Accelerated Calvarial Healing in Mice Lacking Toll-Like Receptor 4

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Wang, Dan ^a,b   Gilbert, James R ^a   Cray, James J ^c   Kubala, Adam A ^a   Shaw, Melissa A ^a   Billiar, Timothy R ^d   Cooper, Gregory M ^a,e  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b TENTH PEOPLE S HOSPITAL OF TONGJI UNIVERSITY   (China)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

^d UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 1BETA; INTERLEUKIN 6; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PLATELET DERIVED GROWTH FACTOR; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; TOLL LIKE RECEPTOR 4; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA3; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE REMODELING; CALVARIA; CELL ACTIVITY; CONTROLLED STUDY; DISEASE SEVERITY; FRACTURE HEALING; GENE EXPRESSION; HISTOPATHOLOGY; MORPHOMETRICS; MOUSE; NONHUMAN; OSTEOCLAST; POSTOPERATIVE PERIOD; PROTEIN EXPRESSION; SKULL DEFECT; SKULL RADIOGRAPHY;

EID: 84867389287     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046945     Document Type: Article

References (29)

1. Lorenzo J, Horowitz M, Choi Y, (2008) Osteoimmunology: interactions of the bone and immune system. Endocr Rev 29: 403-440.
2. Kobbe P, Vodovotz Y, Kaczorowski DJ, Mollen KP, Billiar TR, et al. (2008) Patterns of cytokines release and evolution of remote organ dysfunction after bilateral femur fracture. Shock 30: 43-47.
3. Strecker W, Gebhard F, Rager J, Brückner UB, Steinbach G, et al. (1999) Early biochemical characterization of soft-tissue trauma and fracture trauma. J trauma 47: 358-364.
4. Schindeler A, McDonald MM, Bokko P, Little DG, (2008) Bone remodeling during fracture repair: The cellular picture. Semin Cell Dev Biol 19: 459-466.
5. Takayanaqi H, (2009) Osteoimmunology and the effects of the immune system on bone. Nat Rev Rheumatol 5: 667-676.
6. Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, et al. (2002) Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest 109: 1405-1415.
7. Toben D, Schroeder I, El Khassawna T, Mehta M, Hoffmann JE, et al. (2011) Fracture healing is accelerated in the absence of the adaptive immune system. J Bone Miner Res 26: 113-124.
8. Brown J, Wang H, Hajishengallis GN, Martin M, (2011) TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk. J Dent Res 90: 417-427.
9. Takami M, Kim N, Rho J, Choi Y, (2002) Stimulation by toll-like receptors inhibits osteoclast differentiation. J Immunol 169: 1516-1523.
10. Nair SP, Meghji S, Wilson M, Reddi K, White P, et al. (1996) Bacterially induced bone destruction: mechanisms and misconceptions. Infect Immun 64: 2371-2380.
11. Kikuchi T, Matsuguchi T, Tsuboi N, Mitani A, Tanaka S, et al. (2001) Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via Toll-like receptors. J Immunol 166: 3574-3579.
12. Hayashi S, Yamada T, Tsuneto M, Yamane T, Takahashi M, et al. (2003) Distinct osteoclast precursors in the bone marrow and extramedullary organs characterized by responsiveness to Toll-like receptor ligands and TNF-alpha. J Immunol 171: 5130-5139.
13. Miyake K, (2007) Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors. Semin Immunol 19: 3-10.
14. Kobbe P, Kaczorowski DJ, Vodovotz Y, Tzioupis CH, Mollen KP, et al. (2008) Local exposure of bone components to injured soft tissue induces Toll-like receptor 4-dependent systemic inflammation with acute lung injury. Shock 30: 686-691.
15. Nakashima T, Takayanagi H, (2009) Osteoimmunology: crosstalk between the immune and bone systems. J Clin Immunol 29: 555-567.
16. Kolar P, Schmidt-Bleek K, Schell H, Gaber T, Toben D, et al. (2010) The early fracture hematoma and its potential role in fracture healing. Tissue Eng Part B Rev 16: 427-434.
17. Choudhary S, Halbout P, Alander C, Raisz L, Pilbeam C, (2007) Strontium ranelate promotes osteoblastic differentiation and mineralization of murine bone marrow stromal cells: involvement of prostaglandins. J Bone Miner Res 22: 1002-1010.
18. Gosain AK, Song L, Yu P, Mehrara BJ, Maeda CY, et al. (2000) Osteogenesis in cranial defects: reassessment of the concept of critical size and the expression of TGF-beta isoforms. Plast Reconstr Surg 106: 360-372.
19. Ai-Aql ZS, Alagl AS, Graves DT, Gerstenfeld LC, Einhorn TA, (2008) Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis. J Dent Res 87: 107-118.
20. Dimitriou R, Tsiridis E, Giannoudis PV, (2005) Current concepts of molecular aspects of bone healing. Injury 36: 1392-1404.
21. de Gorter DJ, van Dinther M, Korchynskyi O, ten Dijke P, (2011) Biphasic effects of transforming growth factor β on bone morphogenetic protein-induced osteoblast differentiation. J Bone Miner Res 26: 1178-1187.
22. Zimmermann G, Henle P, Küsswetter M, Moghaddam A, Wentzensen A, et al. (2005) TGF- beta 1 as a marker of delayed fracture healing. Bone 36: 779-785.
23. Cho TJ, Gerstenfeld LC, Einhorn TA, (2002) Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healng. J Bone Miner Res 17: 513-520.
24. Lange J, Sapozhnikova A, Lu C, Hu D, Li X, et al. (2010) Action of IL-1beta during fracture healing. J Orthop Res 28: 778-784.
25. Lee YM, Fujikado N, Manaka H, Yasuda H, Iwakura Y, (2010) IL-1 plays an important role in the bone metabolism under physiological conditions. Int Immunol 22: 805-816.
26. Hoyland JA, Freemont AJ, Sharpe PT, (1994) Interleukin-6, IL-6 receptor, and IL-6 nuclear factor gene expression in Paget's disease. J Bone Miner Res 9: 75-80.
27. Balto K, Sasaki H, Stashenko P, (2001) Interleukin-6 deficiency increases inflammatory bone destruction. Infect Immun 69: 744-750.
28. Darowish M, Rahman R, Li P, Bukata SV, Gelinas J, et al. (2009) Reduction of particle-induced osteolysis by interleukin-6 involves anti-inflammatory effect and inhibition of early osteoclast precursor differentiation. Bone 45: 661-668.
29. Wallace A, Cooney TE, Englund R, Lubahn JD, (2011) Effects of interleukin-6 ablation on fracture healing in mice. J Orthop Res 29: 1437-1442.