Molecular determinants of A 2AR-D 2R allosterism: Role of the intracellular loop 3 of the D 2R

Journal of Neurochemistry

Volumn 123, Issue 3, 2012, Pages 373-384

  Fernández Dueñas, Víctor ^a   Gõmez Soler, Maricel ^a   Jacobson, Kenneth A ^b   Kumar, Santhosh T ^b   Fuxe, Kjell ^c   Borroto Escuela, Dasiel O ^c   Ciruela, Francisco ^a  

^a HOSPITAL UNIVERSITARI DE BELLVITGE   (Spain)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

A 2AR; allosterism; D 2R; fluorescent agonist; FRET; oligomerization

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; ARGININE; INTERLEUKIN 3; ADENOSINE A2 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR STIMULATING AGENT; QUINPIROLE;

ALLOSTERISM; AMINO ACID COMPOSITION; AMINO ACID SUBSTITUTION; ARTICLE; BIOLUMINESCENCE RESONANCE ENERGY TRANSFER; CELL SURFACE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; EMBRYO; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; LIGAND BINDING; MUTATION; OLIGOMERIZATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; GENETICS; INTRACELLULAR FLUID; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE;

ADENOSINE A2 RECEPTOR AGONISTS; ADENOSINE A2 RECEPTOR ANTAGONISTS; ALLOSTERIC REGULATION; ARGININE; DOPAMINE AGONISTS; HEK293 CELLS; HUMANS; INTRACELLULAR FLUID; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; QUINPIROLE; RECEPTOR, ADENOSINE A2A; RECEPTORS, DOPAMINE D2;

EID: 84867331019     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2012.07956.x     Document Type: Article

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