Structure-Based Design, Synthesis, and Antimicrobial Activity of Indazole-Derived SAH/MTA Nucleosidase Inhibitors

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5663-5673

  Li, Xiaoming ^a   Chu, Sam ^a   Feher, Victoria A ^a   Khalili, Mitra ^a   Nie, Zhe ^a   Margosiak, Stephen ^a   Nikulin, Victor ^a   Levin, James ^a   Sprankle, Kelly G ^a   Tedder, Martina E ^a   Almassy, Robert ^a   Appelt, Krzysztof ^a   Yager, Kraig M ^a  

^a Quorex Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3',4' DICHLOROBIPHENYL 3 SULFONIC ACID (3 CHLORO 7 ISOBUTYLAMINO 1H INDAZOL 5 YL)AMIDE; AMIDE; ANTIBIOTIC AGENT; INDAZOLE DERIVATIVE; METHYLTHIOADENOSINE NUCLEOSIDASE INHIBITOR; S ADENOSYLHOMOCYSTEINE NUCLEOSIDASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; METHODOLOGY; NONHUMAN; PROTEIN FOLDING; STRUCTURE ANALYSIS;

ANTI-BACTERIAL AGENTS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; INDAZOLES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; N-GLYCOSYL HYDROLASES; NEISSERIA MENINGITIDIS; STREPTOCOCCUS PNEUMONIAE; STREPTOCOCCUS PYOGENES; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 10744223757     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0302039     Document Type: Article

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