Role of MRE11 in cell proliferation, tumor invasion, and DNA repair in breast cancer

Journal of the National Cancer Institute

Volumn 104, Issue 19, 2012, Pages 1485-1502

  Yuan, Shyng Shiou F ^a,b   Hou, Ming Feng ^c   Hsieh, Ya Ching ^a   Huang, Chien Yiu ^a   Lee, Yi Chen ^d   Chen, Yun Ju ^a   Lo, Steven ^a  

^a E DA HOSPITAL   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^d KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

MRE11 PROTEIN; STAT3 PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER INVASION; CANCER PATIENT; CANCER STAGING; CANCER SURVIVAL; CELL CYCLE; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN MCF 7; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE ASSOCIATION; DNA REPAIR; DNA REPLICATION; FEMALE; GENE SILENCING; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MAJOR CLINICAL STUDY; ORTHOTOPIC TRANSPLANTATION; OVERALL SURVIVAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIOSENSITIVITY; TUMOR GROWTH; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL CYCLE; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; COLORIMETRY; DISEASE MODELS, ANIMAL; DNA REPAIR; DNA-BINDING PROTEINS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MICE; MICE, INBRED NOD; MICE, SCID; MIDDLE AGED; NEOPLASM INVASIVENESS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; TISSUE ARRAY ANALYSIS; TRANSPLANTATION, HETEROLOGOUS; TUMOR STEM CELL ASSAY; UP-REGULATION;

EID: 84867314458     PISSN: 00278874     EISSN: 14602105     Source Type: Journal    
DOI: 10.1093/jnci/djs355     Document Type: Article

References (59)

