메뉴 건너뛰기




Volumn 226, Issue , 2012, Pages 178-196

Ageing alters behavioural function and brain arginine metabolism in male Sprague-Dawley rats

Author keywords

Ageing; Hippocampus; L arginine metabolites; Memory; Parahippocampal region; Prefrontal cortex

Indexed keywords

4 AMINOBUTYRIC ACID; AGMATINE; ARGINASE; ARGININE; CITRULLINE; GLUTAMIC ACID; NITRIC OXIDE SYNTHASE; ORNITHINE; SPERMIDINE; SPERMINE;

EID: 84867318102     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.09.013     Document Type: Article
Times cited : (34)

References (82)
  • 1
    • 79956192109 scopus 로고    scopus 로고
    • Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation
    • Aimone J.B., Deng W., Gage F.H. Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron 2011, 70:589-596.
    • (2011) Neuron , vol.70 , pp. 589-596
    • Aimone, J.B.1    Deng, W.2    Gage, F.H.3
  • 2
    • 77954621167 scopus 로고    scopus 로고
    • 25-35-induced memory impairments in the rat
    • 25-35-induced memory impairments in the rat. Neuroscience 2010, 169:794-811.
    • (2010) Neuroscience , vol.169 , pp. 794-811
    • Bergin, D.H.1    Liu, P.2
  • 3
    • 0037130360 scopus 로고    scopus 로고
    • Emotional changes related to age in rats - a behavioral analysis
    • Boguszewski P., Zagrodzka J. Emotional changes related to age in rats - a behavioral analysis. Behav Brain Res 2002, 133:323-332.
    • (2002) Behav Brain Res , vol.133 , pp. 323-332
    • Boguszewski, P.1    Zagrodzka, J.2
  • 4
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254.
    • (1976) Anal Biochem , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 5
    • 29244439038 scopus 로고    scopus 로고
    • Neural plasticity in the ageing brain
    • Burke S.N., Barnes C.A. Neural plasticity in the ageing brain. Nat Rev Neurosci 2006, 7:30-40.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 30-40
    • Burke, S.N.1    Barnes, C.A.2
  • 7
    • 77951498581 scopus 로고    scopus 로고
    • New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
    • Deng W., Aimone J.B., Gage F.H. New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?. Nat Rev 2010, 11:339-350.
    • (2010) Nat Rev , vol.11 , pp. 339-350
    • Deng, W.1    Aimone, J.B.2    Gage, F.H.3
  • 8
    • 47349131818 scopus 로고    scopus 로고
    • Stem cell review series: role of neurogenesis in age-related memory disorders
    • Drapeau E., Nora Abrous D. Stem cell review series: role of neurogenesis in age-related memory disorders. Aging Cell 2008, 7:569-589.
    • (2008) Aging Cell , vol.7 , pp. 569-589
    • Drapeau, E.1    Nora Abrous, D.2
  • 9
    • 57149105135 scopus 로고    scopus 로고
    • Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas
    • Eichenbaum H., Lipton P.A. Towards a functional organization of the medial temporal lobe memory system: role of the parahippocampal and medial entorhinal cortical areas. Hippocampus 2008, 18:1314-1324.
    • (2008) Hippocampus , vol.18 , pp. 1314-1324
    • Eichenbaum, H.1    Lipton, P.A.2
  • 10
    • 48849109215 scopus 로고    scopus 로고
    • Physical activity and the regulation of neurogenesis in the adult and aging Brain
    • Fabel K., Kempermann G. Physical activity and the regulation of neurogenesis in the adult and aging Brain. Neuromol Med 2008, 10:59-66.
    • (2008) Neuromol Med , vol.10 , pp. 59-66
    • Fabel, K.1    Kempermann, G.2
  • 11
    • 0026719497 scopus 로고
    • Selective release of spermine and spermidine from the rat striatum by N-methyl-d-aspartate receptor activation in vivo
    • Fage D., Voltz C., Scatton B., Carter C. Selective release of spermine and spermidine from the rat striatum by N-methyl-d-aspartate receptor activation in vivo. J Neurochem 1992, 58:2170-2175.
    • (1992) J Neurochem , vol.58 , pp. 2170-2175
    • Fage, D.1    Voltz, C.2    Scatton, B.3    Carter, C.4
  • 12
    • 39349090970 scopus 로고    scopus 로고
    • NO/cGMP-dependent modulation of synaptic transmission
    • Feil R., Kleppisch T. NO/cGMP-dependent modulation of synaptic transmission. Handb Exp Pharmacol 2008, 529-560.
