FTO, RNA epigenetics and epilepsy

Epigenetics

Volumn 7, Issue 10, 2012, Pages 1094-1097

  Rowles, Joie ^a   Wong, Morgan ^b   Powers, Ryan ^b   Olsen, Mark ^a  

^a MIDWESTERN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

Author keywords

Epilepsy; Fto; microRNA; RNA demethylation; RNA epigenetics; RNA methylation

Indexed keywords

2 OXOGLUTARIC ACID; 3 METHYLTHYMINE; 3 METHYLURACIL; 6 N METHYLADENOSINE; ANTAGOMIR; BRAIN DERIVED NEUROTROPHIC FACTOR; CCAAT ENHANCER BINDING PROTEIN BETA; FERROUS ION; FTO PROTEIN; LIM KINASE 1; METHYLTRANSFERASE; METHYLTRANSFERASE LIKE 3; MICRORNA 134; MICRORNA 146A; NUCLEAR RNA; PROTEIN; RESTRICTION ENDONUCLEASE; RNA; RNA POLYMERASE II; SINGLE STRANDED DNA; THYMINE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ALZHEIMER DISEASE; ARTICLE; BRAIN SIZE; BRAIN TISSUE; CATALYSIS; CELL NUCLEUS; CENTRAL NERVOUS SYSTEM; CONSENSUS SEQUENCE; DEMETHYLATION; DEPRESSION; ENZYME ACTIVITY; ENZYME BINDING; ENZYME PHOSPHORYLATION; EPIGENETICS; EPILEPSY; EPILEPTIC STATE; FRONTAL LOBE; GENE EXPRESSION; GENETIC ASSOCIATION; GENETIC VARIABILITY; GROWTH RETARDATION; HIPPOCAMPAL SCLEROSIS; HUMAN; NERVE CELL PLASTICITY; NEUROLOGIC DISEASE; NONHUMAN; OCCIPITAL LOBE; PHENOTYPE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RNA DEGRADATION; RNA INTERFERENCE; RNA METHYLATION; RNA PROCESSING; RNA SPLICING; TEMPORAL LOBE EPILEPSY; TRANSLATION REGULATION; UPREGULATION;

EID: 84867184467     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.21977     Document Type: Article

References (27)

