Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents

European Journal of Medicinal Chemistry

Volumn 57, Issue , 2012, Pages 240-249

  Abbassi, Najat ^a   Chicha, Hakima ^a   Rakib, El Mostapha ^a   Hannioui, Abdellah ^a   Alaoui, Mdaghri ^a   Hajjaji, Abdelouahed ^a   Geffken, Detlef ^b   Aiello, Cinzia ^c   Gangemi, Rosaria ^c   Rosano, Camillo ^c   Viale, Maurizio ^c  

^a SULTAN MOULAY SLIMANE UNIVERSITY   (Morocco)

^b UNIVERSITY OF HAMBURG   (Germany)

^c UNIVERSITY OF GENOA   (Italy)

Author keywords

Antiproliferative; Apoptosis; Cell cycle arrest; N (6(4) Indazolyl)benzenesulfonamides; Nitroindazoles

Indexed keywords

1 ALLYL 4 NITRO 1H INDAZOLE; 1 METHYL 4 NITRO 1H INDAZOLE; 2 ALLYL 4 NITRO 2H INDAZOLE; 2 METHYL 4 NITRO 2H INDAZOLE; 4 METHYL N [1 (TOLUENE 4 SULFONYL) 1H INDAZOL 6 YL]BENZENESULFONAMIDE; 4 METHYL N [1 (TOLUENE 4 SULFONYL) 3 BROMO 1H INDAZOL 6 YL]BENZENESULFONAMIDE; 7 ETHOXY N [6(4) INDAZOLYL]BENZENESULFONAMIDE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; BETA TUBULIN; N (1 ALLYL 2H INDAZOL 4 YL) 4 METHYLBENZENESULFONAMIDE; N (1 ALLYL 7 ETHOXY 2H INDAZOL 4 YL) 4 METHYLBENZENESULFONAMIDE; N (1 METHYL 2H INDAZOL 4 YL) 4 METHYLBENZENESULFONAMIDE; N (1 METHYL 7 ETHOXY 2H INDAZOL 4 YL) 4 METHYLBENZENESULFONAMIDE; N (1H 4 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N (1H 7 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N (1H INDAZOL 6 YL) 4 METHYLBENZENESULFONAMIDE; N (2 ALLYL 2H INDAZOL 6 YL) 4 METHYLBENZENESULFONAMIDE; N (2 ALLYL 7 ETHOXY 2H INDAZOL 6 YL) 4 METHYLBENZENESULFONAMIDE; N (2 METHYL 7 ETHOXY 2H INDAZOL 4 YL) 4 METHYLBENZENESULFONAMIDE; N (3 BROMO 1H 4 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N (3 BROMO 7 ETHOXY 1H 4 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N (3 CHLORO 1H 4 INDAZOLYL) 4 METHOXYBENZENESULFONAMIDE; N (3 CHLORO 7 ETHOXY 1H 4 INDAZOLYL) 4 METHOXYBENZENESULFONAMIDE; N (4 ETHOXY 1H 7 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N (7 ETHOXY 1H 4 INDAZOLYL) 4 METHYLBENZENESULFONAMIDE; N [6(4) INDAZOLYL]BENZENESULFONAMIDE DERIVATIVE; PROTEIN BAX; PROTEIN P53; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOFLUOROMETRY; DRUG ACTIVITY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MICROTUBULE; MITOSIS INHIBITION; MOLECULAR DOCKING; NONHUMAN; PROTEIN INDUCTION; UPREGULATION;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FLOW CYTOMETRY; G0 PHASE; G1 PHASE; G2 PHASE CELL CYCLE CHECKPOINTS; HUMANS; INDAZOLES; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MICROTUBULES; MOLECULAR DOCKING SIMULATION; POLYPLOIDY; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; TUBULIN;

EID: 84867305981     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.09.013     Document Type: Article

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