Activation of protein kinase B/Akt and endothelial nitric oxide synthase mediates agmatine-induced endothelium-dependent relaxation

European Journal of Pharmacology

Volumn 572, Issue 2-3, 2007, Pages 189-196

  Santhanam, Anantha Vijay R ^a   Viswanathan, Shivkumar ^b   Dikshit, Madhu ^c  

^a MAYO GRADUATE SCHOOL   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Akt; Nitric oxide synthase; Potassium channels; Rat aorta; Soluble guanylate cyclase; Vasorelaxation

Indexed keywords

AGMANTINE; APAMIN; BARIUM CHLORIDE; CHARYBDOTOXIN; CYCLIC AMP; CYCLIC GMP; GLIBENCLAMIDE; IDAZOXAN; INDOMETACIN; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PHENYLEPHRINE; PROSTAGLANDIN SYNTHASE; PROTEIN KINASE B; SEROTONIN; TETRYLAMMONIUM; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; HOMEOSTASIS; HYPERTENSION; MALE; MEASUREMENT; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; VASODILATATION; WESTERN BLOTTING;

AGMATINE; ANIMALS; AORTA, THORACIC; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; KATP CHANNELS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; POTASSIUM CHANNELS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SMALL-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS;

EID: 34548800397     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2007.06.031     Document Type: Article

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