Synthesis and structure-activity relationships of novel pyrimido[1,2-b]indazoles as potential anticancer agents against A-549 cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 12, 2007, Pages 3445-3453

  Yakaiah, T ^a   Lingaiah, B P V ^a   Narsaiah, B ^a   Shireesha, B ^b   Ashok Kumar, B ^c   Gururaj, S ^d   Parthasarathy, T ^c   Sridhar, B ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b KAKATIYA UNIVERSITY   (India)

^c OSMANIA UNIVERSITY   (India)

^d Global Institute of Biotechnology   (India)

Author keywords

1,3 Diketones; A 549 cell lines; Cyclisation; Indazoles; Pyrimido 1,2 b indazoles; QSAR modelling studies; Regioisomers; Tubuline

Indexed keywords

ANILINE DERIVATIVE; ANTINEOPLASTIC AGENT; BENZENE DERIVATIVE; ETOPOSIDE; FLUORINE DERIVATIVE; INDAZOLE DERIVATIVE; NITRILE; PYRIMIDINE DERIVATIVE; TUBULIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; VALIDATION PROCESS;

ADENOCARCINOMA; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; HUMANS; INDAZOLES; LUNG NEOPLASMS; PYRIMIDINES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 34249752731     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.03.087     Document Type: Article

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