Cellular events and biomarkers of wound healing

Indian Journal of Plastic Surgery

Volumn 45, Issue 2, 2012, Pages 220-228

  Yussof, Shah Jumaat Mohd ^a   Omar, Effat ^a   Pai, Dinker R ^b   Sood, Suneet ^c  

^a UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^b MELAKA MANIPAL MEDICAL COLLEGE   (India)

^c MONASH UNIVERSITY MALAYSIA   (Malaysia)

Author keywords

Cytokines; growth factors; matrix metalloproteinases; platelet derived growth factor; wound healing

Indexed keywords

EID: 84867305222     PISSN: 09700358     EISSN: 1998376X     Source Type: Journal    
DOI: 10.4103/0970-0358.101282     Document Type: Review

References (70)

1. Buchanan EP, Lorenz HP. Wound healing, including fetal skin healing. In: Bahman G, Eriksson E, Persing JA, editors. Plastic Surgery: Indications and Practice. Elsevier, 2009. p. 9-26.
2. Chin GC, Diegelmann RF, Schultz GS. Cellular and molecular regulation of wound healing. In: Falabella AF, Kirsner RS, editors. Wound Healing. Boca Raton: Taylor & Francis Group; 2005. p. 17-37.
3. Antoniades HN, Scher CD, Stiles CD. Purifi cation of human platelet-derived growth factor. Proc Natl Acad Sci U S A 1979;76:1809-13.
4. Tissue renewal and repair: regeneration, healing, and fi brosis. In: Kumar V, Abbas AA, Fausto N, editors. Robbins and Cotran's Pathologic Basis of Disease, 7th Edition. Philadelphia : Elsevier;2005. p. 87-118.
5. LeBlanc S, Arabzadeh A, Benlolo S, Breton V, Turbide C, Beauchemin N, et al. CEACAM1 defi ciency delays important wound healing processes. Wound Repair Regen 2011;19: 745-52.
6. Diegelmann RF, Evans MC. Wound healing: An overview of acute, fi brotic and delayed healing. Front Biosci 2004;9:283-9.
7. Li J, Kirsner RS. Extracellular matrix and wound healing. In: Falabella AF, Kirsner RS, editors. Wound Healing. Boca Raton: Taylor & Francis Group; 2005. p. p39-48.
8. Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, et al. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP. FASEB J 1999;13:1774-86.
9. Montesinos MC, Desai A, Chen JF, Yee H, Schwarzschild MA, Fink JS, et al. Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am J Pathol 2002;160:2009-18.
10. Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen 2009;17:153-62.
11. Rumalla VK, Borah GL. Cytokines, growth factors, and plastic surgery. Plast Reconstr Surg 2001;108:719-33.
12. Bao P, Kodra A, Tomic-Canic M, Golinko MS, Ehrlich HP, Brem H. The role of vascular endothelial growth factor in wound healing. J Surg Res 2009;153:347-58.
13. Katz MH, Alvarez AF, Kirsner RS, Eaglstein WH, Falanga V. Human wound fl uid from acute wounds stimulates fi broblast and endothelial cell growth. J Am Acad Dermatol 1991;25:1054-8.
14. Mendez MV, Raffetto JD, Phillips T, Menzoian JO, Park HY. The proliferative capacity of neonatal skin fi broblasts is reduced after exposure to venous ulcer wound fl uid: A potential mechanism for senescence in venous ulcers. J Vasc Surg 1999;30:734-43.
15. Bucalo B, Eaglstein WH, Falanga V. Inhibition of cell proliferation by chronic wound fl uid. Wound Repair Regen 1993;1:181-6.
16. Agren MS, Eaglstein WH, Ferguson MW, Harding KG, Moore K, Saarialho-Kere UK, et al. Causes and effects of the chronic infl ammation in venous leg ulcers. Acta Derm Venereol Suppl (Stockh) 2000;210:3-17.
17. Mendez MV, Stanley A, Park HY, Shon K, Phillips T, Menzoian JO. Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg 1998;28:876-83.