    • (2008) Handb Exp Pharmacol , pp. 529-560
    • Feil, R.1    Kleppisch, T.2
  • 13
    • 61649117283 scopus 로고    scopus 로고
    • The neurobiology of middle-age has arrived
    • Finch C. The neurobiology of middle-age has arrived. Neurobiol Aging 2009, 30:515-520.
    • (2009) Neurobiol Aging , vol.30 , pp. 515-520
    • Finch, C.1
  • 14
    • 0030639472 scopus 로고    scopus 로고
    • The use of animal models to study the effects of aging on cognition
    • Gallagher M., Rapp P.R. The use of animal models to study the effects of aging on cognition. Annu Rev Psychol 1997, 48:339-370.
    • (1997) Annu Rev Psychol , vol.48 , pp. 339-370
    • Gallagher, M.1    Rapp, P.R.2
  • 15
    • 36148938688 scopus 로고    scopus 로고
    • Functional plasticity in cognitive aging: review and hypothesis
    • Greenwood P.M. Functional plasticity in cognitive aging: review and hypothesis. Neuropsychology 2007, 21:657-673.
    • (2007) Neuropsychology , vol.21 , pp. 657-673
    • Greenwood, P.M.1
  • 16
    • 67349220182 scopus 로고    scopus 로고
    • Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats
    • Gupta N., Zhang H., Liu P. Behavioral and neurochemical effects of acute putrescine depletion by difluoromethylornithine in rats. Neuroscience 2009, 161:691-706.
    • (2009) Neuroscience , vol.161 , pp. 691-706
    • Gupta, N.1    Zhang, H.2    Liu, P.3
  • 17
    • 80155125095 scopus 로고    scopus 로고
    • Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats
    • Gupta N., Zhang H., Liu P. Chronic difluoromethylornithine treatment impairs spatial learning and memory in rats. Pharmacol Biochem Behav 2012, 100:464-473.
    • (2012) Pharmacol Biochem Behav , vol.100 , pp. 464-473
    • Gupta, N.1    Zhang, H.2    Liu, P.3
  • 18
    • 35048891421 scopus 로고    scopus 로고
    • Agmatine: metabolic pathway and spectrum of activity in brain
    • Halaris A., Plietz J. Agmatine: metabolic pathway and spectrum of activity in brain. CNS Drugs 2007, 21:885-900.
    • (2007) CNS Drugs , vol.21 , pp. 885-900
    • Halaris, A.1    Plietz, J.2
  • 19
    • 0040830408 scopus 로고    scopus 로고
    • Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity
    • Holscher C. Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity. Trends Neurosci 1997, 20:298-303.
    • (1997) Trends Neurosci , vol.20 , pp. 298-303
    • Holscher, C.1
  • 20
    • 0031104935 scopus 로고    scopus 로고
    • Synaptic plasticity: a role for nitric oxide in LTP
    • Huang E.P. Synaptic plasticity: a role for nitric oxide in LTP. Curr Biol 1997, 7:R141-R143.
    • (1997) Curr Biol , vol.7
    • Huang, E.P.1
  • 21
    • 60549116669 scopus 로고    scopus 로고
    • Tapestry of memory
    • Kesner R.P. Tapestry of memory. Behav Neurosci 2009, 123:1-13.
    • (2009) Behav Neurosci , vol.123 , pp. 1-13
    • Kesner, R.P.1
  • 22
    • 8844287596 scopus 로고    scopus 로고
    • A behavioral assessment of hippocampal function based on a subregional analysis
    • Kesner R.P., Lee I., Gilbert P. A behavioral assessment of hippocampal function based on a subregional analysis. Rev Neurosci 2004, 15:333-351.
    • (2004) Rev Neurosci , vol.15 , pp. 333-351
    • Kesner, R.P.1    Lee, I.2    Gilbert, P.3
  • 24
    • 80053600171 scopus 로고    scopus 로고
    • Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus
    • Knox L.T., Jing Y., Fleete M.S., Collie N.D., Zhang H., Liu P. Scopolamine impairs behavioural function and arginine metabolism in the rat dentate gyrus. Neuropharmacology 2011, 61:1452-1462.