1. Peters T, Ausmeier K, Ruther U. Cloning of Fatso (Fto), a novel gene deleted by the Fused toes (Ft) mouse mutation. Mamm Genome 1999; 10:9836. PMID: 10501967; http://dx.doi.org/10.1007/s003359901144.
2. Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, Lindgren CM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 2007; 316:889-94. PMID:17434869; http://dx.doi.org/10.1126/science.1141634.
3. Larder R, Cheung MK, Tung YC, Yeo GS, Coll AP, Where to go with FTO? Trends Endocrinol Metab 2011; 22:53-9. PMID:21131211; http://dx.doi.org/10.1016/j.tem.2010.11.001.
4. Rivera M, Cohen-Woods S, Kapur K, Breen G, Ng MY, Butler AW, et al. Depressive disorder moderates the effect of the FTO gene on body mass index. Mol Psychiatry 2012; 17:604-11. PMID:21502950;http://dx.doi.org/10.1038/mp.2011.45.
5. Keller L, Xu W, Wang HX, Winblad B, Fratiglioni L, Graff C. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis 2011; 23:461-9.PMID:21098976.
6. Yeo GSH. FTO and obesity: a problem for a billion people. J Neuroendocrinol 2012; 24:393-4.PMID:22248259; http://dx.doi.org/10.1111/j.1365-2826.2011.02254.x.
7. Boissel S, Reish O, Proulx K, Kawagoe-Takaki H, Sedgwick B, Yeo GS, et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet 2009; 85:106-11.PMID:19559399; http://dx.doi.org/10.1016/j.ajhg.2009.06.002.
8. Gao X, Shin YH, Li M, Wang F, Tong Q, Zhang P. The fat mass and obesity associated gene FTO functions in the brain to regulate postnatal growth in mice. PLoS One 2010; 5:e14005.PMID:21103374; http://dx.doi.org/10.1371/journal.pone.0014005.
9. Ho AJ, Stein JL, Hua X, Lee S, Hibar DP, Leow AD, et al.; Alzheimer's Disease Neuroimaging Initiative. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A 2010; 107:8404-9.PMID:20404173; http://dx.doi.org/10.1073/pnas.0910878107.
10. Rask-Andersen M, Almen MS, Olausen HR, Olszewski PK, Eriksson J, Chavan RA, et al. Functional coupling analysis suggests link between the obesity gene FTO and the BDNF-NTRK2 signaling pathway. BMC Neurosci 2011; 12:117.PMID:22087873; http://dx.doi.org/10.1186/1471-2202-12-117.
11. Gerken T, Girard CA, Tung YC, Webby CJ, Saudek V, Hewitson KS, et al. The obesity-associated FTO gene encodes a 2-oxoglutarate-dependent nucleic acid demethylase. Science 2007; 318:1469-72.PMID:17991826; http://dx.doi.org/10.1126/sci-ence.1151710.
12. Jia G, Yang CG, Yang S, Jian X, Yi C, Zhou Z, et al. Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO. FEBS Lett 2008; 582:33139.PMID:18775698; http://dx.doi.org/10.1016/j.feb-slet.2008.08.019.
13. Jia GF, Fu Y, Zhao X, Dai Q, Zheng GQ, Yang Y, et al. N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol 2011; 7:885-7.PMID:22002720; http://dx.doi.org/10.1038/nchembio.687.
14. Bokar JA, Shambaugh ME, Polayes D, Matera AG, Rottman FM. Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA 1997; 3:1233-47.PMID:9409616.
15. Harper JE, Miceli SM, Roberts RJ, Manley JL. Sequence specificity of the human mRNA N6-adenosine methylase in vitro. Nucleic Acids Res 1990; 18:5735-41. PMID:2216767; http://dx.doi.org/10.1093/nar/18.19.5735.
16. Shimba S, Bokar JA, Rottman F, Reddy R. Accurate and efficient N-6-adenosine methylation in spli-ceosomal U6 small nuclear RNA by HeLa cell extract in vitro. Nucleic Acids Res 1995; 23:24216.PMID: 763 0720; http://dx.doi.org/10.1093/nar/23.13.2421.
17. Dominissini D, Moshitch-Moshkovitz S, Schwartz S, Salmon-Divon M, Ungar L, Osenberg S, et al. Topology of the human and mouse m6A RNA meth-ylomes revealed by m6A-seq. Nature 2012; 485:2016.PMID:22575960; http://dx.doi.org/10.1038/ nature11112.
18. Meyer KD, Saletore Y, Zumbo P, Elemento O, Mason CE, Jaffrey SR. Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codons. Cell 2012; 149:163546.PMID:22608085; http://dx.doi.org/10.1016/j. cell.2012.05.003.
19. He C. Grand challenge commentary: RNA epi-genetics? Nat Chem Biol 2010; 6:863-5.MID:21079590; http://dx.doi.org/10.1038/nchem-bio.482.
20. Kim VN, Nam JW. Genomics of microRNA. Trends Genet 2006; 22:165-73. PMID:16446010; http://dx.doi.org/10.1016/j.tig.2006.01.003.
21. Bian S, Sun T. Functions of noncoding RNAs in neural development and neurological diseases. Mol Neurobiol 2011; 44:359-73.PMID:21969146; http://dx.doi.org/10.1007/s12035-011-8211-3.
22. Aronica E, Fluiter K, Iyer A, Zurolo E, Vreijling J, van Vliet EA, et al. Expression pattern of miR-146a, an inflammation-associated microRNA, in experimental and human temporal lobe epilepsy. Eur J Neurosci 2010; 31:1100-7.PMID:20214679; http://dx.doi.org/10.1111/j.1460-9568.2010.07122.x.
23. Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, et al. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nat Med 2012; In press. PMID:22683779; http://dx.doi.org/10.1038/nm.2834.
24. Ji L, Chen X. Regulation of small RNA stability: methylation and beyond. Cell Res 2012; 22:62436.PMID:22410795; http://dx.doi.org/10.1038/cr.2012.36.
25. Kierzek E, Kierzek R. The thermodynamic stability of RNA duplexes and hairpins containing N6-alkyladenosines and 2-methylthio-N6-alkyl-adenosines. Nucleic Acids Res 2003; 31:4472-80.PMID:12888507; http://dx.doi.org/10.1093/nar/ gkg633.
26. Cullen BR. Transcription and processing of human microRNA precursors. Mol Cell 2004; 16:861-5.PMID:15610730; http://dx.doi.org/10.1016/j.mol-cel.2004.12.002.
27. Glisovic T, Bachorik JL, Yong J, Dreyfuss G. RNA-binding proteins and post-transcriptional gene regulation. FEBS Lett 2008; 582:1977-86.PMID:18342629; http://dx.doi.org/10.1016/j.febs-let.2008.03.004.