A retinoic acid-rich tumor microenvironment provides clonal survival cues for tumor-specific CD8+ T cells

Cancer Research

Volumn 72, Issue 20, 2012, Pages 5230-5239

  Guo, Yanxia ^a   Pino Lagos, Karina ^a   Ahonen, Cory A ^a   Bennett, Kathy A ^a   Wang, Jinshan ^c   Napoli, Joseph L ^c   Blomhoff, Rune ^e   Sockanathan, Shanthini ^f   Chandraratna, Roshantha A ^d   Dmitrovsky, Ethan ^b   Turk, Mary Jo ^a   Noelle, Randolph J ^a,g  

^a NORRIS COTTON CANCER CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d IO Therapeutics   (United States)

^e UNIVERSITY OF OSLO   (Norway)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^g GUY S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; CD8 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CELL SURVIVAL; IN VIVO STUDY; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TISSUE SPECIFICITY; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT;

ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; MICE; MICE, INBRED C57BL; SIGNAL TRANSDUCTION; TRETINOIN; TUMOR MICROENVIRONMENT;

EID: 84867501402     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1727     Document Type: Article

References (26)

1. Casci T. Functional genomics: an array of bacterial interactions. Nat Rev Genet 2008;9:652.
2. Niederreither K, Dolle P. Retinoic acid in development: towards an integrated view. Nat Rev Genet 2008;9:541-53. (Pubitemid 351861538)
3. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song SY. Retinoic acid imprints gut-homing speci ficity on T cells. Immunity 2004;21:527-38. (Pubitemid 39370508)
4. + T cells. Mucosal Immunol 2008;1:38-48.
5. Eksteen B, Mora JR, Haughton EL, Henderson NC, Lee-Turner L, Villablanca EJ, et al. Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells. Gastroenterology 2009;137:320-9.
6. Mora JR, Iwata M, Eksteen B, Song SY, Junt T, Senman B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science 2006;314:1157-60. (Pubitemid 44789048)
7. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, Mora JR, et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 2007;204:1775-85. (Pubitemid 47236316)
8. Benson MJ, Pino-Lagos K, Rosemblatt M, Noelle RJ. All-trans retinoic acid mediates enhanced Treg cell growth, differentiation, and gut homing in the face of high levels of co-stimulation. J Exp Med 2007;204:1765-74. (Pubitemid 47236315)
9. Mucida D, Park Y, Kim G, Turovskaya O, Scott I, Kronenberg M, et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 2007;317:256-60. (Pubitemid 47076203)
10. Hall JA, Cannons JL, Grainger JR, Dos Santos LM, Hand TW, Naik S, et al. Essential role for retinoic acid in the promotion of CD4(+) T cell effector responses via retinoic acid receptor alpha. Immunity 2011;34:435-47.
11. + T cell-mediated immunity. J Exp Med 2011;208:1767-75.
12. Kusmartsev S, Cheng F, Yu B, Nefedova Y, Sotomayor E, Lush RM, et al. All-trans-retinoic acid eliminates immature myeloid cells from tumor-bearing mice and improves the effect of vaccination. Cancer Res 2003;63:4441-9. (Pubitemid 36951016)
13. Mirza N, Fishman M, Fricke I, Dunn M, Neuger AM, Frost TJ, et al. All-trans-retinoic acid improves differentiation of myeloid cells and immune response in cancer patients. Cancer Res 2006;66:9299-307. (Pubitemid 44521152)
14. Rosenberg SA, Yang JC, Restifo NP. Cancer immunotherapy: moving beyond current vaccines. Nat Med 2004;10:909-15. (Pubitemid 39273730)
15. Rajaii F, Bitzer ZT, Xu Q, Sockanathan S. Expression of the dominant negative retinoid receptor, RAR403, alters telencephalic progenitor proliferation, survival, and cell fate specification. Dev Biol 2008;316:371-82.
16. + regulatory T cells. Proc Natl Acad Sci U S A 2008;105:9331-6.
17. Kane MA, Folias AE, Wang C, Napoli JL. Quantitative profiling of endogenous retinoic acid in vivo and in vitro by tandem mass spectrometry. Anal Chem 2008;80:1702-8. (Pubitemid 351429576)
18. Yokota A, Takeuchi H, Maeda N, Ohoka Y, Kato C, Song SY, et al. GM-CSF and IL-4 synergistically trigger dendritic cells to acquire retinoic acid-producing capacity. Int Immunol 2009;21:361-77.
19. + T cell expansion with variable dependence on type I IFN. J Exp Med 2004;199:775-84.
20. Turk MJ, Guevara-Patino JA, Rizzuto GA, Engelhorn ME, Sakaguchi S, Houghton AN. Concomitant tumor immunity to a poorly immunogenic melanoma is prevented by regulatory T cells. J Exp Med 2004;200:771-82. (Pubitemid 39299463)
21. + T cell precursor frequency regulates primary and memory responses to infection. Immunity 2008;28:859-69.
22. Guilliams M, Crozat K, Henri S, Tamoutounour S, Grenot P, Devilard E, et al. Skin-draining lymph nodes contain dermis-derived CD103(-) dendritic cells that constitutively produce retinoic acid and induce Foxp3(+) regulatory T cells. Blood 2010;115:1958-68.
23. Chambon P. A decade of molecular biology of retinoic acid receptors. FASEB J 1996;10:940-54. (Pubitemid 26285969)
24. Zhang P, Cote AL, de Vries VC, Usherwood EJ, Turk MJ. Induction of postsurgical tumor immunity and T-cell memory by a poorly immunogenic tumor. Cancer Res 2007;67:6468-76. (Pubitemid 47037532)
25. Engedal N, Ertesvag A, Blomhoff HK. Survival of activated human T lymphocytes is promoted by retinoic acid via induction of IL-2. Int Immunol 2004;16:443-53. (Pubitemid 38313153)
26. Ertesvag A, Austenaa LM, Carlsen H, Blomhoff R, Blomhoff HK. Retinoic acid inhibits in vivo interleukin-2 gene expression and T-cell activation in mice. Immunology 2009;126:514-22.