    • (2011) Neuropharmacology , vol.61 , pp. 1452-1462
    • Knox, L.T.1    Jing, Y.2    Fleete, M.S.3    Collie, N.D.4    Zhang, H.5    Liu, P.6
  • 25
    • 0034638487 scopus 로고    scopus 로고
    • Alteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans rats
    • Law A., Dore S., Blackshaw S., Gauthier S., Quirion R. Alteration of expression levels of neuronal nitric oxide synthase and haem oxygenase-2 messenger RNA in the hippocampi and cortices of young adult and aged cognitively unimpaired and impaired Long-Evans rats. Neuroscience 2000, 100:769-775.
    • (2000) Neuroscience , vol.100 , pp. 769-775
    • Law, A.1    Dore, S.2    Blackshaw, S.3    Gauthier, S.4    Quirion, R.5
  • 26
    • 0035105932 scopus 로고    scopus 로고
    • Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type
    • Law A., Gauthier S., Quirion R. Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type. Brain Res Brain Res Rev 2001, 35:73-96.
    • (2001) Brain Res Brain Res Rev , vol.35 , pp. 73-96
    • Law, A.1    Gauthier, S.2    Quirion, R.3
  • 27
    • 0037129914 scopus 로고    scopus 로고
    • Neuronal and inducible nitric oxide synthase expressions and activities in the hippocampi and cortices of young adult, aged cognitively unimpaired, and impaired Long-Evans rats
    • Law A., O'Donnell J., Gauthier S., Quirion R. Neuronal and inducible nitric oxide synthase expressions and activities in the hippocampi and cortices of young adult, aged cognitively unimpaired, and impaired Long-Evans rats. Neuroscience 2002, 112:267-275.
    • (2002) Neuroscience , vol.112 , pp. 267-275
    • Law, A.1    O'Donnell, J.2    Gauthier, S.3    Quirion, R.4
  • 28
    • 78650034964 scopus 로고    scopus 로고
    • Spatial learning induced increase in agmatine levels at hippocampal CA1 synapses
    • Leitch B., Shevtsova O., Reusch K., Bergin D.H., Liu P. Spatial learning induced increase in agmatine levels at hippocampal CA1 synapses. Synapse 2011, 65:146-153.
    • (2011) Synapse , vol.65 , pp. 146-153
    • Leitch, B.1    Shevtsova, O.2    Reusch, K.3    Bergin, D.H.4    Liu, P.5
  • 30
    • 62249150177 scopus 로고    scopus 로고
    • Differential effects of icv microinfusion of agmatine on spatial working and reference memory in the rat
    • Liu P., Bergin D. Differential effects of icv microinfusion of agmatine on spatial working and reference memory in the rat. Neuroscience 2009, 159:951-961.
    • (2009) Neuroscience , vol.159 , pp. 951-961
    • Liu, P.1    Bergin, D.2
  • 31
    • 68349127366 scopus 로고    scopus 로고
    • Behavioral effects of agmatine in naive rats are task- and delay-dependent
    • Liu P., Collie N.D. Behavioral effects of agmatine in naive rats are task- and delay-dependent. Neuroscience 2009, 163:82-96.
    • (2009) Neuroscience , vol.163 , pp. 82-96
    • Liu, P.1    Collie, N.D.2
  • 32
    • 0038058801 scopus 로고    scopus 로고
    • Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: regional variations and age-related changes
    • Liu P., Smith P.F., Appleton I., Darlington C.L., Bilkey D.K. Nitric oxide synthase and arginase in the rat hippocampus and the entorhinal, perirhinal, postrhinal, and temporal cortices: regional variations and age-related changes. Hippocampus 2003, 13:859-867.
    • (2003) Hippocampus , vol.13 , pp. 859-867
    • Liu, P.1    Smith, P.F.2    Appleton, I.3    Darlington, C.L.4    Bilkey, D.K.5
  • 33
    • 0037844786 scopus 로고    scopus 로고
    • Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus
    • Liu P., Smith P.F., Appleton I., Darlington C.L., Bilkey D.K. Regional variations and age-related changes in nitric oxide synthase and arginase in the sub-regions of the hippocampus. Neuroscience 2003, 119:679-687.
    • (2003) Neuroscience , vol.119 , pp. 679-687
    • Liu, P.1    Smith, P.F.2    Appleton, I.3    Darlington, C.L.4    Bilkey, D.K.5
  • 34
    • 1542358122 scopus 로고    scopus 로고
    • Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex
    • Liu P., Smith P.F., Appleton I., Darlington C.L., Bilkey D.K. Age-related changes in nitric oxide synthase and arginase in the rat prefrontal cortex. Neurobiol Aging 2004, 25:547-552.
