Acetoxy drug: Protein transacetylase of buffalo liver - Characterization and mass spectrometry of the acetylated protein product

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1698, Issue 1, 2004, Pages 55-66

  Kohli, Ekta ^a   Gaspari, Marco ^b   Raj, Hanumantharao G ^a   Parmar, Virinder S ^c,d   Sharma, Sunil K ^c,d   Van Der Greef, Jan ^b,e   Kumari, Ranju ^a   Gupta, Garima ^a   Seema, ^a   Khurana, Pulkit ^a   Tyagi, Yogesh K ^a   Watterson, Arthur C ^d   Olsen, Carl E ^f  

^a UNIVERSITY OF DELHI   (India)

^b TNO   (Netherlands)

^c UNIVERSITY OF DELHI   (India)

^d University of Massachusetts Lowell   (United States)

^e LEIDEN UNIVERSITY   (Netherlands)

^f UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Acetoxy drug; MALDI TOF; Protein acetylation; Protein mass spectrometry; Transacetylase

Indexed keywords

7,8 DIACETOXY 4 METHYLCOUMARIN; 7,8 DIHYDROXY 4 METHYLCOUMARIN; ACYLTRANSFERASE; COUMARIN DERIVATIVE; LIVER ENZYME; MONOACETOXYMONOHYDROXY 4 METHYLCOUMARIN; PEPTIDE DERIVATIVE; TRYPSIN; UNCLASSIFIED DRUG;

ACETYLATION; ANIMAL CELL; ARTICLE; BUFFALO; CATALYSIS; ENZYME ANALYSIS; ENZYME PURIFICATION; LIVER MICROSOME; MASS SPECTROMETRY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MODEL; MOLECULAR WEIGHT; NONHUMAN; PEPTIDE MAPPING; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL;

ACETYLATION; ACETYLTRANSFERASES; AMINO ACID SEQUENCE; ANIMALS; BUFFALOES; COUMARINS; GLUTATHIONE TRANSFERASE; LIVER; MICROSOMES, LIVER; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

BUBALUS;

EID: 11144357313     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2003.10.004     Document Type: Article

References (17)

1. Mizzen C.A., Brownell J.E., Cook R.G., Allis C.D. Histone acetyl transferase: preparation of substrates and assay procedure. Methods Enzymol. 304:1999;675-704.
2. Gu W., Roeder R.G. Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell. 90:1997;595-606.
3. Wakil S.J. Fatty acid synthase, a proficient multifunctional enzyme. J. Biochem. 45(28(11)):1981;23-30.
4. Vane J.R. Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nature (New Biol.). 231:1971;232-234.
5. Raj H.G., Parmar V.S., Jain S.C., Kohli E., Ahmad N., Goel S., Tyagi Y.K., Sharma S.K., Wengel J., Olsen C.E. Mechanism of biochemical action of substituted 4-mehtylbenzopyran-2-ones. Part 7: assay and characterization from rat liver microsomes based on the irreversible inhibition of cytosolic glutathione S-transferase. Bioorg. Med. Chem. 8:2000;1707-1712.
6. Singh I., Kohli E., Raj H.G., Gyanda K., Jain S.K., Tyagi Y.K., Gupta G., Kumari R., Kumar A., Pal G., Prasad A.K., Rastogi R.C., Olsen C.E., Jain S.C., Parmar V.S. Mechanism of Biochemical Action of substituted 4-methylbenzopyran-2- ones. Part 9: comparison of acetoxy 4-methylcoumarins and other polyphenolacetates reveal the specificity to acetoxy drug: protein transacetylase for pyrancarbonyl group in proximity to the oxygen heteroatom. Bioorg. Med. Chem. 10:2002;4103-4111.
7. Kohli E., Gaspari G., Raj H.G., Parmar V.S., Vander Greef J., Gupta G., Kumari R., Prasad A.K., Goel S., Pal G., Tyagi Y.K., Jain S.C., Ahmad N., Watterson A.C., Olsen C.E. Establishment of the enzymatic protein acetylation independent of acetyl CoA: recombinant glutathione S-transferase 3-3 is acetylated by a novel membrane bound transacetylase using 7,8-diacetoxy-4- methylcoumarin as the acetyl donor. FEBS Lett. 530:2002;139-142.
8. 5 reductase. Anal. Biochem. 110:1981;373.
9. Lamelli U.K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.). 227:1970;680-685.
10. Shevchenko A., Wilm M., Vorm O., Mann M. Mass spectrometry sequencing of proteins silver stained polyacrylamide. Anal. Chem. 68:1996;850-858.
11. Roepstroff P., Fohlman J. Proposal for a common nomenclature for sequence ions in mass spectra of peptide 11. Biomed. Mass Spectrom. 1984;601.
12. Gianazza E. Isoelectric focussing as a tool for the investigation of post translational processing and chemical modifications of proteins. J. Chromatogr. 705:1995;67-87.
13. Raj H.G., Parmar V.S., Kohli E., Tyagi Y.K., Olsen C.E. Discovery of new player in drug metabolism: acetoxy drug: protein transacetylase. FASEB J. 14:2000;A1445.
14. Kohli E., Kumari R., Gupta G., Raj H.G., Parmar V.S., Ahmad N., Jain S.C., Pal G., Olsen C.E. Acetoxy drug: protein transacetylase mediates acetyl CoA independent protein acetylation. Drug Metab. Rev. 33(Suppl. 1):2001;39.
15. Raj H.G., Parmar V.S., Jain S.C., Goel S., Tyagi Y.K., Sharma S.K., Olsen C.E., Wengel J. Mechanism of biochemical action of substituted 4-methylbenzopyran-2-ones. Part 6: hydrolysis of 7,8-diacetoxy-4-methylcoumarin by a novel deacetylase in the rat liver microsomes - a simple method for assay and characterization. Bioorg. Med. Chem. 8:2000;2333-2336.
16. Uemura Y., Lee T.C., Synder F. A coenzyme A transacylase is linked to the formation of platelet activating factor (PAF) by generating the LysoPAF intermediate in the remodeling pathways. J. Biol. Chem. 266:1991;8268-8272.
17. Weber W.W., Hein D.W. N-acetylation pharmacogenetics. Pharmacol. Rev. 37:1985;25-79.