroup analysis of data from the S-ACCESS trial reported in this article suggests that sarpogrelate might be more effective than aspirin for secondary prevention of stroke
    • Shinohara Y and Nishimaru K, for the S-ACCESS Study Group (2009) Sarpogrelate versus aspirin in secondary prevention of cerebral infarction: Differential efficacy in diabetes? Subgroup analysis from S-ACCESS. Stroke 40:2862-2865. The subgroup analysis of data from the S-ACCESS trial reported in this article suggests that sarpogrelate might be more effective than aspirin for secondary prevention of stroke.
    • (2009) Stroke , vol.40 , pp. 2862-2865
    • Shinohara, Y.1    Nishimaru, K.2
  • 84
    • 70349338807 scopus 로고    scopus 로고
    • APD791, 3-methoxy- N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy) phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: Pharmacological profile, pharmacokinetics, platelet activity and vascular biology
    • Adams JW, Ramirez J, Shi Y, Thomsen W, Frazer J, Morgan M, Edwards JE, Chen W, Teegarden BR, Xiong Y, et al. (2009) APD791, 3-methoxy- N-(3-(1-methyl-1H-pyrazol-5-yl)-4-(2-morpholinoethoxy)phenyl)benzamide, a novel 5-hydroxytryptamine 2A receptor antagonist: Pharmacological profile, pharmacokinetics, platelet activity and vascular biology. J Pharmacol Exp Ther 331:96-103.
    • (2009) J Pharmacol Exp Ther , vol.331 , pp. 96-103
    • Adams, J.W.1    Ramirez, J.2    Shi, Y.3    Thomsen, W.4    Frazer, J.5    Morgan, M.6    Edwards, J.E.7    Chen, W.8    Teegarden, B.R.9    Xiong, Y.10
  • 85
    • 42249105887 scopus 로고    scopus 로고
    • Platelet GPIb complex as a target for anti-thrombotic drug development
    • DOI 10.1160/TH07-12-0718
    • Clemetson KJ and Clemetson JM (2008) Platelet GPIb complex as a target for anti-thrombotic drug development. Thromb Haemost 99:473-479. (Pubitemid 351549283)
    • (2008) Thrombosis and Haemostasis , vol.99 , Issue.3 , pp. 473-479
    • Clemetson, K.J.1    Clemetson, J.M.2
  • 86
    • 77954742078 scopus 로고    scopus 로고
    • Platelet-vessel wall interaction in health and disease
    • Löwenberg EC, Meijers JCM, and Levi M (2010) Platelet-vessel wall interaction in health and disease. Neth J Med 68:242-251.
    • (2010) Neth J Med , vol.68 , pp. 242-251
    • Löwenberg, E.C.1    Meijers, J.C.M.2    Levi, M.3
  • 87
    • 78649677591 scopus 로고    scopus 로고
    • Targeting von Willebrand factor and platelet glycoprotein Ib receptor
    • Firbas C, Siller-Matula JM, and Jilma B (2010) Targeting von Willebrand factor and platelet glycoprotein Ib receptor. Expert Rev Cardiovasc Ther 8:1689-1701.
    • (2010) Expert Rev Cardiovasc Ther , vol.8 , pp. 1689-1701
    • Firbas, C.1    Siller-Matula, J.M.2    Jilma, B.3
  • 90
    • 70449429345 scopus 로고    scopus 로고
    • The development of nanobodies for therapeutic applications
    • Van Bockstaele F, Holz JB, and Revets H (2009) The development of nanobodies for therapeutic applications. Curr Opin Investig Drugs 10:1212-1224.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 1212-1224
    • Van Bockstaele, F.1    Holz, J.B.2    Revets, H.3
  • 91
    • 76549094772 scopus 로고    scopus 로고
    • Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases
    • Siller-Matula JM, Krumphuber J, and Jilma B (2010) Pharmacokinetic, pharmacodynamic and clinical profile of novel antiplatelet drugs targeting vascular diseases. Br J Pharmacol 159:502-517.
    • (2010) Br J Pharmacol , vol.159 , pp. 502-517
    • Siller-Matula, J.M.1    Krumphuber, J.2    Jilma, B.3
  • 95
    • 33847344290 scopus 로고    scopus 로고
    • 1 and von Willebrand factor binding to collagen
    • DOI 10.1111/j.1742-4658.2007.05689.x
    • White TC, Berny MA, Robinson DK, Yin H, DeGrado WF, Hanson SR, and McCarty OJ (2007) The leech product saratin is a potent inhibitor of platelet integrin a2ß1 and von Willebrand factor binding to collagen. FEBS J 274:1481-1491. (Pubitemid 46333741)
    • (2007) FEBS Journal , vol.274 , Issue.6 , pp. 1481-1491
    • White, T.C.1    Berny, M.A.2    Robinson, D.K.3    Yin, H.4    DeGrado, W.F.5    Hanson, S.R.6    McCarty, O.J.T.7
  • 96
    • 70349664622 scopus 로고    scopus 로고
    • Novel antiplatelet agents in development: Prasugrel, ticagrelor, and cangrelor and beyond
    • Shalito I, Kopyleva O, and Serebruany V (2009) Novel antiplatelet agents in development: Prasugrel, ticagrelor, and cangrelor and beyond. Am J Ther 16:451-458.
    • (2009) Am J Ther , vol.16 , pp. 451-458
    • Shalito, I.1    Kopyleva, O.2    Serebruany, V.3
  • 97
    • 79952432680 scopus 로고    scopus 로고
    • PR-15 a novel intravenous inhibitor of platelet adhesion: A phase I dose ascending pharmacokinetic, pharmacodynamic, and tolerance study
    • P-T-683 (abstract)
    • Combe S, Rosport K, and Kennedy A (2007) PR-15 a novel intravenous inhibitor of platelet adhesion: A phase I dose ascending pharmacokinetic, pharmacodynamic, and tolerance study. J Thromb Haemost 5 (Suppl 2):P-T-683 (abstract).
    • (2007) J Thromb Haemost , vol.5 , Issue.SUPPL. 2
    • Combe, S.1    Rosport, K.2    Kennedy, A.3
  • 99
    • 78751550507 scopus 로고    scopus 로고
    • PI3K inhibitors in cardiovascular disease
    • Eisenreich A and Rauch U (2011) PI3K inhibitors in cardiovascular disease. Cardiovasc Ther 29:29-36.
    • (2011) Cardiovasc Ther , vol.29 , pp. 29-36
    • Eisenreich, A.1    Rauch, U.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.