    • (2004) Neurobiol Aging , vol.25 , pp. 547-552
    • Liu, P.1    Smith, P.F.2    Appleton, I.3    Darlington, C.L.4    Bilkey, D.K.5
  • 35
    • 3543092144 scopus 로고    scopus 로고
    • Potential involvement of NOS and arginase in age-related behavioural impairments
    • Liu P., Smith P.F., Appleton I., Darlington C.L., Bilkey D.K. Potential involvement of NOS and arginase in age-related behavioural impairments. Exp Gerontol 2004, 39:1207-1222.
    • (2004) Exp Gerontol , vol.39 , pp. 1207-1222
    • Liu, P.1    Smith, P.F.2    Appleton, I.3    Darlington, C.L.4    Bilkey, D.K.5
  • 36
    • 23844474754 scopus 로고    scopus 로고
    • Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits
    • Liu P., Smith P.F., Appleton I., Darlington C.L., Bilkey D.K. Hippocampal nitric oxide synthase and arginase and age-associated behavioral deficits. Hippocampus 2005, 15:642-655.
    • (2005) Hippocampus , vol.15 , pp. 642-655
    • Liu, P.1    Smith, P.F.2    Appleton, I.3    Darlington, C.L.4    Bilkey, D.K.5
  • 38
    • 55549139201 scopus 로고    scopus 로고
    • Spatial learning results in elevated agmatine levels in the rat brain
    • Liu P., Collie N., Chary S., Jing Y., Zhang H. Spatial learning results in elevated agmatine levels in the rat brain. Hippocampus 2008, 18:1094-1098.
    • (2008) Hippocampus , vol.18 , pp. 1094-1098
    • Liu, P.1    Collie, N.2    Chary, S.3    Jing, Y.4    Zhang, H.5
  • 39
    • 49249086117 scopus 로고    scopus 로고
    • Age-related changes in polyamines in memory-associated brain structures in rats
    • Liu P., Gupta N., Jing Y., Zhang H. Age-related changes in polyamines in memory-associated brain structures in rats. Neuroscience 2008, 155:789-796.
    • (2008) Neuroscience , vol.155 , pp. 789-796
    • Liu, P.1    Gupta, N.2    Jing, Y.3    Zhang, H.4
  • 40
    • 44649106241 scopus 로고    scopus 로고
    • Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats
    • Liu P., Rushaidhi M., Collie N.D., Leong M.T., Zhang H. Behavioral effects of intracerebroventricular microinfusion of agmatine in adult rats. Behav Neurosci 2008, 122:557-569.
    • (2008) Behav Neurosci , vol.122 , pp. 557-569
    • Liu, P.1    Rushaidhi, M.2    Collie, N.D.3    Leong, M.T.4    Zhang, H.5
  • 41
    • 67649672109 scopus 로고    scopus 로고
    • Memory-related changes in l-citrulline and agmatine in the rat brain
    • Liu P., Jing Y., Collie N.D., Chary S., Zhang H. Memory-related changes in l-citrulline and agmatine in the rat brain. Hippocampus 2009, 19:597-602.
    • (2009) Hippocampus , vol.19 , pp. 597-602
    • Liu, P.1    Jing, Y.2    Collie, N.D.3    Chary, S.4    Zhang, H.5
  • 42
    • 70349753470 scopus 로고    scopus 로고
    • Age-related changes in arginine and its metabolites in memory-associated brain structures
    • Liu P., Jing Y., Zhang H. Age-related changes in arginine and its metabolites in memory-associated brain structures. Neuroscience 2009, 164:611-628.
    • (2009) Neuroscience , vol.164 , pp. 611-628
    • Liu, P.1    Jing, Y.2    Zhang, H.3
  • 43
    • 77956338859 scopus 로고    scopus 로고
    • A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus
    • Liu P., Zhang H., Devaraj R., Ganesalingam G.S., Smith P.F. A multivariate analysis of the effects of aging on glutamate, GABA and arginine metabolites in the rat vestibular nucleus. Hear Res 2010, 269:122-133.
