High order interactions of xenobiotic metabolizing genes and P53 codon 72 polymorphisms in acute leukemia

Environmental and Molecular Mutagenesis

Volumn 53, Issue 8, 2012, Pages 619-630

  Chauhan, Pradeep Singh ^a   Ihsan, Rakhshan ^a   Mishra, Ashwani Kumar ^a   Yadav, Dhirendra Singh ^a   Saluja, Sumita ^b   Mittal, Vishakha ^b   Saxena, Sunita ^a   Kapur, Sujala ^a  

^a SAFDARJUNG HOSPITAL CAMPUS   (India)

^b SAFDARJUNG HOSPITAL   (India)

Author keywords

Gene gene interactions; Leukemia; Polymorphism; Xenobiotic genes

Indexed keywords

ASPARAGINASE; CYTOCHROME P450 1A1; DAUNORUBICIN; DNA; DOXORUBICIN; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; METHOTREXATE; PREDNISONE; RETINOIC ACID; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADOLESCENT; ADULT; AGED; ARTICLE; CANCER RISK; CHILD; CODON; CONTROLLED STUDY; FEMALE; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PREDICTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; XENOBIOTIC METABOLISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; EPOXIDE HYDROLASES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; HUMANS; LEUKEMIA; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TUMOR SUPPRESSOR PROTEIN P53; XENOBIOTICS; YOUNG ADULT;

EID: 84867405338     PISSN: 08936692     EISSN: 10982280     Source Type: Journal    
DOI: 10.1002/em.21723     Document Type: Article

References (54)

