Silencing of MicroRNA-21 Confers Radio-Sensitivity through Inhibition of the PI3K/AKT Pathway and Enhancing Autophagy in Malignant Glioma Cell Lines

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Gwak, Ho Shin ^a   Kim, Tae Hoon ^a   Jo, Guk Heui ^a   Kim, Youn Jae ^a   Kwak, Hee Jin ^a   Kim, Jong Heon ^a   Yin, Jinlong ^a   Yoo, Heon ^a   Lee, Seung Hoon ^a   Park, Jong Bae ^a  

^a National Cancer Center   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

DOUBLE STRANDED DNA; HISTONE H2AX; MICRORNA 21; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL CYCLE ARREST; CELL ORGANELLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; ENZYME INHIBITION; G2 PHASE CELL CYCLE CHECKPOINT; GAMMA IRRADIATION; GENE OVEREXPRESSION; GENE SILENCING; GLIOBLASTOMA; HUMAN; HUMAN CELL; PHASE TRANSITION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RADIOSENSITIVITY; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

APOPTOSIS; AUTOPHAGY; BRAIN NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; GAMMA RAYS; GENE SILENCING; GLIOMA; HISTONES; HUMANS; MICRORNAS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RADIATION TOLERANCE; SIGNAL TRANSDUCTION;

EID: 84867500470     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047449     Document Type: Article

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