Augmentation of anti-tumour activity of cisplatin by pectin nano-conjugates in B-16 mouse model: Pharmacokinetics and in-vivo biodistribution of radio-labelled, hydrophilic nano-conjugates

International Journal of Nanotechnology

Volumn 9, Issue 10-12, 2012, Pages 872-886

  Verma, Anita Kamra ^a   Chanchal, Abhishek ^a   Chutani, Krishna ^b  

^a UNIVERSITY OF DELHI   (India)

^b INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

Author keywords

Bio distribution; CDDP; DDS; Nephrotoxicity; Pectin cisplatin nano conjugates; Tumour regression; Zeta potential

Indexed keywords

DERMATOLOGY; MAMMALS; NANOCONJUGATES; ONCOLOGY; PHARMACOKINETICS; ZETA POTENTIAL;

BIODISTRIBUTIONS; CDDP; NEPHROTOXICITY; PECTIN-CISPLATIN NANO-CONJUGATES; TUMOUR REGRESSIONS;

TUMORS;

EID: 84867310062     PISSN: 14757435     EISSN: None     Source Type: Journal    
DOI: 10.1504/IJNT.2012.049452     Document Type: Article

References (30)

1. Ringsdorf, H. (1975) 'Structure and properties of pharmacologically active polymers', J Polym. Sci. Polym. Symp., Vol. 51, p.135.
2. Duncan, R. (2003) 'Polymer-drug conjugates', in Budman, D., Calvert, H. and Rowinsky, E. (Eds.): Handbook of Anticancer Drug Development, Lippincott, Williams & Wilkins, Philadelphia, USA, pp.239-260.
3. Pitt, C.G. (1990) 'The controlled parenteral delivery of polypeptides and proteins', Int. J. Pharm., Vol. 59, 173-196.
4. Garnier, C., Axelos, M.A.V. and Thibault, J.F. (1993) 'Phase diagrams of pectin-calcium systems: Influence of pH, ionic strength, and temperature on the gelation of pectins with different degrees of methylation', Carbohydr. Res., Vol. 240, pp.219-232.
5. Rolin, C., Nielsen, B.U. and Glahn, P-E. (1998) 'Pectin', in Dumitriu, S. (Eds.): Polysaccharides: Structural Diversity and Functional Versatility, Marcel Dekker, New York, NY, 1 May, pp.401-409.
6. Ashford, M., Fell, J. and Attwood, D. (1994) 'Studies on pectin formulations for colonic drug delivery', J. Controlled Release, Vol. 30, pp.225-232.
7. Ashford, M., Fell, J., Attwood, D., Sharma, H. and Woodhead, P. (1993) 'An evaluation of pectin as a carrier for drug targeting to the colon', J. Controlled Release, Vol. 26, pp.213-220.
8. Murata, Y., Miyashita, M., Kofuji, K., Miyamoto, E. and Kawashima, S. (2004) 'Drug release properties of a gel bead prepared with pectin and hydrolysate', J. Controlled Release, Vol. 95, pp.61-66.
9. Esposito, E., Cortese, R., Luca, G. and Nastruzzi, C. (2001) 'Pectin-based microspheres a preformulatory study', Ann. N.Y. Acad. Sci., Vol. 944, November, pp.160-179.
10. Wakerly, Z., Fell, J., Attwood, D. and Parkins, D. (1996) 'Pectin/ethylcellulose film coating formulations for colonic drug delivery', Pharm. Res., Vol. 13, No. 8, pp.1210-1212.
11. Liu, L., Fishman M.L., Kost J. and Hicks K.B., (2003) 'Pectin-based systems for colonspecific drug delivery via oral route', Biomaterials, Vol. 24, No. 19, pp.3333-3343.
12. Moghimi, S.M., Hunter, A.C. and Murray, J.C. (2001) 'Long-circulating and target-specific nanoparticles: theory to practice', Pharmacol. Rev., Vol. 53, No. 2, pp.283-318.
13. Glinsky, V.V. and Raz, A. (2009) 'Modified citrus pectin anti-metastasis: one bullet, multiple targets', Carbohydr. Res., Vol. 344, No. 14, pp.1788-1791.
