Potential pitfalls with the use of acetoxy (CH3COO) drugs in studies on nitric oxide synthase in platelets

Nitric Oxide - Biology and Chemistry

Volumn 28, Issue , 2013, Pages 14-16

  Böhmer, Anke ^a   Niemann, Jonas ^a   Schwedhelm, Kathrin S ^a   Meyer, Hartmut H ^b   Gambaryan, Stepan ^c   Tsikas, Dimitrios ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b LEIBNIZ UNIVERSITY HANNOVER   (Germany)

^c UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Acetoxy drugs; Aggregation; COX; NOS; Platelets; Thromboxane

Indexed keywords

ACETYLSALICYLIC ACID CYSTEINE ETHYL ESTER; ACETYLSALICYLIC ACID DERIVATIVE; COUMARIC ACID; CYCLIC GMP; CYCLOOXYGENASE 1; DI O ACETYLSALICYLIC ACID CYSTEINE ETHYL ESTER; GLUTATHIONE TRANSFERASE; GUAIMESAL; NITRIC OXIDE SYNTHASE; THROMBOXANE; UNCLASSIFIED DRUG;

BIOTRANSFORMATION; COMPETITIVE INHIBITION; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; IC 50; INCUBATION TIME; LETTER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; SINGLE NUCLEOTIDE POLYMORPHISM; THROMBOCYTE; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION INHIBITION; WESTERN BLOTTING;

ACETATES; BLOOD PLATELETS; HUMANS; MOLECULAR STRUCTURE; NITRIC OXIDE SYNTHASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867234834     PISSN: 10898603     EISSN: 10898611     Source Type: Journal    
DOI: 10.1016/j.niox.2012.09.002     Document Type: Letter

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