1H NMR-based metabolomic analysis of triptolide-induced toxicity in liver-specific cytochrome P450 reductase knockout mice

Metabolomics

Volumn 8, Issue 5, 2012, Pages 907-918

  Liu, Xia ^a   Xue, Xiang ^a   Gong, Likun ^a   Qi, Xinming ^a   Wu, Yuanfeng ^a   Xing, Guozhen ^a   Luan, Yang ^a   Xiao, Ying ^a   Wu, Xiongfei ^a   Li, Yan ^a   Chen, Min ^a   Miao, Lingling ^a   Yao, Jun ^a   Gu, Jun ^c   Lin, Donghai ^b   Ren, Jin ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b XIAMEN UNIVERSITY   (China)

^c STATE UNIVERSITY OF NEW YORK   (United States)

Author keywords

Cytochrome P450; Hepatotoxicity; Metabolomics; Toxicity; Triptolide

Indexed keywords

ACETYL COENZYME A HYDROLASE; ALANINE AMINOTRANSFERASE; ASPARTATE AMMONIA LYASE; ASPARTIC ACID; CHOLINE; CITRATE SYNTHASE; CYSTATHIONINE GAMMA LYASE; CYSTEINE DIOXYGENASE; CYTOCHROME P450 REDUCTASE; FUCOSE; FUMARATE HYDRATASE; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; GLUTATHIONE SYNTHASE; GLYCEROPHOSPHORYLCHOLINE; GLYCINE; GLYCINE AMIDINOTRANSFERASE; ISOLEUCINE; LACTATE DEHYDROGENASE; LACTIC ACID; LEUCINE; LYSINE; MALIC ACID; PHENYLALANINE 4 MONOOXYGENASE; SUCCINATE DEHYDROGENASE; TAURINE; TRIPTOLIDE; VALINE;

AMINO ACID METABOLISM; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CONTROLLED STUDY; CORRELATION ANALYSIS; ENERGY METABOLISM; ENZYME INACTIVATION; HISTOPATHOLOGY; INTESTINE FLORA; KNOCKOUT MOUSE; LIVER TOXICITY; METABOLOMICS; MOLECULAR MECHANICS; MOUSE; MULTIVARIATE ANALYSIS; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; WILD TYPE;

MUS; TRIPTERYGIUM WILFORDII;

EID: 84867218416     PISSN: 15733882     EISSN: 15733890     Source Type: Journal    
DOI: 10.1007/s11306-011-0385-1     Document Type: Article

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