    • (2010) Hear Res , vol.269 , pp. 122-133
    • Liu, P.1    Zhang, H.2    Devaraj, R.3    Ganesalingam, G.S.4    Smith, P.F.5
  • 44
    • 80052448797 scopus 로고    scopus 로고
    • Pre-aggregated Aβ(25-35) alters arginine metabolism in the rat hippocampus and prefrontal cortex
    • Liu P., Jing Y., Collie N.D., Campbell S.A., Zhang H. Pre-aggregated Aβ(25-35) alters arginine metabolism in the rat hippocampus and prefrontal cortex. Neuroscience 2011, 193:269-282.
    • (2011) Neuroscience , vol.193 , pp. 269-282
    • Liu, P.1    Jing, Y.2    Collie, N.D.3    Campbell, S.A.4    Zhang, H.5
  • 46
    • 34347383021 scopus 로고    scopus 로고
    • Nitric oxide and nitroxidative stress in Alzheimer's disease
    • Malinski T. Nitric oxide and nitroxidative stress in Alzheimer's disease. J Alzheimers Dis 2007, 11:207-218.
    • (2007) J Alzheimers Dis , vol.11 , pp. 207-218
    • Malinski, T.1
  • 47
    • 0030846399 scopus 로고    scopus 로고
    • The nitric oxide hypothesis of brain aging
    • McCann S.M. The nitric oxide hypothesis of brain aging. Exp Gerontol 1997, 32:431-440.
    • (1997) Exp Gerontol , vol.32 , pp. 431-440
    • McCann, S.M.1
  • 50
    • 15344340623 scopus 로고    scopus 로고
    • Polyamines: metabolism and implications in human diseases
    • Moinard C., Cynober L., Bandt J.P. Polyamines: metabolism and implications in human diseases. Clin Nutr 2005, 24:184-197.
    • (2005) Clin Nutr , vol.24 , pp. 184-197
    • Moinard, C.1    Cynober, L.2    Bandt, J.P.3
  • 51
    • 0019957779 scopus 로고
    • Place navigation impaired in rats with hippocampal lesions
    • Morris R., Garrud P., Rawlins J., O'Keefe J. Place navigation impaired in rats with hippocampal lesions. Nature 1982, 297:681-683.
    • (1982) Nature , vol.297 , pp. 681-683
    • Morris, R.1    Garrud, P.2    Rawlins, J.3    O'Keefe, J.4
  • 52
    • 0032434817 scopus 로고    scopus 로고
    • Functional differentiation in the hippocampus
    • Moser M.B., Moser E.I. Functional differentiation in the hippocampus. Hippocampus 1998, 8:608-619.
    • (1998) Hippocampus , vol.8 , pp. 608-619
    • Moser, M.B.1    Moser, E.I.2
  • 53
    • 0037066407 scopus 로고    scopus 로고
    • Regional alterations of the NO/NOS system in the aging brain: a biochemical, histochemical and immunochemical study in the rat
    • Necchi D., Virgili M., Monti B., Contestabile A., Scherini E. Regional alterations of the NO/NOS system in the aging brain: a biochemical, histochemical and immunochemical study in the rat. Brain Res 2002, 933:31-41.
    • (2002) Brain Res , vol.933 , pp. 31-41
    • Necchi, D.1    Virgili, M.2    Monti, B.3    Contestabile, A.4    Scherini, E.5
  • 54
    • 0037398138 scopus 로고    scopus 로고
    • Polyamine dependence of normal cell-cycle progression
    • Oredsson S.M. Polyamine dependence of normal cell-cycle progression. Biochem Soc Trans 2003, 31:366-370.
    • (2003) Biochem Soc Trans , vol.31 , pp. 366-370
    • Oredsson, S.M.1
  • 55
    • 0022374863 scopus 로고
    • Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat
    • Pellow S., Chopin P., File S.E., Briley M. Validation of open: closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 1985, 14:149-167.
    • (1985) J Neurosci Methods , vol.14 , pp. 149-167
    • Pellow, S.1    Chopin, P.2    File, S.E.3    Briley, M.4
  • 56
    • 0034703445 scopus 로고    scopus 로고
    • Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats
    • Pisarska M., Mulchahey J.J., Welge J.A., Geracioti T.D., Kasckow J.W. Age-related alterations in emotional behaviors and amygdalar corticotropin-releasing factor (CRF) and CRF-binding protein expression in aged Fischer 344 rats. Brain Res 2000, 877:184-190.