14. Furukawa, T., Kumai, K., Kubota, T., Hirahata, S., Shimizu, H., Matsui, H., Takahara, T., Aizawa, K., Shibata, S. and Shimada A. (1993) 'Experimental and clinical studies on the intraperitoneal administration of cisdiammine-dichloroplatinum (II) for peritoneal carcinomatosis caused by gastric cancers', Surg. Today, Vol. 23, No. 4, pp.298-306.
15. Bielack, S., Erttmann, R., Looft, G., Purürst C., Delling G., Winkler K. and Landbeck G. (1989) 'Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma', Cancer Chemother. Pharmacol., Vol. 24, No. 6, pp.376-380.
16. Eckman W.W., Patlak C.S. and Fenstermacher J.D. (1974) 'A critical evaluation of the principles governing the advantages of intra-arterial infusions', J. Pharm. Biopharm., Vol. 2, No. 3, pp.257-285.
17. Lukas, G., Brindle, S.D. and Greengard, P. (1981) 'The route of absorption of intraperitoneally administered compounds', J. Pharmacol. Exp. Ther., Vol. 178, No. 3, pp.562-566.
18. Schneider J.G. (1994) 'Intraperitoneal chemotherapy', Obstet. Gynecol. Clin. North Am., Vol. 21, No. 1, pp.195-212.
19. Deurloo, M.J.M., Kop W., Tellingen O.V., Bartelink H. and Begg A.C. (1991) 'Intratumoural administration of cisplatin in slow-releasing devices: II. Pharmacokinetics and intratumoural distribution', Cancer Chemother. Pharmacol., Vol. 27, pp.347-353.
20. Kumagai, S., Sugiyama, T., Nishida, T., Ushijima, K. and Yakushiji, M. (1996) "Improvement of intraperitoneal chemotherapy for rat ovarian cancer using cisplatin-containing microspheres', Jpn. J. Cancer Res., Vol. 87, No. 4, pp.412-417.
21. Shikani, A.H., Eisele, D.W. and Domb A.J. (1994) 'Polymer delivery of chemotherapy for squamous cell carcinoma of the head and neck', Arch. Otolaryngol. Head Neck Surg., Vol. 120, No. 11, pp.1242-1247.
22. Hagiwara, A., Takahashi, T., Sawai, K., Sakakura, C., Tsujimoto, H., Osaki, K., Sakakibara, T., Ohyama, T., Ohgaki, M., Muranishi, S., Ikada, Y. and Hyon, S.H. (1993) 'Clinical trials with intraperitoneal cisplatin microspheres for malignant ascites: a pilot study', Anticancer Drug Des., Vol. 8, No. 6, pp.463-470.
23. Verma, A K. and Sachin, K. (2008) 'Novel hydrophilic drug polymer nano-conjugates of Cisplatin showing long blood retention profile: its release kinetics, cellular uptake and bio-distribution', Curr. Drug Deliv., Vol. 5, No. 2, April, pp.120-126.
24. Mosmann, T. (1983) 'Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays', J. Immun. Methods, Vol. 65, Nos. 1-2, 16 December, pp.55-63.
25. Singh, N.P., McCoy, M.T., Tice, R.R. and Schneider, E.L. (1988) 'A simple technique for quantitation of low levels of DNA damage in individual cells', Exp. Cell Res., Vol. 175, No. 1, pp.184-191.
26. Duthie, S.J. and Collins, A.R. (1997) 'The influence of cell growth, detoxifying enzymes and DNA repair on hydrogen per oxide-mediated DNA damage (measured using the comet assay) in human cells', Free Radic Biol. Med., Vol. 22, No. 4, pp.717-724.
27. Maeda, H., Wu, J., Sawa, T., Matsumura, Y. and Hori, K. (2000) 'Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review', J. Control Release, Vol. 65, Nos. 1-2, 1 March, pp.271-284.
28. Loehrer, P.J. and Einhorn, L.H. (1984) 'Drugs five years later. Cisplatin', Ann. Intern. Med., Vol. 100, No. 5, May, pp.704-713.
29. Zahid, H.S. (2003) 'Cisplatin: mode of cytotoxic action and molecular basis of resistance', Oncogene, Vol. 22, pp.7265-7279.
30. Wong, T.W., Lee, H.Y., Chan, L.W. and Heng, P.W.S. (2002) 'Drug release properties of pectinate microspheres prepared by emulsification method', Int. J. Pharm., Vol. 242, Nos. 1-2, pp.233-237.