1. Alexandrov K, Cascorbi I, Rojas M, Bouvier G, Kriek E, Bartsch H. 2002. CYP1A1 and GSTM1 genotypes affect benzo[a]pyrene DNA adducts in smokers' lung: Comparison with aromatic/hydrophobic adduct formation. Carcinogenesis 23: 1969-1977.
2. Aydin-Sayitoglu M, Hatirnaz O, Erensoy N, Ozbek U. 2006. Role of CYP2D6, CYP1A1, CYP2E1, GSTT1 and GSTM1 genes in the susceptibility to acute leukemias. Am J Hematol 81: 162-170.
3. Bartsch H, Nair U, Risch A, Rojas M, Wikman H, Alexandrov K. 2000. Genetic polymorphism of CYP genes, alone or in combination, as a risk modifier of tobacco-related cancers. Cancer Epidemiol Biomarkers Prev 9: 3-28.
4. Bhushan B, Chauhan PS, Saluja S, Verma S, Mishra AK, Siddiqui S, Kapur S. 2010. Aberrant phenotypes in childhood and adult acute leukemia and its association with adverse prognostic factors and clinical outcome. Clin Exp Med 10: 33-40.
5. Bolufer P, Collado M, Barragán E, Cervera J, Calasanz MJ, Colomer D, Roman-Gómez J, Sanz MA. 2007. The potential effect of gender in combination with common genetic polymorphisms of drug-metabolizing enzymes on the risk of developing acute leukemia. Haematologica 92: 308-314.
6. Chan JY, Ugrasena DG, Lum DW, Lu Y, Yeoh AE. 2010. Xenobiotic and folate pathway gene polymorphisms and risk of childhood acute lymphoblastic leukaemia in Javanese children. Hematol Oncol 29: 116-123.
7. Chauhan PS, Ihsan R, Yadav DS, Mishra AK, Bhushan B, Soni A, Kaushal M, Devi TR, Saluja S, Gupta DK, Mittal V, Saxena S, Kapur S. 2011. Association of glutathione S-transferase, EPHX, and p53codon72 gene polymorphisms with adult acute myeloid leukemia. DNA Cell Biol 30: 39-46.
8. Chen HC, Hu WX, Liu QX, Li WK, Chen FZ, Rao ZZ, Liu XF, Luo YP, Cao YF. 2008. Genetic polymorphisms of metabolic enzymes CYP1A1, CYP2D6, GSTM1 and GSTT1 and leukemia susceptibility. Eur J Cancer Prev 17: 251-258.
9. Chen M, Kamat AM, Huang M, Grossman HB, Dinney CP, Lerner SP, Wu X, Gu J. 2007. High-order interactions among genetic polymorphisms in nucleotide excision repair pathway genes and smoking in modulating bladder cancer risk. Carcinogenesis 28: 2160-2165.
10. Chung HH, Kim MK, Kim JW, Park NH, Song YS, Kang SB, Lee HP. 2006. XRCC1R399Q polymorphism is associated with response to platinum-based neoadjuvant chemotherapy in bulky cervical cancer. Gynecol Oncol 103: 1031-1037.
11. D Alo F, Voso MT, Guidi F, Massini G, Scardocci A, Sica S, Pagano L, Hohaus S, Leone G. 2004. Polymorphisms of CYP1A1 and glutathione S-transferase and susceptibility to adult acute myeloid leukemia. Haematologica 89: 664-670.
12. Demsar J, Zupan B. 2004. Orange: From Experimental Machine Learning to Interactive Data Mining. White Paper, Faculty of Computer and Information Science, University of Ljublijana, Ljublijana, Slovenia. Madison, WI: Omni press.
13. Di Bernardo MC, Crowther-Swanepoel D, Broderick P, Webb E, Sellick G, Wild R, Sullivan K. 2008. A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia. Nat Genet 40: 1204-1210.
14. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, Ballinger DG. 2007. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087-1093.
15. Gallegos-Arreola MP, Batista-González CM, Delgado-Lamas JL, Figuera LE, Puebla-Pérez AM, Arnaud-López L, Peralta-Leal V, Ramírez-Jirano LJ, Zúñiga-González GM. 2004. Cytochrome P4501A1 polymorphism is associated with susceptibility to acute lymphoblastic leukemia in adult Mexican patients. Blood Cells Mol Dis 33: 326-329.
16. Hahn LW, Ritchie MD, Moore JH. 2003. Multifactor dimensionality reduction software for detecting gene-gene and gene-environment interactions. Bioinformatics 12: 376-382.
17. Haiman CA, Chen GK, Blot WJ, Strom SS, Berndt SI, Kittles RA, Rybicki BA. 2011. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nat Genet 43: 570-573.
18. Hein DW. 2002. Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis. Mutat Res 30: 65-77.
19. Ihsan R, Chauhan PS, Mishra AK, Yadav DS, Kaushal M, Sharma JD, Zomawia E, Verma Y, Kapur S, Saxena S. 2011. Multiple analytical approaches reveal distinct gene-environment interactions in smokers and non smokers in lung cancer. PLoS One 6: e29431.
20. Jakulin A, Bratko I. 2003. Analyzing attribute dependencies. In: Lavrac N, Gamberger D, Blockeel H, Todorovski L, editors. PKDD 2003, Vol. 2838. Cavtat, Croatia: Springer-Verlag.
21. Joseph T, Kusumakumary P, Chacko P, Abraham A, Radhakrishna Pillai M. 2004. Genetic polymorphism of CYP1A1, CYP2D6, GSTM1 and GSTT1 and susceptibility to acute lymphoblastic leukaemia in Indian children. Pediatr Blood Cancer 43: 560-567.
22. Kilpivaara O, Mukherjee S, Schram AM, Wadleigh M, Mullally A, Ebert BL. 2009. A germlineJAK2SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms. Nat Genet 41: 455-459.
23. Kim HC, Lee JY, Sung H, Choi JY, Park SK, Lee KM. 2012. A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: Results from the Seoul Breast Cancer Study. Breast Cancer Res 14: R56.
24. Knight JA, Skol AD, Shinde A, Hastings D, Walgren RA, Shao J, Tennant TR. 2009. Genome-wide association study to identify novel loci associated with therapy-related myeloid leukemia susceptibility. Blood 113: 5575-5582.
25. Krajinovic M, Labuda D, Richer C, Karimi S, Sinnett D. 1999. Susceptibility to childhood acute lymphoblastic leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 genetic polymorphisms. Blood 93: 1496-1501.
26. Lavender NA, Benford ML, VanCleave TT, Brock GN, Kittles RA, Moore JH, Hein DW, Kidd LC. 2009. Examination of polymorphic glutathione S-transferase (GST) genes, tobacco smoking and prostate cancer risk among men of African descent: A case-control study. BMC Cancer 9: 397-406.