    • (2000) Brain Res , vol.877 , pp. 184-190
    • Pisarska, M.1    Mulchahey, J.J.2    Welge, J.A.3    Geracioti, T.D.4    Kasckow, J.W.5
  • 57
    • 0034193104 scopus 로고    scopus 로고
    • Is agmatine a novel neurotransmitter in brain?
    • Reis D.J., Regunathan S. Is agmatine a novel neurotransmitter in brain?. Trends Pharmacol Sci 2000, 21:187-193.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 187-193
    • Reis, D.J.1    Regunathan, S.2
  • 58
    • 0028987875 scopus 로고
    • Polyamine regulation of N-methyl-d-aspartate receptor channels
    • Rock D., Macdonald R. Polyamine regulation of N-methyl-d-aspartate receptor channels. Annu Rev Pharmacol Toxicol 1995, 35:463-482.
    • (1995) Annu Rev Pharmacol Toxicol , vol.35 , pp. 463-482
    • Rock, D.1    Macdonald, R.2
  • 59
    • 0030782744 scopus 로고    scopus 로고
    • Anxiety, defence and the elevated plus-maze
    • Rodgers R., Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 1997, 21:801-810.
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 801-810
    • Rodgers, R.1    Dalvi, A.2
  • 60
    • 0032484561 scopus 로고    scopus 로고
    • Reactivity to novelty in cognitively-impaired and cognitively-unimpaired aged rats and young rats
    • Rowe W.B., Spreekmeester E., Meaney M.J., Quirion R., Rochford J. Reactivity to novelty in cognitively-impaired and cognitively-unimpaired aged rats and young rats. Neuroscience 1998, 83:669-680.
    • (1998) Neuroscience , vol.83 , pp. 669-680
    • Rowe, W.B.1    Spreekmeester, E.2    Meaney, M.J.3    Quirion, R.4    Rochford, J.5
  • 61
    • 61649112904 scopus 로고    scopus 로고
    • When does age-related cognitive decline begin?
    • Salthouse T. When does age-related cognitive decline begin?. Neurobiol Aging 2009, 30:507-514.
    • (2009) Neurobiol Aging , vol.30 , pp. 507-514
    • Salthouse, T.1
  • 62
    • 34548800397 scopus 로고    scopus 로고
    • Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation
    • Santhanam A.V., Viswanathan S., Dikshit M. Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation. Eur J Pharmacol 2007, 572:189-196.
    • (2007) Eur J Pharmacol , vol.572 , pp. 189-196
    • Santhanam, A.V.1    Viswanathan, S.2    Dikshit, M.3
  • 63
    • 1342326717 scopus 로고    scopus 로고
    • Agmatine: at the crossroads of the arginine pathways
    • Satriano J. Agmatine: at the crossroads of the arginine pathways. Ann NY Acad Sci 2003, 1009:34-43.
    • (2003) Ann NY Acad Sci , vol.1009 , pp. 34-43
    • Satriano, J.1
  • 64
    • 0032191601 scopus 로고    scopus 로고
    • Combination of open field and elevated plus-maze: a suitable test battery to assess strain as well as treatment differences in rat behavior
    • Schmitt U., Hiemke C. Combination of open field and elevated plus-maze: a suitable test battery to assess strain as well as treatment differences in rat behavior. Prog Neuropsychopharmacol Biol Psychiatry 1998, 22:1197-1215.
    • (1998) Prog Neuropsychopharmacol Biol Psychiatry , vol.22 , pp. 1197-1215
    • Schmitt, U.1    Hiemke, C.2
  • 65
    • 80052271496 scopus 로고    scopus 로고
    • Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals
    • Seo S., Liu P., Leitch B. Spatial learning-induced accumulation of agmatine and glutamate at hippocampal CA1 synaptic terminals. Neuroscience 2011, 192:28-36.
    • (2011) Neuroscience , vol.192 , pp. 28-36
    • Seo, S.1    Liu, P.2    Leitch, B.3
  • 66
    • 0029549045 scopus 로고
    • Memory and the prefrontal cortex
    • Shimamura A.P. Memory and the prefrontal cortex. Ann NY Acad Sci 1995, 769:151-160.