18. Loot MA, Kenter SB, Au FL, van Galen WJ, Middelkoop E, Bos JD, et al. Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls. Eur J Cell Biol 2002;81:153-60.
19. Cowin AJ, Hatzirodos N, Holding CA, Dunaiski V, Harries RH, Rayner TE, et al. Effect of healing on the expression of transforming growth factor beta(s) and their receptors in chronic venous leg ulcers. J Invest Dermatol 2001;117:1282-9.
20. Trengove NJ, Bielefeldt-Ohmann H, Stacey MC. Mitogenic activity and cytokine levels in non-healing and healing chronic leg ulcers. Wound Repair Regen 2000;8:13-25.
21. Yager DR, Zhang LY, Liang HX, Diegelmann RF, Cohen IK. Wound fl uids from human pressure ulcers contain elevated matrix metalloproteinase levels and activity compared to surgical wound fl uids. J Invest Dermatol 1996;107:743-8.
22. Snyder RJ, Driver V, Fife CE, Lantis J, Peirce B, Serena T, et al. Using a diagnostic tool to identify elevated protease activity levels in chronic and stalled wounds: A consensus panel discussion. Ostomy Wound Manage 2011;57:36-46.
23. Ladwig GP, Robson MC, Liu R, Kuhn MA, Muir DF, Schultz GS. Ratios of activated matrix metalloproteinase-9 to tissue inhibitor of matrix metalloproteinase-1 in wound fl uids are inversely correlated with healing of pressure ulcers. Wound Repair Regen 2002;10:26-37.
24. White RJ, Cutting KF. Critical colonization-the concept under scrutiny. Ostomy Wound Manage 2006;52:50-6.
25. Hahm G, Glaser JJ, Elster EA. Biomarkers to predict wound healing: The future of complex war wound management. Plast Reconstr Surg 2011;127(Suppl 1):21S-6S.
26. Beidler SK, Douillet CD, Berndt DF, Keagy BA, Rich PB, Marston WA. Infl ammatory cytokine levels in chronic venous insuffi ciency ulcer tissue before and after compression therapy. J Vasc Surg 2009;49:1013-20.
27. Gohel MS, Windhaber RA, Tarlton JF, Whyman MR, Poskitt KR. The relationship between cytokine concentrations and wound healing in chronic venous ulceration. J Vasc Surg 2008;48:1272-7.
28. Harris IR, Yee KC, Walters CE, Cunliffe WJ, Kearney JN, Wood EJ, et al. Cytokine and protease levels in healing and nonhealing chronic venous leg ulcers. Exp Dermatol 1995;4:342-9.
29. Forsberg JA, Elster EA, Andersen RC, Nylen E, Brown TS, Rose MW, et al. Correlation of procalcitonin and cytokine expression with dehiscence of wartime extremity wounds. J Bone Joint Surg Am 2008;90:580-8.
30. Utz ER, Elster EA, Tadaki DK, Gage F, Perdue PW, Forsberg JA, et al. Metalloproteinase expression is associated with traumatic wound failure. J Surg Res 2010;159:633-9.
31. Asada M, Nakagami G, Minematsu T, Nagase T, Akase T, Huang L, et al. Novel biomarkers for the detection of wound infection by wound fl uid RT-PCR in rats. Exp Dermatol 2012;21:118-22.
32. Butte AJ, Dzau VJ, Glueck SB. Further defi ning housekeeping, or "maintenance," genes Focus on "A compendium of gene expression in normal human tissues". Physiol Genomics 2001;7:95-6.
33. Moor AN, Vachon DJ, Gould LJ. Proteolytic activity in wound fl uids and tissues derived from chronic venous leg ulcers. Wound Repair Regen 2009;17:832-9.
34. Thomas AN, Riazanskaia S, Cheung W, Xu Y, Goodacre R, Thomas CL, et al. Novel noninvasive identifi cation of biomarkers by analytical profi ling of chronic wounds using volatile organic compounds. Wound Repair Regen 2010;18:391-400.
35. Robson MC. Wound infection. A failure of wound healing caused by an imbalance of bacteria. Surg Clin North Am 1997;77:637-50.
