Identification of NAE inhibitors exhibiting potent activity in leukemia cells: Exploring the structural determinants of NAE specificity

ACS Medicinal Chemistry Letters

Volumn 2, Issue 8, 2011, Pages 577-582

  Lukkarila, Julie L ^a   Da Silva, Sara R ^a   Ali, Mohsin ^b   Shahani, Vijay M ^a   Xu, G Wei ^b   Berman, Judd ^c   Roughton, Andrew ^c   Dhe Paganon, Sirano ^a   Schimmer, Aaron D ^b   Gunning, Patrick T ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b PRINCESS MARGARET HOSPITAL   (Canada)

^c Dalton Medicinal Chemistry Inc   (Canada)

Author keywords

anticancer drugs; leukemia; NAE inhibitors; proteasomal inhibitors

Indexed keywords

ANTILEUKEMIC AGENT; ANTINEOPLASTIC AGENT; ENZYME; ENZYME INHIBITOR; MLN 4924; NEDD8 ACTIVATING ENZYME; NEDD8 ACTIVATING ENZYME INHIBITOR; NEDD8 PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN K 562; CELL VIABILITY; CONJUGATION; DRUG ACTIVITY; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; LEUKEMIA CELL; MOLECULAR DOCKING; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 80051734349     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml2000615     Document Type: Article

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