1. Benson JR, Jatoi I, Keisch M, Esteva FJ, Makris A, Jordan VC. Early breast cancer. Lancet. 2009;373(9673):1463-1479.
2. Amir E, Freedman OC, Seruga B, Evans DG. Assessing women at high risk of breast cancer: a review of risk assessment models. J Natl Cancer Inst. 2010;102(10):680-691.
3. Ganz PA. Assessing the quality and value of quality-of-life measurement in breast cancer clinical trials. J Natl Cancer Inst. 2011;103(3):196-199.
4. Boyd NF, Martin LJ, Bronskill M, Yaffe MJ, Duric N, Minkin S. Breast tissue composition and susceptibility to breast cancer. J Natl Cancer Inst. 2010;102(16):1224-1237.
5. Hakem R. DNA-damage repair; the good, the bad, and the ugly. EMBO J. 2008;27(4):589-605. (Pubitemid 351273123)
6. Powell SN, Bindra RS. Targeting the DNA damage response for cancer therapy. DNA Repair (Amst). 2009;8(9):1153-1165.
7. Scott SP, Pandita TK. The cellular control of DNA double-strand breaks. J Cell Biochem. 2006;99(6):1463-1475. (Pubitemid 44845708)
8. Schultz J. Data from DNA repair studies questioned as leading researcher investigated. J Natl Cancer Inst. 2003;95(18):1358-1359. (Pubitemid 37220450)
9. Helleday T, Lo J, van Gent DC, Engelward BP. DNA double-strand break repair: from mechanistic understanding to cancer treatment. DNA Repair (Amst). 2007;6(7):923-935. (Pubitemid 46880473)
10. Kobayashi J, Iwabuchi K, Miyagawa K, et al. Current topics in DNA double-strand break repair. J Radiat Res. 2008;49(2):93-103. (Pubitemid 351468636)
11. Natarajan AT, Palitti F. DNA repair and chromosomal alterations. Mutat Res. 2008;657(1):3-7.
12. Hartlerode AJ, Scully R. Mechanisms of double-strand break repair in somatic mammalian cells. Biochem J. 2009;423(2):157-168.
13. Assenmacher N, Hopfner KP. MRE11/RAD50/NBS1: complex activities. Chromosoma. 2004;113(4):157-166. (Pubitemid 39409786)
14. Shrivastav M, De Haro LP, Nickoloff JA. Regulation of DNA doublestrand break repair pathway choice. Cell Res. 2008;18(1):134-147.
15. Williams RS, Williams JS, Tainer JA. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem Cell Biol. 2007;85(4):509-520. (Pubitemid 47518045)
16. Hopfner KP. DNA double-strand breaks come into focus. Cell. 2009;139(1):25-27.
17. Call E, Surrall J. Telomere dysfunction in genome instability syndromes. Mutat Res. 2004;567(1):85-104.
18. Stewart SA, Weinberg RA. Telomeres: cancer to human aging. Annu Rev Cell Dev Biol. 2006;22:531-557.
19. Chai W, Sfeir AJ, Hoshiyama H, Shay JW, Wright WE. The involvement of the Mre11/Rad50/Nbs1 complex in the generation of G-overhangs at human telomeres. EMBO Rep. 2006;7(2):225-230.
20. Royle NJ, M?dez-Berm?ez A, Gravani A, et al. The role of recombination in telomere length maintenance. Biochem Soc Trans. 2009;37(pt 3):589-595.
21. Ueno M. Roles of DNA repair proteins in telomere maintenance. Biosci Biotechnol Biochem. 2010;74(1):1-6.
22. Xiao Y, Weaver DT. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 1997;25(15):2985-2991. (Pubitemid 27331390)
23. Petrini JH, Walsh ME, DiMare C, Chen XN, Korenberg JR, Weaver DT. Isolation and characterization of the human MRE11 homologue. Genomics. 1995;29(1):80-86.
24. Lanson NA Jr, Egeland DB, Royals BA, Claycomb WC. The MRE11-NBS1-RAD50 pathway is perturbed in SV40 large T antigen-immortalized AT-1, AT-2 and HL-1 cardiomyocytes. Nucleic Acids Res. 2000;28(15):2882-2892. (Pubitemid 30599262)
25. Ermilova VD. International histological classification of breast cancer by the WHO (1968) and its prognostic value. Arkh Patol. 1980;42(4):13-19. (Pubitemid 10091248)
26. Frierson HF Jr, Wolber RA, Berean KW, et al. Interobserver reproducibility of the Nottingham modification of the Bloom and Richardson histologic grading scheme for infiltrating ductal carcinoma. Am J Clin Pathol. 1995;103(2):195-198.
27. Lee YC, Yang YH, Su JH, Chang HL, Hou MF, Yuan SS. High visfatin expression in breast cancer tissue is associated with poor survival. Cancer Epidemiol Biomarkers Prev. 2011;20(9):1892-1901.
28. Yeh YT, Hou MF, Chung YF, et al. Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival. Int J Cancer. 2006;118(11):2678-2684.
29. Schust J, Sperl B, Hollis A, Mayer TU, Berg T. Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol. 2006;13(11):1235- 1242. (Pubitemid 44750735)
30. Chang HL, Hsu HK, Su JH, et al. The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model. Gynecol Oncol. 2006;102(2):309-314.
31. Jiang Y, Rom WN, Yie TA, Chi CX, Tchou-Wong KM. Induction of tumor suppression and glandular differentiation of A549 lung carcinoma cells by dominant-negative IGF-I receptor. Oncogene. 1999;18(44):6071-6077. (Pubitemid 29535019)
32. Konttinen YT, Ainola M, Valleala H, et al. Analysis of 16 different matrix metalloproteinases (MMP-1 to MMP-20) in the synovial membrane: different profiles in trauma and rheumatoid arthritis. Ann Rheum Dis. 1999;58(11):691-697. (Pubitemid 29517255)