36. Robson MC, Stenberg BD, Heggers JP. Wound healing alterations caused by infection. Clin Plast Surg 1990;17:485-92.
37. Robson MC. Wound healing and wound closure. In: Heggers JP, Robson MC, editors. Quantitative bacteriology: Its role in the armamentarium of the surgeon. Boca Raton, FL: CRC Press; 1991:43-54.
38. Gope R. The effect of epidermal growth factor & platelet-derived growth factors on wound healing process. Indian J Med Res 2002;116:201-6.
39. Victor-Vega C, Desai A, Montesinos MC, Cronstein BN. Adenosine A2A receptor agonists promote more rapid wound healing than recombinant human platelet-derived growth factor (Becaplermin gel). Infl ammation 2002;26:19-24.
40. Montesinos MC, Shaw JP, Yee H, Shamamian P, Cronstein BN. Adenosine A(2A) receptor activation promotes wound neovascularization by stimulating angiogenesis and vasculogenesis. Am J Pathol 2004;164:1887-92.
41. Macedo L, Pinhal-Enfi eld G, Alshits V, Elson G, Cronstein BN, Leibovich SJ. Wound healing is impaired in MyD88-defi cient mice: A role for MyD88 in the regulation of wound healing by adenosine A2A receptors. Am J Pathol 2007;171:1774-88.
42. Mogford JE, Tawil B, Jia S, Mustoe TA. Fibrin sealant combined with fi broblasts and platelet-derived growth factor enhance wound healing in excisional wounds. Wound Repair Regen 2009;17:405-10.
43. Lariviere B, Rouleau M, Picard S, Beaulieu AD. Human plasma fi bronectin potentiates the mitogenic activity of platelet-derived growth factor and complements its wound healing effects. Wound Repair Regen 2003;11:79-89.
44. Cheng B, Liu HW, Fu XB, Sun TZ, Sheng ZY. Recombinant human platelet-derived growth factor enhanced dermal wound healing by a pathway involving ERK and c-fos in diabetic rats. J Dermatol Sci 2007;45:193-201.
45. Engrav LH, Richey KJ, Kao CC, Murray MJ. Topical growth factors and wound contraction in the rat: Part II. Platelet-derived growth factor and wound contraction in normal and steroidimpaired rats. Ann Plast Surg 1989;23:245-8.
46. Uhl E, Rosken F, Sirsjo A, Messmer K. Infl uence of plateletderived growth factor on microcirculation during normal and impaired wound healing. Wound Repair Regen 2003;11:361-7.
47. Mustoe TA, Purdy J, Gramates P, Deuel TF, Thomason A, Pierce GF. Reversal of impaired wound healing in irradiated rats by platelet-derived growth factor-BB. Am J Surg 1989;158:345-50.
48. Blume P, Driver VR, Tallis AJ, Kirsner RS, Kroeker R, Payne WG, et al. Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers. Wound Repair Regen 2011;19:302-8.
49. Liechty KW, Nesbit M, Herlyn M, Radu A, Adzick NS, Crombleholme TM. Adenoviral-mediated overexpression of platelet-derived growth factor-B corrects ischemic impaired wound healing. J Invest Dermatol 1999;113:375-83.
50. Breitbart AS, Laser J, Parrett B, Porti D, Grant RT, Grande DA, et al. Accelerated diabetic wound healing using cultured dermal fi broblasts retrovirally transduced with the platelet-derived growth factor B gene. Ann Plast Surg 2003;51:409-14.
51. Chan RK, Liu PH, Pietramaggiori G, Ibrahim SI, Hechtman HB, Orgill DP. Effect of recombinant platelet-derived growth factor (Regranex) on wound closure in genetically diabetic mice. J Burn Care Res 2006;27:202-5.
52. Karr BP, Bubak PJ, Sprugel KH, Pavlin EG, Engrav LH. Plateletderived growth factor and wound contraction in the rat. J Surg Res 1995;59:739-42.