27. Majumdar S, Mondal BC, Ghosh M, Dey S, Mukhopadhyay A, Chandra S, Dasgupta UB. 2008. Association of cytochrome P450, glutathione S-transferase and N-acetyl transferase 2 gene polymorphisms with incidence of acute myeloid leukemia. Eur J Cancer Prev 17: 125-132.
28. Miller DP, Liu G, DeVivo I, Lynch TJ, Wain JC, Su L, Christiani DC. 2002. Combinations of the variant genotypes of GSTP1, GSTM1, and P53 are associated with an increased lung cancer risk. Cancer Res 15: 2819-2823.
29. Nagai F, Hiyoshi Y, Sugimachi K, Tamura HO. 2002. Cytochrome P450 (CYP) expression in human myeloblastic and lymphoid cell lines. Biol Pharm Bull 25: 383-385.
30. Nazar-Stewart V, Vaughan TL, Stapleton P, Van Loo J, Nicol-Blades B, Eaton DL. 2003. Population-based study of glutathione S-transferase M1, T1 and P1genotypes and risk for lung cancer. Lung Cancer 40: 247-258.
31. Nordlinder R, Jarvholm B. 1997. Environmental exposure to gasoline and leukemia in children and young adults-an ecology study. Int Arch Occup Environ Health 70: 57-60.
32. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E. 2009. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 41: 1006-1010.
33. Perera FP. 1996. Molecular epidemiology: Insights into cancer susceptibility, risk assessment, and prevention. J Natl Cancer Inst 884: 96-509.
34. Preston DL, Kusumi S, Tomonaga M, Izumi S, Ron E, Kuramoto A, Kamada N, Dohy H, Matsuo T, Matsuo T. 1994. Cancer incidence in atomic bomb survivors. PartIII. Leukemia, lymphoma and multiple myeloma, 1950-1987. Radiat Res 137: S68-97.
35. Quinones LA, Irarrázabal CE, Rojas CR, Orellana CE, Acevedo C, Huidobro C, Varela NE, Cáceres DD. 2006. Joint effect among P53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: An exploratory genotype-environment interaction study. Asian J Androl 8: 349-355.
36. Ritchie MD, Hahn LW, Roodi N, Bailey LR, Dupont WD, Parl FF, Moore JH. 2001. Multifactor-dimensionality reduction reveals high-order interactions among estrogen-metabolism genes in sporadic breast cancer. Am J Hum Genet 69: 138-147.
37. Ritchie MD, Hahn LW, Moore JH. 2003. Power of multifactor dimensionality reduction for detecting gene-gene interactions in the presence of genotyping error, missing data, phenocopy, and genetic heterogeneity. Genet Epidemiol 24: 150-157.
38. Rollinson S, Roddam P, Kane E, Roman E, Cartwright R, Jack A, Morgan GJ. 2000. Polymorphic variation within the glutathione S-transferase genes and risk of adult acute leukaemia. Carcinogenesis 21: 43-47.
39. Saadat I, Saadat M. 2000. The glutathione S-transferase mu polymorphism and susceptibility to acute lymphocytic leukemia. Cancer Lett 29: 43-45.
40. Sam SS, Thomas V, Reddy SK, Surianarayanan G, Chandrasekaran A. 2008. CYP1A1 polymorphisms and the risk of upper aerodigestive tract cancers in an Indian population. Head Neck 30: 1566-1574.
41. Shimada T, Yamazaki H, Oda Y, Hiratsuka A, Watabe T, Guengerich FP. 1996. Activation and inactivation of carcinogenic dihaloalkanes and other compounds by glutathione S-transferase 5-5 in Salmonella typhimurium tester strain NM5004. Chem Res Toxicol 9: 333-340.
42. Sinnett D, Krajinovic M, Labuda 2000. Genetic susceptibility to childhood acute lymphoblastic leukemia. Leuk Lymphoma 38: 447-462.
43. Skibola CF, Bracci PM, Halperin E, Conde L, Craig DW, Agana L, Iyadurai K. 2009. Geneticvariants at 6p21.33 are associated withsusceptibility to follicular lymphoma. Nat Genet 41: 873-875.
44. Sparks R, Ulrich CM, Bigler J, Tworoger SS, Yasui Y, Rajan KB, Porter P, Stanczyk FZ, Ballard-Barbash R, Yuan X, Lin MG, McVarish L, Aiello EJ, McTiernan A. 2004. UDP-glucuronosyltransferase and sulfotransferase polymorphisms, sex hormone concentrations, and tumor receptor status in breast cancer patients. Breast Cancer Res 6: R488-498.
45. Steinberg D, Colla PP. 1997. CART-classification and regression trees. San Diego: Salford Systems.
46. Talseth BA, Meldrum C, Suchy J, Kurzawski G, Lubinski J, Scott RJ. 2006. Genetic polymorphisms in xenobiotic clearance genes and their influence on disease expression in hereditary nonpolyposis colorectal cancer patients. Cancer Epidemiol Biomarkers Prev 15: 2307-2310.
47. Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M. 2009. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 41: 1001-1005.
48. Vijayakrishnan J, Houlston RS. 2010. Candidate gene association studies and risk of childhood acute lymphoblastic leukemia: A systematic review and meta-analysis. Haematologica 95: 1405-1414.
49. Wacholder S, Chanock S, Garcia-Closas M, El Ghormli L, Rothman N. 2004. Assessing the probability that a positive report is false: An approach for molecular epidemiology studies. J Natl Cancer Inst 17: 434-442.
50. Wani MA, Zhu Q, El-Mahdy M, Venkatachalam S, Wani AA. 2000. Enhanced sensitivity to anti-benzo(a)pyrene-diol-epoxide DNA damage correlates with decreased global genomic repair attributable to abrogated P53 function in human cells. Cancer Res 60: 2273-2280.
51. Wormhoudt LW, Commandeur JN, Vermeulen NP. 1999. Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: Relevance to xenobiotic metabolism and toxicity. Crit Rev Toxicol 29: 59-124.
52. Yang H, Lippman SM, Huang M, Jack Lee J, Wang W, Spitz MR, Wu X. 2008. Genetic polymorphisms in double-strand break DNA repair genes associated with risk of oral premalignant lesions. Eur J Cancer 44: 1603-1611.
53. Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK. 1993. Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14: 1821-1824.
54. Zienolddiny S, Campa D, Lind H, Ryberg D, Skaug V, Stangeland LB, Canzian F, Haugen A. 2008. A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers. Carcinogenesis 29: 1164-1169.