    • (1995) Ann NY Acad Sci , vol.769 , pp. 151-160
    • Shimamura, A.P.1
  • 67
    • 0029878229 scopus 로고    scopus 로고
    • Molecular indices of neuronal and glial plasticity in the hippocampal formation in a rodent model of age-induced spatial learning impairment
    • Sugaya K., Chouinard M., Greene R., Robbins M., Personett D., Kent C., Gallagher M., McKinney M. Molecular indices of neuronal and glial plasticity in the hippocampal formation in a rodent model of age-induced spatial learning impairment. J Neurosci 1996, 16:3427-3443.
    • (1996) J Neurosci , vol.16 , pp. 3427-3443
    • Sugaya, K.1    Chouinard, M.2    Greene, R.3    Robbins, M.4    Personett, D.5    Kent, C.6    Gallagher, M.7    McKinney, M.8
  • 68
    • 81255202394 scopus 로고    scopus 로고
    • Spatial navigation (water maze) tasks
    • CRC Press, Boca Raton, FL, Chapter 13, J.J. Buccafusco (Ed.)
    • Terry A.V. Spatial navigation (water maze) tasks. Methods of behavior analysis in neuroscience 2009, CRC Press, Boca Raton, FL, Chapter 13. 2nd ed. J.J. Buccafusco (Ed.).
    • (2009) Methods of behavior analysis in neuroscience
    • Terry, A.V.1
  • 70
    • 0242332243 scopus 로고    scopus 로고
    • On the involvement of prefrontal networks in cognitive aging
    • Tisserand D., Jolles J. On the involvement of prefrontal networks in cognitive aging. Cortex 2003, 39:1107-1128.
    • (2003) Cortex , vol.39 , pp. 1107-1128
    • Tisserand, D.1    Jolles, J.2
  • 72
    • 0035903060 scopus 로고    scopus 로고
    • Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulation in the spinal cord of aged rats
    • Virgili M., Necchi D., Scherini E., Contestabile A. Increase of the ornithine decarboxylase/polyamine system and transglutaminase upregulation in the spinal cord of aged rats. Neurosci Lett 2001, 309:62-66.
    • (2001) Neurosci Lett , vol.309 , pp. 62-66
    • Virgili, M.1    Necchi, D.2    Scherini, E.3    Contestabile, A.4
  • 73
    • 0033956687 scopus 로고    scopus 로고
    • The physiological role of the polyamines
    • Wallace H.M. The physiological role of the polyamines. Eur J Clin Invest 2000, 30:72-78.
    • (2000) Eur J Clin Invest , vol.30 , pp. 72-78
    • Wallace, H.M.1
  • 74
    • 0033371435 scopus 로고    scopus 로고
    • Calibrating space. exploration is important for allothetic and idiothetic navigation
    • Whishaw I.Q., Brooks B.L. Calibrating space. exploration is important for allothetic and idiothetic navigation. Hippocampus 1999, 9:659-667.
    • (1999) Hippocampus , vol.9 , pp. 659-667
    • Whishaw, I.Q.1    Brooks, B.L.2
  • 75
    • 0035081701 scopus 로고    scopus 로고
    • Arginine metabolism and the synthesis of nitric oxide in the nervous system
    • Wiesinger H. Arginine metabolism and the synthesis of nitric oxide in the nervous system. Prog Neurobiol 2001, 64:365-391.
    • (2001) Prog Neurobiol , vol.64 , pp. 365-391
    • Wiesinger, H.1
  • 76
    • 0030853492 scopus 로고    scopus 로고
    • Interactions of polyamines with ion channels
    • Williams K. Interactions of polyamines with ion channels. Biochem J 1997, 325:289-297.
    • (1997) Biochem J , vol.325 , pp. 289-297
    • Williams, K.1
  • 78
    • 33751178775 scopus 로고    scopus 로고
    • Neurocognitive aging: prior memories hinder new hippocampal encoding
    • Wilson I.A., Gallagher M., Eichenbaum H., Tanila H. Neurocognitive aging: prior memories hinder new hippocampal encoding. Trends Neurosci 2006, 29:662-670.
    • (2006) Trends Neurosci , vol.29 , pp. 662-670
    • Wilson, I.A.1    Gallagher, M.2    Eichenbaum, H.3    Tanila, H.4
  • 80
    • 0032533159 scopus 로고    scopus 로고
    • Arginine metabolism: nitric oxide and beyond
    • Wu G., Morris S.M. Arginine metabolism: nitric oxide and beyond. Biochem J 1998, 336:1-17.
    • (1998) Biochem J , vol.336 , pp. 1-17
    • Wu, G.1    Morris, S.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.