53. Hammacher A, Mellstrom K, Heldin CH, Westermark B. Isoformspecifi c induction of actin reorganization by platelet-derived growth factor suggests that the functionally active receptor is a dimer. EMBO J 1989;8:2489-95.
54. Watts SA. Platelet-derived growth factor for foot ulcerations. An effective adjunct to good wound care. Adv Nurse Pract 2001;9:60-3.
55. Ehrlich HP, Freedman BM. Topical platelet-derived growth factor in patients enhances wound closure in the absence of wound contraction. Cytokines Cell Mol Ther 2002;7:85-90.
56. Fernandez-Montequin JI, Betancourt BY, Leyva-Gonzalez G, Mola EL, Galan-Naranjo K, Ramirez-Navas M, et al. Intralesional administration of epidermal growth factor-based formulation (Heberprot-P) in chronic diabetic foot ulcer: Treatment up to complete wound closure. Int Wound J 2009;6: 67-72.
57. Kurtz MP, Svensson E, Heimann TM. Use of platelet-derived growth factor for delayed perineal wound healing in patients with infl ammatory bowel disease: A case series. Ostomy Wound Manage 2011;57:24-31.
58. Shackelford DP, Fackler E, Hoffman MK, Atkinson S. Use of topical recombinant human platelet-derived growth factor BB in abdominal wound separation. Am J Obstet Gynecol 2002;186:701-4.
59. Rees RS, Robson MC, Smiell JM, Perry BH. Becaplermin gel in the treatment of pressure ulcers: A phase II randomized, double-blind, placebo-controlled study. Wound Repair Regen 1999;7:141-7.
60. Ono I, Akasaka Y, Kikuchi R, Sakemoto A, Kamiya T, Yamashita T, et al. Basic fi broblast growth factor reduces scar formation in acute incisional wounds. Wound Repair Regen 2007;15:617-23.
61. Richard JL, Parer-Richard C, Daures JP, Clouet S, Vannereau D, Bringer J, et al. Effect of topical basic fi broblast growth factor on the healing of chronic diabetic neuropathic ulcer of the foot. A pilot, randomized, double-blind, placebo-controlled study. Diabetes Care 1995;18:64-9.
62. Tsang MW, Wong WK, Hung CS, Lai KM, Tang W, Cheung EY, et al. Human epidermal growth factor enhances healing of diabetic foot ulcers. Diabetes Care 2003;26:1856-61.
63. Mohan VK. Recombinant human epidermal growth factor (REGEN-D 150): Effect on healing of diabetic foot ulcers. Diabetes Res Clin Pract 2007;78:405-11.
64. Ginsburg GS, Willard HF. Genomic and personalized medicine: Foundations and applications. Transl Res 2009;154:277-87.
65. Jones J, Libermann TA. Genomics of renal cell cancer: The biology behind and the therapy ahead. Clin Cancer Res 2007;13:685s-92s.
66. Auffray C, Chen Z, Hood L. Systems medicine: The future of medical genomics and healthcare. Genome Med 2009;1:2.
67. Hawksworth JS, Stojadinovic A, Gage FA, Tadaki DK, Perdue PW, Forsberg J, et al. Infl ammatory biomarkers in combat wound healing. Ann Surg 2009;250:1002-7.
68. Lantis JC 2nd, Boone D, Gendics C, Todd G. Analysis of patient cost for recombinant human platelet-derived growth factor therapy as the fi rst-line treatment of the insured patient with a diabetic foot ulcer. Adv Skin Wound Care 2009;22:167-71.
69. Langer A, Rogowski W. Systematic review of economic evaluations of human cell-derived wound care products for the treatment of venous leg and diabetic foot ulcers. BMC Health Serv Res 2009;9:115.
70. Pomahac B, Hirsch T, Eriksson E. Wound management. In: Bahman G, Eriksson E, Persing JA, editors. Plastic Surgery: Indications and Practice. Elsevier, 2009. p. 27-36.