33. Robison JG, Elliott J, Dixon K, Oakley GG. Replication protein A and the Mre11.Rad50.Nbs1 complex co-localize and interact at sites of stalled replication forks. J Biol Chem. 2004;279(33):34802-34810. (Pubitemid 39318113)
34. Olive PL, Banh JP, Durand RE. Heterogeneity in radiation-induced DNA damage and repair in tumor and normal cells measured using the "comet" assay. Radiat Res. 1990;122(1):86-94. (Pubitemid 20130057)
35. Hellman B, Vaghef H, Bostr? B. The concepts of tail moment and tail inertia in the single cell gel electrophoresis assay. Mutat Res. 1995;336(2):123-131.
36. Bauer E, Recknagel RD, Fiedler U, Wollweber L, Bock C, Greulich KO. The distribution of the tail moments in single cell gel electrophoresis (comet assay) obeys a chi-square (chi2) not a gaussian distribution. Mutat Res. 1998;398(1-2):101-110. (Pubitemid 28225028)
37. Chen HM, Chang FR, Hsieh YC, et al. A novel synthetic protoapigenone analogue, WYC02-9, induces DNA damage and apoptosis in DU145 prostate cancer cells through generation of reactive oxygen species. Free Radic Biol Med. 2011;50(9):1151-1162.
38. Ange S, Treilleux I, Br?ond A, Tani?e P, Hall J. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Histopathology. 2003;43(4):347-353. (Pubitemid 37249148)
39. Serlund K, St O, Skoog L, Rutqvist LE, Nordenskj?d B, Askmalm MS. Intact Mre11/Rad50/Nbs1 complex predicts good response to radiotherapy in early breast cancer. Int J Radiat Oncol Biol Phys. 2007;68(1):50-58. (Pubitemid 46589837)
40. Bartkova J, Tommiska J, Oplustilova L, et al. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Mol Oncol. 2008;2(4):296-316.
41. Bowman T, Garcia R, Turkson J, Jove R. STATs in oncogenesis. Oncogene. 2000;19(21):2474-2488. (Pubitemid 30339203)
42. Watanabe H. Extracellular matrix-regulation of cancer invasion and metastasis. Gan To Kagaku Ryoho. 2010;37(11):2058-2061.
43. Bernhard EJ, Gruber SB, Muschel RJ. Direct evidence linking expression of matrix metalloproteinase 9 (92-kDa gelatinase/collagenase) to the metastatic phenotype in transformed rat embryo cells. Proc Natl Acad Sci USA. 1994;91(10):4293-4297. (Pubitemid 24143419)
44. Kinner A, Wu W, Staudt C, Iliakis G. Gamma-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 2008;36(17):5678-5694.
45. Pilch DR, Sedelnikova OA, Redon C, Celeste A, Nussenzweig A, Bonner WM. Characteristics of gamma-H2AX foci at DNA double-strand breaks sites. Biochem Cell Biol. 2003;81(3):123-129. (Pubitemid 37076234)
46. Kuo LJ, Yang LX. Gamma-H2AX-a novel biomarker for DNA double-strand breaks. In Vivo. 2008;22(3):305-309.
47. Dzikiewicz-Krawczyk A. The importance of making ends meet: mutations in genes and altered expression of proteins of the MRN complex and cancer. Mutat Res. 2008;659(3):262-273.
48. Gao J, Zhang H, Arbman G, Sun XF. RAD50/MRE11/NBS1 proteins in relation to tumour development and prognosis in patients with microsatellite stable colorectal cancer. Histol Histopathol. 2008;23(12):1495-1502.
49. Le Scodan R, Cizeron-Clairac G, Fourme E, et al. DNA repair gene expression and risk of locoregional relapse in breast cancer patients. Int J Radiat Oncol Biol Phys. 2010;78(2):328-336.
50. Choudhury A, Nelson LD, Teo MT, et al. MRE11 expression is predictive of cause-specific survival following radical radiotherapy for muscle-invasive bladder cancer. Cancer Res. 2010;70(18):7017-7026.
51. Gatti RA. The inherited basis of human radiosensitivity. Acta Oncol. 2001;40(6):702-711. (Pubitemid 33081978)
52. Ewald B, Sampath D, Plunkett W. ATM and the Mre11-Rad50-Nbs1 complex respond to nucleoside analogue-induced stalled replication forks and contribute to drug resistance. Cancer Res. 2008;68(19):7947-7955.
53. Kuroda S, Fujiwara T, Shirakawa Y, et al. Telomerase-dependent oncolytic adenovirus sensitizes human cancer cells to ionizing radiation via inhibition of DNA repair machinery. Cancer Res. 2010;70(22): 9339-9348.
54. Liikanen I, Dias JD, Nokisalmi P, et al. Adenoviral E4orf3 and E4orf6 proteins, but not E1B55K, increase killing of cancer cells by radiotherapy in vivo. Int J Radiat Oncol Biol Phys. 2010;78(4):1201-1209.
55. Deng R, Tang J, Ma JG, et al. PKB/Akt promotes DSB repair in cancer cells through upregulating Mre11 expression following ionizing radiation. Oncogene. 2011;30(8):944-955.
56. Zhang J, Xin X, Chen Q, et al. Oligomannurarate sulfate sensitizes cancer cells to doxorubicin by inhibiting atypical activation of NF-kappaB via targeting of Mre11. Int J Cancer. 2012;130(2):467-477.
57. Huang C, Cao J, Huang KJ, et al. Inhibition of STAT3 activity with AG490 decreases the invasion of human pancreatic cancer cells in vitro. Cancer Sci. 2006;97(12):1417-1423. (Pubitemid 44614996)
58. Xie TX, Wei D, Liu M, et al. Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. Oncogene. 2004;23(20):3550-3560. (Pubitemid 38658421)
59. Wu X, Yan Q, Zhang Z, Du G, Wan X. Acrp30 inhibits leptin-induced metastasis by downregulating the JAK/STAT3 pathway via AMPK activation in aggressive SPEC-2 endometrial cancer cells. Oncol Rep. 2012;27(5):1488-1496.